PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24128860-1 2014 The purpose of this study was to evaluate the existence of a possible simultaneous regulation of fatty acid (FA) metabolism and lactate production by PPAR alpha and PPAR beta/delta activation in Sertoli cells (SC). Fatty Acids 97-107 peroxisome proliferator-activated receptor delta Rattus norvegicus 165-174 27631677-2 2016 Peroxisome proliferator-activated receptor delta (PPARdelta), a vital regulator of glucose and lipid metabolism, may reduce fatty acid-induced pancreatic beta cell lipotoxicity in diabetes. Fatty Acids 124-134 peroxisome proliferator-activated receptor delta Rattus norvegicus 0-48 27631677-2 2016 Peroxisome proliferator-activated receptor delta (PPARdelta), a vital regulator of glucose and lipid metabolism, may reduce fatty acid-induced pancreatic beta cell lipotoxicity in diabetes. Fatty Acids 124-134 peroxisome proliferator-activated receptor delta Rattus norvegicus 50-59 26558146-4 2015 PPARbeta/delta is more broadly expressed and is implicated in fatty acid oxidation, keratinocyte differentiation, wound healing, and macrophage response to very low density lipoprotein metabolism. Fatty Acids 62-72 peroxisome proliferator-activated receptor delta Rattus norvegicus 0-8 24269940-4 2014 In the present study, we aimed to investigate the underlying molecular mechanisms that PPARbeta/delta activation suppressed apoptosis and improved beta cell function impaired by fatty acids, focusing on contribution of GLP-1R. Fatty Acids 178-189 peroxisome proliferator-activated receptor delta Rattus norvegicus 87-95 19965574-0 2010 PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction. Fatty Acids 15-25 peroxisome proliferator-activated receptor delta Rattus norvegicus 0-9 23225238-9 2013 The obtained results show that increase of PPARdelta by digoxin is related to regulation of fatty acid oxidation genes in cardiac cells mediated by calcium-triggered signals. Fatty Acids 92-102 peroxisome proliferator-activated receptor delta Rattus norvegicus 43-52 23959725-7 2013 T0901317 increased muscle expression of peroxisome proliferator-activated receptor-delta and its target genes involved in fatty acid uptake and oxidation. Fatty Acids 122-132 peroxisome proliferator-activated receptor delta Rattus norvegicus 40-88 19965574-0 2010 PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction. Fatty Acids 119-129 peroxisome proliferator-activated receptor delta Rattus norvegicus 0-9 19965574-5 2010 Using short hairpin RNA-mediated knockdown, we demonstrate that the ability of unsaturated fatty acids to stimulate fatty acid metabolism is dependent on PPARdelta. Fatty Acids 91-101 peroxisome proliferator-activated receptor delta Rattus norvegicus 154-163 19965574-6 2010 Activation of PPARdelta increases the fatty acid oxidation capacity in INS-1E beta-cells, enhances glucose-stimulated insulin secretion (GSIS) from islets, and protects GSIS against adverse effects of prolonged fatty acid exposure. Fatty Acids 38-48 peroxisome proliferator-activated receptor delta Rattus norvegicus 14-23 19965574-6 2010 Activation of PPARdelta increases the fatty acid oxidation capacity in INS-1E beta-cells, enhances glucose-stimulated insulin secretion (GSIS) from islets, and protects GSIS against adverse effects of prolonged fatty acid exposure. Fatty Acids 211-221 peroxisome proliferator-activated receptor delta Rattus norvegicus 14-23 19965574-7 2010 The presented results indicate that the nuclear receptor PPARdelta is a fatty acid sensor that adapts beta-cell mitochondrial function to long-term changes in unsaturated fatty acid levels. Fatty Acids 72-82 peroxisome proliferator-activated receptor delta Rattus norvegicus 57-66 17726146-1 2007 Peroxisome proliferator-activated receptor-delta (PPARdelta) activation results in upregulation of genes associated with skeletal muscle fatty acid oxidation and mitochondrial uncoupling. Fatty Acids 137-147 peroxisome proliferator-activated receptor delta Rattus norvegicus 0-48 18591261-10 2008 Related changes in the skeletal muscle Slc2a4, Ucp3, and Ppard indicate that fetal glucocorticoid excess disturbs adult glucose/fatty acid transport and metabolism. Fatty Acids 128-138 peroxisome proliferator-activated receptor delta Rattus norvegicus 57-62 19131364-8 2009 Activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta/delta counteracted Ang II-mediated reduction of the fatty acid oxidation pathway. Fatty Acids 140-150 peroxisome proliferator-activated receptor delta Rattus norvegicus 79-87 17643263-8 2007 Selective activation of either PPARalpha or PPARbeta/delta completely restored expression of regulatory genes of fatty acid metabolism but did not influence cardiac myocyte size and markers of hypertrophy. Fatty Acids 113-123 peroxisome proliferator-activated receptor delta Rattus norvegicus 44-52 17643263-11 2007 Inactivation of PPARalpha and PPARbeta/delta accounts for downregulation of the fatty acid oxidation pathway, whereas inactivation of PPARgamma enables development of hypertrophy. Fatty Acids 80-90 peroxisome proliferator-activated receptor delta Rattus norvegicus 30-38 17726146-1 2007 Peroxisome proliferator-activated receptor-delta (PPARdelta) activation results in upregulation of genes associated with skeletal muscle fatty acid oxidation and mitochondrial uncoupling. Fatty Acids 137-147 peroxisome proliferator-activated receptor delta Rattus norvegicus 50-59 17869249-0 2007 The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells. Fatty Acids 42-52 peroxisome proliferator-activated receptor delta Rattus norvegicus 4-13 17869249-1 2007 Peroxisome proliferator-activated receptor-delta (PPARdelta) activation enhances skeletal muscle fatty acid oxidation and improves whole body glucose homeostasis and insulin sensitivity. Fatty Acids 97-107 peroxisome proliferator-activated receptor delta Rattus norvegicus 0-48 17869249-1 2007 Peroxisome proliferator-activated receptor-delta (PPARdelta) activation enhances skeletal muscle fatty acid oxidation and improves whole body glucose homeostasis and insulin sensitivity. Fatty Acids 97-107 peroxisome proliferator-activated receptor delta Rattus norvegicus 50-59 16139565-9 2005 These results suggest that LPS-mediated NF-kappaB activation inhibits the expression of genes involved in fatty acid metabolism by a mechanism involving reduced expression of PGC-1, which in turn affects the PPARbeta/delta transactivation of target genes involved in cardiac fatty acid oxidation. Fatty Acids 106-116 peroxisome proliferator-activated receptor delta Rattus norvegicus 208-216 16960684-0 2006 Activation of PPAR-delta in isolated rat skeletal muscle switches fuel preference from glucose to fatty acids. Fatty Acids 98-109 peroxisome proliferator-activated receptor delta Rattus norvegicus 14-24 17478558-6 2007 This T(3)-induced early UCP3 expression depended on fatty acid-PPAR signaling because depleting serum fatty acid levels abolished its expression, restorable by administration of the PPARdelta agonist L165,041 (4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid). Fatty Acids 52-62 peroxisome proliferator-activated receptor delta Rattus norvegicus 182-191 16139565-9 2005 These results suggest that LPS-mediated NF-kappaB activation inhibits the expression of genes involved in fatty acid metabolism by a mechanism involving reduced expression of PGC-1, which in turn affects the PPARbeta/delta transactivation of target genes involved in cardiac fatty acid oxidation. Fatty Acids 275-285 peroxisome proliferator-activated receptor delta Rattus norvegicus 208-216 32612543-4 2020 We sought to determine whether reduced PPARdelta content in insulin-resistant rat skeletal muscle of a non-obese rat model of T2DM (Goto-Kakizaki, GK) ameliorate the inhibitory effect of fatty acid (i.e., palmitoylcarnitine) on mitochondrial carbohydrate oxidization (i.e., pyruvate) in muscle fibers. Fatty Acids 187-197 peroxisome proliferator-activated receptor delta Rattus norvegicus 39-48 15728586-3 2005 Phenylephrine-induced cardiac hypertrophy in neonatal rat cardiomyocytes caused a reduction in the expression of pyruvate dehydrogenase kinase 4 (Pdk4), a target gene of PPARbeta/delta involved in fatty acid utilization, and a fall in palmitate oxidation that was reversed by NF-kappaB inhibitors. Fatty Acids 197-207 peroxisome proliferator-activated receptor delta Rattus norvegicus 170-178 11714844-7 2001 Surprisingly, mRNA levels of the fatty acid- activated transcription factors PPARalpha and PPARbeta/delta were reduced in hearts of fasted rats, whereas in livers, fasting led to a marked rise in PPARalpha mRNA. Fatty Acids 33-43 peroxisome proliferator-activated receptor delta Rattus norvegicus 91-99 15728586-8 2005 These results indicate that NF-kappaB activation during cardiac hypertrophy down-regulates PPARbeta/delta activity, leading to a fall in fatty acid oxidation, through a mechanism that involves enhanced protein-protein interaction between the p65 subunit of NF-kappaB and PPARbeta/delta. Fatty Acids 137-147 peroxisome proliferator-activated receptor delta Rattus norvegicus 91-99 15728586-8 2005 These results indicate that NF-kappaB activation during cardiac hypertrophy down-regulates PPARbeta/delta activity, leading to a fall in fatty acid oxidation, through a mechanism that involves enhanced protein-protein interaction between the p65 subunit of NF-kappaB and PPARbeta/delta. Fatty Acids 137-147 peroxisome proliferator-activated receptor delta Rattus norvegicus 271-279 11007938-8 2000 PPAR beta/delta, which is not very well known yet, appears to be more specifically activated by fatty acids. Fatty Acids 96-107 peroxisome proliferator-activated receptor delta Rattus norvegicus 0-9 32612543-14 2020 Conclusion: With competing fuels, the presence of fatty acids diminishes mitochondria ability to utilize carbohydrate derived substrates in insulin-resistant muscle despite reduced PPARdelta content. Fatty Acids 50-61 peroxisome proliferator-activated receptor delta Rattus norvegicus 181-190