PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11385507-0 2001 Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Fatty Acids 19-29 apolipoprotein E Mus musculus 77-93 17130485-6 2006 Adenoviral expression of apoE in apoE(-/-)-cultured adipocytes increases triglyceride and fatty acid content. Fatty Acids 90-100 apolipoprotein E Mus musculus 25-29 17130485-6 2006 Adenoviral expression of apoE in apoE(-/-)-cultured adipocytes increases triglyceride and fatty acid content. Fatty Acids 90-100 apolipoprotein E Mus musculus 33-37 17130485-8 2006 The absence of apoE expression in primary cultured adipocytes also leads to changes in the expression of genes involved in the metabolism/turnover of fatty acids and the triglyceride droplet. Fatty Acids 150-161 apolipoprotein E Mus musculus 15-19 11902115-3 2002 Apolipoprotein E (apoE) is a major apolipoprotein in the CNS, mediating the transport of cholesterol, phospholipids and their fatty acids, particularly in reparative mechanisms during neuronal injury. Fatty Acids 126-137 apolipoprotein E Mus musculus 0-16 15023399-3 2004 To test the hypothesis that apoE expression is required for n-3 fatty acid-dependent regulation of serum lipid levels and hepatic fatty acid metabolism, we examined the effect of fish oil and n-3 fatty acid ethyl esters on the activity and gene expression of hepatic enzymes involved in fatty acid oxidation and synthesis using an alternative apoE-deficient mouse model with the BALB/c genetic background (BALB/c.KOR-Apoeshl). Fatty Acids 64-74 apolipoprotein E Mus musculus 28-32 15023399-3 2004 To test the hypothesis that apoE expression is required for n-3 fatty acid-dependent regulation of serum lipid levels and hepatic fatty acid metabolism, we examined the effect of fish oil and n-3 fatty acid ethyl esters on the activity and gene expression of hepatic enzymes involved in fatty acid oxidation and synthesis using an alternative apoE-deficient mouse model with the BALB/c genetic background (BALB/c.KOR-Apoeshl). Fatty Acids 130-140 apolipoprotein E Mus musculus 28-32 11902115-3 2002 Apolipoprotein E (apoE) is a major apolipoprotein in the CNS, mediating the transport of cholesterol, phospholipids and their fatty acids, particularly in reparative mechanisms during neuronal injury. Fatty Acids 126-137 apolipoprotein E Mus musculus 18-22 10533050-8 1999 There were, however, changes in the fatty acid composition of PE and phosphatidylserine (PS), which resulted in a lower ratio of polyunsaturated to saturated fatty acids in PE and in a higher ratio in apoE-deficient mice compared to the corresponding control values. Fatty Acids 36-46 apolipoprotein E Mus musculus 201-205 34830135-8 2021 Thus, this study demonstrated that increased capacity for fatty acid oxidation, an adaptive response to dyslipidemia leads to improved cellular energetics that translates to increased skeletal muscle strength and contributes to increased exercise capacity in ApoE/LDLR -/- mice. Fatty Acids 58-68 apolipoprotein E Mus musculus 259-263 8761448-10 1996 When incubations were performed at 37 degrees C the triacylglycerols of normal and apo E-free chylomicrons were hydrolysed by LPL and there was a significant uptake of [14C]fatty acids and [3H]retinol by the hepatocytes. Fatty Acids 173-184 apolipoprotein E Mus musculus 83-88 34653759-9 2021 DHA treatment efficiently meliorated lipid metabolism caused by ApoE deficient through the regulation of gene and protein expressions of molecules involved in liver fatty acids transport and lipid metabolism. Fatty Acids 165-176 apolipoprotein E Mus musculus 64-68 30342191-7 2018 WD and ApoE deficiency had a detrimental impact in muscle metabolome, followed by perturbed gene expression for fatty acid uptake and oxidation. Fatty Acids 112-122 apolipoprotein E Mus musculus 7-11 31129318-0 2019 Anti-atherosclerotic action of GW9508 - Free fatty acid receptors activator - In apoE-knockout mice. Fatty Acids 45-55 apolipoprotein E Mus musculus 81-85 30905828-5 2019 Interestingly, the free fatty acid profile in the APOE-/- epidermis shifted towards shorter and unsaturated chains. Fatty Acids 24-34 apolipoprotein E Mus musculus 50-54 30905828-6 2019 Genes involved in the synthesis of cholesterol and fatty acids were downregulated in APOE-/- skin suggesting a compensation for the higher influx of plasma lipids, most probably as cholesteryl esters. Fatty Acids 51-62 apolipoprotein E Mus musculus 85-89 30611282-0 2019 Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-gamma and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet. Fatty Acids 156-167 apolipoprotein E Mus musculus 171-175 33058853-8 2021 The evaluation of the cardiac proteomic pattern revealed that ApoE-/-/LDLR-/- as compared with WT mice were characterised by coordinated increased expression of mitochondrial proteins, including enzymes of fatty acids" and branched-chain amino acids" oxidation, accompanied by decreased expression levels of glycolytic enzymes. Fatty Acids 206-217 apolipoprotein E Mus musculus 62-66 31919912-9 2020 Our results indicated PPARdelta activation by fatty acid resulted in the activation of myeloid DCs and subsequent polarization of T lymphocytes, which contributed to atherosclerosis in Apoe-/- mice. Fatty Acids 46-56 apolipoprotein E Mus musculus 185-189 31622728-0 2020 APOE genotype and postnatal chlorpyrifos exposure modulate gut microbiota and cerebral short-chain fatty acids in preweaning mice. Fatty Acids 99-110 apolipoprotein E Mus musculus 0-4 30999225-6 2019 Meanwhile, we found that the Lyso-PL profiles of ApoE-/- mice and C57BL/6 J mice were distinguished by altered metabolism of different Lyso-PLs classes, while C57BL/6 J mice fed with high-fat diet and normal diet were discriminated by the content differences of Lyso-PLs with same fatty acid composition. Fatty Acids 281-291 apolipoprotein E Mus musculus 49-53 25381750-0 2015 Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice. Fatty Acids 59-69 apolipoprotein E Mus musculus 0-16 30355932-9 2018 Moreover, lipid accumulation in liver, particularly total cholesterol, free cholesterol, fatty acids, and glycerol, was increased with olanzapine treatment in apoE-/- mice by upregulating the expression of de novo lipid synthesis-related proteins and downregulating that of cholesterol clearance- or very low-density lipoprotein secretion-related proteins. Fatty Acids 89-100 apolipoprotein E Mus musculus 159-163 26500845-10 2015 Apelin is a regulator of fatty acid oxidation, and we found a reduction in the levels of enzymes involved in fatty acid oxidation in the left ventricle of ApoE(-/-)TIMP3(-/-) mice. Fatty Acids 109-119 apolipoprotein E Mus musculus 155-159 25777360-8 2015 Furthermore, ApoE-/-ITCH-/- mice exhibit reduced hepatic steatosis, increased mitochondrial oxidative capacity and an increased reliance on fatty acids as energy source. Fatty Acids 140-151 apolipoprotein E Mus musculus 13-17 25381750-0 2015 Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice. Fatty Acids 59-69 apolipoprotein E Mus musculus 18-22 25381750-2 2015 In this study, we investigated whether the APOE genotype affects body weight and energy metabolism through regulation of fatty acid utilization. Fatty Acids 121-131 apolipoprotein E Mus musculus 43-47 24204574-6 2013 The plasma levels of non-esterified fatty acids were significantly lower in the Herp(-/-); apoE(-/-) mice when they were eight and 16 weeks old. Fatty Acids 36-47 apolipoprotein E Mus musculus 91-95 24324736-0 2013 An immunomodulating fatty acid analogue targeting mitochondria exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in apoe(-/-) mice. Fatty Acids 20-30 apolipoprotein E Mus musculus 145-149 25241798-7 2014 Multiple biochemical disorders involving lipid metabolism, energy and fatty acid metabolism were observed in the progression of atherosclerosis in apoE(-/-) mice. Fatty Acids 70-80 apolipoprotein E Mus musculus 147-151 19924462-0 2010 Olive oils modulate fatty acid content and signaling protein expression in apolipoprotein E knockout mice brain. Fatty Acids 20-30 apolipoprotein E Mus musculus 75-91 23650230-5 2013 Concomitant induction of hepatic mRNA expression of carnitine palmitoyltransferase-1a in ApoE-/- mice-administered XN suggests increased fatty acid beta-oxidation. Fatty Acids 137-147 apolipoprotein E Mus musculus 89-93 22610982-10 2012 CONCLUSION: B vitamin deficiency perturbs lipid metabolism in ApoE null mice, causing accumulation of proatherogenic cholesterol and fatty acids in the aorta adventitia. Fatty Acids 133-144 apolipoprotein E Mus musculus 62-66