PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10638699-2	2000	To confirm this, in rats we modified phospholipid AA levels by dietary manipulation of the delta-6-desaturase, the rate-limiting enzyme of the fatty acid biosynthetic pathway, and evaluated the effect on cellular and renal functions predisposing to lithogenesis.	Fatty Acids	143-153	fatty acid desaturase 2	Rattus norvegicus	91-109	
1904970-8	1991	These data indicate that the qualitative properties of the dietary protein source may influence the fatty acid pattern of rat hepatic microsomes by interfering with delta 6 desaturase activity.	Fatty Acids	100-110	fatty acid desaturase 2	Rattus norvegicus	165-183	
8591704-2	1995	Suppression of delta 6 desaturase in the liver, a key enzyme of fatty acid desaturation, has been reported to be responsible for these phenomena.	Fatty Acids	64-74	fatty acid desaturase 2	Rattus norvegicus	15-33	
8361989-4	1993	This variation of fatty acid composition could be due to the simultaneous effect of vitamin B6 deficiency, which reduces the oxidation of linolenate, and of a low intake of EFAs which stimulates delta-6-desaturase.	Fatty Acids	18-28	fatty acid desaturase 2	Rattus norvegicus	195-213	
3342019-6	1988	The activity of the delta 6-desaturase in vitro is consistent with the fatty acid composition observed for the microsomal membranes on which this enzyme is localized.	Fatty Acids	71-81	fatty acid desaturase 2	Rattus norvegicus	20-38	
3167694-6	1988	These data suggest that (1) jejunal and ileal microsomal membranes differ from each other in terms of lipid composition and lipid synthesis, (2) site variations in the specificity of acyltransferases for different fatty acids exist, and (3) higher delta 9-, delta 6-, delta 5-, and delta 4-desaturase activities exist in ileal compared with jejunal enterocytes.	Fatty Acids	214-225	fatty acid desaturase 2	Rattus norvegicus	248-300	
23313470-6	2013	Omega 3 fatty acids readily incorporated into hepatic phospholipids, decreased stearoyl-CoA desaturase 16, stearoyl-CoA desaturase, delta 6 desaturase, and delta 5 desaturase activities (calculated as product/substrate ratio) and decreased the "lipogenesis index", i.e., the proportion of fatty acids endogenously synthesized in the liver and not provided with the diet.	Fatty Acids	8-19	fatty acid desaturase 2	Rattus norvegicus	132-150	
2994732-9	1985	delta 5 and delta 6 desaturase reaction-rates were increased both at low and high fatty acid substrate concentrations.	Fatty Acids	82-92	fatty acid desaturase 2	Rattus norvegicus	12-30	
6822904-1	1983	The effect of protein deficiency on the activity of delta 6 desaturase in the mother during lactation was determined in the liver microsomal fraction and the fatty acid composition of milk lipids from the analyzed stomach contents.	Fatty Acids	158-168	fatty acid desaturase 2	Rattus norvegicus	52-70	
25701799-2	2015	In addition, at least 9 other very structurally different fatty acids have been shown to be Delta6- or even Delta8-desaturated by the FADS2 protein.	Fatty Acids	58-69	fatty acid desaturase 2	Rattus norvegicus	134-139	
7305962-5	1981	These changes, other than the decreases proportion of C20:3 fatty acid, which may be due to the diminished delta 6 desaturase activity, cannot be attributed to changes in fatty-acid desaturation.	Fatty Acids	60-70	fatty acid desaturase 2	Rattus norvegicus	107-125	
12470654-3	2002	This response of D6D is paradoxical because SREBP-1c transactivates genes for fatty acid synthesis in liver, while PP induce enzymes for fatty acid oxidation.	Fatty Acids	78-88	fatty acid desaturase 2	Rattus norvegicus	17-20	
12470654-3	2002	This response of D6D is paradoxical because SREBP-1c transactivates genes for fatty acid synthesis in liver, while PP induce enzymes for fatty acid oxidation.	Fatty Acids	137-147	fatty acid desaturase 2	Rattus norvegicus	17-20	
11988075-0	2002	The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis.	Fatty Acids	74-85	fatty acid desaturase 2	Rattus norvegicus	19-30	
12470654-4	2002	We hypothesized that the induction of D6D gene by PP is a compensatory response to the increased HUFA demand caused by peroxisome proliferation and induction of fatty acid oxidation.	Fatty Acids	161-171	fatty acid desaturase 2	Rattus norvegicus	38-41	
11739860-4	2001	The aim of our study was to examine whether the changes in membrane fatty acid composition resulting from the inhibition of Delta-6 desaturase may be involved in the decreased Na(+),K(+)-ATPase activity observed in the outer MTAL after 12 wk of diabetes.	Fatty Acids	68-78	fatty acid desaturase 2	Rattus norvegicus	124-142	
11739860-5	2001	GLA is a fatty acid that by-passes the Delta-6 desaturase step.	Fatty Acids	9-19	fatty acid desaturase 2	Rattus norvegicus	39-57