PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16461407-1 2006 Secretory human phospholipase A2 type IIA (PLA2-IIA) catalyzes the hydrolysis of the sn-2 ester bond in glycerolipids to produce fatty acids and lysolipids. Fatty Acids 129-140 phospholipase A2 group IIA Homo sapiens 43-47 21415526-3 2011 In the present study, we examined the possible involvement of intracellular phospholipase A(2) (PLA(2))s including group IVA, IVC, VIA, and VIB PLA(2)s, which catalyze the release of endogenous fatty acids, in the deposition of TG in hepatocytes. Fatty Acids 194-205 phospholipase A2 group IIA Homo sapiens 96-104 17355873-5 2007 The lyso-lipid leaves the membrane while the number of PLA(2) molecules bound to the interface increases with increasing fatty acid content. Fatty Acids 121-131 phospholipase A2 group IIA Homo sapiens 55-60 17355873-7 2007 These are discussed in terms of a model of fatty-acid mediated activation of PLA(2). Fatty Acids 43-53 phospholipase A2 group IIA Homo sapiens 77-83 16824796-1 2006 Phospholipases A(2) (PLA(2)s) are responsible for releasing the fatty acid moiety from the sn-2 position of phospholipids. Fatty Acids 64-74 phospholipase A2 group IIA Homo sapiens 21-28 16967904-1 2006 Phospholipase A2s (PLA2) are a class of enzymes, which catalyze the hydrolysis of membrane phospholipids at the sn-2 position to release fatty acids and lysophospholipids. Fatty Acids 137-148 phospholipase A2 group IIA Homo sapiens 19-23 16392040-2 2005 Common among all sPLA2 is the ability to cleave acyl groups of phospholipids at C2 of the glycerol backbone, thereby releasing fatty acid and a lysophospholipid. Fatty Acids 127-137 phospholipase A2 group IIA Homo sapiens 17-22 16443151-1 2006 Phospholipases A2 (PLA2) comprise a set of extracellular and intracellular enzymes that catalyze the hydrolysis of the sn-2 fatty acyl bond of phospholipids to yield fatty acids and lysophospholipids. Fatty Acids 166-177 phospholipase A2 group IIA Homo sapiens 19-23 12876405-1 2003 Phospholipases A(2) (PLA(2)s) are enzymes responsible for mobilization of fatty acids, including arachidonic acid (AA), from phospholipids. Fatty Acids 74-85 phospholipase A2 group IIA Homo sapiens 21-28 12742226-5 2003 It is required to identify the downstream events that occur upon PLA(2) activation, particularly target protein or metabolic pathway for liberated arachidonic acid or other fatty acids. Fatty Acids 173-184 phospholipase A2 group IIA Homo sapiens 65-71 11141053-4 2001 Here we describe the crystal structure of one such Lys49 PLA2, piratoxin-II, in which a fatty acid molecule is observed within the substrate channel. Fatty Acids 88-98 phospholipase A2 group IIA Homo sapiens 57-61 11469536-2 2001 Secretory type IIA PLA2 (sPLA2-IIA), which hydrolyzes fatty acids bound at the sn-2 position of glycerophospholipids, has been detected universally in a variety of mammalian tissues and cells. Fatty Acids 54-65 phospholipase A2 group IIA Homo sapiens 19-23 14499668-3 2003 Low concentrations of melittin and PLAP were observed to inhibit sPLA2-triggered release of fatty acids from erythrocyte membranes. Fatty Acids 92-103 phospholipase A2 group IIA Homo sapiens 65-70 12531539-4 2002 Among the fatty acids released by PLA(2), arachidonic acid (AA) is of particular biological importance, because it is subsequently converted to prostanoids and leukotrienes by cyclooxygenases (COX) and lipoxygenases (LOX), respectively. Fatty Acids 10-21 phospholipase A2 group IIA Homo sapiens 34-40 11141053-6 2001 Comparison of the present structure with other PLA2s, both active and inactive, identifies Lys122 as one of the likely causes of the increased affinity for fatty acid in Lys49 enzymes. Fatty Acids 156-166 phospholipase A2 group IIA Homo sapiens 47-52 10905638-1 2000 Phospholipases A2 (PLA2s) regulate hydrolysis of fatty acids, including arachidonic acid, from the sn-2 position of phospholipid membranes. Fatty Acids 49-60 phospholipase A2 group IIA Homo sapiens 19-24 10807743-1 2000 Phospholipase A(2)s (PLA(2)s) constitute a family of enzymes that hydrolyze fatty acids of membrane phospholipids, thus initiating the synthesis of proinflammatory mediators. Fatty Acids 76-87 phospholipase A2 group IIA Homo sapiens 0-19 10807743-1 2000 Phospholipase A(2)s (PLA(2)s) constitute a family of enzymes that hydrolyze fatty acids of membrane phospholipids, thus initiating the synthesis of proinflammatory mediators. Fatty Acids 76-87 phospholipase A2 group IIA Homo sapiens 21-28 10207008-5 1999 In this study, we demonstrate that exogenous hsPLA2-V has much greater activity than does group IIa PLA2 to release fatty acids from various mammalian cells and to elicit leukotriene B4 formation from human neutrophils. Fatty Acids 116-127 phospholipase A2 group IIA Homo sapiens 47-51 10735945-1 2000 Phospholipases A2 (PLA2) catalyse the release of fatty acids from the sn-2 position of phospholipids and have been suggested to play a key part in permeability barrier homeostasis. Fatty Acids 49-60 phospholipase A2 group IIA Homo sapiens 19-23 10064828-8 1999 Studies of the cellular role played by PLA2 suggest that decreased calcium-stimulated PLA2 activity, as also occurs in striatum of chronic human cocaine users, may be due, in part, to increased dopaminergic activity in the disorder, whereas increased calcium-independent PLA2 activity may be related to abnormal fatty acid metabolism and oxidative stress in schizophrenia. Fatty Acids 312-322 phospholipase A2 group IIA Homo sapiens 39-43 10064828-8 1999 Studies of the cellular role played by PLA2 suggest that decreased calcium-stimulated PLA2 activity, as also occurs in striatum of chronic human cocaine users, may be due, in part, to increased dopaminergic activity in the disorder, whereas increased calcium-independent PLA2 activity may be related to abnormal fatty acid metabolism and oxidative stress in schizophrenia. Fatty Acids 312-322 phospholipase A2 group IIA Homo sapiens 86-90 10064828-8 1999 Studies of the cellular role played by PLA2 suggest that decreased calcium-stimulated PLA2 activity, as also occurs in striatum of chronic human cocaine users, may be due, in part, to increased dopaminergic activity in the disorder, whereas increased calcium-independent PLA2 activity may be related to abnormal fatty acid metabolism and oxidative stress in schizophrenia. Fatty Acids 312-322 phospholipase A2 group IIA Homo sapiens 86-90 9822691-8 1998 3) The rates of exogenous hIIa-PLA2-catalyzed fatty acid release from wild type CHO-K1 cells and two mutant lines, one lacking glycosaminoglycan and one lacking heparan sulfate, were similar. Fatty Acids 46-56 phospholipase A2 group IIA Homo sapiens 31-35 10080349-11 1999 Whether the fatty acid release is due to the enzymatic activity of the K49 PLA2 or stimulation of tissue lipases, is unknown. Fatty Acids 12-22 phospholipase A2 group IIA Homo sapiens 75-79 9748613-5 1998 In contrast, high concentrations of group I PLA2 were required to release fatty acids from a promyelocytic cell line (HL-60) and this release was not selective for AA. Fatty Acids 74-85 phospholipase A2 group IIA Homo sapiens 44-48 9799801-12 1998 As sPLA2-induced hydrolysis of the lipoproteins leads to accumulation of lysophosphatidylcholine and potentially toxic oxygenated fatty acids, overexpression of this enzyme may be proatherogenic. Fatty Acids 130-141 phospholipase A2 group IIA Homo sapiens 3-8 9822691-9 1998 Thus basic residues that modulate interfacial binding are important for plasma membrane fatty acid release by exogenously added hIIa-PLA2. Fatty Acids 88-98 phospholipase A2 group IIA Homo sapiens 133-137 7655056-6 1995 Compared to phospholipids containing other fatty acids, only arachidonyl-phospholipid (arachidonyl-PL) was significantly hydrolyzed by PLA2 activity in A23187-stimulated glands. Fatty Acids 43-54 phospholipase A2 group IIA Homo sapiens 135-139 9421195-1 1997 Several lines of evidence have suggested that the plasma membranes of cells elicited by proinflammatory stimuli or microvesicles shed from activated cells are sensitive to extracellular type II secretory phospholipase A2 (sPLA2) that liberates fatty acids and lysophospholipids. Fatty Acids 244-255 phospholipase A2 group IIA Homo sapiens 222-227 9032172-1 1997 Phospholipases A2 (PLA2) hydrolyze phospholipids resulting in the release of fatty acids including arachidonic acid (AA) and lysophospholipids. Fatty Acids 77-88 phospholipase A2 group IIA Homo sapiens 19-23 8934451-3 1996 Sterols structurally related to cholesterol and some steryl esters inhibited the activity of L. giganteum phospholipase A2 (PLA2), an enzyme that hydrolyzes fatty acids from the sn-2 position of glycerophospholipids. Fatty Acids 157-168 phospholipase A2 group IIA Homo sapiens 124-128 7722506-1 1995 Phospholipases A2 (PLA2) are a family of enzymes that catalyze the removal of fatty acid residues from phosphoglycerides. Fatty Acids 78-88 phospholipase A2 group IIA Homo sapiens 19-23 8328965-10 1993 Changes in the ability of PLA2 to associate with cellular membranes may thus be regarded as an important molecular mechanism underlying the increase in fatty acid metabolism observed in activated cells. Fatty Acids 152-162 phospholipase A2 group IIA Homo sapiens 26-30 8053897-5 1994 By contrast, Type I and Type II PLA2s were less selective in releasing AA from phospholipids and released a variety of unsaturated fatty acids at molar ratios that were proportional to the ratios of these fatty acids in U937 microsomal membranes. Fatty Acids 131-142 phospholipase A2 group IIA Homo sapiens 32-37 8422369-2 1993 The temporal relationship between the burst of PLA2 activity and the lateral distribution of substrate and product lipids was examined by simultaneously recording product accumulation and the fluorescence of 1-pyrenyldecanoate, a fatty acid derivative sensitive to lipid distribution and lateral diffusion. Fatty Acids 230-240 phospholipase A2 group IIA Homo sapiens 47-51 34478892-4 2021 Herein, we review the existing literature about the implications of phospholipases 2 (PLA2s), a large family of enzymes that catalyze the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, in ARDS-related pathology. Fatty Acids 152-163 phospholipase A2 group IIA Homo sapiens 86-91 2377623-11 1990 The final steps of secretion can thus be subdivided into a Ca2(+)-dependent and -independent process: first, a Ca2(+)-dependent activation of PLA2 liberating fatty acids from phospholipids and second, a Ca2(+)-independent processing to the terminal fusogen and subsequent Ca2(+)-independent fusion of the CGs with the PM. Fatty Acids 158-169 phospholipase A2 group IIA Homo sapiens 142-146 30412818-1 2019 Phospholipases A2 (PLA2) are a diverse group of enzymes that cleave the fatty acids of membrane phospholipids. Fatty Acids 72-83 phospholipase A2 group IIA Homo sapiens 19-23 29129849-4 2017 Recent evidence indicates that PLA2s also contribute to phospholipid remodeling for membrane homeostasis or energy production for fatty acid beta-oxidation. Fatty Acids 130-140 phospholipase A2 group IIA Homo sapiens 31-36 29505564-1 2018 Phospholipases A2 (PLA2) are enzymes acting on the cell membrane phospholipids resulting in fatty acids and lysophospholipids and deconstructing the cell membrane. Fatty Acids 92-103 phospholipase A2 group IIA Homo sapiens 19-23 23681524-4 2013 PLA2 specifically hydrolyzes the fatty acid ester linkage in the sn-2-position of phospholipids to liberate sn-2-linked fatty acids and the corresponding LPL. Fatty Acids 33-49 phospholipase A2 group IIA Homo sapiens 0-4 24573693-1 2014 Phospholipases A(2) (PLA(2)s) are important enzymes for the metabolism of fatty acids in membrane phospholipids. Fatty Acids 74-85 phospholipase A2 group IIA Homo sapiens 21-28 22923652-5 2012 We found that a selective inhibitor of human pla2g2a (5-(4-benzyloxyphenyl)-(4S)-(phenyl-heptanoylamino)-pentanoic acid [KH064]) attenuated secretion of PGE(2) from human immune cells stimulated with the fatty acid, palmitic acid, or with lipopolysaccharide. Fatty Acids 204-214 phospholipase A2 group IIA Homo sapiens 45-52