PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23867797-3 2013 We report that patients with diabetic nephropathy develop alterations in glomerular gene expression of enzymes involved in fatty acid metabolism, including induction of stearoyl-CoA desaturase (SCD)-1, which converts saturated to monounsaturated FFAs. Fatty Acids 123-133 stearoyl-CoA desaturase Homo sapiens 169-200 25001539-5 2014 Recent studies show that for its apoptosis induction activity ORCTL3 targets the enzyme stearoyl-CoA desaturase-1 (SCD-1) that is involved in the fatty acid metabolism. Fatty Acids 146-156 stearoyl-CoA desaturase Homo sapiens 88-113 25001539-5 2014 Recent studies show that for its apoptosis induction activity ORCTL3 targets the enzyme stearoyl-CoA desaturase-1 (SCD-1) that is involved in the fatty acid metabolism. Fatty Acids 146-156 stearoyl-CoA desaturase Homo sapiens 115-120 24759262-7 2014 The stearoyl-CoA desaturase 1 (SCD1) indices were represented as the fatty acid product : precursor ratios. Fatty Acids 69-79 stearoyl-CoA desaturase Homo sapiens 4-29 24759262-7 2014 The stearoyl-CoA desaturase 1 (SCD1) indices were represented as the fatty acid product : precursor ratios. Fatty Acids 69-79 stearoyl-CoA desaturase Homo sapiens 31-35 24022589-3 2013 The purpose of this study was to evaluate interactions of polymorphisms in the fatty acid desaturase (FADS) genes, FADS1 and FADS2, and changes in diet on fatty acid concentrations in serum and colon. Fatty Acids 79-89 stearoyl-CoA desaturase Homo sapiens 102-106 23331615-3 2013 Stearoyl-CoA desaturase-1 (SCD1) is the main isoform of SCDs, the rate-limiting enzymes in the biosynthesis of monounsaturated fatty acids from saturated fatty acids, which is extensively activated in cancer progression. Fatty Acids 117-138 stearoyl-CoA desaturase Homo sapiens 0-25 23671091-2 2013 The kinase Akt is known to up-regulate fatty acid synthesis and desaturation, which is carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1. Fatty Acids 39-49 stearoyl-CoA desaturase Homo sapiens 130-153 23671091-2 2013 The kinase Akt is known to up-regulate fatty acid synthesis and desaturation, which is carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1. Fatty Acids 39-49 stearoyl-CoA desaturase Homo sapiens 155-160 22877655-3 2013 Whether FADS genotypes influence the amounts of umbilical cord fatty acids has not been investigated until now. Fatty Acids 63-74 stearoyl-CoA desaturase Homo sapiens 8-12 22877655-7 2013 Both maternal and child FADS genotypes and haplotypes influenced amounts of cord plasma LC-PUFA and fatty acid ratios. Fatty Acids 100-110 stearoyl-CoA desaturase Homo sapiens 24-28 22690737-1 2013 The aim of this study was to evaluate the effect of genetic variants on candidate genes corresponding to the sterol recognition element-binding protein-1 (SREBP-1) signaling pathway and stearoyl-CoA desaturases (SCD1 and SCD5) on muscle fatty acid (FA) composition of Brangus steers fattened on grass. Fatty Acids 237-247 stearoyl-CoA desaturase Homo sapiens 212-216 23331615-3 2013 Stearoyl-CoA desaturase-1 (SCD1) is the main isoform of SCDs, the rate-limiting enzymes in the biosynthesis of monounsaturated fatty acids from saturated fatty acids, which is extensively activated in cancer progression. Fatty Acids 117-138 stearoyl-CoA desaturase Homo sapiens 27-31 23208590-1 2013 Stearoyl-CoA desaturase 1 (SCD1) is an essential regulator of fatty acid synthesis. Fatty Acids 62-72 stearoyl-CoA desaturase Homo sapiens 0-25 23419767-1 2013 Fatty acid composition, which is altered in patients with abdominal obesity, is influenced not only by dietary intake but also by the desaturating enzymes stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D). Fatty Acids 0-10 stearoyl-CoA desaturase Homo sapiens 155-178 23419767-1 2013 Fatty acid composition, which is altered in patients with abdominal obesity, is influenced not only by dietary intake but also by the desaturating enzymes stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D). Fatty Acids 0-10 stearoyl-CoA desaturase Homo sapiens 180-183 22897446-2 2013 Elevated SCD-1 activity thus signifies impaired fatty acid metabolism and excess saturated fat intake. Fatty Acids 48-58 stearoyl-CoA desaturase Homo sapiens 9-14 22897446-2 2013 Elevated SCD-1 activity thus signifies impaired fatty acid metabolism and excess saturated fat intake. Fatty Acids 81-94 stearoyl-CoA desaturase Homo sapiens 9-14 22897446-7 2013 SCD-1 activity indices were calculated as the product-to-precursor fatty acid ratio (palmitoleic acid/palmitic acid) in each fraction to reflect SCD-1 activities in the liver and adipose tissue. Fatty Acids 67-77 stearoyl-CoA desaturase Homo sapiens 0-5 23404690-1 2013 OBJECTIVE: Stearoyl-coenzyme A desaturase-1 (SCD1) is a key enzyme in fatty acid and energy metabolism. Fatty Acids 70-80 stearoyl-CoA desaturase Homo sapiens 11-43 23404690-1 2013 OBJECTIVE: Stearoyl-coenzyme A desaturase-1 (SCD1) is a key enzyme in fatty acid and energy metabolism. Fatty Acids 70-80 stearoyl-CoA desaturase Homo sapiens 45-49 23245208-1 2013 Stearoyl-CoA desaturase-1 (SCD1) catalyzes de novo synthesis of monounsaturated fatty acids from saturated fatty acids. Fatty Acids 70-91 stearoyl-CoA desaturase Homo sapiens 0-25 23245208-1 2013 Stearoyl-CoA desaturase-1 (SCD1) catalyzes de novo synthesis of monounsaturated fatty acids from saturated fatty acids. Fatty Acids 70-91 stearoyl-CoA desaturase Homo sapiens 27-31 23208590-1 2013 Stearoyl-CoA desaturase 1 (SCD1) is an essential regulator of fatty acid synthesis. Fatty Acids 62-72 stearoyl-CoA desaturase Homo sapiens 27-31 23015656-3 2012 Desaturation of fatty acids by stearoyl-CoA desaturase 1 (SCD1) can prevent these deleterious effects. Fatty Acids 16-27 stearoyl-CoA desaturase Homo sapiens 31-56 24312911-1 2013 Stearoyl-CoA desaturase (SCD) is a key enzyme that converts saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs) in the biosynthesis of fat. Fatty Acids 60-81 stearoyl-CoA desaturase Homo sapiens 0-23 24312911-1 2013 Stearoyl-CoA desaturase (SCD) is a key enzyme that converts saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs) in the biosynthesis of fat. Fatty Acids 60-81 stearoyl-CoA desaturase Homo sapiens 25-28 24312911-1 2013 Stearoyl-CoA desaturase (SCD) is a key enzyme that converts saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs) in the biosynthesis of fat. Fatty Acids 83-87 stearoyl-CoA desaturase Homo sapiens 0-23 24312911-1 2013 Stearoyl-CoA desaturase (SCD) is a key enzyme that converts saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs) in the biosynthesis of fat. Fatty Acids 83-87 stearoyl-CoA desaturase Homo sapiens 25-28 23000367-4 2013 Although in quantitative terms, the endogenous synthesis of fatty acids in humans is not great in most circumstances, it is becoming increasingly evident that SCD plays important structural and metabolic roles. Fatty Acids 60-71 stearoyl-CoA desaturase Homo sapiens 159-162 22819528-4 2013 METHODS: In 2738 white participants (aged 45-64 yrs, 47% men) who were free of diabetes at baseline, SCD-1 activity was estimated at baseline by plasma fatty acid ratios in cholesterol esters (SCD16c=16:1n-7/16:0, SCD18c =18:1n-9/18:0) and in phospholipids (SCD16p=16:1n-7/16:0, SCD18p=18:1n-9/18:0). Fatty Acids 152-162 stearoyl-CoA desaturase Homo sapiens 101-106 23015656-3 2012 Desaturation of fatty acids by stearoyl-CoA desaturase 1 (SCD1) can prevent these deleterious effects. Fatty Acids 16-27 stearoyl-CoA desaturase Homo sapiens 58-62 23019225-9 2012 Pharmacologic inhibition of SCD1 blocked fatty acid desaturation and also exerted antitumor activity in vitro and in vivo. Fatty Acids 41-51 stearoyl-CoA desaturase Homo sapiens 28-32 22057664-0 2012 Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells. Fatty Acids 88-99 stearoyl-CoA desaturase Homo sapiens 23-48 22946088-1 2012 Stearoyl-CoA desaturase-1 (SCD1), the main enzyme that converts saturated fatty acids into monounsaturated fatty acids, is a key factor in the mechanisms of cancer cell proliferation, survival and tumorigenesis. Fatty Acids 64-85 stearoyl-CoA desaturase Homo sapiens 0-25 22946088-1 2012 Stearoyl-CoA desaturase-1 (SCD1), the main enzyme that converts saturated fatty acids into monounsaturated fatty acids, is a key factor in the mechanisms of cancer cell proliferation, survival and tumorigenesis. Fatty Acids 64-85 stearoyl-CoA desaturase Homo sapiens 27-31 22923631-6 2012 DESIGN: Case-control study nested within a prospective longitudinal cohort comparing prenatal and postnatal diet, blood measures and variants in fatty acid desaturase (FADS) genes that influence the metabolism of fatty acids. Fatty Acids 213-224 stearoyl-CoA desaturase Homo sapiens 145-166 22923631-6 2012 DESIGN: Case-control study nested within a prospective longitudinal cohort comparing prenatal and postnatal diet, blood measures and variants in fatty acid desaturase (FADS) genes that influence the metabolism of fatty acids. Fatty Acids 213-224 stearoyl-CoA desaturase Homo sapiens 168-172 22057664-8 2012 We showed that C18:1 fatty acids controlled the expression of scd1 at the transcriptional level in HASMC, leading to an increase in scd1 mRNA content by trans-9 elaidic acid treatment, whereas a decrease in scd1 mRNA content was observed with cis-9 oleic acid and trans-11 vaccenic acid treatments. Fatty Acids 21-32 stearoyl-CoA desaturase Homo sapiens 62-66 22057664-8 2012 We showed that C18:1 fatty acids controlled the expression of scd1 at the transcriptional level in HASMC, leading to an increase in scd1 mRNA content by trans-9 elaidic acid treatment, whereas a decrease in scd1 mRNA content was observed with cis-9 oleic acid and trans-11 vaccenic acid treatments. Fatty Acids 21-32 stearoyl-CoA desaturase Homo sapiens 132-136 22057664-8 2012 We showed that C18:1 fatty acids controlled the expression of scd1 at the transcriptional level in HASMC, leading to an increase in scd1 mRNA content by trans-9 elaidic acid treatment, whereas a decrease in scd1 mRNA content was observed with cis-9 oleic acid and trans-11 vaccenic acid treatments. Fatty Acids 21-32 stearoyl-CoA desaturase Homo sapiens 132-136 22057664-9 2012 Altogether, this work highlights a differential capability of C18:1 fatty acid isomers to control scd1 gene expression, which presumes of different consequent effects on cell functions. Fatty Acids 68-78 stearoyl-CoA desaturase Homo sapiens 98-102 22279139-6 2012 This reduction was due to the decreased expression of SREBP-1c and its responsive genes in fatty acid synthesis, including FAS, SCD1, and ACC1. Fatty Acids 91-101 stearoyl-CoA desaturase Homo sapiens 128-132 22194195-1 2012 Minor alleles of polymorphisms in the fatty acid desaturase (FADS) gene cluster have been associated with reduced desaturation of the precursor polyunsaturated fatty acids (FAs) in small studies. Fatty Acids 173-176 stearoyl-CoA desaturase Homo sapiens 38-59 22194195-1 2012 Minor alleles of polymorphisms in the fatty acid desaturase (FADS) gene cluster have been associated with reduced desaturation of the precursor polyunsaturated fatty acids (FAs) in small studies. Fatty Acids 173-176 stearoyl-CoA desaturase Homo sapiens 61-65 22457791-9 2012 Our data outline an effective strategy for interrogation of on-mechanism potency and pathway-node-specificity of fatty acid synthesis inhibitors, establish an unambiguous link between fatty acid synthesis and cancer cell survival, and point toward SCD1 as a key target in this pathway. Fatty Acids 113-123 stearoyl-CoA desaturase Homo sapiens 248-252 22209225-0 2012 Enzymatic activity and genetic variation in SCD1 modulate the relationship between fatty acids and inflammation. Fatty Acids 83-94 stearoyl-CoA desaturase Homo sapiens 44-48 22457791-3 2012 Using RNAi we have demonstrated that depletion of fatty-acid synthesis pathway enzymes SCD1, FASN, or ACC1 in HCT116 colon cancer cells results in cytotoxicity that is reversible by addition of exogenous fatty acids. Fatty Acids 50-60 stearoyl-CoA desaturase Homo sapiens 87-91 22745828-1 2012 Recent studies have demonstrated that human stearoylCoA desaturase-1 (SCD1), a Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, controls the rate of lipogenesis, cell proliferation and tumorigenic capacity in cancer cells. Fatty Acids 111-132 stearoyl-CoA desaturase Homo sapiens 44-68 22745828-1 2012 Recent studies have demonstrated that human stearoylCoA desaturase-1 (SCD1), a Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, controls the rate of lipogenesis, cell proliferation and tumorigenic capacity in cancer cells. Fatty Acids 111-132 stearoyl-CoA desaturase Homo sapiens 70-74 22745828-1 2012 Recent studies have demonstrated that human stearoylCoA desaturase-1 (SCD1), a Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, controls the rate of lipogenesis, cell proliferation and tumorigenic capacity in cancer cells. Fatty Acids 111-132 stearoyl-CoA desaturase Homo sapiens 79-96 22745828-1 2012 Recent studies have demonstrated that human stearoylCoA desaturase-1 (SCD1), a Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, controls the rate of lipogenesis, cell proliferation and tumorigenic capacity in cancer cells. Fatty Acids 134-137 stearoyl-CoA desaturase Homo sapiens 44-68 22745828-1 2012 Recent studies have demonstrated that human stearoylCoA desaturase-1 (SCD1), a Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, controls the rate of lipogenesis, cell proliferation and tumorigenic capacity in cancer cells. Fatty Acids 134-137 stearoyl-CoA desaturase Homo sapiens 70-74 22745828-1 2012 Recent studies have demonstrated that human stearoylCoA desaturase-1 (SCD1), a Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, controls the rate of lipogenesis, cell proliferation and tumorigenic capacity in cancer cells. Fatty Acids 134-137 stearoyl-CoA desaturase Homo sapiens 79-96 22457791-3 2012 Using RNAi we have demonstrated that depletion of fatty-acid synthesis pathway enzymes SCD1, FASN, or ACC1 in HCT116 colon cancer cells results in cytotoxicity that is reversible by addition of exogenous fatty acids. Fatty Acids 204-215 stearoyl-CoA desaturase Homo sapiens 87-91 21980230-4 2011 Stearoyl-coA desaturase, delta-6 desaturase and delta-5 desaturase were estimated as precursor to fatty acid ratios. Fatty Acids 98-108 stearoyl-CoA desaturase Homo sapiens 0-23 21831035-4 2011 In this review, we will evaluate the role of SCD-1 as a homeostatic check-point between glucose and fatty acid metabolism in the development and progression of obesity. Fatty Acids 100-110 stearoyl-CoA desaturase Homo sapiens 45-50 21457203-2 2011 Animal data indicate that stearoyl-coenzyme A desaturase (SCD), a key enzyme in fatty acid biosynthesis, is involved in sebaceous lipogenesis and proinflammatory signalling in the sebaceous gland. Fatty Acids 80-90 stearoyl-CoA desaturase Homo sapiens 26-56 21457203-2 2011 Animal data indicate that stearoyl-coenzyme A desaturase (SCD), a key enzyme in fatty acid biosynthesis, is involved in sebaceous lipogenesis and proinflammatory signalling in the sebaceous gland. Fatty Acids 80-90 stearoyl-CoA desaturase Homo sapiens 58-61 20876744-13 2010 Taken together these findings show that rapamycin decreases SCD1 expression, establishing an important link between cell signaling and cancer cell fatty acid synthesis and growth. Fatty Acids 147-157 stearoyl-CoA desaturase Homo sapiens 60-64 21145173-0 2011 Association analyses of single nucleotide polymorphisms in the LEP and SCD1 genes on the fatty acid profile of muscle fat in Simmental bulls. Fatty Acids 89-99 stearoyl-CoA desaturase Homo sapiens 71-75 21145173-1 2011 The aim was to investigate the effect of the genetic polymorphisms of leptin (LEP) and stearoyl-CoA desaturase (SCD1) genes on the fatty acid (FA) composition of the muscle of 103 Simmental bulls. Fatty Acids 131-141 stearoyl-CoA desaturase Homo sapiens 112-116 20935562-0 2011 The fatty acid desaturation index of blood lipids, as a biomarker of hepatic stearoyl-CoA desaturase expression, is a predictive factor of breast cancer risk. Fatty Acids 4-14 stearoyl-CoA desaturase Homo sapiens 77-100 20935562-1 2011 PURPOSE OF REVIEW: This review summarizes epidemiological data linking the fatty acid desaturation index measured in blood lipids, as a biomarker of hepatic stearoyl-CoA desaturase activity, the key enzyme involved in the synthesis of monounsaturated fatty acids from saturated fatty acids, to breast cancer risk. Fatty Acids 75-85 stearoyl-CoA desaturase Homo sapiens 157-180 20935562-1 2011 PURPOSE OF REVIEW: This review summarizes epidemiological data linking the fatty acid desaturation index measured in blood lipids, as a biomarker of hepatic stearoyl-CoA desaturase activity, the key enzyme involved in the synthesis of monounsaturated fatty acids from saturated fatty acids, to breast cancer risk. Fatty Acids 241-262 stearoyl-CoA desaturase Homo sapiens 157-180 22211186-2 2011 Alteration in SCD1 expression changes the fatty acid profile of these lipids and produces diverse effects on cellular function. Fatty Acids 42-52 stearoyl-CoA desaturase Homo sapiens 14-18 20713121-4 2011 Furthermore, oleic acid, the main product of SCD1 reaction, is the predominant fatty acid of human adipose tissue triacylglycerols, associating SCD1 with the development of obesity and the metabolic syndrome. Fatty Acids 79-89 stearoyl-CoA desaturase Homo sapiens 45-49 20713121-4 2011 Furthermore, oleic acid, the main product of SCD1 reaction, is the predominant fatty acid of human adipose tissue triacylglycerols, associating SCD1 with the development of obesity and the metabolic syndrome. Fatty Acids 79-89 stearoyl-CoA desaturase Homo sapiens 144-148 21307609-2 2011 Desaturating enzymes, stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D) modulate fatty acid composition and are thus associated with the development of metabolic syndrome. Fatty Acids 116-126 stearoyl-CoA desaturase Homo sapiens 22-45 21307609-2 2011 Desaturating enzymes, stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D) modulate fatty acid composition and are thus associated with the development of metabolic syndrome. Fatty Acids 116-126 stearoyl-CoA desaturase Homo sapiens 47-50 21179554-2 2010 This change in fatty acid metabolism is associated with overexpression of stearoyl-CoA desaturase 1 (Scd1), which catalyses the transformation of saturated fatty acids into monounsaturated fatty acids (e.g., oleic acid). Fatty Acids 15-25 stearoyl-CoA desaturase Homo sapiens 74-99 21179554-2 2010 This change in fatty acid metabolism is associated with overexpression of stearoyl-CoA desaturase 1 (Scd1), which catalyses the transformation of saturated fatty acids into monounsaturated fatty acids (e.g., oleic acid). Fatty Acids 15-25 stearoyl-CoA desaturase Homo sapiens 101-105 21179554-2 2010 This change in fatty acid metabolism is associated with overexpression of stearoyl-CoA desaturase 1 (Scd1), which catalyses the transformation of saturated fatty acids into monounsaturated fatty acids (e.g., oleic acid). Fatty Acids 146-167 stearoyl-CoA desaturase Homo sapiens 74-99 21179554-2 2010 This change in fatty acid metabolism is associated with overexpression of stearoyl-CoA desaturase 1 (Scd1), which catalyses the transformation of saturated fatty acids into monounsaturated fatty acids (e.g., oleic acid). Fatty Acids 146-167 stearoyl-CoA desaturase Homo sapiens 101-105 20382866-1 2010 Stearoyl CoA desaturase (SCD) is responsible for converting SFA into MUFA and plays an important role in regulating the fatty acid composition of tissues. Fatty Acids 120-130 stearoyl-CoA desaturase Homo sapiens 0-23 20595235-3 2010 In cancer cells, the tandem activation of the fatty acid biosynthetic enzymes adenosine triphosphate citrate lyase, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) leads to increased synthesis of SFA and their further conversion into MUFA by stearoyl-CoA desaturase (SCD) 1. Fatty Acids 46-56 stearoyl-CoA desaturase Homo sapiens 253-284 20595235-3 2010 In cancer cells, the tandem activation of the fatty acid biosynthetic enzymes adenosine triphosphate citrate lyase, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) leads to increased synthesis of SFA and their further conversion into MUFA by stearoyl-CoA desaturase (SCD) 1. Fatty Acids 207-210 stearoyl-CoA desaturase Homo sapiens 253-284 20382866-1 2010 Stearoyl CoA desaturase (SCD) is responsible for converting SFA into MUFA and plays an important role in regulating the fatty acid composition of tissues. Fatty Acids 120-130 stearoyl-CoA desaturase Homo sapiens 25-28 20382866-7 2010 Previous studies have indicated that there may be species differences in the regulation of SCD promoter activity by fatty acids. Fatty Acids 116-127 stearoyl-CoA desaturase Homo sapiens 91-94 20382866-11 2010 Thus, any species differences in previously reported regulation of SCD expression by fatty acids are not due to differences in promoter structure between species, but are more likely to depend on the cell type being studied or the relative concentrations and distribution of sterol regulatory element binding proteins or other transcription factors. Fatty Acids 85-96 stearoyl-CoA desaturase Homo sapiens 67-70 20599700-1 2010 The effect of human SCD1 heterologous expression on cellular fatty acid synthesis was investigated in the current study. Fatty Acids 61-71 stearoyl-CoA desaturase Homo sapiens 20-24 18982375-3 2009 Previous studies by our group have demonstrated that atorvastatin in oxidized LDL incubated macrophages modifies the gene expression profile of certain enzymes involved in fatty acid metabolism, mainly stearoyl-CoA desaturase (SCD). Fatty Acids 172-182 stearoyl-CoA desaturase Homo sapiens 202-225 20489212-4 2010 In this study we showed that stearoyl-CoA desaturase 1 (SCD1) knockdown increased the amount of saturated fatty acids and decreased that of monounsaturated fatty acids in phospholipids without affecting the amount or the composition of free fatty acid and induced unfolded protein response (UPR), evidenced by increased expression of C/EBP homologous protein (CHOP) and glucose-regulated protein 78 (GRP78) mRNAs and splicing of Xbox-binding protein 1 (XBP1) mRNA. Fatty Acids 96-117 stearoyl-CoA desaturase Homo sapiens 29-54 20489212-4 2010 In this study we showed that stearoyl-CoA desaturase 1 (SCD1) knockdown increased the amount of saturated fatty acids and decreased that of monounsaturated fatty acids in phospholipids without affecting the amount or the composition of free fatty acid and induced unfolded protein response (UPR), evidenced by increased expression of C/EBP homologous protein (CHOP) and glucose-regulated protein 78 (GRP78) mRNAs and splicing of Xbox-binding protein 1 (XBP1) mRNA. Fatty Acids 96-117 stearoyl-CoA desaturase Homo sapiens 56-60 20489212-5 2010 SCD1 knockdown-induced UPR was rescued by various unsaturated fatty acids and was enhanced by saturated fatty acid. Fatty Acids 52-72 stearoyl-CoA desaturase Homo sapiens 0-4 19850634-0 2009 Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios. Fatty Acids 113-123 stearoyl-CoA desaturase Homo sapiens 30-62 19119140-7 2009 Hepatic SCD1 expression increased in experimental steatosis resulting from high fat diet and decreased in a methionine-choline-deficient (MCD) dietary model of steatohepatitis resulting in the latter situation in significantly increased hepatic SFA levels. Fatty Acids 245-248 stearoyl-CoA desaturase Homo sapiens 8-12 20613975-9 2010 Finally, exogenous oleic acid restored the globally decreased levels of cell lipids in cells undergoing a blockade of SCD activity, indicating that active lipid synthesis is required for the fatty acid-mediated restoration of proliferation in SCD1-inhibited cells. Fatty Acids 191-201 stearoyl-CoA desaturase Homo sapiens 118-121 20613975-9 2010 Finally, exogenous oleic acid restored the globally decreased levels of cell lipids in cells undergoing a blockade of SCD activity, indicating that active lipid synthesis is required for the fatty acid-mediated restoration of proliferation in SCD1-inhibited cells. Fatty Acids 191-201 stearoyl-CoA desaturase Homo sapiens 243-247 20216310-5 2010 RECENT FINDINGS: SCD1 converts saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs). Fatty Acids 31-52 stearoyl-CoA desaturase Homo sapiens 17-21 19710915-2 2009 We have previously shown that a stable knockdown of stearoyl-CoA desaturase 1 (SCD1), the main Delta9-desaturase that converts SFA into MUFA, in cancer cells decreases the rate of lipogenesis, reduces proliferation and in vitro invasiveness, and dramatically impairs tumor formation and growth. Fatty Acids 127-130 stearoyl-CoA desaturase Homo sapiens 52-77 19710915-2 2009 We have previously shown that a stable knockdown of stearoyl-CoA desaturase 1 (SCD1), the main Delta9-desaturase that converts SFA into MUFA, in cancer cells decreases the rate of lipogenesis, reduces proliferation and in vitro invasiveness, and dramatically impairs tumor formation and growth. Fatty Acids 127-130 stearoyl-CoA desaturase Homo sapiens 79-83 19710915-2 2009 We have previously shown that a stable knockdown of stearoyl-CoA desaturase 1 (SCD1), the main Delta9-desaturase that converts SFA into MUFA, in cancer cells decreases the rate of lipogenesis, reduces proliferation and in vitro invasiveness, and dramatically impairs tumor formation and growth. Fatty Acids 127-130 stearoyl-CoA desaturase Homo sapiens 95-112 19710915-6 2009 Our data suggest that cancer cells require active SCD1 to control the rate of glucose-mediated lipogenesis, and that when SCD1 activity is impaired cells downregulate SFA synthesis via AMPK-mediated inactivation of acetyl-CoA carboxylase, thus preventing the harmful effects of SFA accumulation. Fatty Acids 167-170 stearoyl-CoA desaturase Homo sapiens 122-126 19710915-6 2009 Our data suggest that cancer cells require active SCD1 to control the rate of glucose-mediated lipogenesis, and that when SCD1 activity is impaired cells downregulate SFA synthesis via AMPK-mediated inactivation of acetyl-CoA carboxylase, thus preventing the harmful effects of SFA accumulation. Fatty Acids 278-281 stearoyl-CoA desaturase Homo sapiens 122-126 18599738-1 2008 Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the conversion of stearate (18:0) to oleate (18:1n-9) and of palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty acid metabolic network. Fatty Acids 205-215 stearoyl-CoA desaturase Homo sapiens 0-32 18599738-1 2008 Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the conversion of stearate (18:0) to oleate (18:1n-9) and of palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty acid metabolic network. Fatty Acids 205-215 stearoyl-CoA desaturase Homo sapiens 34-38 18599738-2 2008 This study investigated the role of SCD1 in fatty acid metabolism in HepG2 cells using SCD1 inhibitors and stable isotope tracers. Fatty Acids 44-54 stearoyl-CoA desaturase Homo sapiens 36-40 18599738-11 2008 The effects of SCD1 inhibition on fatty acid composition in HepG2 cells occurred through changes in the dynamics of the fatty acid metabolic network and not through transcriptional regulatory mechanisms. Fatty Acids 34-44 stearoyl-CoA desaturase Homo sapiens 15-19 18599738-11 2008 The effects of SCD1 inhibition on fatty acid composition in HepG2 cells occurred through changes in the dynamics of the fatty acid metabolic network and not through transcriptional regulatory mechanisms. Fatty Acids 120-130 stearoyl-CoA desaturase Homo sapiens 15-19 16908084-7 2007 Compared with non-diabetic controls, macrophages from men and women with T2DM had significantly different fatty acid profiles consistent with increased stearoyl-CoA desaturase (SCD) activity and increased C18:2 accumulation. Fatty Acids 106-116 stearoyl-CoA desaturase Homo sapiens 152-175 18825276-1 2008 Gene expression studies in humans and animals have shown that elevated stearoyl-CoA desaturase (SCD1) activity is associated with increased fat accumulation and monounsaturation of saturated fatty acids in skeletal muscle. Fatty Acids 181-202 stearoyl-CoA desaturase Homo sapiens 71-94 18825276-1 2008 Gene expression studies in humans and animals have shown that elevated stearoyl-CoA desaturase (SCD1) activity is associated with increased fat accumulation and monounsaturation of saturated fatty acids in skeletal muscle. Fatty Acids 181-202 stearoyl-CoA desaturase Homo sapiens 96-100 18825276-4 2008 Genotyping these SNPs on a Wagyu x Limousin reference population revealed that the SCD1 gene was significantly associated with six fat deposition and fatty acid composition traits in skeletal muscle, but not with subcutaneous fat depth and percent kidney-pelvic-heart fat. Fatty Acids 150-160 stearoyl-CoA desaturase Homo sapiens 83-87 18825276-5 2008 In particular, we confirmed that the high stearoyl-CoA desaturase activities/alleles were positively correlated with beef marbling score, amount of monounsaturated fatty acids and conjugated linoleic acid content, but negatively with amount of saturated fatty acids. Fatty Acids 154-175 stearoyl-CoA desaturase Homo sapiens 42-65 18523127-11 2008 We conclude that upregulation of hSCD-1 leads to a desaturation of saturated fatty acids and facilitates their esterification and storage, thereby preventing downstream effects of lipotoxicity in HAECs. Fatty Acids 67-88 stearoyl-CoA desaturase Homo sapiens 33-39 18222430-7 2008 RESULT(S): Genes involved in fatty acid synthesis, such as stearoyl-CoA desaturase, fatty acid synthase, acetyl-coenzyme A carboxylase alpha, and fatty acid desaturase 1 were decreased by estrogen treatment in a subgroup of women. Fatty Acids 29-39 stearoyl-CoA desaturase Homo sapiens 59-82 16443825-1 2006 Stearoyl-coenzyme A desaturase (SCD) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammalian cells. Fatty Acids 67-88 stearoyl-CoA desaturase Homo sapiens 0-30 16571147-1 2006 Stearoyl-CoA desaturase (SCD) is a key enzyme that determines the composition and metabolic fate of ingested fatty acids, in particular the conversion of trans-vaccenic acid (TVA) to conjugated linoleic acid (CLA). Fatty Acids 109-120 stearoyl-CoA desaturase Homo sapiens 0-23 16571147-1 2006 Stearoyl-CoA desaturase (SCD) is a key enzyme that determines the composition and metabolic fate of ingested fatty acids, in particular the conversion of trans-vaccenic acid (TVA) to conjugated linoleic acid (CLA). Fatty Acids 109-120 stearoyl-CoA desaturase Homo sapiens 25-28 16443825-1 2006 Stearoyl-coenzyme A desaturase (SCD) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammalian cells. Fatty Acids 67-88 stearoyl-CoA desaturase Homo sapiens 32-35 15260504-1 2004 Stearoyl-acyl carrier protein Delta(9) desaturase (Delta9D) produces oleic acid, a nutritionally valuable fatty acid containing a cis double bond between C-9 and C-10. Fatty Acids 106-116 stearoyl-CoA desaturase Homo sapiens 30-49 16213227-3 2005 High expression and activity of SCD1, an enzyme that catalyzes the synthesis of monounsaturated fatty acids, corresponded with low rates of fatty acid oxidation, increased triacylglycerol synthesis and increased monounsaturation of muscle lipids. Fatty Acids 96-106 stearoyl-CoA desaturase Homo sapiens 32-36 15851470-1 2005 Saturated and monounsaturated fatty acids are the most abundant fatty acid species in mammalian organisms, and their distribution is regulated by stearoyl-CoA desaturase, the enzyme that converts saturated into monounsaturated fatty acids. Fatty Acids 30-40 stearoyl-CoA desaturase Homo sapiens 146-169 15708362-4 2005 Thus, the activity of SCD on exogenous [14C]stearic acid and endogenous [14C]acetate-labeled fatty acids was increased by 2.2- and 2.6-fold, respectively, in SV40-WI38 compared to WI38 fibroblasts. Fatty Acids 93-104 stearoyl-CoA desaturase Homo sapiens 22-25 15708362-8 2005 SCD activity appeared linked to the events of programmed cell death, since incubations with 40 microM etoposide induced apoptosis in SV40 cells, and led to a decrease in fatty acid synthesis, SCD activity and in MUFA cellular levels. Fatty Acids 170-180 stearoyl-CoA desaturase Homo sapiens 0-3 15590999-9 2004 Deficiency of stearoyl CoA desaturase, although having no role in gluconeogenesis, powerfully induces fatty acid oxidation and weight loss despite increased food intake in rodents. Fatty Acids 102-112 stearoyl-CoA desaturase Homo sapiens 14-37 16132958-6 2005 Stearoyl-CoA desaturase (SCD-1), Delta6 (D6D) and Delta5 (D5D) desaturases were estimated as precursor to fatty acid ratios. Fatty Acids 106-116 stearoyl-CoA desaturase Homo sapiens 0-23 15907797-1 2005 Stearoyl-CoA desaturase (SCD) is an integral membrane protein of the endoplasmic reticulum (ER) that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. Fatty Acids 134-155 stearoyl-CoA desaturase Homo sapiens 0-23 15907797-1 2005 Stearoyl-CoA desaturase (SCD) is an integral membrane protein of the endoplasmic reticulum (ER) that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. Fatty Acids 134-155 stearoyl-CoA desaturase Homo sapiens 25-28 15610069-1 2005 SCD (stearoyl-CoA desaturase) catalyses the conversion of saturated fatty acids into mono-unsaturated fatty acids, a critical step involved in lipid metabolism and various other biological functions. Fatty Acids 58-79 stearoyl-CoA desaturase Homo sapiens 0-3 15610069-1 2005 SCD (stearoyl-CoA desaturase) catalyses the conversion of saturated fatty acids into mono-unsaturated fatty acids, a critical step involved in lipid metabolism and various other biological functions. Fatty Acids 58-79 stearoyl-CoA desaturase Homo sapiens 5-28 15260504-1 2004 Stearoyl-acyl carrier protein Delta(9) desaturase (Delta9D) produces oleic acid, a nutritionally valuable fatty acid containing a cis double bond between C-9 and C-10. Fatty Acids 106-116 stearoyl-CoA desaturase Homo sapiens 51-58 11397803-2 2001 The regulation of SCD is of physiological importance because the ratio of saturated fatty acids to unsaturated fatty acids is thought to modulate membrane fluidity. Fatty Acids 74-95 stearoyl-CoA desaturase Homo sapiens 18-21 12820892-1 2003 The fatty acid analogues 9- and 10-thiastearate were converted to acyl-ACP derivatives by in vitro enzymatic synthesis and reacted with the reconstituted soluble stearoyl-ACP Delta9 desaturase complex. Fatty Acids 4-14 stearoyl-CoA desaturase Homo sapiens 175-192 12538081-2 2003 Recently, studies in vivo and in cell lines have shown that vitamin A and its active metabolite, retinoic acid, regulate the expression of fatty acid desaturases including stearoyl-CoA desaturase and delta-5 desaturase. Fatty Acids 139-149 stearoyl-CoA desaturase Homo sapiens 172-195 12069848-1 2002 Stearoyl-CoA desaturase (SCD) is a short-lived integral membrane protein of the endoplasmic reticulum (ER) that catalyzes the insertion of a double bond in the delta 9 position of saturated fatty acids. Fatty Acids 180-201 stearoyl-CoA desaturase Homo sapiens 0-23 12069848-1 2002 Stearoyl-CoA desaturase (SCD) is a short-lived integral membrane protein of the endoplasmic reticulum (ER) that catalyzes the insertion of a double bond in the delta 9 position of saturated fatty acids. Fatty Acids 180-201 stearoyl-CoA desaturase Homo sapiens 25-28 12482877-7 2003 SCD activity led to an increased content of plasma membrane monounsaturated fatty acids (18:1) at the expense of saturated fatty acids (18:0). Fatty Acids 66-87 stearoyl-CoA desaturase Homo sapiens 0-3 23214140-4 2012 Recent studies have shown that SCD1 plays also a significant role, directly or indirectly, in the regulation of diverse metabolic processes, including lipogenesis, fatty acid oxidation, insulin signaling, thermogenesis, carcinogenesis, and inflammation. Fatty Acids 164-174 stearoyl-CoA desaturase Homo sapiens 31-35 10907781-0 2000 Changes in fatty acid composition in plant tissues expressing a mammalian delta9 desaturase. Fatty Acids 11-21 stearoyl-CoA desaturase Homo sapiens 74-91 8939925-1 1996 The effects of arachidonic acid (20:4, n-6) and other fatty acids on the expression of stearoyl-CoA desaturase gene 1 were investigated in fully differentiated 3T3-L1 adipocytes. Fatty Acids 54-65 stearoyl-CoA desaturase Homo sapiens 87-110 1279471-3 1992 Stearoyl CoA desaturase (SCD) catalyzes a key step in the biosynthesis of oleic acid (C18:1, n-9), a major fatty acid in myelin. Fatty Acids 107-117 stearoyl-CoA desaturase Homo sapiens 25-28 9803467-14 1998 In mature adipocytes, PPAR gamma stimulation inhibits stearoyl-CoA desaturase 1 (SCD1) enzyme activity resulting in a change of cell membrane fatty acid composition. Fatty Acids 142-152 stearoyl-CoA desaturase Homo sapiens 54-79 9803467-14 1998 In mature adipocytes, PPAR gamma stimulation inhibits stearoyl-CoA desaturase 1 (SCD1) enzyme activity resulting in a change of cell membrane fatty acid composition. Fatty Acids 142-152 stearoyl-CoA desaturase Homo sapiens 81-85 7480063-2 1995 Because of the important role that the SCD gene product plays in fat cell metabolism, future studies on SCD1 gene expression could provide new insights into the role of fatty acids in cellular regulation, metabolism, and gene expression both in normal and disease states. Fatty Acids 169-180 stearoyl-CoA desaturase Homo sapiens 39-42 7480063-2 1995 Because of the important role that the SCD gene product plays in fat cell metabolism, future studies on SCD1 gene expression could provide new insights into the role of fatty acids in cellular regulation, metabolism, and gene expression both in normal and disease states. Fatty Acids 169-180 stearoyl-CoA desaturase Homo sapiens 104-108 1279471-3 1992 Stearoyl CoA desaturase (SCD) catalyzes a key step in the biosynthesis of oleic acid (C18:1, n-9), a major fatty acid in myelin. Fatty Acids 107-117 stearoyl-CoA desaturase Homo sapiens 0-23 34674740-1 2021 BACKGROUND: Stearoyl-coenzyme A desaturase 1 (SCD1) is required for de novo synthesis of fatty acids. Fatty Acids 89-100 stearoyl-CoA desaturase Homo sapiens 12-44 34287816-2 2022 Stearoyl-CoA desaturase-1 (SCD-1) is one of major enzymes in the de novo synthesis of fatty acids and is related to cancer aggressiveness and poor patient prognosis. Fatty Acids 86-97 stearoyl-CoA desaturase Homo sapiens 0-25 34287816-2 2022 Stearoyl-CoA desaturase-1 (SCD-1) is one of major enzymes in the de novo synthesis of fatty acids and is related to cancer aggressiveness and poor patient prognosis. Fatty Acids 86-97 stearoyl-CoA desaturase Homo sapiens 27-32 34287816-11 2022 CONCLUSIONS: Exosomes loaded SCD-1 siRNA inhibited ATC cellular proliferation and promoted cellular apoptosis, and the mechanisms involved maybe the regulation of fatty acids metabolism and ROS level. Fatty Acids 163-174 stearoyl-CoA desaturase Homo sapiens 29-34 34486791-2 2021 Here, by using the in vitro BCSC models, mammosphere-derived MCF-7 cells and HMLE-Twist-ER cells, we found that the cells with stem cell-like properties exhibited a very distinct profile of fatty acid metabolism compared with that of their parental cancer cells, characterized by increased lipogenesis, especially the activity of stearoyl-CoA desaturase 1 (SCD1) responsible for the production of monounsaturated fatty acids (MUFA), and augmented synthesis and utilization of the omega-6 arachidonic acid (AA). Fatty Acids 190-200 stearoyl-CoA desaturase Homo sapiens 330-355 34486791-2 2021 Here, by using the in vitro BCSC models, mammosphere-derived MCF-7 cells and HMLE-Twist-ER cells, we found that the cells with stem cell-like properties exhibited a very distinct profile of fatty acid metabolism compared with that of their parental cancer cells, characterized by increased lipogenesis, especially the activity of stearoyl-CoA desaturase 1 (SCD1) responsible for the production of monounsaturated fatty acids (MUFA), and augmented synthesis and utilization of the omega-6 arachidonic acid (AA). Fatty Acids 190-200 stearoyl-CoA desaturase Homo sapiens 357-361 34674740-1 2021 BACKGROUND: Stearoyl-coenzyme A desaturase 1 (SCD1) is required for de novo synthesis of fatty acids. Fatty Acids 89-100 stearoyl-CoA desaturase Homo sapiens 46-50 34680068-4 2021 The modeling of SCD1:fatty acid interactions suggests that: (1) SCD1:CoA moiety interactions open the substrate-binding tunnel, (2) SCD1 stabilizes a substrate conformation favorable for desaturation, and (3) SCD1:product interactions result in an opening of the tunnel, possibly allowing product exit into the surrounding membrane. Fatty Acids 21-31 stearoyl-CoA desaturase Homo sapiens 16-20 34293334-3 2021 Treatment with KPT-9274, a NAMPT inhibitor, suppressed the conversion of saturated fatty acids to monounsaturated fatty acids, a reaction catalyzed by the stearoyl-CoA desaturase (SCD) enzyme, resulting in apoptosis of AML cells. Fatty Acids 73-94 stearoyl-CoA desaturase Homo sapiens 155-178 34293334-3 2021 Treatment with KPT-9274, a NAMPT inhibitor, suppressed the conversion of saturated fatty acids to monounsaturated fatty acids, a reaction catalyzed by the stearoyl-CoA desaturase (SCD) enzyme, resulting in apoptosis of AML cells. Fatty Acids 73-94 stearoyl-CoA desaturase Homo sapiens 180-183 34680068-4 2021 The modeling of SCD1:fatty acid interactions suggests that: (1) SCD1:CoA moiety interactions open the substrate-binding tunnel, (2) SCD1 stabilizes a substrate conformation favorable for desaturation, and (3) SCD1:product interactions result in an opening of the tunnel, possibly allowing product exit into the surrounding membrane. Fatty Acids 21-31 stearoyl-CoA desaturase Homo sapiens 64-68 34680068-4 2021 The modeling of SCD1:fatty acid interactions suggests that: (1) SCD1:CoA moiety interactions open the substrate-binding tunnel, (2) SCD1 stabilizes a substrate conformation favorable for desaturation, and (3) SCD1:product interactions result in an opening of the tunnel, possibly allowing product exit into the surrounding membrane. Fatty Acids 21-31 stearoyl-CoA desaturase Homo sapiens 132-136 34680068-4 2021 The modeling of SCD1:fatty acid interactions suggests that: (1) SCD1:CoA moiety interactions open the substrate-binding tunnel, (2) SCD1 stabilizes a substrate conformation favorable for desaturation, and (3) SCD1:product interactions result in an opening of the tunnel, possibly allowing product exit into the surrounding membrane. Fatty Acids 21-31 stearoyl-CoA desaturase Homo sapiens 209-213 34171462-1 2021 The stearoyl-CoA desaturase 1 (SCD1) gene at 10q24.31 encodes the rate limiting enzyme SCD1 that catalyzes the biosynthesis of monounsaturated fatty acids (MUFAs) from saturated fatty acids (SFAs). Fatty Acids 168-189 stearoyl-CoA desaturase Homo sapiens 4-29 34171462-1 2021 The stearoyl-CoA desaturase 1 (SCD1) gene at 10q24.31 encodes the rate limiting enzyme SCD1 that catalyzes the biosynthesis of monounsaturated fatty acids (MUFAs) from saturated fatty acids (SFAs). Fatty Acids 168-189 stearoyl-CoA desaturase Homo sapiens 31-35 34171462-1 2021 The stearoyl-CoA desaturase 1 (SCD1) gene at 10q24.31 encodes the rate limiting enzyme SCD1 that catalyzes the biosynthesis of monounsaturated fatty acids (MUFAs) from saturated fatty acids (SFAs). Fatty Acids 168-189 stearoyl-CoA desaturase Homo sapiens 87-91 34171462-1 2021 The stearoyl-CoA desaturase 1 (SCD1) gene at 10q24.31 encodes the rate limiting enzyme SCD1 that catalyzes the biosynthesis of monounsaturated fatty acids (MUFAs) from saturated fatty acids (SFAs). Fatty Acids 191-195 stearoyl-CoA desaturase Homo sapiens 4-29 34171462-1 2021 The stearoyl-CoA desaturase 1 (SCD1) gene at 10q24.31 encodes the rate limiting enzyme SCD1 that catalyzes the biosynthesis of monounsaturated fatty acids (MUFAs) from saturated fatty acids (SFAs). Fatty Acids 191-195 stearoyl-CoA desaturase Homo sapiens 31-35 34171462-1 2021 The stearoyl-CoA desaturase 1 (SCD1) gene at 10q24.31 encodes the rate limiting enzyme SCD1 that catalyzes the biosynthesis of monounsaturated fatty acids (MUFAs) from saturated fatty acids (SFAs). Fatty Acids 191-195 stearoyl-CoA desaturase Homo sapiens 87-91 34997498-11 2022 The expression of stearoyl-CoA desaturase (SCD), ELOVL fatty acid elongase 1 (ELOVL1) promoted, and fatty acid desaturase 1 (FADS1) inhibited the key fatty acids of unsaturated fatty acids metabolism compared to the control cell group. Fatty Acids 150-161 stearoyl-CoA desaturase Homo sapiens 18-41 35361481-6 2022 ferase to determine the target gene as stearoyl-CoA desaturase 1 (SCD1) while controlling rates of fatty acids synthesis and de novo brown fat biogenesis. Fatty Acids 99-110 stearoyl-CoA desaturase Homo sapiens 39-64 35361481-6 2022 ferase to determine the target gene as stearoyl-CoA desaturase 1 (SCD1) while controlling rates of fatty acids synthesis and de novo brown fat biogenesis. Fatty Acids 99-110 stearoyl-CoA desaturase Homo sapiens 66-70 35046108-8 2022 In summary, our data revealed that acidosis could significantly trigger fatty acid synthesis to promote liver tumorigenesis by upregulating SCD1 in a PI3K/AKT activation dependent manner and simultaneously promote SCD1 binding to PPARalpha. Fatty Acids 72-82 stearoyl-CoA desaturase Homo sapiens 140-144 35046108-8 2022 In summary, our data revealed that acidosis could significantly trigger fatty acid synthesis to promote liver tumorigenesis by upregulating SCD1 in a PI3K/AKT activation dependent manner and simultaneously promote SCD1 binding to PPARalpha. Fatty Acids 72-82 stearoyl-CoA desaturase Homo sapiens 214-218 35533489-7 2022 Moreover, the overexpression of DDX17 was accompanied by a significant decrease in the expression of genes involved in de novo fatty acid synthesis (FAS, ACC, and SCD-1) in both HepG2 and Hep1-6 cells. Fatty Acids 127-137 stearoyl-CoA desaturase Homo sapiens 163-168 35609330-1 2022 The primary regulatory gene for fatty acid synthesis, stearoyl-CoA desaturase 1 (SCD1), has been linked to the progression of several malignancies. Fatty Acids 32-42 stearoyl-CoA desaturase Homo sapiens 54-79 35609330-1 2022 The primary regulatory gene for fatty acid synthesis, stearoyl-CoA desaturase 1 (SCD1), has been linked to the progression of several malignancies. Fatty Acids 32-42 stearoyl-CoA desaturase Homo sapiens 81-85 34997498-11 2022 The expression of stearoyl-CoA desaturase (SCD), ELOVL fatty acid elongase 1 (ELOVL1) promoted, and fatty acid desaturase 1 (FADS1) inhibited the key fatty acids of unsaturated fatty acids metabolism compared to the control cell group. Fatty Acids 150-161 stearoyl-CoA desaturase Homo sapiens 43-46 2860925-1 1985 The sources of octadecenoic acid (18:1) and the importance of the stearoyl-CoA desaturase system in maintaining elevated levels of this fatty acid in the Morris hepatoma 7288C have been investigated. Fatty Acids 136-146 stearoyl-CoA desaturase Homo sapiens 66-89 35173454-12 2022 Conclusion: Inhibition of SCD1 in monocytes prevents their transformation into macrophages after exposure to saturated fatty acid derivatives contained in eye drops, which may contribute to the limitation of latent inflammation within ocular adnexa and could possibly translate into better tolerability of the topical treatment. Fatty Acids 109-129 stearoyl-CoA desaturase Homo sapiens 26-30 35126846-6 2022 Among several lipogenic genes, the endoplasmic reticulum-bound stearoyl-CoA desaturase 1 (SCD1) is the key determinant of triglycerides biosynthesis pathway, by providing monounsaturated fatty acids, through the incorporation of a double bond at the delta-9 position of saturated fatty acids, specifically, palmitic (C16:0) and stearic (C18:0) acids, yielding palmitoleic (C16:1) and oleic (C18:1) acids, respectively. Fatty Acids 270-291 stearoyl-CoA desaturase Homo sapiens 63-88 35126846-6 2022 Among several lipogenic genes, the endoplasmic reticulum-bound stearoyl-CoA desaturase 1 (SCD1) is the key determinant of triglycerides biosynthesis pathway, by providing monounsaturated fatty acids, through the incorporation of a double bond at the delta-9 position of saturated fatty acids, specifically, palmitic (C16:0) and stearic (C18:0) acids, yielding palmitoleic (C16:1) and oleic (C18:1) acids, respectively. Fatty Acids 270-291 stearoyl-CoA desaturase Homo sapiens 90-94 35276817-2 2022 Few studies have addressed the association between fatty acid desaturase (FADS) gene expression patterns and fatty acids in breast milk. Fatty Acids 109-120 stearoyl-CoA desaturase Homo sapiens 51-72 35276817-2 2022 Few studies have addressed the association between fatty acid desaturase (FADS) gene expression patterns and fatty acids in breast milk. Fatty Acids 109-120 stearoyl-CoA desaturase Homo sapiens 74-78 2569740-10 1989 The deficiency of stearoyl-CoA desaturase in T cells may represent the basis for the differing sensitivities of T and B lymphocytes to inhibition by saturated fatty acids. Fatty Acids 149-170 stearoyl-CoA desaturase Homo sapiens 18-41 2860925-2 1985 Sterculic acid, an inhibitor of the stearoyl-CoA desaturase system, when added to the culture medium, inhibited the production of monoenoic fatty acids through de novo synthesis by 90% while the production of saturated fatty acids and cholesterol was unaffected. Fatty Acids 209-230 stearoyl-CoA desaturase Homo sapiens 36-59 33612070-4 2021 The main effect of SCD1 inhibition on the fatty acid contents of colorectal cancer cells was a decrease in monounsaturated fatty acids (MUFAs). Fatty Acids 42-52 stearoyl-CoA desaturase Homo sapiens 19-23 33628242-7 2021 Stearoyl-CoA desaturase, responsible for the fatty acid desaturation, improves the fluidity and permeability of cell membranes, which is one of the key factors affecting metabolic rate. Fatty Acids 45-55 stearoyl-CoA desaturase Homo sapiens 0-23 34030117-8 2021 Mechanistically, SCD1 leads to fatty acid (FA) desaturation and FABP4 derived from TEM enhances lipid droplet (LD) in cancer cells, which cooperatively protect from oxidative stress-induced ferroptosis. Fatty Acids 31-41 stearoyl-CoA desaturase Homo sapiens 17-21 33218679-7 2021 Whereas LXR is mainly recognized for its role as a cholesterol sensor, finally promoting the loss of cellular cholesterol and whole-body homeostasis, SCD1 acts as the major regulator of new fatty acids, finely tuning the monounsaturated fatty acids (MUFA) to saturated fatty acids (SFA) ratio. Fatty Acids 190-201 stearoyl-CoA desaturase Homo sapiens 150-154 33218679-7 2021 Whereas LXR is mainly recognized for its role as a cholesterol sensor, finally promoting the loss of cellular cholesterol and whole-body homeostasis, SCD1 acts as the major regulator of new fatty acids, finely tuning the monounsaturated fatty acids (MUFA) to saturated fatty acids (SFA) ratio. Fatty Acids 227-248 stearoyl-CoA desaturase Homo sapiens 150-154 33218679-7 2021 Whereas LXR is mainly recognized for its role as a cholesterol sensor, finally promoting the loss of cellular cholesterol and whole-body homeostasis, SCD1 acts as the major regulator of new fatty acids, finely tuning the monounsaturated fatty acids (MUFA) to saturated fatty acids (SFA) ratio. Fatty Acids 282-285 stearoyl-CoA desaturase Homo sapiens 150-154 32767911-6 2021 Pharmacological or gene therapy aimed to reduce the activity of enzymes involved in de novo synthesis of fatty acids, FASN, ACLY (ATP citrate lyase) or SCD-1 (stearoyl-CoA desaturase) in particular, may result in cells growth arrest. Fatty Acids 105-116 stearoyl-CoA desaturase Homo sapiens 159-182 33049404-1 2021 A large body of research has demonstrated that human stearoyl-CoA desaturase 1 (SCD1), a universally expressed fatty acid Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, is a central regulator of metabolic and signaling pathways involved in cell proliferation, differentiation, and survival. Fatty Acids 111-121 stearoyl-CoA desaturase Homo sapiens 53-78 33049404-1 2021 A large body of research has demonstrated that human stearoyl-CoA desaturase 1 (SCD1), a universally expressed fatty acid Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, is a central regulator of metabolic and signaling pathways involved in cell proliferation, differentiation, and survival. Fatty Acids 111-121 stearoyl-CoA desaturase Homo sapiens 80-84 33049404-1 2021 A large body of research has demonstrated that human stearoyl-CoA desaturase 1 (SCD1), a universally expressed fatty acid Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, is a central regulator of metabolic and signaling pathways involved in cell proliferation, differentiation, and survival. Fatty Acids 111-121 stearoyl-CoA desaturase Homo sapiens 122-139 33049404-1 2021 A large body of research has demonstrated that human stearoyl-CoA desaturase 1 (SCD1), a universally expressed fatty acid Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, is a central regulator of metabolic and signaling pathways involved in cell proliferation, differentiation, and survival. Fatty Acids 154-175 stearoyl-CoA desaturase Homo sapiens 53-78 33049404-1 2021 A large body of research has demonstrated that human stearoyl-CoA desaturase 1 (SCD1), a universally expressed fatty acid Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, is a central regulator of metabolic and signaling pathways involved in cell proliferation, differentiation, and survival. Fatty Acids 154-175 stearoyl-CoA desaturase Homo sapiens 80-84 33049404-1 2021 A large body of research has demonstrated that human stearoyl-CoA desaturase 1 (SCD1), a universally expressed fatty acid Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, is a central regulator of metabolic and signaling pathways involved in cell proliferation, differentiation, and survival. Fatty Acids 154-175 stearoyl-CoA desaturase Homo sapiens 122-139 33049404-1 2021 A large body of research has demonstrated that human stearoyl-CoA desaturase 1 (SCD1), a universally expressed fatty acid Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, is a central regulator of metabolic and signaling pathways involved in cell proliferation, differentiation, and survival. Fatty Acids 177-180 stearoyl-CoA desaturase Homo sapiens 53-78 33049404-1 2021 A large body of research has demonstrated that human stearoyl-CoA desaturase 1 (SCD1), a universally expressed fatty acid Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, is a central regulator of metabolic and signaling pathways involved in cell proliferation, differentiation, and survival. Fatty Acids 177-180 stearoyl-CoA desaturase Homo sapiens 80-84 33049404-1 2021 A large body of research has demonstrated that human stearoyl-CoA desaturase 1 (SCD1), a universally expressed fatty acid Delta9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids, is a central regulator of metabolic and signaling pathways involved in cell proliferation, differentiation, and survival. Fatty Acids 177-180 stearoyl-CoA desaturase Homo sapiens 122-139 33396940-7 2020 Given the beneficial effects of a MUFA-rich Mediterranean diet, we also present the most recent data on the role of SCD1 activity in the modulation of SFA-induced chronic inflammation. Fatty Acids 151-154 stearoyl-CoA desaturase Homo sapiens 116-120 33041516-4 2020 In this study, we investigated the roles of the stearoyl-CoA desaturase (SCD), which catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, in skeletal muscle on muscle atrophy in CKD model animals. Fatty Acids 113-134 stearoyl-CoA desaturase Homo sapiens 73-76 33343508-4 2020 ChREBP regulates fatty acid synthesis, elongation, and desaturation by inducing Acc1 and Fasn, elongation of long-chain fatty acids family member 6 (encoded by Elovl6), and Scd1 expression, respectively. Fatty Acids 17-27 stearoyl-CoA desaturase Homo sapiens 173-177 32952654-4 2020 Lipogenic enzyme stearoyl-CoA desaturase (SCD1) drives the production of endogenous monounsaturated fatty acids (MUFAs) in cells and protects against toxic buildup of saturated fatty acids. Fatty Acids 90-111 stearoyl-CoA desaturase Homo sapiens 17-40 32952654-4 2020 Lipogenic enzyme stearoyl-CoA desaturase (SCD1) drives the production of endogenous monounsaturated fatty acids (MUFAs) in cells and protects against toxic buildup of saturated fatty acids. Fatty Acids 90-111 stearoyl-CoA desaturase Homo sapiens 42-46 32452400-1 2020 The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP). Fatty Acids 61-71 stearoyl-CoA desaturase Homo sapiens 106-127 32726752-2 2020 Thereinto, Stearoyl-CoA Desaturase 1 (SCD1), an enzymatic node located in the conversion of saturated fatty acids into monounsaturated fatty acids (MUFAs), has been reported to accelerate the tumorigenesis of multiple cancers. Fatty Acids 92-113 stearoyl-CoA desaturase Homo sapiens 11-36 32726752-2 2020 Thereinto, Stearoyl-CoA Desaturase 1 (SCD1), an enzymatic node located in the conversion of saturated fatty acids into monounsaturated fatty acids (MUFAs), has been reported to accelerate the tumorigenesis of multiple cancers. Fatty Acids 92-113 stearoyl-CoA desaturase Homo sapiens 38-42 31708235-5 2020 Fatty acid ratios 18:1/18:0 and 16:1/16:0 were used as markers for SCD-1 activity ("desaturation indices", DIs). Fatty Acids 0-10 stearoyl-CoA desaturase Homo sapiens 67-72 32464305-5 2020 Moreover, sterol regulatory element-binding protein 1 (SREBP-1c) was activated in human gastric cancer tissues, and it promoted the expression of a series of genes associated with the synthesis of fatty acids, such as SCD1 and FASN. Fatty Acids 197-208 stearoyl-CoA desaturase Homo sapiens 218-222 32133634-2 2020 As such, SCD play important roles in maintaining the intracellular balance between saturated fatty acid (SFAs) and MUFAs. Fatty Acids 83-103 stearoyl-CoA desaturase Homo sapiens 9-12 32315834-1 2020 Stearyl coenzyme A desaturase enzyme 1 (SCD1) is a key enzyme that catalyzes the conversion of saturated fatty acids (SFA) into monounsaturated fatty acids (MUFA) and plays a vital role in lipid metabolism of tumor cells. Fatty Acids 95-116 stearoyl-CoA desaturase Homo sapiens 0-38 32315834-1 2020 Stearyl coenzyme A desaturase enzyme 1 (SCD1) is a key enzyme that catalyzes the conversion of saturated fatty acids (SFA) into monounsaturated fatty acids (MUFA) and plays a vital role in lipid metabolism of tumor cells. Fatty Acids 95-116 stearoyl-CoA desaturase Homo sapiens 40-44 32315834-1 2020 Stearyl coenzyme A desaturase enzyme 1 (SCD1) is a key enzyme that catalyzes the conversion of saturated fatty acids (SFA) into monounsaturated fatty acids (MUFA) and plays a vital role in lipid metabolism of tumor cells. Fatty Acids 118-121 stearoyl-CoA desaturase Homo sapiens 0-38 32315834-1 2020 Stearyl coenzyme A desaturase enzyme 1 (SCD1) is a key enzyme that catalyzes the conversion of saturated fatty acids (SFA) into monounsaturated fatty acids (MUFA) and plays a vital role in lipid metabolism of tumor cells. Fatty Acids 118-121 stearoyl-CoA desaturase Homo sapiens 40-44 32122301-0 2020 Fatty acid biosynthesis and transcriptional regulation of Stearoyl-CoA Desaturase 1 (SCD1) in buffalo milk. Fatty Acids 0-10 stearoyl-CoA desaturase Homo sapiens 58-83 32097464-4 2020 This phenotypic shift was controlled by stearoyl-CoA desaturase-1 (SCD1), an enzyme responsible for the desaturation of saturated fatty acids. Fatty Acids 120-141 stearoyl-CoA desaturase Homo sapiens 40-65 32097464-4 2020 This phenotypic shift was controlled by stearoyl-CoA desaturase-1 (SCD1), an enzyme responsible for the desaturation of saturated fatty acids. Fatty Acids 120-141 stearoyl-CoA desaturase Homo sapiens 67-71 32122301-0 2020 Fatty acid biosynthesis and transcriptional regulation of Stearoyl-CoA Desaturase 1 (SCD1) in buffalo milk. Fatty Acids 0-10 stearoyl-CoA desaturase Homo sapiens 85-89 32218693-10 2020 The expression level of fatty acid oxidation pathway PPARgamma was significantly down-regulated compared with the control group, as were genes associated with fatty acid synthesis pathways: SREBP1, ACC, FAS, and SCD1. Fatty Acids 24-34 stearoyl-CoA desaturase Homo sapiens 212-216 32218693-10 2020 The expression level of fatty acid oxidation pathway PPARgamma was significantly down-regulated compared with the control group, as were genes associated with fatty acid synthesis pathways: SREBP1, ACC, FAS, and SCD1. Fatty Acids 159-169 stearoyl-CoA desaturase Homo sapiens 212-216 31481234-2 2019 Stearoyl-CoA desaturase 1 (SCD1), which converts fully saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs), has been suggested as a vulnerable target for selective elimination of cancer stem cells (CSCs). Fatty Acids 55-76 stearoyl-CoA desaturase Homo sapiens 0-25 31678479-8 2019 Altogether, our results identify FASN and SCD1 as conserved druggable cofactors of Alphavirus genome replication and support the broad-spectrum activity of drugs targeting the host fatty acids metabolism. Fatty Acids 181-192 stearoyl-CoA desaturase Homo sapiens 42-46 31936134-1 2020 In many tissues, stearoyl-CoA desaturase 1 (SCD1) catalyzes the biosynthesis of monounsaturated fatty acids (MUFAS),(i.e., palmitoleate and oleate) from their saturated fatty acid (SFA) precursors (i.e., palmitate and stearate), influencing cellular membrane physiology and signaling, leading to broad effects on human physiology. Fatty Acids 96-106 stearoyl-CoA desaturase Homo sapiens 17-42 31936134-1 2020 In many tissues, stearoyl-CoA desaturase 1 (SCD1) catalyzes the biosynthesis of monounsaturated fatty acids (MUFAS),(i.e., palmitoleate and oleate) from their saturated fatty acid (SFA) precursors (i.e., palmitate and stearate), influencing cellular membrane physiology and signaling, leading to broad effects on human physiology. Fatty Acids 96-106 stearoyl-CoA desaturase Homo sapiens 44-48 31481234-2 2019 Stearoyl-CoA desaturase 1 (SCD1), which converts fully saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs), has been suggested as a vulnerable target for selective elimination of cancer stem cells (CSCs). Fatty Acids 55-76 stearoyl-CoA desaturase Homo sapiens 27-31 31199678-4 2019 Given that SCD1 catalyzes the most crucial and rate-limiting step in the synthesis of monounsaturated fatty acids (FAs), we performed a lipidomic analysis, which showed a dramatically altered lipid profile in sorafenib-treated cells. Fatty Acids 115-118 stearoyl-CoA desaturase Homo sapiens 11-15 31284458-3 2019 An increase in the expression of stearoyl-CoA desaturase 1 (SCD1), the enzyme that converts saturated fatty acids to 9-monounsaturated fatty acids, has been observed in a wide range of cancer cells, and this increase is correlated with cancer aggressiveness and poor outcomes for patients. Fatty Acids 92-113 stearoyl-CoA desaturase Homo sapiens 60-64 31019378-1 2019 Background: Cancer cells are characterized by aberrant activation of lipid biosynthesis, producing saturated fatty acids and monounsaturated fatty acids via stearoyl-CoA desaturases (SCD) for regulating metabolic and signaling platforms. Fatty Acids 99-120 stearoyl-CoA desaturase Homo sapiens 183-186 30790642-4 2019 At the endoplasmic reticulum (ER), SCD provides the monounsaturated fatty acid to PORCN, which adds it to the Wnt ligand; at the extracellular matrix, the fatty acid is removed by Notum. Fatty Acids 68-78 stearoyl-CoA desaturase Homo sapiens 35-38 30453627-3 2018 Genome-wide association studies of delta-5-desaturase (D5D), delta-6-desaturase (D6D) and stearoyl-CoA desaturase-1 (SCD) activities (estimated by product-to-precursor ratios of fatty acids analyzed by gas chromatography) in serum cholesterol esters (n = 1453) and adipose tissue (n = 783, all men) were performed in two Swedish population-based cohorts. Fatty Acids 178-189 stearoyl-CoA desaturase Homo sapiens 90-121 30871048-0 2019 The Effect of an Infant Formula Supplemented with AA and DHA on Fatty Acid Levels of Infants with Different FADS Genotypes: The COGNIS Study. Fatty Acids 64-74 stearoyl-CoA desaturase Homo sapiens 108-112 30656903-2 2018 Stearoyl-CoA desaturase (SCD) is an enzyme that converts saturated fatty acids to monounsaturated fatty acids. Fatty Acids 57-78 stearoyl-CoA desaturase Homo sapiens 0-23 30475958-7 2018 Conclusion: To our knowledge, this study was the first in South East Asia on FADS genotypes and arterial cord blood fatty acids to show an association between fetal LC-PUFA composition and fetal FADS SNPs. Fatty Acids 116-127 stearoyl-CoA desaturase Homo sapiens 195-199 30656903-2 2018 Stearoyl-CoA desaturase (SCD) is an enzyme that converts saturated fatty acids to monounsaturated fatty acids. Fatty Acids 57-78 stearoyl-CoA desaturase Homo sapiens 25-28 27992526-2 2016 Recently, overexpression of LM-related genes, apolipoproteins related to metabolic syndrome, and ACSL/SCD network involved in fatty acid activation have been proposed as prognostic markers of colon cancer (CC). Fatty Acids 126-136 stearoyl-CoA desaturase Homo sapiens 102-105 29869888-1 2018 Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Fatty Acids 76-97 stearoyl-CoA desaturase Homo sapiens 0-23 29869888-1 2018 Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Fatty Acids 76-97 stearoyl-CoA desaturase Homo sapiens 25-28 29530061-2 2018 Stearoyl-CoA desaturase 1 (SCD1), the main enzyme responsible for producing monounsaturated fatty acids(MUFA) from saturated fatty acids, is frequently deregulated in both diabetes and CRC. Fatty Acids 82-103 stearoyl-CoA desaturase Homo sapiens 0-25 29530061-2 2018 Stearoyl-CoA desaturase 1 (SCD1), the main enzyme responsible for producing monounsaturated fatty acids(MUFA) from saturated fatty acids, is frequently deregulated in both diabetes and CRC. Fatty Acids 82-103 stearoyl-CoA desaturase Homo sapiens 27-31 28230778-6 2017 Met downregulated expression of enzymes of fatty acid de novo synthesis, such as ATP Citrate Lyase (ACLY), Fatty Acid Synthase (FAS), Fatty Acyl-CoA Elongase 6 (ELOVL6), and Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells. Fatty Acids 43-53 stearoyl-CoA desaturase Homo sapiens 174-199 28230778-6 2017 Met downregulated expression of enzymes of fatty acid de novo synthesis, such as ATP Citrate Lyase (ACLY), Fatty Acid Synthase (FAS), Fatty Acyl-CoA Elongase 6 (ELOVL6), and Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells. Fatty Acids 43-53 stearoyl-CoA desaturase Homo sapiens 201-205 27838812-9 2017 Interestingly, BSCL2 knockdown induces SCD1 expression and activity, potentially leading to increased basal phosphorylation of proteins involved in the insulin signaling cascade, as well as further increasing fatty acid uptake and de novo lipogenesis. Fatty Acids 209-219 stearoyl-CoA desaturase Homo sapiens 39-43 27527582-5 2017 In conclusion, available research findings suggest that FADS minor alleles are also associated with reduced inflammation and CVD risk, and that dietary total fat and fatty acid intake have the potential to modify relationships between FADS gene variants and circulating fatty acid levels. Fatty Acids 166-176 stearoyl-CoA desaturase Homo sapiens 235-239 27527582-5 2017 In conclusion, available research findings suggest that FADS minor alleles are also associated with reduced inflammation and CVD risk, and that dietary total fat and fatty acid intake have the potential to modify relationships between FADS gene variants and circulating fatty acid levels. Fatty Acids 270-280 stearoyl-CoA desaturase Homo sapiens 235-239 30157936-9 2018 CONCLUSIONS: Our findings suggest that genetic variants in the FADS region are major genetic modifiers that can regulate fatty acid metabolism through epigenetic gene regulation. Fatty Acids 121-131 stearoyl-CoA desaturase Homo sapiens 63-67 30317781-1 2018 Stearoyl-CoA desaturase-1 (SCD-1) is the key rate-limiting enzyme to catalyze the conversion of saturated fatty acids to monounsaturated fatty acids. Fatty Acids 96-117 stearoyl-CoA desaturase Homo sapiens 0-25 30317781-1 2018 Stearoyl-CoA desaturase-1 (SCD-1) is the key rate-limiting enzyme to catalyze the conversion of saturated fatty acids to monounsaturated fatty acids. Fatty Acids 96-117 stearoyl-CoA desaturase Homo sapiens 27-32 29955721-1 2018 Background: Stearoyl-coenzyme A desaturase (SCD) is a key enzyme in fatty acid metabolism, and elevated SCD activity is associated with multiple adverse health outcomes. Fatty Acids 68-78 stearoyl-CoA desaturase Homo sapiens 12-42 29955721-1 2018 Background: Stearoyl-coenzyme A desaturase (SCD) is a key enzyme in fatty acid metabolism, and elevated SCD activity is associated with multiple adverse health outcomes. Fatty Acids 68-78 stearoyl-CoA desaturase Homo sapiens 44-47 28515069-2 2017 One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old.Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in the d2 Test of Attention and a reading test were analyzed in multiple regression models including all SNPs, SNP-sex interactions, and covariates related to testing conditions.Results:FADS, rs1535 minor allele carriage associated with lower whole-blood arachidonic acid (P <= 0.002), and minor alleles of rs174448 tended to associate with lower docosahexaenoic acid (DHA) (P = 0.052). Fatty Acids 91-101 stearoyl-CoA desaturase Homo sapiens 114-118 28515069-2 2017 One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old.Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in the d2 Test of Attention and a reading test were analyzed in multiple regression models including all SNPs, SNP-sex interactions, and covariates related to testing conditions.Results:FADS, rs1535 minor allele carriage associated with lower whole-blood arachidonic acid (P <= 0.002), and minor alleles of rs174448 tended to associate with lower docosahexaenoic acid (DHA) (P = 0.052). Fatty Acids 91-101 stearoyl-CoA desaturase Homo sapiens 224-228 28515069-2 2017 One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old.Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in the d2 Test of Attention and a reading test were analyzed in multiple regression models including all SNPs, SNP-sex interactions, and covariates related to testing conditions.Results:FADS, rs1535 minor allele carriage associated with lower whole-blood arachidonic acid (P <= 0.002), and minor alleles of rs174448 tended to associate with lower docosahexaenoic acid (DHA) (P = 0.052). Fatty Acids 91-101 stearoyl-CoA desaturase Homo sapiens 224-228 28145413-1 2017 BACKGROUND/OBJECTIVES: Conversion of saturated fatty acids to monounsaturated fatty acids by the enzyme stearoyl-Co-A-desaturase (SCD-1) is emerging as a major factor in promoting carcinogenesis including breast cancer. Fatty Acids 37-58 stearoyl-CoA desaturase Homo sapiens 104-128 28145413-1 2017 BACKGROUND/OBJECTIVES: Conversion of saturated fatty acids to monounsaturated fatty acids by the enzyme stearoyl-Co-A-desaturase (SCD-1) is emerging as a major factor in promoting carcinogenesis including breast cancer. Fatty Acids 37-58 stearoyl-CoA desaturase Homo sapiens 130-135 28315997-5 2017 Incorporation of EA, a common industrial TFA, increased the ratio of the stearoyl-CoA desaturase (SCD-1), a key enzyme involved in fatty acid metabolism. Fatty Acids 131-141 stearoyl-CoA desaturase Homo sapiens 73-96 28315997-5 2017 Incorporation of EA, a common industrial TFA, increased the ratio of the stearoyl-CoA desaturase (SCD-1), a key enzyme involved in fatty acid metabolism. Fatty Acids 131-141 stearoyl-CoA desaturase Homo sapiens 98-103 27639967-2 2016 The critical participation of stearoyl CoA desaturase-1 (SCD1), the fatty acyl Delta9-desaturing enzyme that converts saturated fatty acids (SFA) into monounsaturated fatty acids (MUFA), in the mechanisms of replication and survival of mammalian cells, as well as their implication in the biological alterations of cancer have been actively investigated in recent years. Fatty Acids 118-139 stearoyl-CoA desaturase Homo sapiens 30-55 27639967-2 2016 The critical participation of stearoyl CoA desaturase-1 (SCD1), the fatty acyl Delta9-desaturing enzyme that converts saturated fatty acids (SFA) into monounsaturated fatty acids (MUFA), in the mechanisms of replication and survival of mammalian cells, as well as their implication in the biological alterations of cancer have been actively investigated in recent years. Fatty Acids 118-139 stearoyl-CoA desaturase Homo sapiens 57-61 27639967-2 2016 The critical participation of stearoyl CoA desaturase-1 (SCD1), the fatty acyl Delta9-desaturing enzyme that converts saturated fatty acids (SFA) into monounsaturated fatty acids (MUFA), in the mechanisms of replication and survival of mammalian cells, as well as their implication in the biological alterations of cancer have been actively investigated in recent years. Fatty Acids 141-144 stearoyl-CoA desaturase Homo sapiens 30-55 27562731-1 2016 BACKGROUND: Sleep deprivation has been associated with obesity among adults, and accumulating data suggests that stearoyl-CoA desaturase 1 (SCD1) expression has a relevant impact on fatty acid (FA) composition of lipid pools and obesity. Fatty Acids 182-192 stearoyl-CoA desaturase Homo sapiens 113-138 27639967-2 2016 The critical participation of stearoyl CoA desaturase-1 (SCD1), the fatty acyl Delta9-desaturing enzyme that converts saturated fatty acids (SFA) into monounsaturated fatty acids (MUFA), in the mechanisms of replication and survival of mammalian cells, as well as their implication in the biological alterations of cancer have been actively investigated in recent years. Fatty Acids 141-144 stearoyl-CoA desaturase Homo sapiens 57-61 27861513-1 2016 Stearoyl-CoA desaturase 1 (SCD1), the rate-limiting enzymes in the biosynthesis of monounsaturated fatty acids from saturated fatty acids, have been gradually recognized as a potential therapeutic target for various malignancies, particularly in clear-cell renal cell carcinoma (ccRCC). Fatty Acids 89-110 stearoyl-CoA desaturase Homo sapiens 0-25 27861513-1 2016 Stearoyl-CoA desaturase 1 (SCD1), the rate-limiting enzymes in the biosynthesis of monounsaturated fatty acids from saturated fatty acids, have been gradually recognized as a potential therapeutic target for various malignancies, particularly in clear-cell renal cell carcinoma (ccRCC). Fatty Acids 89-110 stearoyl-CoA desaturase Homo sapiens 27-31 27550503-1 2016 Stearoyl-CoA desaturase (SCD), the central enzyme in the biosynthesis of monounsaturated fatty acids, introduces a cis-Delta9 double bond into saturated fatty acids. Fatty Acids 79-100 stearoyl-CoA desaturase Homo sapiens 25-28 27562731-1 2016 BACKGROUND: Sleep deprivation has been associated with obesity among adults, and accumulating data suggests that stearoyl-CoA desaturase 1 (SCD1) expression has a relevant impact on fatty acid (FA) composition of lipid pools and obesity. Fatty Acids 182-192 stearoyl-CoA desaturase Homo sapiens 140-144 27562731-9 2016 CONCLUSION: Our results suggest a relevant link between TSD, hepatic SCD1 expression and de-novo fatty acid synthesis via epigenetically driven regulatory mechanisms. Fatty Acids 97-107 stearoyl-CoA desaturase Homo sapiens 69-73 26481476-0 2016 SCD1 mediates the influence of exogenous saturated and monounsaturated fatty acids in adipocytes: Effects on cellular stress, inflammatory markers and fatty acid elongation. Fatty Acids 71-81 stearoyl-CoA desaturase Homo sapiens 0-4 26344107-1 2016 Stearoyl-CoA desaturase 1 (SCD1) is a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids from their saturated fatty acid precursors. Fatty Acids 88-108 stearoyl-CoA desaturase Homo sapiens 0-25 26344107-1 2016 Stearoyl-CoA desaturase 1 (SCD1) is a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids from their saturated fatty acid precursors. Fatty Acids 88-108 stearoyl-CoA desaturase Homo sapiens 27-31 27004414-1 2016 BACKGROUND: To explore whether plasma fatty acids and SNPs in the fatty acid desaturase (FADS) gene associated with type 2 diabetes (T2D) and coronary artery disease (CAD). Fatty Acids 38-49 stearoyl-CoA desaturase Homo sapiens 89-93 27004414-5 2016 CONCLUSIONS: Our results show that SNPs in FADS gene (particularly rs174537) associate with plasma fatty acids and desaturase levels in patients with both T2D and CAD, which maybe increases the risk of CAD in diabetic patients. Fatty Acids 99-110 stearoyl-CoA desaturase Homo sapiens 43-47 24769897-3 2015 For its cell death effect ORCTL3 targets the enzyme stearoyl-CoA desaturase-1 (SCD1) in fatty acid metabolism. Fatty Acids 88-98 stearoyl-CoA desaturase Homo sapiens 52-77 26022099-6 2015 SCD-1 activity was assessed by measuring cellular monounsaturated/saturated fatty acid (MUFA/SFA) ratios, and SCD-1 expression was measured by qPCR, immunoblot, and immunofluorescence analyses. Fatty Acids 66-86 stearoyl-CoA desaturase Homo sapiens 0-5 25497832-2 2015 The protein sequence of yellow catfish SCD1 and Fads2 (Delta6) possessed all the characteristics of microsomal fatty acid Fads2 (Delta6), including three histidine boxes, two transmembrane regions and one N-terminal cytochrome b5 domain containing heme-binding motif. Fatty Acids 111-121 stearoyl-CoA desaturase Homo sapiens 39-43 26098370-2 2015 Because the monounsaturated products of SCD are key precursors of membrane phospholipids, cholesterol esters and triglycerides, SCD is pivotal in fatty acid metabolism. Fatty Acids 146-156 stearoyl-CoA desaturase Homo sapiens 40-43 26098370-2 2015 Because the monounsaturated products of SCD are key precursors of membrane phospholipids, cholesterol esters and triglycerides, SCD is pivotal in fatty acid metabolism. Fatty Acids 146-156 stearoyl-CoA desaturase Homo sapiens 128-131 25675381-3 2015 We investigated the effects of targeted inhibition of stearoyl-CoA desaturase 1 (SCD1), a constituent of fatty acid metabolism overexpressed in ATC. Fatty Acids 105-115 stearoyl-CoA desaturase Homo sapiens 54-79 25675381-3 2015 We investigated the effects of targeted inhibition of stearoyl-CoA desaturase 1 (SCD1), a constituent of fatty acid metabolism overexpressed in ATC. Fatty Acids 105-115 stearoyl-CoA desaturase Homo sapiens 81-85 24769897-3 2015 For its cell death effect ORCTL3 targets the enzyme stearoyl-CoA desaturase-1 (SCD1) in fatty acid metabolism. Fatty Acids 88-98 stearoyl-CoA desaturase Homo sapiens 79-83 25116600-2 2014 The activity of SCD1 can be monitored using the desaturation index (DI), the ratio of product (16:1n-7 and 18:1n-9) to precursor (16:0 and 18:0) fatty acids. Fatty Acids 145-156 stearoyl-CoA desaturase Homo sapiens 16-20 25527748-1 2015 BACKGROUND: Biochemical evidence has linked the coordinate control of fatty acid (FA) synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1). Fatty Acids 70-80 stearoyl-CoA desaturase Homo sapiens 117-142 25527748-1 2015 BACKGROUND: Biochemical evidence has linked the coordinate control of fatty acid (FA) synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1). Fatty Acids 70-80 stearoyl-CoA desaturase Homo sapiens 144-148 25116600-4 2014 A novel effective approach was the use of the SCD1-independent fatty acid (16:1n-10) as a negative control. Fatty Acids 63-73 stearoyl-CoA desaturase Homo sapiens 46-50 25116600-11 2014 After 3 days of high-carbohydrate diet, only the specific fatty acids in human plasma VLDL showed a significant increase in DI and associated SCD1 activity. Fatty Acids 58-69 stearoyl-CoA desaturase Homo sapiens 142-146 25013434-2 2014 The present study was designed to investigate the effect of the pharmacologic inhibition of SCD1 on fatty acid composition in tissue explant cultures of human breast cancer and to compare these effects with those in adjacent nonneoplastic breast tissue. Fatty Acids 100-110 stearoyl-CoA desaturase Homo sapiens 92-96 24977108-0 2014 Genetic Variants in the FADS Gene: Implications for Dietary Recommendations for Fatty Acid Intake. Fatty Acids 80-90 stearoyl-CoA desaturase Homo sapiens 24-28 24827925-3 2014 Variations in stearoyl CoA desaturase (SCD) activity (a key enzyme in the fatty acid metabolism) may be involved in various processes that can lead to diseases such as obesity. Fatty Acids 74-84 stearoyl-CoA desaturase Homo sapiens 39-42 25013434-10 2014 The SCD1 inhibitor also elevated saturated fatty acid (1.46-fold, p=0.001) levels only in the tumor tissue explant. Fatty Acids 33-53 stearoyl-CoA desaturase Homo sapiens 4-8 25013434-11 2014 CONCLUSION: The fatty acid composition and response to SCD1 inhibition differed between the explant cultures from breast cancer and the adjacent normal-appearing tissue. Fatty Acids 16-26 stearoyl-CoA desaturase Homo sapiens 55-59 25013434-12 2014 Altered fatty acid composition induced by SCD1 inhibition may also, in addition to Delta9 desaturation, modulate other reactions in de novo fatty acid synthesis and lipogenesis, and subsequently affect the overall survival and progression of breast cancer. Fatty Acids 8-18 stearoyl-CoA desaturase Homo sapiens 42-46 25013434-12 2014 Altered fatty acid composition induced by SCD1 inhibition may also, in addition to Delta9 desaturation, modulate other reactions in de novo fatty acid synthesis and lipogenesis, and subsequently affect the overall survival and progression of breast cancer. Fatty Acids 140-150 stearoyl-CoA desaturase Homo sapiens 42-46 24864084-1 2014 Stearoyl-CoA desaturase is an enzyme from the class of oxidoreductase, which catalyzes the formation of a fatty acid double bond between C9 and C10. Fatty Acids 106-116 stearoyl-CoA desaturase Homo sapiens 0-23 24577432-1 2014 OBJECTIVE: Enhanced fatty-acid desaturation by stearoyl-CoA desaturase enzyme-1 (SCD1) is associated with obesity. Fatty Acids 20-30 stearoyl-CoA desaturase Homo sapiens 47-79 24577432-1 2014 OBJECTIVE: Enhanced fatty-acid desaturation by stearoyl-CoA desaturase enzyme-1 (SCD1) is associated with obesity. Fatty Acids 20-30 stearoyl-CoA desaturase Homo sapiens 81-85 24650127-5 2014 High expression of SCD1 is corresponded with low rates of fatty acid oxidation, therefore it might reduce inflammatory responses and be beneficial for the growth of induced endothelial cells. Fatty Acids 58-68 stearoyl-CoA desaturase Homo sapiens 19-23 24368438-1 2014 BACKGROUND: A high proportion of monounsaturated fatty acids (MUFAs) or a high ratio of MUFAs to saturated fatty acids in plasma, reflecting a high activity of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1), has been shown to be related to cancer death and incidence in some studies. Fatty Acids 39-60 stearoyl-CoA desaturase Homo sapiens 181-206