PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33716957-6	2021	This was confirmed by increased levels of cardiac ACSL-1, a key enzyme for fatty acid degradation and decreased GLUT-1, a glucose transporter in obese rats.	Fatty Acids	75-85	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	50-56	
33437196-3	2021	Our results have shown that during natural activation of HSC, the level of miR-34c was increased significantly whereas acyl-CoA synthetase long-chain family member-1(ACSL1), which is a key enzyme can affect fatty acid(FA) synthesis, was decreased.	Fatty Acids	207-217	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	119-165	
33437196-3	2021	Our results have shown that during natural activation of HSC, the level of miR-34c was increased significantly whereas acyl-CoA synthetase long-chain family member-1(ACSL1), which is a key enzyme can affect fatty acid(FA) synthesis, was decreased.	Fatty Acids	207-217	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	166-171	
16466685-7	2006	ACSL1, 4, and 6 were able to rescue fatty acid transport activity and triglyceride synthesis.	Fatty Acids	36-46	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	0-5	
23545238-2	2013	The main function of ACS is to provide cells with acetylCoA, a key molecule for numerous metabolic pathways including fatty acid and cholesterol synthesis and the Krebs cycle.	Fatty Acids	118-128	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	21-24	
31141985-5	2019	Genes (Acadl, Acsl1 and Fabp4) implicated in fatty acid oxidation were significantly upregulated in the skeletal muscle of GK aged four weeks compared to those of age-matched Wistar rats.	Fatty Acids	45-55	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	14-19	
31141985-6	2019	The overexpression or knockout of Tbc1d4, Pdk4, Acadl, Acsl1 and Fabp4 has been reported to change glucose uptake and fatty acid oxidation directly in rodents.	Fatty Acids	118-128	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	55-60	
31141985-7	2019	By taking the results of previous studies into consideration, we speculated that dysregulation of key dysregulated genes (Tbc1d4, Pdk4, Acadl, Acsl1 and Fabp4) may lead to a decrease in glucose uptake and oxidation, and an increase in fatty acid oxidation in GK skeletal muscle at three and four weeks, which may, in turn, contribute to postprandial hyperglycemia.	Fatty Acids	235-245	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	143-148	
29645002-6	2018	Western blot validation results showed that peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) and long-chain fatty acid-CoA ligase 1 (ACSL1), two proteins involved in fatty acid metabolism, were expressed differently in the berberine8998 group than in the untreated group and the berberine treatment group.	Fatty Acids	105-115	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	130-135	
29027371-6	2017	Glucose metabolism disorder in DMN model rats is demonstrated by a decrease in key enzymes (e.g., ACSL1) in fatty acid metabolism, a tricabolic acid cycle-related enzyme (SDH), glycogenolysis enzyme, and gluconeogenesis enzymes (PC, PCKGC) and by an increase in glycolysis enzymes (e.g., HXK1).	Fatty Acids	108-118	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	98-103	
17028193-0	2006	Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes.	Fatty Acids	62-72	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	22-54	
14711823-3	2004	Escherichia coli has a single ACS, FadD, that is essential for growth when fatty acids are the sole carbon and energy source.	Fatty Acids	75-86	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	30-33	
15811777-13	2005	This research demonstrates a coordinated regulation of ACS, CPT-I, and ACC mRNA levels and serves to enhance our understanding of the molecular mechanisms underlying fatty acid metabolism during starvation.	Fatty Acids	166-176	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	55-58	
14711823-4	2004	Rodents have five ACS isoforms that differ in substrate specificity, tissue expression, and subcellular localization and are believed to channel fatty acids toward distinct metabolic pathways.	Fatty Acids	145-156	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	18-21	
12787488-11	2003	These results facilitate our understanding of the coordinated regulation of the ACS, CPT-I, and ACC mRNA levels and will serve to enhance our understanding of the molecular mechanisms that underlie the regulation of fatty acid metabolism.	Fatty Acids	216-226	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	80-83	
9353271-1	1997	Intracellular fatty acid (FA) concentrations are in part determined by a regulated import/export system that is controlled by two key proteins, i.e. fatty acid transport protein (FATP) and acyl-CoA synthetase (ACS), which respectively facilitate the transport of FAs across the cell membrane and their esterification to prevent their efflux.	Fatty Acids	14-24	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	189-208	
12147264-2	2002	Recently, individual acyl-CoA synthetase (ACS) isoforms have been implicated in the channeling of fatty acids either toward lipid synthesis or toward oxidation.	Fatty Acids	98-109	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	21-40	
12147264-2	2002	Recently, individual acyl-CoA synthetase (ACS) isoforms have been implicated in the channeling of fatty acids either toward lipid synthesis or toward oxidation.	Fatty Acids	98-109	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	42-45	
10777552-2	2000	Uptake of fatty acids into cells is a controlled process determined in part by a regulated import/export system that is controlled at least by two key groups of proteins, i.e. the fatty acid transport protein (FATP) and acyl-CoA synthetase (ACS), which facilitate, respectively, the transport of fatty acids across the cell membrane and catalyze their esterification to prevent their efflux.	Fatty Acids	10-21	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	220-239	
10777552-2	2000	Uptake of fatty acids into cells is a controlled process determined in part by a regulated import/export system that is controlled at least by two key groups of proteins, i.e. the fatty acid transport protein (FATP) and acyl-CoA synthetase (ACS), which facilitate, respectively, the transport of fatty acids across the cell membrane and catalyze their esterification to prevent their efflux.	Fatty Acids	10-21	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	241-244	
10777552-2	2000	Uptake of fatty acids into cells is a controlled process determined in part by a regulated import/export system that is controlled at least by two key groups of proteins, i.e. the fatty acid transport protein (FATP) and acyl-CoA synthetase (ACS), which facilitate, respectively, the transport of fatty acids across the cell membrane and catalyze their esterification to prevent their efflux.	Fatty Acids	296-307	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	220-239	
10777552-2	2000	Uptake of fatty acids into cells is a controlled process determined in part by a regulated import/export system that is controlled at least by two key groups of proteins, i.e. the fatty acid transport protein (FATP) and acyl-CoA synthetase (ACS), which facilitate, respectively, the transport of fatty acids across the cell membrane and catalyze their esterification to prevent their efflux.	Fatty Acids	296-307	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	241-244	
9353271-1	1997	Intracellular fatty acid (FA) concentrations are in part determined by a regulated import/export system that is controlled by two key proteins, i.e. fatty acid transport protein (FATP) and acyl-CoA synthetase (ACS), which respectively facilitate the transport of FAs across the cell membrane and their esterification to prevent their efflux.	Fatty Acids	14-24	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	210-213	
7642600-0	1995	Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter.	Fatty Acids	65-76	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	17-43	
34958885-13	2022	Among them, eight proteins (ACOX1, ACOX2, ACOX3, ACSL1, EHHADH, GOT2, MTOR and ACAA1) were related to oxidation of fatty acids and two proteins (ASS1 and CPS1) were found to be associated with urea cycle disorder.	Fatty Acids	115-126	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	49-54	
1859447-5	1991	The activity of long-chain acyl-CoA synthetase (ACS), an enzyme essential for both oxidation and esterification of fatty acids, was reduced in hepatocytes incubated with 1 mM PFDA.	Fatty Acids	115-126	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	48-51	
7642600-9	1995	In conclusion, the regulation of C-ACS mRNA expression by fibrates and fatty acids is mediated by PPAR.retinoid X receptor heterodimers interacting through a PPRE in the C-ACS promoters.	Fatty Acids	71-82	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	35-38	
7642600-9	1995	In conclusion, the regulation of C-ACS mRNA expression by fibrates and fatty acids is mediated by PPAR.retinoid X receptor heterodimers interacting through a PPRE in the C-ACS promoters.	Fatty Acids	71-82	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	172-175