PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7718624-1	1995	The 5"-AMP-activated protein kinase (AMPK) regulates the fatty acid and sterol synthesizing pathways via phosphorylation of acetyl-CoA carboxylase and HMG-CoA reductase, respectively.	Fatty Acids	57-67	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	151-168	
12890564-3	2003	In typical target tissues for androgen action such as the ventral prostate and the lacrimal gland, androgen deprivation resulted in a marked reduction in the mRNA and protein levels of genes involved in fatty acid (fatty acid synthase and acetyl-CoA-carboxylase) and cholesterol synthesis (HMG-CoA-reductase and farnesyl diphosphate synthase).	Fatty Acids	203-213	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	290-307	
15337832-5	2004	We demonstrated that the upregulation of HMG-CoA reductase by a acid is due to an increase of the HMG-CoA reductase protein; therefore, protein synthesis would be required for the increase of HMG-CoA reductase activity caused by this fatty acid.	Fatty Acids	234-244	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	41-58	
15337832-5	2004	We demonstrated that the upregulation of HMG-CoA reductase by a acid is due to an increase of the HMG-CoA reductase protein; therefore, protein synthesis would be required for the increase of HMG-CoA reductase activity caused by this fatty acid.	Fatty Acids	234-244	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	98-115	
15337832-5	2004	We demonstrated that the upregulation of HMG-CoA reductase by a acid is due to an increase of the HMG-CoA reductase protein; therefore, protein synthesis would be required for the increase of HMG-CoA reductase activity caused by this fatty acid.	Fatty Acids	234-244	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	98-115	
15337832-6	2004	In contrast, the downregulation of HMG-CoA reductase caused by eicosapentaenoic acid is not due to decreased protein synthesis, since similar levels of protein were found in the presence and absence of this fatty acid.	Fatty Acids	207-217	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	35-52	
15134389-4	2004	D-003 is a mixture of high molecular weight fatty acids isolated from sugar cane wax, which inhibits cholesterol biosynthesis through indirect regulation of HMGCoA reductase activity.	Fatty Acids	44-55	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	157-173	
29600657-8	2018	These data indicated that leech may affect the expression of ACAT-2, Fas and HMGCR in liver tissue to reduce the synthesis of cholesterol and fatty acid, and promote the cholesterol transforming, then regulate lipid metabolism to decrease the levels of serum lipid, and reduce lipid accumulation in liver tissue and ease liver injury of rats, then slowing down the process of nonalcoholic fatty liver disease(NAFLD) in hyperlipidemia rats.	Fatty Acids	142-152	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	77-82	
6113851-0	1981	[Activities of 3-hydroxy-3-methylglutaryl-CoA reductase and acetyl-CoA carboxylase and rate of biosynthesis of mevalonic acid, squalene, sterols and fatty acids from [1-14C]acetyl-CoA and [2-14C]malonyl-CoA in rat liver: changes induced by daily rhythm].	Fatty Acids	149-160	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	15-55