PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26628791-1 2015 This cross-sectional study was to evaluate the levels of urinary liver-type fatty acid binding protein (u-LFABP pg/mg urine creatinine ratio) at different stages of diabetic nephropathy and to see its correlation with other clinical parameters in South Indian patients with type 2 diabetes mellitus (T2DM). Fatty Acids 76-86 fatty acid binding protein 1 Homo sapiens 106-111 25581374-4 2015 Genes associated with metabolism regulation and encoding liver fatty acid-binding protein (FABP1), aldehyde dehydrogenase 1 family member L1 (ALDH1L1), and vitronectin (VTN) were the most-significantly down-regulated in KS, as confirmed by quantitative reverse transcription PCR. Fatty Acids 63-73 fatty acid binding protein 1 Homo sapiens 91-96 25732850-1 2015 Although expression of the human liver fatty acid binding protein (FABP1) T94A variant alters serum lipoprotein cholesterol levels in human subjects, nothing is known whereby the variant elicits these effects. Fatty Acids 39-49 fatty acid binding protein 1 Homo sapiens 67-72 24875102-0 2014 Human FABP1 T94A variant impacts fatty acid metabolism and PPAR-alpha activation in cultured human female hepatocytes. Fatty Acids 33-43 fatty acid binding protein 1 Homo sapiens 6-11 24875102-1 2014 Although human liver fatty acid-binding protein (FABP1) T94A variant has been associated with nonalcoholic fatty liver disease and reduced ability of fenofibrate to lower serum triglycerides (TG) to target levels, molecular events leading to this phenotype are poorly understood. Fatty Acids 21-31 fatty acid binding protein 1 Homo sapiens 49-54 24371263-6 2014 Fatty acid beta-oxidation pathways including PPAR-alpha, carnitine palmitoyltransferase 1, acyl-CoA oxidase, and L-FABP were downregulated. Fatty Acids 0-10 fatty acid binding protein 1 Homo sapiens 113-119 24628888-0 2014 Structural and functional interaction of fatty acids with human liver fatty acid-binding protein (L-FABP) T94A variant. Fatty Acids 41-52 fatty acid binding protein 1 Homo sapiens 64-96 24628888-0 2014 Structural and functional interaction of fatty acids with human liver fatty acid-binding protein (L-FABP) T94A variant. Fatty Acids 41-52 fatty acid binding protein 1 Homo sapiens 98-104 24205707-2 2013 Fatty acids are bound with L-FABP and transported to the mitochondria or peroxisomes, where fatty acids are beta-oxidized, and this may play a role in fatty acid homeostasis. Fatty Acids 0-11 fatty acid binding protein 1 Homo sapiens 27-33 23803374-2 2013 Liver-type fatty acid binding protein (L-FABP) plays a key role in the fatty acid metabolism of the liver. Fatty Acids 11-21 fatty acid binding protein 1 Homo sapiens 39-45 24006842-2 2013 Liver fatty acid binding protein (L-FABP) is expressed highly in hepatocytes and binds fatty acids. Fatty Acids 87-98 fatty acid binding protein 1 Homo sapiens 0-32 24006842-2 2013 Liver fatty acid binding protein (L-FABP) is expressed highly in hepatocytes and binds fatty acids. Fatty Acids 87-98 fatty acid binding protein 1 Homo sapiens 34-40 24006842-4 2013 In the present study, the binding interaction of 17 structurally diverse PFCs with human L-FABP was investigated to assess their potential disruption effect on fatty acid binding. Fatty Acids 160-170 fatty acid binding protein 1 Homo sapiens 89-95 24205707-2 2013 Fatty acids are bound with L-FABP and transported to the mitochondria or peroxisomes, where fatty acids are beta-oxidized, and this may play a role in fatty acid homeostasis. Fatty Acids 92-103 fatty acid binding protein 1 Homo sapiens 27-33 24205707-2 2013 Fatty acids are bound with L-FABP and transported to the mitochondria or peroxisomes, where fatty acids are beta-oxidized, and this may play a role in fatty acid homeostasis. Fatty Acids 92-102 fatty acid binding protein 1 Homo sapiens 27-33 23065214-1 2013 Liver fatty acid binding protein (L-FABP) is a member of intracellular lipid-binding proteins responsible for the transportation of fatty acids. Fatty Acids 132-143 fatty acid binding protein 1 Homo sapiens 0-32 23318274-0 2013 The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARalpha; and repressed by C/EBPalpha: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease. Fatty Acids 16-26 fatty acid binding protein 1 Homo sapiens 44-49 23318274-0 2013 The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARalpha; and repressed by C/EBPalpha: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease. Fatty Acids 16-26 fatty acid binding protein 1 Homo sapiens 138-143 23318274-1 2013 Liver fatty acid binding protein (FABP1) prevents lipotoxicity of free fatty acids and regulates fatty acid trafficking and partition. Fatty Acids 6-16 fatty acid binding protein 1 Homo sapiens 34-39 23318274-1 2013 Liver fatty acid binding protein (FABP1) prevents lipotoxicity of free fatty acids and regulates fatty acid trafficking and partition. Fatty Acids 71-81 fatty acid binding protein 1 Homo sapiens 34-39 23365010-5 2013 qRT-PCR profiles of CLAs and their precursor FAs clearly showed upregulation of FAT, GLUT-2, and L-FABP (~0.5-2.0-fold). Fatty Acids 45-48 fatty acid binding protein 1 Homo sapiens 97-103 23065214-1 2013 Liver fatty acid binding protein (L-FABP) is a member of intracellular lipid-binding proteins responsible for the transportation of fatty acids. Fatty Acids 132-143 fatty acid binding protein 1 Homo sapiens 34-40 21856370-0 2012 Human liver fatty acid binding protein (hFABP1) gene is regulated by liver-enriched transcription factors HNF3beta and C/EBPalpha. Fatty Acids 12-22 fatty acid binding protein 1 Homo sapiens 40-46 22658694-2 2012 Urinary liver-type fatty acid binding protein (U-L-FABP), which is produced in the proximal tubule by renal hypoxia and oxidative stress, has been identified as a useful marker for diagnosis of acute kidney disease and a predictor of future events in chronic kidney disease. Fatty Acids 19-29 fatty acid binding protein 1 Homo sapiens 49-55 22763949-2 2012 Two lipid-functionalized gadolinium chelates have been investigated for the targeting of the human liver fatty acid binding protein (hL-FABP) as a means of increasing the sensitivity and specificity of intracellular-directed MRI probes. Fatty Acids 105-115 fatty acid binding protein 1 Homo sapiens 133-140 22763949-4 2012 The interaction modes of a fatty acid and a bile acid based gadolinium complex with hL-FABP have been characterized by relaxometric and NMR experiments in solution with close-to-physiological protein concentrations. Fatty Acids 27-37 fatty acid binding protein 1 Homo sapiens 84-91 22713574-1 2012 Liver fatty acid binding protein (L-FABP), a cytosolic protein most abundant in liver, is associated with intracellular transport of fatty acids, nuclear signaling, and regulation of intracellular lipolysis. Fatty Acids 133-144 fatty acid binding protein 1 Homo sapiens 0-32 22713574-1 2012 Liver fatty acid binding protein (L-FABP), a cytosolic protein most abundant in liver, is associated with intracellular transport of fatty acids, nuclear signaling, and regulation of intracellular lipolysis. Fatty Acids 133-144 fatty acid binding protein 1 Homo sapiens 34-40 22713574-2 2012 Among the members of the intracellular lipid binding protein family, L-FABP is of particular interest as it can i), bind two fatty acid molecules simultaneously and ii), accommodate a variety of bulkier physiological ligands such as bilirubin and fatty acyl CoA. Fatty Acids 125-135 fatty acid binding protein 1 Homo sapiens 69-75 22465531-1 2012 Liver fatty acid-binding protein (FABP1) serves as a key regulator of hepatic lipid metabolism, and polymorphisms within the FABP1 gene have been associated with several metabolic traits. Fatty Acids 6-16 fatty acid binding protein 1 Homo sapiens 34-39 22465531-1 2012 Liver fatty acid-binding protein (FABP1) serves as a key regulator of hepatic lipid metabolism, and polymorphisms within the FABP1 gene have been associated with several metabolic traits. Fatty Acids 6-16 fatty acid binding protein 1 Homo sapiens 125-130 21856370-1 2012 The human liver fatty acid binding protein (hFABP1) participates in cellular long-chain fatty acid trafficking and regulation of lipid metabolism and changes in hFABP1 are associated with an increased risk for type 2 diabetes, cardiovascular disease (CVD), and metabolic syndromes. Fatty Acids 16-26 fatty acid binding protein 1 Homo sapiens 44-50 21856370-1 2012 The human liver fatty acid binding protein (hFABP1) participates in cellular long-chain fatty acid trafficking and regulation of lipid metabolism and changes in hFABP1 are associated with an increased risk for type 2 diabetes, cardiovascular disease (CVD), and metabolic syndromes. Fatty Acids 16-26 fatty acid binding protein 1 Homo sapiens 161-167 21573793-1 2012 Liver-type fatty acid-binding protein (L-FABP) is a member of intracellular lipid-binding proteins involved in the transportation of fatty acids. Fatty Acids 133-144 fatty acid binding protein 1 Homo sapiens 0-37 21573793-1 2012 Liver-type fatty acid-binding protein (L-FABP) is a member of intracellular lipid-binding proteins involved in the transportation of fatty acids. Fatty Acids 133-144 fatty acid binding protein 1 Homo sapiens 39-45 21757748-1 2011 We crystallized human liver fatty acid-binding protein (LFABP) in apo, holo, and intermediate states of palmitic acid engagement. Fatty Acids 28-38 fatty acid binding protein 1 Homo sapiens 56-61 21757748-2 2011 Structural snapshots of fatty acid recognition, entry, and docking within LFABP support a heads-in mechanism for ligand entry. Fatty Acids 24-34 fatty acid binding protein 1 Homo sapiens 74-79 21539932-1 2011 Intestinal and liver fatty acid binding proteins (IFABP and LFABP, respectively) are cytosolic soluble proteins with the capacity to bind and transport hydrophobic ligands between different sub-cellular compartments. Fatty Acids 21-31 fatty acid binding protein 1 Homo sapiens 60-65 20721681-0 2010 L-FABP T94A decreased fatty acid uptake and altered hepatic triglyceride and cholesterol accumulation in Chang liver cells stably transfected with L-FABP. Fatty Acids 22-32 fatty acid binding protein 1 Homo sapiens 0-6 21226535-1 2011 Liver fatty acid-binding protein (LFABP) is a 14 kDa cytosolic polypeptide, differing from other family members in the number of ligand binding sites, the diversity of bound ligands, and the transfer of fatty acid(s) to membranes primarily via aqueous diffusion rather than direct collisional interactions. Fatty Acids 6-16 fatty acid binding protein 1 Homo sapiens 34-39 20721681-2 2010 This study was undertaken to verify whether the T94A mutation in the L-FABP gene affects fatty acid uptake and intracellular esterification into specific lipid pools. Fatty Acids 89-99 fatty acid binding protein 1 Homo sapiens 69-75 17425983-10 2007 Expression of L-FABP is associated with VEGF expression, suggesting that L-FABP promotes the growth of blood vessels by taking up the fatty acids from the bloodstream, and both of them produce a marked effect on energy metabolism in HCC. Fatty Acids 134-145 fatty acid binding protein 1 Homo sapiens 14-20 20628144-4 2010 In living cells, glucose stimulated cellular uptake and nuclear localization of a nonmetabolizable fluorescent fatty acid analog (BODIPY C-16), particularly in the presence of L-FABP. Fatty Acids 111-121 fatty acid binding protein 1 Homo sapiens 176-182 20185732-1 2010 OBJECTIVE: Urinary liver-type fatty acid-binding protein (u-LFABP) is a marker of tubulointerstitial inflammation and has been shown to be increased in patients with type 1 diabetes and is further increased in patients who progress to micro- and macroalbuminuria. Fatty Acids 30-40 fatty acid binding protein 1 Homo sapiens 60-65 19943703-6 2010 Three fatty acid binding proteins (L-FABP, FABP-6, and I-FABP) showed changes in MSBR animals. Fatty Acids 6-16 fatty acid binding protein 1 Homo sapiens 35-41 19564911-2 2009 Liver fatty acid binding protein (LFABP) is a unique family member which accommodates two molecules of fatty acids in its cavity and exhibits the capability of interacting with a variety of ligands with different chemical structures and properties. Fatty Acids 103-114 fatty acid binding protein 1 Homo sapiens 0-32 19564911-2 2009 Liver fatty acid binding protein (LFABP) is a unique family member which accommodates two molecules of fatty acids in its cavity and exhibits the capability of interacting with a variety of ligands with different chemical structures and properties. Fatty Acids 103-114 fatty acid binding protein 1 Homo sapiens 34-39 18094680-2 2008 We examined whether levels of liver fatty acid-binding protein (L-FABP) can be an early biomarker for ischemic injury by measuring this protein in the urine of 40 pediatric patients prior to and following cardiopulmonary bypass surgery. Fatty Acids 36-46 fatty acid binding protein 1 Homo sapiens 64-70 20541621-1 2010 Liver fatty acid-binding protein (LFABP) is distinctive among fatty acid-binding proteins because it binds more than one molecule of long-chain fatty acid and a variety of diverse ligands. Fatty Acids 6-16 fatty acid binding protein 1 Homo sapiens 34-39 19217864-3 2009 In this study, we demonstrate the direct, albeit weak, interaction between MES and human liver fatty acid binding protein (hLFABP). Fatty Acids 95-105 fatty acid binding protein 1 Homo sapiens 123-129 17485234-7 2007 These results support previous findings in fenofibrate-treated individuals and thereby provide some additional indication of the functional relevance of the FABP1 T94A SNP in hepatic fatty acid and lipid metabolism in humans. Fatty Acids 183-193 fatty acid binding protein 1 Homo sapiens 157-162 17425983-10 2007 Expression of L-FABP is associated with VEGF expression, suggesting that L-FABP promotes the growth of blood vessels by taking up the fatty acids from the bloodstream, and both of them produce a marked effect on energy metabolism in HCC. Fatty Acids 134-145 fatty acid binding protein 1 Homo sapiens 73-79 16223942-3 2006 The liver fatty acid binding protein gene (Fabp1) has binding sites for both factors, and chromatin precipitation assays were utilized to demonstrate that HNF-4alpha increased HNF-1alpha Fabp1 promoter occupancy during cooperative transcriptional activation. Fatty Acids 10-20 fatty acid binding protein 1 Homo sapiens 43-48 16223942-3 2006 The liver fatty acid binding protein gene (Fabp1) has binding sites for both factors, and chromatin precipitation assays were utilized to demonstrate that HNF-4alpha increased HNF-1alpha Fabp1 promoter occupancy during cooperative transcriptional activation. Fatty Acids 10-20 fatty acid binding protein 1 Homo sapiens 187-192 16374067-9 2005 CONCLUSIONS: L-FABP, FAS and VEGF are highly expressed in human lung cancer, and expression of L-FABP is associated with that of VEGF but not that of FAS, suggesting that L-FABP might be involved in the uptake of fatty acid(s) from the bloodstream. Fatty Acids 213-223 fatty acid binding protein 1 Homo sapiens 95-101 16471039-2 2005 Liver fatty acid binding protein (L-FABP) and intestine fatty acid binding proteins were shown to be up-regulated in breast cancer cell lines while adipose- and epidermal-fatty acid binding proteins were down regulated in breast cancer cells compared to normal breast cell lines. Fatty Acids 6-16 fatty acid binding protein 1 Homo sapiens 34-40 16374067-9 2005 CONCLUSIONS: L-FABP, FAS and VEGF are highly expressed in human lung cancer, and expression of L-FABP is associated with that of VEGF but not that of FAS, suggesting that L-FABP might be involved in the uptake of fatty acid(s) from the bloodstream. Fatty Acids 213-223 fatty acid binding protein 1 Homo sapiens 95-101 14534295-0 2003 Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. Fatty Acids 56-66 fatty acid binding protein 1 Homo sapiens 103-135 15138477-1 2004 Liver fatty acid binding protein is a member of the fatty acid binding group of proteins that are involved in the intracellular transport of bioactive fatty acids and participate in intracellular signalling pathways, cell growth and differentiation. Fatty Acids 151-162 fatty acid binding protein 1 Homo sapiens 0-32 15249972-4 2004 LFABP is a small cytosolic protein of 14 kDa present in the liver and the intestine and is a member of the superfamily of the fatty acid binding proteins (FABPs). Fatty Acids 126-136 fatty acid binding protein 1 Homo sapiens 0-5 15249972-7 2004 Since PPARs are known to regulate the transcription of many genes involved in lipid metabolism, the importance of LFABP in fatty acid uptake has to be considered. Fatty Acids 123-133 fatty acid binding protein 1 Homo sapiens 114-119 15124915-7 2004 L-FABP expression enhanced uptake of BODIPY-C16 1.7-fold demonstrating that L-FABP enhanced saturated fatty acid uptake independent of metabolism. Fatty Acids 92-112 fatty acid binding protein 1 Homo sapiens 0-6 15124915-7 2004 L-FABP expression enhanced uptake of BODIPY-C16 1.7-fold demonstrating that L-FABP enhanced saturated fatty acid uptake independent of metabolism. Fatty Acids 92-112 fatty acid binding protein 1 Homo sapiens 76-82 15035630-1 2004 Intestinal fatty acid binding protein (IFABP) and liver FABP (LFABP), homologous proteins expressed at high levels in intestinal absorptive cells, employ markedly different mechanisms for the transfer of fatty acids (FAs) to acceptor membranes. Fatty Acids 204-215 fatty acid binding protein 1 Homo sapiens 62-67 15035630-1 2004 Intestinal fatty acid binding protein (IFABP) and liver FABP (LFABP), homologous proteins expressed at high levels in intestinal absorptive cells, employ markedly different mechanisms for the transfer of fatty acids (FAs) to acceptor membranes. Fatty Acids 217-220 fatty acid binding protein 1 Homo sapiens 62-67 15035630-9 2004 These results demonstrate that the alpha-helical region of LFABP is responsible for its diffusional mechanism of fatty acid transfer to membranes. Fatty Acids 113-123 fatty acid binding protein 1 Homo sapiens 59-64 14992586-7 2004 Finally, solid-phase extraction and HPLC analysis revealed that, depending on the fatty acid content of the culture medium, L-FABP expression also increased the cellular LCFA-CoA pool size and altered the LCFA-CoA acyl chain composition. Fatty Acids 82-92 fatty acid binding protein 1 Homo sapiens 124-130 12479568-1 2002 Liver fatty acid binding protein (LFABP) is unique among the various types of FABPs in that it can bind a variety of ligands in addition to fatty acids. Fatty Acids 140-151 fatty acid binding protein 1 Homo sapiens 0-32 12707994-2 2003 The proximal tubular epithelial cells express liver-type fatty acid binding protein(L-FABP), an intracellular carrier protein of fatty acids. Fatty Acids 129-140 fatty acid binding protein 1 Homo sapiens 46-83 12707994-2 2003 The proximal tubular epithelial cells express liver-type fatty acid binding protein(L-FABP), an intracellular carrier protein of fatty acids. Fatty Acids 129-140 fatty acid binding protein 1 Homo sapiens 84-90 12479568-1 2002 Liver fatty acid binding protein (LFABP) is unique among the various types of FABPs in that it can bind a variety of ligands in addition to fatty acids. Fatty Acids 140-151 fatty acid binding protein 1 Homo sapiens 34-39 12479568-2 2002 LFABP is able to bind long chain fatty acids with a 2:1 stoichiometry and the crystal structure has identified two fatty acid binding sites in the binding cavity. Fatty Acids 33-43 fatty acid binding protein 1 Homo sapiens 0-5 11134959-2 2001 Two fatty acid-binding proteins (FABP), FABP-1 and FABP-2, were purified from the liver cytosol of the teleost, Lateolabrax japonicus (Japan sea bass), and characterized. Fatty Acids 4-14 fatty acid binding protein 1 Homo sapiens 40-46 11226238-0 2001 Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus. Fatty Acids 0-11 fatty acid binding protein 1 Homo sapiens 136-168 11226238-9 2001 This correlation constitutes a nucleus-directed signaling by fatty acids and hypolipidemic drugs where L-FABP acts as a cytosolic gateway for these PPARalpha and PPARgamma agonists. Fatty Acids 61-72 fatty acid binding protein 1 Homo sapiens 103-109 10331654-5 1999 Within the iLBP family, liver fatty acid binding protein or LFABP, has the unique property of binding two fatty acids within its internalized binding cavity rather than the commonly observed stoichiometry of one. Fatty Acids 106-117 fatty acid binding protein 1 Homo sapiens 60-65 10744786-1 2000 Intestinal enterocytes contain high concentrations of two cytosolic fatty acid-binding proteins (FABP), liver FABP (L-FABP) and intestinal FABP (I-FABP), which are hypothesized to play a role in cellular fatty acid trafficking. Fatty Acids 204-214 fatty acid binding protein 1 Homo sapiens 116-122 11329616-1 2001 Intestinal and liver fatty acid binding proteins (I- and L-FABP) are thought to play a role in enterocyte fatty acid (FA) trafficking. Fatty Acids 21-31 fatty acid binding protein 1 Homo sapiens 57-63 11329616-1 2001 Intestinal and liver fatty acid binding proteins (I- and L-FABP) are thought to play a role in enterocyte fatty acid (FA) trafficking. Fatty Acids 106-116 fatty acid binding protein 1 Homo sapiens 57-63 10684629-1 2000 Liver-type fatty acid binding protein (L-FABP) has been proposed to be involved in the transport of fatty acids and peroxisome proliferators from the cytosol into the nucleus for interaction with the peroxisome proliferator-activated receptors (PPARs). Fatty Acids 100-111 fatty acid binding protein 1 Homo sapiens 0-37 10684629-1 2000 Liver-type fatty acid binding protein (L-FABP) has been proposed to be involved in the transport of fatty acids and peroxisome proliferators from the cytosol into the nucleus for interaction with the peroxisome proliferator-activated receptors (PPARs). Fatty Acids 100-111 fatty acid binding protein 1 Homo sapiens 39-45 9914484-9 1999 L-FABP binds two fatty acids per molecule but Lb-FABP displays a fatty-acid-conformation-dependent binding stoichiometry; L-FABP shows a higher affinity for fatty acids, especially oleic acid, while Lb-FABP has a higher affinity for other hydrophobic ligands, especially retinoic acid. Fatty Acids 17-28 fatty acid binding protein 1 Homo sapiens 0-6 9914484-9 1999 L-FABP binds two fatty acids per molecule but Lb-FABP displays a fatty-acid-conformation-dependent binding stoichiometry; L-FABP shows a higher affinity for fatty acids, especially oleic acid, while Lb-FABP has a higher affinity for other hydrophobic ligands, especially retinoic acid. Fatty Acids 157-168 fatty acid binding protein 1 Homo sapiens 122-128 10064902-1 1999 The liver-type fatty acid binding protein (L-FABP), a member of a family of mostly cytosolic 14-15 kDa proteins known to bind fatty acids in vitro and in vivo, is discussed to play a role in fatty acid uptake. Fatty Acids 126-137 fatty acid binding protein 1 Homo sapiens 4-41 10064902-1 1999 The liver-type fatty acid binding protein (L-FABP), a member of a family of mostly cytosolic 14-15 kDa proteins known to bind fatty acids in vitro and in vivo, is discussed to play a role in fatty acid uptake. Fatty Acids 126-137 fatty acid binding protein 1 Homo sapiens 43-49 10064902-1 1999 The liver-type fatty acid binding protein (L-FABP), a member of a family of mostly cytosolic 14-15 kDa proteins known to bind fatty acids in vitro and in vivo, is discussed to play a role in fatty acid uptake. Fatty Acids 15-25 fatty acid binding protein 1 Homo sapiens 43-49 10064902-3 1999 First, L-FABP content was more than doubled upon treating the cells with the potent peroxisome proliferators bezafibrate and Wy14,643 and incubation of these cells with [1-14C]oleic acid led to an increase in fatty acid uptake rate from 0.55 to 0.74 and 0.98 nmol/min per mg protein, respectively. Fatty Acids 209-219 fatty acid binding protein 1 Homo sapiens 7-13 10064902-7 1999 The analysis of peroxisome proliferator-treated cells and L-FABP mRNA antisense clones revealed a direct correlation between L-FABP content and fatty acid uptake. Fatty Acids 144-154 fatty acid binding protein 1 Homo sapiens 58-64 10064902-7 1999 The analysis of peroxisome proliferator-treated cells and L-FABP mRNA antisense clones revealed a direct correlation between L-FABP content and fatty acid uptake. Fatty Acids 144-154 fatty acid binding protein 1 Homo sapiens 125-131 9397406-4 1997 In contrast, the other major fatty-acid binding protein in liver, fatty-acid binding protein (L-FABP), displayed a much narrower carbon chain preference in general: polyunsaturated fatty acids > branched-chain phytol-derived fatty acids > 14- and 16-carbon saturated > branched-chain isoprenoids. Fatty Acids 29-39 fatty acid binding protein 1 Homo sapiens 59-92 9688651-7 1998 The differential effect of these proteins on fatty acid uptake and intracellular trafficking in single cells illustrates a possible difference in the physiological function of I- and L-FABP in intact cells. Fatty Acids 45-55 fatty acid binding protein 1 Homo sapiens 183-189 9397406-4 1997 In contrast, the other major fatty-acid binding protein in liver, fatty-acid binding protein (L-FABP), displayed a much narrower carbon chain preference in general: polyunsaturated fatty acids > branched-chain phytol-derived fatty acids > 14- and 16-carbon saturated > branched-chain isoprenoids. Fatty Acids 29-39 fatty acid binding protein 1 Homo sapiens 94-100 9012666-1 1997 The effect of fatty acyl CoA and fatty acid on the solution structure and dynamics of two intestinal enterocyte fatty acid binding proteins, intestinal (I-FABP) and liver (L-FABP), was examined by time-resolved fluorescence of FABP aromatic amino acid residues. Fatty Acids 112-122 fatty acid binding protein 1 Homo sapiens 172-178 9370361-5 1997 The catfish basic L-FABP binds only one fatty acid/molecule, while mammalian L-FABP bind two. Fatty Acids 40-50 fatty acid binding protein 1 Homo sapiens 18-24 9012666-13 1997 Further, ligands such as fatty acids, fatty acyl CoAs, and/or CoASH differentially modulate the I-FABP and L-FABP dynamics, and the ligand binding sites of these proteins differ in their ability to order the ligands. Fatty Acids 25-36 fatty acid binding protein 1 Homo sapiens 107-113 8662836-10 1996 In contrast, the characteristics of fatty acid transfer from L-FABP are consistent with an aqueous diffusion-mediated process. Fatty Acids 36-46 fatty acid binding protein 1 Homo sapiens 61-67 8664328-1 1996 The role of cytosolic liver fatty acid binding protein (L-FABP) in fatty acid uptake and metabolism was examined using cultured L-cell fibroblasts transfected with the cDNA encoding for L-FABP. Fatty Acids 28-38 fatty acid binding protein 1 Homo sapiens 56-62 8664328-10 1996 Thus, L-FABP expression not only stimulated fatty acid uptake at all time points, but also stimulated intracellular esterification into specific lipid pools. Fatty Acids 44-54 fatty acid binding protein 1 Homo sapiens 6-12 8664328-11 1996 These results show in detail for the first time using an intact cell culture system that L-FABP expression not only stimulated fatty acid uptake, but also increased intracellular esterification of exogenously supplied fatty acids. Fatty Acids 127-137 fatty acid binding protein 1 Homo sapiens 89-95 8664328-11 1996 These results show in detail for the first time using an intact cell culture system that L-FABP expression not only stimulated fatty acid uptake, but also increased intracellular esterification of exogenously supplied fatty acids. Fatty Acids 218-229 fatty acid binding protein 1 Homo sapiens 89-95 8662836-12 1996 It is hypothesized that L-FABP may act as a cytosolic buffer for fatty acids, maintaining the unbound fatty acid concentration, whereas I-FABP may be involved in the uptake and/or specific targeting of fatty acid to subcellular membrane sites. Fatty Acids 65-76 fatty acid binding protein 1 Homo sapiens 24-30 8662836-12 1996 It is hypothesized that L-FABP may act as a cytosolic buffer for fatty acids, maintaining the unbound fatty acid concentration, whereas I-FABP may be involved in the uptake and/or specific targeting of fatty acid to subcellular membrane sites. Fatty Acids 65-75 fatty acid binding protein 1 Homo sapiens 24-30 8662836-12 1996 It is hypothesized that L-FABP may act as a cytosolic buffer for fatty acids, maintaining the unbound fatty acid concentration, whereas I-FABP may be involved in the uptake and/or specific targeting of fatty acid to subcellular membrane sites. Fatty Acids 102-112 fatty acid binding protein 1 Homo sapiens 24-30 34723386-4 2022 Here we present an approach to designing a fluorescence-based biosensor for the rapid detection of PFAS based on human liver fatty acid binding protein (hLFABP). Fatty Acids 125-135 fatty acid binding protein 1 Homo sapiens 153-159 7547928-2 1995 In this study, recombinant liver fatty acid binding protein (L-FABP) and sterol carrier protein-2 (SCP-2) were used in conjunction with a series of fluorescent fatty acid probe molecules to compare the relative dielectric properties of the ligand binding sites and to examine the effects of ethanol in vitro on ligand interaction with these proteins. Fatty Acids 33-43 fatty acid binding protein 1 Homo sapiens 61-67 7547928-5 1995 Furthermore, affinities of L-FABP for NBD-fatty acid probes were NBD-stearic acid > NBD-lauric acid >>> NBD-hexanoic acid, NBD-acetic acid. Fatty Acids 42-52 fatty acid binding protein 1 Homo sapiens 27-33 7547928-10 1995 In conclusion, the data show that both L-FABP and SCP-2 specifically bind fluorescent fatty acids. Fatty Acids 86-97 fatty acid binding protein 1 Homo sapiens 39-45 8068722-8 1994 L-FABP also binds palmitoyl derivatives and many other hydrophobic ligands--however, generally with a lower affinity than fatty acids. Fatty Acids 122-133 fatty acid binding protein 1 Homo sapiens 0-6 8068722-10 1994 Fatty acids with fluorescent reporter groups are also more tightly bound by L-FABP. Fatty Acids 0-11 fatty acid binding protein 1 Homo sapiens 76-82 8262919-3 1993 Although both long-chain dicarboxylic fatty acids, which are poorly metabolized in hepatocytes, and non-beta-oxidizable fatty acid analogs induce peroxisomal beta-oxidation and liver fatty acid-binding protein (L-FABP) by a pretranslational mechanism, monocarboxylic long-chain fatty acids, which are rapidly esterified and oxidized, do not. Fatty Acids 38-48 fatty acid binding protein 1 Homo sapiens 177-209 8262919-3 1993 Although both long-chain dicarboxylic fatty acids, which are poorly metabolized in hepatocytes, and non-beta-oxidizable fatty acid analogs induce peroxisomal beta-oxidation and liver fatty acid-binding protein (L-FABP) by a pretranslational mechanism, monocarboxylic long-chain fatty acids, which are rapidly esterified and oxidized, do not. Fatty Acids 38-48 fatty acid binding protein 1 Homo sapiens 211-217 8431458-1 1993 Liver fatty acid binding protein, L-FABP, is an abundant protein that binds fatty acids in vitro. Fatty Acids 6-16 fatty acid binding protein 1 Homo sapiens 34-40 8431458-1 1993 Liver fatty acid binding protein, L-FABP, is an abundant protein that binds fatty acids in vitro. Fatty Acids 76-87 fatty acid binding protein 1 Homo sapiens 34-40 8431458-11 1993 These alterations of plasma membrane structure and composition are consistent with a role for L-FABP in regulating intracellular sterol and fatty acid distribution and thereby membrane lipid domain structure. Fatty Acids 140-150 fatty acid binding protein 1 Homo sapiens 94-100 8609911-1 1995 Among the large family of fatty acid binding proteins, the liver L-FABP is unique in that it not only binds fatty acids but also interacts with sterols to enhance sterol transfer between membranes. Fatty Acids 26-36 fatty acid binding protein 1 Homo sapiens 65-71 8609911-1 1995 Among the large family of fatty acid binding proteins, the liver L-FABP is unique in that it not only binds fatty acids but also interacts with sterols to enhance sterol transfer between membranes. Fatty Acids 108-119 fatty acid binding protein 1 Homo sapiens 65-71 8068722-5 1994 The binding characteristics of delipidated recombinant human L-FABP and muscle FABP (M-FABP) for fatty acids of different chain length and saturation grade, and for various hydrophobic ligands, were determined by radiochemical analysis and also by fluorescence for L-FABP. Fatty Acids 97-108 fatty acid binding protein 1 Homo sapiens 61-67 8349710-2 1993 The mouse and rat liver fatty acid-binding protein (L-FABP) genes (Fabpl) represent an excellent model for understanding the mechanisms that determine differentiation-dependent, cell lineage-specific, and distinct regional patterns of expression along the crypt-to-villus and duodenal-to-ileal axes of the gut, as well as within the liver acinus. Fatty Acids 24-34 fatty acid binding protein 1 Homo sapiens 67-72 1894608-4 1991 Second derivative absorbance spectroscopy of the apo- and holoproteins suggested that fatty acid binding altered the conformation of L-FABP, but not of I-FABP. Fatty Acids 86-96 fatty acid binding protein 1 Homo sapiens 133-139 1894608-5 1991 Fatty acid binding also blocked the accessibility of L-FABP tyrosine and I-FABP tryptophan to Stern-Volmer quenching by acrylamide, indicating that these amino acids were present in the fatty acid-binding pocket. Fatty Acids 0-10 fatty acid binding protein 1 Homo sapiens 53-59 1894608-5 1991 Fatty acid binding also blocked the accessibility of L-FABP tyrosine and I-FABP tryptophan to Stern-Volmer quenching by acrylamide, indicating that these amino acids were present in the fatty acid-binding pocket. Fatty Acids 186-196 fatty acid binding protein 1 Homo sapiens 53-59 1894608-11 1991 The two proteins differ in that only L-FABP has two fatty acid-binding sites and appears to undergo significant conformational change upon fatty acid binding. Fatty Acids 52-62 fatty acid binding protein 1 Homo sapiens 37-43 1894608-11 1991 The two proteins differ in that only L-FABP has two fatty acid-binding sites and appears to undergo significant conformational change upon fatty acid binding. Fatty Acids 139-149 fatty acid binding protein 1 Homo sapiens 37-43 1711781-2 1991 We have previously used transgenic mice containing liver fatty acid binding protein/human growth hormone (L-FABP/hGH) fusion genes to analyze the molecular mechanisms responsible for encoding positional information in this epithelium. Fatty Acids 57-67 fatty acid binding protein 1 Homo sapiens 106-112 35599489-2 2022 Liver-type fatty acid-binding protein (L-FABP, also known as FABP1) is critical for fatty acid transport and may be involved in AD. Fatty Acids 84-94 fatty acid binding protein 1 Homo sapiens 0-37 34444927-0 2021 Decreased Fatty Acid Transporter FABP1 and Increased Isoprostanes and Neuroprostanes in the Human Term Placenta: Implications for Inflammation and Birth Weight in Maternal Pre-Gestational Obesity. Fatty Acids 10-20 fatty acid binding protein 1 Homo sapiens 33-38 35599489-2 2022 Liver-type fatty acid-binding protein (L-FABP, also known as FABP1) is critical for fatty acid transport and may be involved in AD. Fatty Acids 84-94 fatty acid binding protein 1 Homo sapiens 39-45 35599489-2 2022 Liver-type fatty acid-binding protein (L-FABP, also known as FABP1) is critical for fatty acid transport and may be involved in AD. Fatty Acids 84-94 fatty acid binding protein 1 Homo sapiens 61-66 2462524-1 1988 The intestine is lined by a continuously regenerating epithelium that maintains gradients in "liver" fatty acid binding protein (L-FABP) gene expression along its horizontal and vertical axes, i.e., from duodenum to colon and from crypt to villus tip. Fatty Acids 101-111 fatty acid binding protein 1 Homo sapiens 129-135 35140289-10 2022 Our findings suggest that direct activation of GLP-1R by Ex-4 reduces OA-induced steatosis in HepG2 cells by reducing fatty acid uptake and transport via FABP1 downregulation. Fatty Acids 118-128 fatty acid binding protein 1 Homo sapiens 154-159 33474764-3 2021 Liver-type fatty-acid binding protein (L-FABP), which is expressed in hepatocytes and the proximal tubules of the kidney, has been reported to be involved in fatty acid metabolism and has attracted attention as a biological marker for identifying and predicting a decline in renal function [3]. Fatty Acids 158-168 fatty acid binding protein 1 Homo sapiens 39-45 33789996-5 2021 The Fatty acids binding protein (FABPs) family of genes, specifically FABP1, FABP4 and FABP7 were also observed to be synergistically up-regulated in hypoxia by KSHV. Fatty Acids 4-15 fatty acid binding protein 1 Homo sapiens 70-75 33474764-3 2021 Liver-type fatty-acid binding protein (L-FABP), which is expressed in hepatocytes and the proximal tubules of the kidney, has been reported to be involved in fatty acid metabolism and has attracted attention as a biological marker for identifying and predicting a decline in renal function [3]. Fatty Acids 158-168 fatty acid binding protein 1 Homo sapiens 0-37 33789996-13 2021 Specifically, the Fatty acids binding protein (FABPs) family genes (FABP1, FABP4 and FABP7). Fatty Acids 18-29 fatty acid binding protein 1 Homo sapiens 68-73 32314395-2 2020 However, interpretation is complicated since ad libitum feeding of such diets induces hyperphagia and upregulates expression of liver fatty acid binding protein (L-FABP)-a protein intimately involved in fatty acid and glucose regulation of lipid metabolism. Fatty Acids 134-144 fatty acid binding protein 1 Homo sapiens 162-168 32922199-3 2020 Fatty acid-binding protein 1 (FABP1) is expressed in renal proximal tubule cells and released into urine in response to hypoxia caused by decreased peritubular capillary blood flow, and FABP2 is responsible for the transport of free fatty acids in the intestinal endothelium cells. Fatty Acids 233-244 fatty acid binding protein 1 Homo sapiens 0-28 32922199-3 2020 Fatty acid-binding protein 1 (FABP1) is expressed in renal proximal tubule cells and released into urine in response to hypoxia caused by decreased peritubular capillary blood flow, and FABP2 is responsible for the transport of free fatty acids in the intestinal endothelium cells. Fatty Acids 233-244 fatty acid binding protein 1 Homo sapiens 30-35 32314395-2 2020 However, interpretation is complicated since ad libitum feeding of such diets induces hyperphagia and upregulates expression of liver fatty acid binding protein (L-FABP)-a protein intimately involved in fatty acid and glucose regulation of lipid metabolism. Fatty Acids 203-213 fatty acid binding protein 1 Homo sapiens 162-168 28668637-4 2017 In our work, we performed a high resolution comparative molecular analysis of L-FABP T94T and L-FABP T94A in their unbound states and in the presence of representative ligands of the fatty acid and bile acid classes. Fatty Acids 183-193 fatty acid binding protein 1 Homo sapiens 78-84 32249562-2 2020 We developed a method by incorporating size exclusion column co-elution (SECC) and NTA, to screen PFASs binding to human liver fatty acid binding protein (hL-FABP). Fatty Acids 127-137 fatty acid binding protein 1 Homo sapiens 155-162 32038102-1 2020 Background: Fatty acid-binding protein 1 (FABP1) (also known as liver-type fatty acid-binding protein or LFABP) is a protein that is mainly expressed in the liver, and is associated with hepatocyte injury in acute transplant rejection. Fatty Acids 75-85 fatty acid binding protein 1 Homo sapiens 12-40 32038102-1 2020 Background: Fatty acid-binding protein 1 (FABP1) (also known as liver-type fatty acid-binding protein or LFABP) is a protein that is mainly expressed in the liver, and is associated with hepatocyte injury in acute transplant rejection. Fatty Acids 75-85 fatty acid binding protein 1 Homo sapiens 42-47 32038102-1 2020 Background: Fatty acid-binding protein 1 (FABP1) (also known as liver-type fatty acid-binding protein or LFABP) is a protein that is mainly expressed in the liver, and is associated with hepatocyte injury in acute transplant rejection. Fatty Acids 75-85 fatty acid binding protein 1 Homo sapiens 105-110 31168516-1 2019 Liver-type fatty acid-binding protein (L-FABP) is a key regulator of fatty acid metabolism, but serum L-FABP levels are not well investigated in chronic liver diseases. Fatty Acids 11-21 fatty acid binding protein 1 Homo sapiens 39-45 28919479-13 2017 Overall, our studies indicate that FABP1 is essential for proper lipid metabolism in differentiated enterocytes, particularly concerning fatty acids uptake and its basolateral secretion. Fatty Acids 137-148 fatty acid binding protein 1 Homo sapiens 35-40 31645505-0 2019 Temporal changes in urinary excretion of liver-type fatty acid binding protein (L-FABP) in acute kidney injury model of domestic cats: a preliminary study. Fatty Acids 52-62 fatty acid binding protein 1 Homo sapiens 80-86 31639005-10 2019 By qPCR analysis, it was revealed that myriocin corrected the expression pattern of fatty acid metabolism associated genes including Fabp1, Pparalpha, Cpt-1alpha and Acox-2. Fatty Acids 84-94 fatty acid binding protein 1 Homo sapiens 133-138 30993401-2 2019 Aim of the study was to investigate the diagnostic value of serum liver fatty acid-binding protein (FABP1) level and associations with disease severity, inflammation or metabolic parameters and influence of systemic treatment in psoriatic patients. Fatty Acids 72-82 fatty acid binding protein 1 Homo sapiens 100-105 29171144-3 2018 Fatty acid-binding proteins (FABPs) bind long-chain free fatty acids (FFAs) and are expressed in a tissue-specific pattern; FABP1 being the predominant hepatic form, and FABP4 the predominant adipocyte form. Fatty Acids 0-10 fatty acid binding protein 1 Homo sapiens 124-129 28864880-3 2018 Their binding mode and affinity to human liver fatty acid binding protein (hL-FABP) were also determined. Fatty Acids 47-57 fatty acid binding protein 1 Homo sapiens 75-82 29258109-1 2017 BACKGROUND/AIMS: Liver fatty acid-binding protein (FABP1) is a key regulator of hepatic lipid metabolism. Fatty Acids 23-33 fatty acid binding protein 1 Homo sapiens 51-56 27687006-9 2017 Decreased expression of the fatty acid storage and glucose regulator, PPARgamma, was associated with the loss of FABP1 (P<0.0001). Fatty Acids 28-38 fatty acid binding protein 1 Homo sapiens 113-118 26443794-3 2015 FABP1 is known to be critical for fatty acid uptake and intracellular transport and also has an important role in regulating lipid metabolism and cellular signaling pathways. Fatty Acids 34-44 fatty acid binding protein 1 Homo sapiens 0-5 26443794-8 2015 FABP1 binds and modulates the action of many molecules such as fatty acids, heme, and other metalloporphyrins. Fatty Acids 63-74 fatty acid binding protein 1 Homo sapiens 0-5