PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34237916-9 2022 The mRNA expression levels of peroxisome proliferator-activated receptor alpha (PPARalpha) and its target fatty acid oxidation- and ketogenesis-related genes were significantly upregulated by the starvation-mediated NEB. Fatty Acids 106-116 peroxisome proliferator activated receptor alpha Bos taurus 30-78 34237916-9 2022 The mRNA expression levels of peroxisome proliferator-activated receptor alpha (PPARalpha) and its target fatty acid oxidation- and ketogenesis-related genes were significantly upregulated by the starvation-mediated NEB. Fatty Acids 106-116 peroxisome proliferator activated receptor alpha Bos taurus 80-89 33309342-11 2021 In silico analysis of bovine PCP1 identified putative peroxisome proliferator-activated receptor alpha and sterol regulatory element binding protein binding sites which may be implicated in fatty acid signaling to alter bovine PCP1 activity. Fatty Acids 190-200 peroxisome proliferator activated receptor alpha Bos taurus 54-102 32880836-4 2020 The enhanced expression of PLIN2, FABP5 and FABP3 genes in mid lactation suggests enrichment of the PPARalpha pathway which is linked to fatty acid metabolism. Fatty Acids 137-147 peroxisome proliferator activated receptor alpha Bos taurus 100-109 33189279-11 2021 The PPARA gene is involved in the regulation of lipid metabolism and fatty liver disease and the ACACA gene encodes an enzyme that catalyzes the carboxylation of acetyl-coenzyme A to malonyl-coenzyme A, which is a rate-limiting step in fatty acid synthesis. Fatty Acids 236-246 peroxisome proliferator activated receptor alpha Bos taurus 4-9 28287130-7 2017 The HC diet also up-regulated the expression of the transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) and its downstream targets involved in fatty acid oxidation, including carnitine palmitoyltransferase-1,2 (CPT-1, CPT-2), liver-fatty acid-binding protein (L-FABP), and acyl-CoA oxidase (ACO). Fatty Acids 173-183 peroxisome proliferator activated receptor alpha Bos taurus 73-121 29310736-11 2018 The PPARgamma gene expression was significantly greater in cells treated with t10,c12 CLA, aLnA and LA, whereas the PPARalpha gene expression levels were significantly lower in cells treated with all different fatty acids, compared with the control. Fatty Acids 210-221 peroxisome proliferator activated receptor alpha Bos taurus 116-125 31304752-5 2019 FASN, LPIN1, PPARalpha, and PPARgamma transcripts were more sensitive to the short-chain FAs (acetic and beta-hydroxybutyric acids). Fatty Acids 89-92 peroxisome proliferator activated receptor alpha Bos taurus 13-22 30478902-6 2019 Activated AMPKalpha increased the expression level and transcriptional activity of peroxisome proliferator-activated receptor alpha, which further increased the expression of fatty acid oxidation genes and lipid oxidation. Fatty Acids 175-185 peroxisome proliferator activated receptor alpha Bos taurus 83-131 28287130-7 2017 The HC diet also up-regulated the expression of the transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) and its downstream targets involved in fatty acid oxidation, including carnitine palmitoyltransferase-1,2 (CPT-1, CPT-2), liver-fatty acid-binding protein (L-FABP), and acyl-CoA oxidase (ACO). Fatty Acids 173-183 peroxisome proliferator activated receptor alpha Bos taurus 123-132 26600505-0 2015 PPARalpha signal pathway gene expression is associated with fatty acid content in yak and cattle longissimus dorsi muscle. Fatty Acids 60-70 peroxisome proliferator activated receptor alpha Bos taurus 0-9 25006962-5 2014 Functional analysis revealed that fat-enriched miRNAs targeted PRKAA1/2, PPARA and PPARG genes to modulate lipid and fatty acid metabolism, and muscle-enriched miRNAs targeted CSRP3 gene to present function involved in skeletal and muscular system development. Fatty Acids 117-127 peroxisome proliferator activated receptor alpha Bos taurus 73-78 24716857-1 2014 BACKGROUND: Peroxisome proliferator-activated receptor alpha (PPARalpha), a central regulator of fatty acid catabolism, has recently been shown to be a transcriptional regulator of the gene encoding the carnitine transporter novel organic cation transporter 2 (OCTN2) in cattle. Fatty Acids 97-107 peroxisome proliferator activated receptor alpha Bos taurus 12-60 24716857-1 2014 BACKGROUND: Peroxisome proliferator-activated receptor alpha (PPARalpha), a central regulator of fatty acid catabolism, has recently been shown to be a transcriptional regulator of the gene encoding the carnitine transporter novel organic cation transporter 2 (OCTN2) in cattle. Fatty Acids 97-107 peroxisome proliferator activated receptor alpha Bos taurus 62-71 24737933-5 2014 Liver from OVE cows responded to postpartal NEB by up-regulating expression of PPARalpha-targets in the fatty acid oxidation and ketogenesis pathways, along with gluconeogenic genes. Fatty Acids 104-114 peroxisome proliferator activated receptor alpha Bos taurus 79-88 23314861-7 2013 Activation of transcription factor PPAR-alpha was identified by IPA software as an important regulator of molecular changes in rumen epithelium that function in papillary development and fatty acid oxidation during the transition from pre-rumination to rumination. Fatty Acids 187-197 peroxisome proliferator activated receptor alpha Bos taurus 35-45 26571137-11 2015 In skeletal muscle, where PPARA and its targets orchestrate carbohydrate metabolism and fatty acid oxidation, the OVE cows had greater glyceroneogenesis (higher mRNA expression of PC and PCK1), whereas CON cows had greater glucose transport (SLC2A4). Fatty Acids 88-98 peroxisome proliferator activated receptor alpha Bos taurus 26-31 22417075-5 2012 From 3 wk prepartum to 1 wk postpartum, mRNA abundances of PPARAlpha and several PPARAlpha target genes involved in fatty acid uptake, fatty acid oxidation and ketogenesis in the liver were strongly increased. Fatty Acids 116-126 peroxisome proliferator activated receptor alpha Bos taurus 59-68 22417075-5 2012 From 3 wk prepartum to 1 wk postpartum, mRNA abundances of PPARAlpha and several PPARAlpha target genes involved in fatty acid uptake, fatty acid oxidation and ketogenesis in the liver were strongly increased. Fatty Acids 116-126 peroxisome proliferator activated receptor alpha Bos taurus 81-90 22417075-5 2012 From 3 wk prepartum to 1 wk postpartum, mRNA abundances of PPARAlpha and several PPARAlpha target genes involved in fatty acid uptake, fatty acid oxidation and ketogenesis in the liver were strongly increased. Fatty Acids 135-145 peroxisome proliferator activated receptor alpha Bos taurus 59-68 22417075-5 2012 From 3 wk prepartum to 1 wk postpartum, mRNA abundances of PPARAlpha and several PPARAlpha target genes involved in fatty acid uptake, fatty acid oxidation and ketogenesis in the liver were strongly increased. Fatty Acids 135-145 peroxisome proliferator activated receptor alpha Bos taurus 81-90 22444613-9 2010 Of interest from a nutritional perspective is the potential to alter PPARgamma signaling in adipose and PPARalpha signaling in liver as a means to enhance insulin sensitivity as well as fatty acid oxidation post partum. Fatty Acids 186-196 peroxisome proliferator activated receptor alpha Bos taurus 104-113 20494149-1 2010 Peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists increase fatty acid oxidation in liver of nonruminants. Fatty Acids 79-89 peroxisome proliferator activated receptor alpha Bos taurus 0-48 20494149-1 2010 Peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists increase fatty acid oxidation in liver of nonruminants. Fatty Acids 79-89 peroxisome proliferator activated receptor alpha Bos taurus 50-59 20494149-3 2010 The objectives of this study were 1) to determine whether partitioning of fatty acid metabolism by liver slices from weaned Holstein calves treated with PPARalpha agonists in vivo is altered compared with partitioning by liver slices from control (untreated) calves, and 2) to measure in vitro metabolism of palmitate and oleate by bovine liver slices and relate these to mRNA abundance for key enzymes. Fatty Acids 74-84 peroxisome proliferator activated receptor alpha Bos taurus 153-162 20494149-11 2010 Clofibrate increased or tended to increase liver expression of several PPARalpha target genes involved in fatty acid oxidation (e.g., ACADVL, ACOX1, CPT1A), whereas fish oil did not significantly affect genes associated with fatty acid oxidation but tended to increase DGAT1. Fatty Acids 106-116 peroxisome proliferator activated receptor alpha Bos taurus 71-80 20494149-13 2010 Applications of PPARalpha agonists may be of interest to increase the rate of hepatic fatty acid oxidation and decrease triacylglycerol accumulation in periparturient dairy cows. Fatty Acids 86-96 peroxisome proliferator activated receptor alpha Bos taurus 16-25 18565938-8 2008 The potency of different fatty acids in activating PPARalpha as assessed by CPT1A mRNA abundance in MDBK cells was also tested. Fatty Acids 25-36 peroxisome proliferator activated receptor alpha Bos taurus 51-60 18565938-11 2008 In addition, fatty acids were proven to have a different potency in modulating expression of CPT1A through PPARalpha. Fatty Acids 13-24 peroxisome proliferator activated receptor alpha Bos taurus 107-116 11795293-2 2001 Peroxiosme proliferator-activated receptors (PPARs) include subfamilies PPARalpha and PPARgamma, which are expressed in endothelial cells and involved in transcriptional regulation of a large number of genes that affect lipoprotein and fatty acid metabolism as well as inflammation. Fatty Acids 236-246 peroxisome proliferator activated receptor alpha Bos taurus 72-81