PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32698439-8 2020 Fasting insulin and hepatic Plin5 protein level increased in the group supplemented with the EPA + DHA optimized product (38.35 g/100 g total fatty acids) compared to obese mice without fish oil supplementation. Fatty Acids 142-153 perilipin 5 Mus musculus 28-33 33373698-7 2021 Old Plin5-/- mice had reduced levels of cardiac triacylglycerides, increased heart weight, and apart from modest elevated expression of mRNAs for beta myosin heavy chain Myh7 and the fatty acid transporter Cd36, other genes involved in fatty acid oxidation, glycogen metabolism and glucose utilization were essentially unchanged by removal of Plin5. Fatty Acids 183-193 perilipin 5 Mus musculus 4-9 33373698-7 2021 Old Plin5-/- mice had reduced levels of cardiac triacylglycerides, increased heart weight, and apart from modest elevated expression of mRNAs for beta myosin heavy chain Myh7 and the fatty acid transporter Cd36, other genes involved in fatty acid oxidation, glycogen metabolism and glucose utilization were essentially unchanged by removal of Plin5. Fatty Acids 236-246 perilipin 5 Mus musculus 4-9 33334871-4 2021 Expression of phosphorylation-defective PLIN5 S155A in Plin5 null cells resulted in decreased rates of lipolysis and triglyceride-derived fatty acid oxidation compared with cells expressing wildtype PLIN5. Fatty Acids 138-148 perilipin 5 Mus musculus 40-45 33334871-4 2021 Expression of phosphorylation-defective PLIN5 S155A in Plin5 null cells resulted in decreased rates of lipolysis and triglyceride-derived fatty acid oxidation compared with cells expressing wildtype PLIN5. Fatty Acids 138-148 perilipin 5 Mus musculus 55-60 33334871-7 2021 Re-expression of PLIN5 S155A in the liver of Plin5 liver-specific null mice reduced lipolysis when compared to mice with wildtype PLIN5 re-expression, but was not associated with other changes in hepatic lipid metabolism, such as fatty acid oxidation, de novo lipogenesis and triglyceride secretion. Fatty Acids 230-240 perilipin 5 Mus musculus 17-22 31291602-0 2019 Plin5 deficiency exacerbates pressure overload-induced cardiac hypertrophy and heart failure by enhancing myocardial fatty acid oxidation and oxidative stress. Fatty Acids 117-127 perilipin 5 Mus musculus 0-5 31932301-8 2020 Taken together, these data show that PLIN5 signals via SIRT1 to promote autophagy and prevent fatty acid-induced inflammation as a means to maintain hepatocyte homeostasis during periods of fasting and FA mobilization. Fatty Acids 94-104 perilipin 5 Mus musculus 37-42 29378767-3 2018 High-fat feeding induced changes in muscle lipid metabolism of Plin5MKO mice, which included increased fatty acid oxidation and oxidative stress but, surprisingly, a reduction in inflammation and endoplasmic reticulum (ER) stress. Fatty Acids 103-113 perilipin 5 Mus musculus 63-68 30617219-4 2019 Hepatocytes isolated from Plin5LKO mice exhibited marked changes in lipid metabolism characterized by decreased fatty acid uptake and storage, decreased fatty acid oxidation that was associated with reduced contact between lipid droplets and mitochondria, and reduced triglyceride secretion. Fatty Acids 112-122 perilipin 5 Mus musculus 26-31 30617219-4 2019 Hepatocytes isolated from Plin5LKO mice exhibited marked changes in lipid metabolism characterized by decreased fatty acid uptake and storage, decreased fatty acid oxidation that was associated with reduced contact between lipid droplets and mitochondria, and reduced triglyceride secretion. Fatty Acids 153-163 perilipin 5 Mus musculus 26-31 29698803-7 2018 Among proteins observed to have higher abundance on LDs in the fasted state we found perilipin-5, and several mitochondrial and peroxisomal marker proteins, supporting the role of LDs in the provision of substrates for fatty acid oxidation. Fatty Acids 219-229 perilipin 5 Mus musculus 85-96 28811250-2 2017 Previously, we showed that deficiency in the lipid droplet protein perilipin 5 (Plin5) markedly reduces triglyceride storage in cardiomyocytes and increases the flux of fatty acids into phospholipids. Fatty Acids 169-180 perilipin 5 Mus musculus 67-78 28811250-2 2017 Previously, we showed that deficiency in the lipid droplet protein perilipin 5 (Plin5) markedly reduces triglyceride storage in cardiomyocytes and increases the flux of fatty acids into phospholipids. Fatty Acids 169-180 perilipin 5 Mus musculus 80-85 27376234-4 2016 Under normal conditions, Plin5(-/-) mice maintained a close to normal heart function by decreasing fatty acid uptake and increasing glucose uptake, thus preserving the energy balance. Fatty Acids 99-109 perilipin 5 Mus musculus 25-30 25418045-10 2015 The strong increase in protein levels of phosphorylated PKA in CM of Plin5 transgenic mice may partially restore fatty acid release from Plin5-enriched LDs, rendering these hearts compatible with normal heart function despite massive steatosis. Fatty Acids 113-123 perilipin 5 Mus musculus 69-74 25179419-6 2015 Using Plin5 knockout mice, we found that Plin5 deficiency resulted in reduced hepatic lipid content and smaller-sized LDs, which was due to the elevated lipolysis rate and fatty acid utilization. Fatty Acids 172-182 perilipin 5 Mus musculus 41-46 25418045-10 2015 The strong increase in protein levels of phosphorylated PKA in CM of Plin5 transgenic mice may partially restore fatty acid release from Plin5-enriched LDs, rendering these hearts compatible with normal heart function despite massive steatosis. Fatty Acids 113-123 perilipin 5 Mus musculus 137-142 24972504-10 2014 We suggest that PLIN5 is an important regulator of lipid droplet turnover in altered conditions of fatty acid supply and consumption. Fatty Acids 99-109 perilipin 5 Mus musculus 16-21 24535284-1 2014 PURPOSE OF REVIEW: We summarize recent mechanistic and physiological studies related to the role of perilipin 5 (Plin5) in regulating lipid droplet accumulation and protection to fatty acids in tissues with high lipid oxidative metabolism. Fatty Acids 179-190 perilipin 5 Mus musculus 100-111 24535284-1 2014 PURPOSE OF REVIEW: We summarize recent mechanistic and physiological studies related to the role of perilipin 5 (Plin5) in regulating lipid droplet accumulation and protection to fatty acids in tissues with high lipid oxidative metabolism. Fatty Acids 179-190 perilipin 5 Mus musculus 113-118 24535284-6 2014 These data suggest a cytoprotective role for Plin5 to promote lipid storage but to limit fatty acid toxicity, parameters critical for tissues with high lipid oxidative metabolism. Fatty Acids 89-99 perilipin 5 Mus musculus 45-50 24535284-7 2014 SUMMARY: In-vivo and in-vitro data suggest that Plin5 is part of a cell-adaptive response to high lipid oxidative metabolism to protect lipid droplet storage against neutral lipases and, so, limit fatty acid accumulation. Fatty Acids 197-207 perilipin 5 Mus musculus 48-53 23606724-0 2013 Fatty acids regulate perilipin5 in muscle by activating PPARdelta. Fatty Acids 0-11 perilipin 5 Mus musculus 21-31 23606724-10 2013 Our analyses demonstrate that FAs require PPARdelta to induce transcription of Plin4 and Plin5. Fatty Acids 30-33 perilipin 5 Mus musculus 89-94 23345410-4 2013 In this study we show that mice with cardiac muscle-specific overexpression of perilipin 5 (CM-Plin5) massively accumulate TG in CM, which is accompanied by moderately reduced fatty acid (FA) oxidizing gene expression levels. Fatty Acids 176-186 perilipin 5 Mus musculus 79-90 23345410-4 2013 In this study we show that mice with cardiac muscle-specific overexpression of perilipin 5 (CM-Plin5) massively accumulate TG in CM, which is accompanied by moderately reduced fatty acid (FA) oxidizing gene expression levels. Fatty Acids 176-186 perilipin 5 Mus musculus 95-100 22532565-0 2012 Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation. Fatty Acids 99-109 perilipin 5 Mus musculus 0-11 22532565-9 2012 Cultured cardiomyocytes from Plin5-null mice more actively oxidized fatty acid than those of wild-type mice. Fatty Acids 68-78 perilipin 5 Mus musculus 29-34 17234449-0 2007 LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. Fatty Acids 49-59 perilipin 5 Mus musculus 0-5 17234449-7 2007 The LSDP5 gene is primarily transcribed in cells that actively oxidize fatty acids, such as heart, red muscle and liver. Fatty Acids 71-82 perilipin 5 Mus musculus 4-9