PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2162754-11 1990 422(aP2) protein was found to bind fatty acids. Fatty Acids 35-46 fatty acid binding protein 4, adipocyte Mus musculus 4-7 2162754-13 1990 Compelling evidence indicates that on binding fatty acid, 422(aP2) protein undergoes a conformational change whereby Tyr19 becomes accessible to the receptor tyrosine kinase and undergoes O-phosphorylation. Fatty Acids 46-56 fatty acid binding protein 4, adipocyte Mus musculus 62-65 34803493-7 2021 Results: We found that upregulation of the LPL/FABP4/CPT1 molecular axis, as a fatty acid metabolic reprogramming process, occurred specifically during the NASH phase. Fatty Acids 79-89 fatty acid binding protein 4, adipocyte Mus musculus 47-52 31802182-0 2020 IL-17A promotes fatty acid uptake through the IL-17A/IL-17RA/p-STAT3/FABP4 axis to fuel ovarian cancer growth in an adipocyte-rich microenvironment. Fatty Acids 16-26 fatty acid binding protein 4, adipocyte Mus musculus 69-74 35088483-9 2022 FABP4 may play a key role in BMSC senescence caused by fatty acid metabolism disorders. Fatty Acids 55-65 fatty acid binding protein 4, adipocyte Mus musculus 0-5 31562532-1 2020 PURPOSE: We hypothesize that different types of dietary fatty acids (FAs) affect gastrointestinal (GI) motility and visceromotor function and that this effect can be regulated by the fatty acid binding protein 4 (FABP4). Fatty Acids 56-67 fatty acid binding protein 4, adipocyte Mus musculus 183-211 31562532-1 2020 PURPOSE: We hypothesize that different types of dietary fatty acids (FAs) affect gastrointestinal (GI) motility and visceromotor function and that this effect can be regulated by the fatty acid binding protein 4 (FABP4). Fatty Acids 56-67 fatty acid binding protein 4, adipocyte Mus musculus 213-218 31562532-1 2020 PURPOSE: We hypothesize that different types of dietary fatty acids (FAs) affect gastrointestinal (GI) motility and visceromotor function and that this effect can be regulated by the fatty acid binding protein 4 (FABP4). Fatty Acids 69-72 fatty acid binding protein 4, adipocyte Mus musculus 183-211 31562532-1 2020 PURPOSE: We hypothesize that different types of dietary fatty acids (FAs) affect gastrointestinal (GI) motility and visceromotor function and that this effect can be regulated by the fatty acid binding protein 4 (FABP4). Fatty Acids 69-72 fatty acid binding protein 4, adipocyte Mus musculus 213-218 35457171-1 2022 The microglial fatty-acid-binding protein 4-uncoupling protein 2 (FABP4-UCP2) axis is a key regulator of neuroinflammation in high-fat-diet (HFD)-fed animals, indicating a role for FABP4 in brain immune response. Fatty Acids 15-25 fatty acid binding protein 4, adipocyte Mus musculus 66-71 35457171-1 2022 The microglial fatty-acid-binding protein 4-uncoupling protein 2 (FABP4-UCP2) axis is a key regulator of neuroinflammation in high-fat-diet (HFD)-fed animals, indicating a role for FABP4 in brain immune response. Fatty Acids 15-25 fatty acid binding protein 4, adipocyte Mus musculus 181-186 34998697-5 2022 METHODS AND RESULTS: When Panc-1 (human) and Pan02 (mouse) pancreatic cancer cells were treated with FABP4 or the-single-point mutant FABP4 (R126Q, fatty acid binding site mutant), only FABP4 stimulated cellular proliferation. Fatty Acids 148-158 fatty acid binding protein 4, adipocyte Mus musculus 101-106 34998697-5 2022 METHODS AND RESULTS: When Panc-1 (human) and Pan02 (mouse) pancreatic cancer cells were treated with FABP4 or the-single-point mutant FABP4 (R126Q, fatty acid binding site mutant), only FABP4 stimulated cellular proliferation. Fatty Acids 148-158 fatty acid binding protein 4, adipocyte Mus musculus 134-139 34998697-5 2022 METHODS AND RESULTS: When Panc-1 (human) and Pan02 (mouse) pancreatic cancer cells were treated with FABP4 or the-single-point mutant FABP4 (R126Q, fatty acid binding site mutant), only FABP4 stimulated cellular proliferation. Fatty Acids 148-158 fatty acid binding protein 4, adipocyte Mus musculus 186-191 32920196-4 2020 Hence, the present study aimed to investigate the role of fatty acid binding protein 4 (FABP4) which is a carrier protein for fatty acids, in regulating apoptosis in RAW264.7 cells infected with Bacillus Calmette-Guerin (BCG). Fatty Acids 126-137 fatty acid binding protein 4, adipocyte Mus musculus 58-86 32920196-4 2020 Hence, the present study aimed to investigate the role of fatty acid binding protein 4 (FABP4) which is a carrier protein for fatty acids, in regulating apoptosis in RAW264.7 cells infected with Bacillus Calmette-Guerin (BCG). Fatty Acids 126-137 fatty acid binding protein 4, adipocyte Mus musculus 88-93 32920196-10 2020 In addition, FABP4 knockdown promoted fatty acid oxidation and ROS production, which result in the activation of ER stress. Fatty Acids 38-48 fatty acid binding protein 4, adipocyte Mus musculus 13-18 33225276-10 2020 The Fabp4 knockout mice had an altered fatty acid composition in the cortex. Fatty Acids 39-49 fatty acid binding protein 4, adipocyte Mus musculus 4-9 32560200-4 2020 PVH also increased the mRNA expression levels of the adipocyte fatty acid-binding protein (aP2) and decreased that of pre-adipocyte factor-1 (Pref-1) (a pre-adipocyte marker gene), suggesting that PVH promotes adipocyte differentiation. Fatty Acids 63-73 fatty acid binding protein 4, adipocyte Mus musculus 91-94 29630878-7 2018 It inhibited fatty acid synthesis related proteins including FAS, FABP4, leptin, and perilipin. Fatty Acids 13-23 fatty acid binding protein 4, adipocyte Mus musculus 66-71 29550588-9 2018 The effects of the FABP4 inhibitor reducing lipid-induced ER stress-associated inflammation were related to the reduction of fatty acid-induced intramyocellular lipid deposits, ROS and nuclear factor-kappaB (NF-kappaB) nuclear translocation. Fatty Acids 125-135 fatty acid binding protein 4, adipocyte Mus musculus 19-24 29572893-9 2018 Moreover, hepatic Fabp1 and Fabp4, two genes for hepatic fatty acid uptake were upregulated in Cd-treated mice. Fatty Acids 57-67 fatty acid binding protein 4, adipocyte Mus musculus 28-33 27568980-1 2017 Fatty acid binding protein 4 (FABP4) is a fatty acid chaperone, which is induced during adipocyte differentiation. Fatty Acids 42-52 fatty acid binding protein 4, adipocyte Mus musculus 0-28 28382782-4 2017 Fatty acid-binding protein 4 (FABP4) is a carrier protein for fatty acids and is involved in fatty acid uptake, transport, and lipid metabolism. Fatty Acids 62-73 fatty acid binding protein 4, adipocyte Mus musculus 0-28 28382782-4 2017 Fatty acid-binding protein 4 (FABP4) is a carrier protein for fatty acids and is involved in fatty acid uptake, transport, and lipid metabolism. Fatty Acids 62-73 fatty acid binding protein 4, adipocyte Mus musculus 30-35 28382782-4 2017 Fatty acid-binding protein 4 (FABP4) is a carrier protein for fatty acids and is involved in fatty acid uptake, transport, and lipid metabolism. Fatty Acids 62-72 fatty acid binding protein 4, adipocyte Mus musculus 0-28 28382782-4 2017 Fatty acid-binding protein 4 (FABP4) is a carrier protein for fatty acids and is involved in fatty acid uptake, transport, and lipid metabolism. Fatty Acids 62-72 fatty acid binding protein 4, adipocyte Mus musculus 30-35 27885273-0 2017 Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells. Fatty Acids 0-10 fatty acid binding protein 4, adipocyte Mus musculus 27-32 27568980-1 2017 Fatty acid binding protein 4 (FABP4) is a fatty acid chaperone, which is induced during adipocyte differentiation. Fatty Acids 42-52 fatty acid binding protein 4, adipocyte Mus musculus 30-35 27568980-3 2017 Here, we investigated the role of FABP4 in endothelial fatty acid metabolism and tumour angiogenesis. Fatty Acids 55-65 fatty acid binding protein 4, adipocyte Mus musculus 34-39 27568980-6 2017 In vitro, siRNA-mediated FABP4 knockdown in endothelial cells led to a marked increase of endothelial fatty acid oxidation, an increase of reactive oxygen species and decreased angiogenesis. Fatty Acids 102-112 fatty acid binding protein 4, adipocyte Mus musculus 25-30 27294862-1 2016 Fatty acid binding protein 4 (FABP4) is a member of the intracellular lipid-binding protein family, responsible for the transportation of fatty acids. Fatty Acids 138-149 fatty acid binding protein 4, adipocyte Mus musculus 0-28 27920274-7 2017 Furthermore, we validated the role of A-FABP in promoting sFA-induced macrophage cell death with primary bone marrow-derived macrophages and high-fat diet-induced obese mice. Fatty Acids 58-61 fatty acid binding protein 4, adipocyte Mus musculus 38-44 27294862-1 2016 Fatty acid binding protein 4 (FABP4) is a member of the intracellular lipid-binding protein family, responsible for the transportation of fatty acids. Fatty Acids 138-149 fatty acid binding protein 4, adipocyte Mus musculus 30-35 26789108-2 2016 Previous work using high fat-fed mice has shown that ablation of the adipocyte fatty acid binding protein (FABP4/aP2) in macrophages leads to an antiinflammatory state both in situ and in vivo, and the mechanism is linked, in part, to increased intracellular monounsaturated fatty acids and the up-regulation of uncoupling protein 2. Fatty Acids 79-89 fatty acid binding protein 4, adipocyte Mus musculus 107-112 26789108-2 2016 Previous work using high fat-fed mice has shown that ablation of the adipocyte fatty acid binding protein (FABP4/aP2) in macrophages leads to an antiinflammatory state both in situ and in vivo, and the mechanism is linked, in part, to increased intracellular monounsaturated fatty acids and the up-regulation of uncoupling protein 2. Fatty Acids 79-89 fatty acid binding protein 4, adipocyte Mus musculus 113-116 26310911-9 2015 Taken together, FABP4 could reverse the activation of the leptin-induced mitochondrial fatty acid oxidation, and the inhibition of Akt/mTOR signal pathway played a key role in this process. Fatty Acids 87-97 fatty acid binding protein 4, adipocyte Mus musculus 16-21 25867423-1 2015 Adipocyte fatty acid-binding protein (A-FABP), the most abundant FABP in adipocytes, controls fatty acid uptake, transport, and metabolism in fat cells. Fatty Acids 10-20 fatty acid binding protein 4, adipocyte Mus musculus 38-44 26310911-0 2015 FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes. Fatty Acids 57-67 fatty acid binding protein 4, adipocyte Mus musculus 0-5 26310911-1 2015 Fatty acid binding protein 4 (FABP4), plays key role in fatty acid transportation and oxidation, and increases with leptin synergistically during adipose inflammation process. Fatty Acids 56-66 fatty acid binding protein 4, adipocyte Mus musculus 0-28 26310911-1 2015 Fatty acid binding protein 4 (FABP4), plays key role in fatty acid transportation and oxidation, and increases with leptin synergistically during adipose inflammation process. Fatty Acids 56-66 fatty acid binding protein 4, adipocyte Mus musculus 30-35 26310911-2 2015 However, the regulation mechanism between FABP4 and leptin on mitochondrial fatty acid oxidation remains unclear. Fatty Acids 76-86 fatty acid binding protein 4, adipocyte Mus musculus 42-47 29124133-10 2015 The fatty-acid-binding protein (fabp4) gene was up-regulated and three genes, including sperm-associated glutamate (E)-rich protein 4d (speer-4d), phospholipase A2-Group 3 (pla2g3) and phospholipase A2-Group 10 (pla2g10), were down-regulated in L110R MM-1alpha mice. Fatty Acids 4-14 fatty acid binding protein 4, adipocyte Mus musculus 32-37 24401215-2 2014 Fatty acid binding proteins (FABP-4/aP2) and CD36 expression are key factors in lipid accumulation in macrophages and foam cell formation in atherogenesis. Fatty Acids 0-10 fatty acid binding protein 4, adipocyte Mus musculus 36-39 25596549-1 2015 Adipocyte fatty acid-binding protein (A-FABP) plays an important role in fatty acid-mediated processes and related metabolic and inflammatory responses. Fatty Acids 10-20 fatty acid binding protein 4, adipocyte Mus musculus 38-44 25446101-4 2015 Thus, ATF3 effectively repressed rosiglitazone-stimulated expression of adipocyte fatty acid binding protein (aP2), PPARgamma target gene, in 3T3-L1 cells. Fatty Acids 82-92 fatty acid binding protein 4, adipocyte Mus musculus 110-113 25383754-6 2014 The fatty acid (FA) binding and co-activator proteins Fabp1, Fabp4 and Acsl1 were increased 2-fold. Fatty Acids 4-14 fatty acid binding protein 4, adipocyte Mus musculus 61-66 24319114-1 2014 Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and implicated in the development of insulin resistance and atherosclerosis. Fatty Acids 73-83 fatty acid binding protein 4, adipocyte Mus musculus 0-28 24319114-1 2014 Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and implicated in the development of insulin resistance and atherosclerosis. Fatty Acids 73-83 fatty acid binding protein 4, adipocyte Mus musculus 30-35 24319114-1 2014 Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and implicated in the development of insulin resistance and atherosclerosis. Fatty Acids 73-83 fatty acid binding protein 4, adipocyte Mus musculus 51-54 24489659-8 2014 Peritoneal macrophages of llee male mice have reduced mRNA expression of FABP4, a fatty acid binding protein implicated in atherosclerosis. Fatty Acids 82-92 fatty acid binding protein 4, adipocyte Mus musculus 73-78 23968980-2 2013 Here, we hypothesize that capillary endothelial fatty acid binding protein 4 (FABP4) and FABP5 play an important role in providing sufficient FAs to the myocardium. Fatty Acids 142-145 fatty acid binding protein 4, adipocyte Mus musculus 48-76 23968980-2 2013 Here, we hypothesize that capillary endothelial fatty acid binding protein 4 (FABP4) and FABP5 play an important role in providing sufficient FAs to the myocardium. Fatty Acids 142-145 fatty acid binding protein 4, adipocyte Mus musculus 78-83 18551191-3 2008 In this study, we have taken advantage of the highly restricted coexpression of adipocyte/macrophage fatty acid-binding proteins (FABPs) aP2 (FABP4) and mal1 (FABP5) to examine the contribution of these lipid chaperones in macrophages and adipocytes to local and systemic inflammation and metabolic homeostasis in mice. Fatty Acids 101-111 fatty acid binding protein 4, adipocyte Mus musculus 137-140 23525438-2 2013 We investigated whether peroxisome proliferator-activated receptor-gamma (PPARgamma) induces expression of fatty acid-binding protein 4 (FABP4) and fatty acid translocase (FAT)/CD36 in capillary endothelial cells (ECs) to promote FA transport into the heart. Fatty Acids 107-117 fatty acid binding protein 4, adipocyte Mus musculus 137-142 22585040-2 2012 In this study, we identified fatty acid-binding protein (FABP4), an intracellular fatty acid chaperone, in the mouse thymus, and examined its role in the control of cytokine production in comparison with FABP5. Fatty Acids 29-39 fatty acid binding protein 4, adipocyte Mus musculus 57-62 22585040-2 2012 In this study, we identified fatty acid-binding protein (FABP4), an intracellular fatty acid chaperone, in the mouse thymus, and examined its role in the control of cytokine production in comparison with FABP5. Fatty Acids 82-92 fatty acid binding protein 4, adipocyte Mus musculus 57-62 21543640-1 2011 The fatty acid binding protein 4 (FABP4) belongs to the family of lipid chaperones that control intracellular fluxes and compartmentalization of their respective ligands (e.g., fatty acids). Fatty Acids 177-188 fatty acid binding protein 4, adipocyte Mus musculus 4-32 21543640-1 2011 The fatty acid binding protein 4 (FABP4) belongs to the family of lipid chaperones that control intracellular fluxes and compartmentalization of their respective ligands (e.g., fatty acids). Fatty Acids 177-188 fatty acid binding protein 4, adipocyte Mus musculus 34-39 21044951-2 2011 Here, we demonstrate that the heart-type fatty acid-binding protein, FABP3, is essential for cold tolerance and efficient fatty acid oxidation in mouse brown adipose tissue, despite the abundant expression of adipose-type fatty acid-binding protein, FABP4 (also known as aP2). Fatty Acids 41-51 fatty acid binding protein 4, adipocyte Mus musculus 271-274 23805908-1 2013 Macrophage adipocyte fatty acid-binding protein (FABP4) plays an important role in foam cell formation and development of atherosclerosis. Fatty Acids 21-31 fatty acid binding protein 4, adipocyte Mus musculus 49-54 23100228-4 2013 In this chapter, I will describe generation of "floxed" PPARgamma mice, which bear loxP sequences in the introns of PPARgamma gene locus flanking the coding exons 1 and 2 of PPARgamma and creation of the aP2-Cre transgenic mice, which express Cre recombinase under the control of the promoter of adipocyte fatty acid binding protein (aP2). Fatty Acids 306-316 fatty acid binding protein 4, adipocyte Mus musculus 204-207 21046125-2 2011 AIM OF THE STUDY: This study was conducted to test the hypothesis that the role of fatty acids in the inflammatory pathways is mediated through the modulation of A-FABP expression in macrophages. Fatty Acids 83-94 fatty acid binding protein 4, adipocyte Mus musculus 162-168 21046125-4 2011 The cells were treated with trichostatin A (TSA), a histone deacetylase inhibitor, for elucidating mechanisms for the regulation of A-FABP expression by fatty acids. Fatty Acids 153-164 fatty acid binding protein 4, adipocyte Mus musculus 132-138 21474828-1 2011 OBJECTIVE: The adipocyte/macrophage fatty acid-binding proteins aP2 (FABP4) and Mal1 (FABP5) are intracellular lipid chaperones that modulate systemic glucose metabolism, insulin sensitivity, and atherosclerosis. Fatty Acids 36-46 fatty acid binding protein 4, adipocyte Mus musculus 64-67 21474828-1 2011 OBJECTIVE: The adipocyte/macrophage fatty acid-binding proteins aP2 (FABP4) and Mal1 (FABP5) are intracellular lipid chaperones that modulate systemic glucose metabolism, insulin sensitivity, and atherosclerosis. Fatty Acids 36-46 fatty acid binding protein 4, adipocyte Mus musculus 69-74 21323331-7 2011 The mRNA expressions of adipocyte fatty acid-binding protein (aP2), lipoprotein lipase (LPL), and glucose-transporter 4 (Glut4) in 3T3-L1 cells were markedly down-regulated by amarouciaxanthin A compared to fucoxanthinol. Fatty Acids 34-44 fatty acid binding protein 4, adipocyte Mus musculus 62-65 19318353-3 2009 We present herein the finding that AFABP/aP2 interacts with JAK2 in a fatty acid-dependent manner. Fatty Acids 70-80 fatty acid binding protein 4, adipocyte Mus musculus 35-40 19318353-3 2009 We present herein the finding that AFABP/aP2 interacts with JAK2 in a fatty acid-dependent manner. Fatty Acids 70-80 fatty acid binding protein 4, adipocyte Mus musculus 41-44 19318353-5 2009 Mutational analysis of AFABP/aP2 (R126L/Y128F) revealed that fatty acid binding activity is necessary for the interaction and that Asp(18) of the helix-turn-helix motif forms a component of the interaction domain. Fatty Acids 61-71 fatty acid binding protein 4, adipocyte Mus musculus 23-28 19318353-5 2009 Mutational analysis of AFABP/aP2 (R126L/Y128F) revealed that fatty acid binding activity is necessary for the interaction and that Asp(18) of the helix-turn-helix motif forms a component of the interaction domain. Fatty Acids 61-71 fatty acid binding protein 4, adipocyte Mus musculus 29-32 19318353-8 2009 These results suggest that ligand-bound AFABP/aP2 binds to and attenuates JAK2 signaling and establishes a new role for AFABP/aP2 as a fatty acid sensor affecting cellular metabolism via protein-protein interactions. Fatty Acids 135-145 fatty acid binding protein 4, adipocyte Mus musculus 40-45 19318353-8 2009 These results suggest that ligand-bound AFABP/aP2 binds to and attenuates JAK2 signaling and establishes a new role for AFABP/aP2 as a fatty acid sensor affecting cellular metabolism via protein-protein interactions. Fatty Acids 135-145 fatty acid binding protein 4, adipocyte Mus musculus 46-49 19318353-8 2009 These results suggest that ligand-bound AFABP/aP2 binds to and attenuates JAK2 signaling and establishes a new role for AFABP/aP2 as a fatty acid sensor affecting cellular metabolism via protein-protein interactions. Fatty Acids 135-145 fatty acid binding protein 4, adipocyte Mus musculus 120-125 19318353-8 2009 These results suggest that ligand-bound AFABP/aP2 binds to and attenuates JAK2 signaling and establishes a new role for AFABP/aP2 as a fatty acid sensor affecting cellular metabolism via protein-protein interactions. Fatty Acids 135-145 fatty acid binding protein 4, adipocyte Mus musculus 126-129 18551191-3 2008 In this study, we have taken advantage of the highly restricted coexpression of adipocyte/macrophage fatty acid-binding proteins (FABPs) aP2 (FABP4) and mal1 (FABP5) to examine the contribution of these lipid chaperones in macrophages and adipocytes to local and systemic inflammation and metabolic homeostasis in mice. Fatty Acids 101-111 fatty acid binding protein 4, adipocyte Mus musculus 142-147 17785468-2 2007 To identify the determinants affecting the interaction fluorescence resonance energy transfer (FRET) imaging was used in conjunction with a mutagenesis strategy to evaluate the roles AFABP/aP2 fatty acid binding and HSL phosphorylation have in complex formation as well as determine the HSL binding site on AFABP/aP2. Fatty Acids 193-203 fatty acid binding protein 4, adipocyte Mus musculus 189-192 17114450-0 2006 Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2. Fatty Acids 64-74 fatty acid binding protein 4, adipocyte Mus musculus 91-94 17554340-1 2007 Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Fatty Acids 10-20 fatty acid binding protein 4, adipocyte Mus musculus 38-41 17554340-1 2007 Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Fatty Acids 10-20 fatty acid binding protein 4, adipocyte Mus musculus 43-48 17481768-5 2007 Also organized establishment of aP2 related mice model revealed the impact of this cytoplasmic fatty acid binding protein in the development of metabolic syndrome. Fatty Acids 95-105 fatty acid binding protein 4, adipocyte Mus musculus 32-35 17111194-7 2007 The present findings altogether suggest that A-FABP and its ligands, fatty acids, play an important role in the process of apoptosis and the immune modulation induced by DEX. Fatty Acids 69-80 fatty acid binding protein 4, adipocyte Mus musculus 45-51 17077479-3 2006 Unlike the known crystal structure of murine aP2 in complex with palmitate, this structure shows that the fatty acid is in a folded conformation and that the loop containing Phe57 acts as a lid to regulate ligand binding by excluding solvent exposure to the central binding cavity. Fatty Acids 106-116 fatty acid binding protein 4, adipocyte Mus musculus 45-48 16675498-11 2006 The expression levels of fatty acid binding protein 4 (FABP4), which reflects fatty acid metabolism, were decreased slightly at 5 and 10 days and then returned to control levels 30 days after muscle denervation. Fatty Acids 25-35 fatty acid binding protein 4, adipocyte Mus musculus 55-60 15353487-1 2004 BACKGROUND: The adipocyte fatty acid-binding protein (FABP) aP2 is expressed by adipocytes and macrophages and modulates insulin resistance, glucose and lipid metabolism, and atherosclerosis. Fatty Acids 26-36 fatty acid binding protein 4, adipocyte Mus musculus 60-63 16704309-1 2006 Fatty acid binding protein 4 (FABP4) is a key mediator of intracellular transport and metabolism of fatty acids in adipose tissues. Fatty Acids 100-111 fatty acid binding protein 4, adipocyte Mus musculus 0-28 16704309-1 2006 Fatty acid binding protein 4 (FABP4) is a key mediator of intracellular transport and metabolism of fatty acids in adipose tissues. Fatty Acids 100-111 fatty acid binding protein 4, adipocyte Mus musculus 30-35 16704309-2 2006 FABP4 binds fatty acids with high affinity and transports them to various compartments in the cell. Fatty Acids 12-23 fatty acid binding protein 4, adipocyte Mus musculus 0-5 16704309-3 2006 When in complex with fatty acids, FABP4 interacts with and modulates the activity of two important regulators of metabolism: hormone-sensitive lipase and peroxisome proliferator-activated receptor gamma. Fatty Acids 21-32 fatty acid binding protein 4, adipocyte Mus musculus 34-39 15705927-3 2005 Adipocyte fatty acid-binding protein (aP2) is present in macrophages and has an important role in atherosclerotic plaque development. Fatty Acids 10-20 fatty acid binding protein 4, adipocyte Mus musculus 38-41 15367400-1 2005 The metabolic impact of the murine adipocyte fatty acid-binding protein (AFABP/aP2) on lipid metabolism was investigated in the AFABP/aP2(-/-) mouse and compared with wild-type C57BL/6J littermates. Fatty Acids 45-55 fatty acid binding protein 4, adipocyte Mus musculus 73-78 15367400-1 2005 The metabolic impact of the murine adipocyte fatty acid-binding protein (AFABP/aP2) on lipid metabolism was investigated in the AFABP/aP2(-/-) mouse and compared with wild-type C57BL/6J littermates. Fatty Acids 45-55 fatty acid binding protein 4, adipocyte Mus musculus 79-82 15367400-10 2005 These data demonstrate that in vivo disruption of AFABP/aP2(-/-) leads to changes in the following two major metabolic processes: 1) decreased adipose NEFA efflux and 2) preferential utilization of glucose relative to fatty acids. Fatty Acids 218-229 fatty acid binding protein 4, adipocyte Mus musculus 50-55 15367400-10 2005 These data demonstrate that in vivo disruption of AFABP/aP2(-/-) leads to changes in the following two major metabolic processes: 1) decreased adipose NEFA efflux and 2) preferential utilization of glucose relative to fatty acids. Fatty Acids 218-229 fatty acid binding protein 4, adipocyte Mus musculus 56-59 12540600-2 2003 The fatty acid binding proteins aP2 (fatty acid binding protein [FABP]-4) and mal1 (FABP5) are closely related and both are expressed in adipocytes. Fatty Acids 4-14 fatty acid binding protein 4, adipocyte Mus musculus 32-35 13129924-9 2003 The activation by A-FABP was dependent upon its fatty acid binding properties because a non-fatty acid binding mutant, R126Q, failed to activate HSL. Fatty Acids 48-58 fatty acid binding protein 4, adipocyte Mus musculus 18-24 13129924-9 2003 The activation by A-FABP was dependent upon its fatty acid binding properties because a non-fatty acid binding mutant, R126Q, failed to activate HSL. Fatty Acids 92-102 fatty acid binding protein 4, adipocyte Mus musculus 18-24 12867536-1 2003 Adipocyte fatty acid binding protein (aP2) is a key mediator of intracellular transport and metabolism of fatty acids. Fatty Acids 106-117 fatty acid binding protein 4, adipocyte Mus musculus 38-41 12867536-4 2003 We investigated the regulation of expression of macrophage aP2 and CD36, a fatty acid membrane binding protein and scavenger receptor, in response to the adipogenic agents isobutylmethylxanthine (IBMX), insulin, and dexamethasone, a combination of agents shown to induce fibroblast-to-adipocyte differentiation. Fatty Acids 75-85 fatty acid binding protein 4, adipocyte Mus musculus 59-62 12540600-2 2003 The fatty acid binding proteins aP2 (fatty acid binding protein [FABP]-4) and mal1 (FABP5) are closely related and both are expressed in adipocytes. Fatty Acids 4-14 fatty acid binding protein 4, adipocyte Mus musculus 65-72 12540600-2 2003 The fatty acid binding proteins aP2 (fatty acid binding protein [FABP]-4) and mal1 (FABP5) are closely related and both are expressed in adipocytes. Fatty Acids 37-47 fatty acid binding protein 4, adipocyte Mus musculus 32-35 12540600-2 2003 The fatty acid binding proteins aP2 (fatty acid binding protein [FABP]-4) and mal1 (FABP5) are closely related and both are expressed in adipocytes. Fatty Acids 37-47 fatty acid binding protein 4, adipocyte Mus musculus 65-72 11396990-2 2001 FABP4/aP2 protein"s function to bind fatty acids in the adipocytes may promote total body energy homeostasis by linking energy depots to the ability to express signaling molecules similar to leptin. Fatty Acids 37-48 fatty acid binding protein 4, adipocyte Mus musculus 0-5 12377750-0 2002 Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Fatty Acids 10-20 fatty acid binding protein 4, adipocyte Mus musculus 38-41 12377750-1 2002 OBJECTIVE: The adipocyte fatty acid-binding protein, aP2, has important effects on insulin resistance, lipid metabolism, and atherosclerosis. Fatty Acids 25-35 fatty acid binding protein 4, adipocyte Mus musculus 53-56 11396990-2 2001 FABP4/aP2 protein"s function to bind fatty acids in the adipocytes may promote total body energy homeostasis by linking energy depots to the ability to express signaling molecules similar to leptin. Fatty Acids 37-48 fatty acid binding protein 4, adipocyte Mus musculus 6-9 10329662-2 1999 We have identified a novel transcriptional repressor, AEBP2, that binds to a regulatory sequence (termed AE-1) located in the proximal promoter region of the aP2 gene that encodes the adipose fatty acid-binding protein. Fatty Acids 192-202 fatty acid binding protein 4, adipocyte Mus musculus 158-161 10965911-1 2000 Adipocyte fatty acid-binding protein, aP2, is a member of the intracellular fatty acid binding protein family. Fatty Acids 10-20 fatty acid binding protein 4, adipocyte Mus musculus 38-41 10866041-1 2000 Mice null for adipocyte fatty acid binding protein (AFABP) compensate by increasing expression of keratinocyte fatty acid binding protein (KFABP) (Hotamisligil et al. Fatty Acids 24-34 fatty acid binding protein 4, adipocyte Mus musculus 52-57 10866041-6 2000 Adipocytes isolated from AFABP-KO and WT mice fed high- or low-fat diets exhibited similar rates of basal and norepinephrine-stimulated lipolysis and insulin-stimulated rates of glucose conversion to fatty acids and glyceride-glycerol. Fatty Acids 200-211 fatty acid binding protein 4, adipocyte Mus musculus 25-30 10866041-7 2000 However, basal glucose conversion to fatty acids was higher in adipocytes of AFABP-KO mice. Fatty Acids 37-48 fatty acid binding protein 4, adipocyte Mus musculus 77-82 11385507-0 2001 Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Fatty Acids 19-29 fatty acid binding protein 4, adipocyte Mus musculus 46-49 11385507-1 2001 The adipocyte fatty-acid-binding protein, aP2, has an important role in regulating systemic insulin resistance and lipid metabolism. Fatty Acids 14-24 fatty acid binding protein 4, adipocyte Mus musculus 42-45 10991946-4 2000 Overexpression of PPARdelta enhanced fatty acid induction of the adipose-related genes for fatty acid translocase, adipocyte lipid binding protein, and PPARgamma and fatty acid effects on terminal differentiation. Fatty Acids 37-47 fatty acid binding protein 4, adipocyte Mus musculus 115-146 10965911-1 2000 Adipocyte fatty acid-binding protein, aP2, is a member of the intracellular fatty acid binding protein family. Fatty Acids 76-86 fatty acid binding protein 4, adipocyte Mus musculus 38-41 10866041-11 2000 As for AFABP, the rate of fatty acid transfer from KFABP to model phospholipid vesicles was increased with acceptor membrane concentration and by inclusion of acidic phospholipids, indicating a similar mechanism of transfer. Fatty Acids 26-36 fatty acid binding protein 4, adipocyte Mus musculus 7-12 10224167-1 1999 The availability of mice containing an adipocyte lipid-binding protein (ALBP/aP2) gene disruption allowed for a direct examination of the presumed role of lipid-binding proteins in the mobilization and trafficking of intracellular fatty acids. Fatty Acids 231-242 fatty acid binding protein 4, adipocyte Mus musculus 72-80 10224167-8 1999 Consistent with a decrease in basal efflux, the non-esterified fatty acid (NEFA) level was nearly 3-fold greater in adipocytes from ALBP/aP2 nulls as compared to wild-type animals. Fatty Acids 63-73 fatty acid binding protein 4, adipocyte Mus musculus 132-140 10224167-9 1999 The significant decrease in both basal and isoproterenol-stimulated lipolysis in adipose tissue of ALBP/aP2 null mice supports the model whereby intracellular lipid-binding proteins function as lipid chaperones, facilitating the movement of fatty acids out of the fat cell. Fatty Acids 241-252 fatty acid binding protein 4, adipocyte Mus musculus 99-107 9664136-1 1998 The adipocyte type fatty acid-binding protein (A-FABP) is a small molecular weight fatty acid-binding protein whose expression correlates both with the grade of atypia and the stage of bladder transitional cell carcinomas (TCCs). Fatty Acids 19-29 fatty acid binding protein 4, adipocyte Mus musculus 47-53 10076998-2 1999 PPARgamma activates many target genes involved in lipid anabolism including the adipocyte fatty acid binding protein (aP2). Fatty Acids 90-100 fatty acid binding protein 4, adipocyte Mus musculus 118-121 7867610-2 1995 We recently showed that overexpression of GLUT4 selectively in adipocytes of transgenic mice using the aP2 (fatty acid-binding protein) promoter/enhancer results in enhanced glucose tolerance and adipocyte hyperplasia. Fatty Acids 108-118 fatty acid binding protein 4, adipocyte Mus musculus 103-106 8910278-0 1996 Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Fatty Acids 96-106 fatty acid binding protein 4, adipocyte Mus musculus 77-80 8910278-5 1996 These results indicate that aP2 is central to the pathway that links obesity to insulin resistance, possibly by linking fatty acid metabolism to expression of TNF-alpha. Fatty Acids 120-130 fatty acid binding protein 4, adipocyte Mus musculus 28-31 8941343-6 1996 Similar treatment also markedly reduced differentiation-dependent expression of mRNAs encoding angiotensinogen and the fat-specific fatty acid binding protein, aP2. Fatty Acids 132-142 fatty acid binding protein 4, adipocyte Mus musculus 160-163 7926726-7 1994 Moreover, forced expression of mPPAR gamma 2 and RXR alpha activates the adipocyte-specific aP2 enhancer in cultured fibroblasts, and this activation is potentiated by peroxisome proliferators, fatty acids, and 9-cis retinoic acid. Fatty Acids 194-205 fatty acid binding protein 4, adipocyte Mus musculus 92-95 2365678-9 1990 Taken together these results indicate that fatty acids traverse the plasma membrane and are bound by ALBP in the cytoplasmic compartment. Fatty Acids 43-54 fatty acid binding protein 4, adipocyte Mus musculus 101-105 1648089-10 1991 These results demonstrate that in vitro the murine adipocyte lipid-binding protein is phosphorylated on tyrosine 19 in an insulin-stimulated fashion by the insulin receptor and that the presence of a bound fatty acid on ALBP increases the affinity of insulin receptor for ALBP. Fatty Acids 206-216 fatty acid binding protein 4, adipocyte Mus musculus 220-224 1648089-10 1991 These results demonstrate that in vitro the murine adipocyte lipid-binding protein is phosphorylated on tyrosine 19 in an insulin-stimulated fashion by the insulin receptor and that the presence of a bound fatty acid on ALBP increases the affinity of insulin receptor for ALBP. Fatty Acids 206-216 fatty acid binding protein 4, adipocyte Mus musculus 272-276 1554730-5 1992 Crystalline ALBP has a conformation which is essentially identical to that of intestinal fatty acid binding protein and myelin P2 protein. Fatty Acids 89-99 fatty acid binding protein 4, adipocyte Mus musculus 12-16 1554730-11 1992 By comparing ALBP with the earlier structural results on intestinal fatty acid binding protein, it is now possible to delineate conserved amino acids which help form the binding site in this family. Fatty Acids 68-78 fatty acid binding protein 4, adipocyte Mus musculus 13-17