PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25307752-1 2015 BACKGROUND: Alpha-methylacyl-CoA racemase (AMACR) is an enzyme involved in fatty acid metabolism that is markedly over-expressed in virtually all prostate cancers (PCa), relative to benign tissue. Fatty Acids 75-85 alpha-methylacyl-CoA racemase Homo sapiens 12-41 29345292-1 2018 Alpha-methylacyl-CoA racemase (AMACR) catalyzes the beta-oxidation of fatty acids and is overexpressed in carcinomas in various organs, while its inactivation results in the inhibition of cancer growth. Fatty Acids 70-81 alpha-methylacyl-CoA racemase Homo sapiens 0-29 29345292-1 2018 Alpha-methylacyl-CoA racemase (AMACR) catalyzes the beta-oxidation of fatty acids and is overexpressed in carcinomas in various organs, while its inactivation results in the inhibition of cancer growth. Fatty Acids 70-81 alpha-methylacyl-CoA racemase Homo sapiens 31-36 28902459-7 2017 Using a significance threshold of FDR < 0.1, association was detected for rs10941112 (p = 2.1 x 10-5 ; q-value = 0.073) in AMACR, a gene involved in fatty acid metabolism and previously implicated in schizophrenia, with significant cis effects on gene expression (p = 5.5 x 10-4 ), including brain tissue data from the Genotype-Tissue Expression project (minimum p = 6.0 x 10-5 ). Fatty Acids 152-162 alpha-methylacyl-CoA racemase Homo sapiens 126-131 25307752-1 2015 BACKGROUND: Alpha-methylacyl-CoA racemase (AMACR) is an enzyme involved in fatty acid metabolism that is markedly over-expressed in virtually all prostate cancers (PCa), relative to benign tissue. Fatty Acids 75-85 alpha-methylacyl-CoA racemase Homo sapiens 43-48 25374912-6 2014 A central role for fatty acid oxidation in supplying energy to the prostate cancer cell is supported by the observation that the peroxisomal enzyme, alpha-methylacyl-CoA racemase (AMACR), which facilitates the transformation of branched chain fatty acids to a form suitable for beta-oxidation, is highly overexpressed in prostate cancer compared with normal prostate. Fatty Acids 19-29 alpha-methylacyl-CoA racemase Homo sapiens 149-178 24833092-2 2014 Through data mining from published transcriptomic database, alpha-methylacyl-CoA racemase (AMACR) was first identified as a differentially upregulated gene in NPC tissues, which is a key enzyme for isometric conversion of fatty acids entering the beta-oxidation. Fatty Acids 222-233 alpha-methylacyl-CoA racemase Homo sapiens 60-89 24833092-2 2014 Through data mining from published transcriptomic database, alpha-methylacyl-CoA racemase (AMACR) was first identified as a differentially upregulated gene in NPC tissues, which is a key enzyme for isometric conversion of fatty acids entering the beta-oxidation. Fatty Acids 222-233 alpha-methylacyl-CoA racemase Homo sapiens 91-96 25374912-6 2014 A central role for fatty acid oxidation in supplying energy to the prostate cancer cell is supported by the observation that the peroxisomal enzyme, alpha-methylacyl-CoA racemase (AMACR), which facilitates the transformation of branched chain fatty acids to a form suitable for beta-oxidation, is highly overexpressed in prostate cancer compared with normal prostate. Fatty Acids 19-29 alpha-methylacyl-CoA racemase Homo sapiens 180-185 21643692-1 2011 Alpha-methylacyl-CoA racemase (AMACR) is involved in the cellular metabolism of fatty acids. Fatty Acids 80-91 alpha-methylacyl-CoA racemase Homo sapiens 0-29 21643692-1 2011 Alpha-methylacyl-CoA racemase (AMACR) is involved in the cellular metabolism of fatty acids. Fatty Acids 80-91 alpha-methylacyl-CoA racemase Homo sapiens 31-36 21686617-1 2009 alpha-Methylacyl-CoA racemase (AMACR) deficiency is a rare disorder of fatty acid metabolism which has recently been described in three adult cases. Fatty Acids 71-81 alpha-methylacyl-CoA racemase Homo sapiens 0-29 20003233-1 2009 Alpha-methylacyl-CoA racemase (AMACR) is an enzyme playing an important role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives. Fatty Acids 117-127 alpha-methylacyl-CoA racemase Homo sapiens 0-29 20003233-1 2009 Alpha-methylacyl-CoA racemase (AMACR) is an enzyme playing an important role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives. Fatty Acids 117-127 alpha-methylacyl-CoA racemase Homo sapiens 31-36 20945498-1 2011 BACKGROUND: Alpha-methylacyl CoA racemase (AMACR) is an enzyme involved in fatty acids metabolism. Fatty Acids 75-86 alpha-methylacyl-CoA racemase Homo sapiens 12-41 20945498-1 2011 BACKGROUND: Alpha-methylacyl CoA racemase (AMACR) is an enzyme involved in fatty acids metabolism. Fatty Acids 75-86 alpha-methylacyl-CoA racemase Homo sapiens 43-48 21686617-1 2009 alpha-Methylacyl-CoA racemase (AMACR) deficiency is a rare disorder of fatty acid metabolism which has recently been described in three adult cases. Fatty Acids 71-81 alpha-methylacyl-CoA racemase Homo sapiens 31-36 18032455-1 2008 Alpha-methylacyl-CoA racemase (AMACR) deficiency is a rare disorder of fatty acid metabolism which has recently been described in three adult cases. Fatty Acids 71-81 alpha-methylacyl-CoA racemase Homo sapiens 0-29 18712414-1 2008 Alpha-methylacyl-CoA racemase (AMACR) is an enzyme playing an important role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives. Fatty Acids 117-127 alpha-methylacyl-CoA racemase Homo sapiens 0-29 18712414-1 2008 Alpha-methylacyl-CoA racemase (AMACR) is an enzyme playing an important role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives. Fatty Acids 117-127 alpha-methylacyl-CoA racemase Homo sapiens 31-36 18712414-10 2008 We hypothesize that the association of AMACR expression with tumor localization may be related to differences in the metabolism/exposure to fatty acids occurring along the colon. Fatty Acids 140-151 alpha-methylacyl-CoA racemase Homo sapiens 39-44 18032455-1 2008 Alpha-methylacyl-CoA racemase (AMACR) deficiency is a rare disorder of fatty acid metabolism which has recently been described in three adult cases. Fatty Acids 71-81 alpha-methylacyl-CoA racemase Homo sapiens 31-36 17922592-1 2007 CONTEXT: Alpha-methylacyl CoA racemase (AMACR) is an oxidative enzyme involved in isomeric transformation of fatty acids entering the beta-oxidation pathway. Fatty Acids 109-120 alpha-methylacyl-CoA racemase Homo sapiens 9-38 17922592-1 2007 CONTEXT: Alpha-methylacyl CoA racemase (AMACR) is an oxidative enzyme involved in isomeric transformation of fatty acids entering the beta-oxidation pathway. Fatty Acids 109-120 alpha-methylacyl-CoA racemase Homo sapiens 40-45 11160375-3 2001 alpha-Methylacyl-CoA racemase plays an important role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives because it catalyzes the conversion of several (2R)-methyl-branched-chain fatty acyl-CoAs to their (2S)-isomers. Fatty Acids 94-104 alpha-methylacyl-CoA racemase Homo sapiens 0-29 15941950-1 2005 Alpha-methylacyl-CoA racemase (AMACR) is an enzyme involved in the metabolism of fatty acids and is an important tissue biomarker in the prostate to distinguish normal glands from prostate cancer. Fatty Acids 81-92 alpha-methylacyl-CoA racemase Homo sapiens 0-29 15941950-1 2005 Alpha-methylacyl-CoA racemase (AMACR) is an enzyme involved in the metabolism of fatty acids and is an important tissue biomarker in the prostate to distinguish normal glands from prostate cancer. Fatty Acids 81-92 alpha-methylacyl-CoA racemase Homo sapiens 31-36 16315020-6 2006 This correlation indicates that increased AMACR expression might be related to hypoxia-induced changes in cancer cell metabolism, such as increased dependence on fatty acid oxidation for energy generation. Fatty Acids 162-172 alpha-methylacyl-CoA racemase Homo sapiens 42-47 12917210-11 2003 AMACR is therefore significantly increased at the protein level in CaP cells, through what appears to be the stabilizing effect of the same fatty acids that are present at appreciable concentrations in beef and dairy products, which have been associated with CaP risk. Fatty Acids 140-151 alpha-methylacyl-CoA racemase Homo sapiens 0-5 12917210-12 2003 Our findings therefore provide a link between the consumption of dietary fatty acids and the enhanced expression of AMACR, an enzyme that may play an important role in genesis and progression of CaP. Fatty Acids 73-84 alpha-methylacyl-CoA racemase Homo sapiens 116-121 12673556-14 2003 Because AMACR is involved in the beta oxidation of branched fatty acids and their derivatives, enhanced expression of the enzyme in evolving carcinomas in BPH nodules, as well as its up-regulation in juxtaposed morphologically benign glands and grade 1 carcinomas, suggests that increased utilization of fatty acids may play an important role in carcinoma development and progression in the TZ. Fatty Acids 60-71 alpha-methylacyl-CoA racemase Homo sapiens 8-13 11060359-1 2000 alpha-Methylacyl-CoA racemase plays an important role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives because it catalyzes the conversion of several (2R)-methyl-branched-chain fatty acyl-CoAs to their (S)-stereoisomers. Fatty Acids 94-104 alpha-methylacyl-CoA racemase Homo sapiens 0-29