PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26582048-5 2016 The mRNA levels of enzymes involved in fatty acid metabolism and beta-oxidation (ACSL1, ACSL3, CPT1, CPT2 and KAT) in Day-7 blastocysts were significantly upregulated by the addition of LR-BSA. Fatty Acids 39-49 acyl-CoA synthetase long chain family member 1 Homo sapiens 81-86 26728456-1 2016 Long-chain acyl-CoA synthetase 1 (ACSL1) plays a key role in fatty acid metabolism. Fatty Acids 61-71 acyl-CoA synthetase long chain family member 1 Homo sapiens 0-32 26728456-1 2016 Long-chain acyl-CoA synthetase 1 (ACSL1) plays a key role in fatty acid metabolism. Fatty Acids 61-71 acyl-CoA synthetase long chain family member 1 Homo sapiens 34-39 23024797-0 2012 Overexpressed FATP1, ACSVL4/FATP4 and ACSL1 increase the cellular fatty acid uptake of 3T3-L1 adipocytes but are localized on intracellular membranes. Fatty Acids 66-76 acyl-CoA synthetase long chain family member 1 Homo sapiens 38-43 23790250-5 2013 Uptake of both fatty acids was inhibited by other LC-PUFAs and, markedly, by the long-chain acyl-CoA synthetase (ACSL) inhibitor, triacsin C. Human trophoblasts obtained from GDM pregnancies (DTB cells) showed a significantly lower (14)C-AA and (14)C-DHA accumulation, through a decrease in both the saturable and the non-saturable components of uptake, which was associated with a decrease in ACSL1 mRNA levels. Fatty Acids 15-26 acyl-CoA synthetase long chain family member 1 Homo sapiens 394-399 20176858-1 2010 Long-chain acyl CoA synthetase 1 (ACSL1) plays an important role in fatty acid metabolism and triacylglycerol (TAG) synthesis. Fatty Acids 68-78 acyl-CoA synthetase long chain family member 1 Homo sapiens 0-32 20176858-1 2010 Long-chain acyl CoA synthetase 1 (ACSL1) plays an important role in fatty acid metabolism and triacylglycerol (TAG) synthesis. Fatty Acids 68-78 acyl-CoA synthetase long chain family member 1 Homo sapiens 34-39 20176858-7 2010 In conclusion, ACSL1 rs9997745 influences MetS risk, most likely via disturbances in fatty acid metabolism, which was modulated by dietary fat consumption, particularly PUFA intake, suggesting novel gene-nutrient interactions. Fatty Acids 85-95 acyl-CoA synthetase long chain family member 1 Homo sapiens 15-20 19880178-7 2009 Since acyl-CoA synthetases are involved in cellular uptake of fatty acids via activation for their channelling to lipid metabolism and/or for storage, the increased expression of ACSL1 and ACLS5 by LCPUFAs may be responsible for the increased fatty acid uptake. Fatty Acids 62-73 acyl-CoA synthetase long chain family member 1 Homo sapiens 179-184 19880178-7 2009 Since acyl-CoA synthetases are involved in cellular uptake of fatty acids via activation for their channelling to lipid metabolism and/or for storage, the increased expression of ACSL1 and ACLS5 by LCPUFAs may be responsible for the increased fatty acid uptake. Fatty Acids 62-72 acyl-CoA synthetase long chain family member 1 Homo sapiens 179-184 16705061-2 2006 Storage of fatty acid as triglyceride (TG) requires the activation of fatty acids to long-chain acyl-CoAs (LC-CoA) by the enzyme acyl-CoA synthetase (ACSL). Fatty Acids 11-21 acyl-CoA synthetase long chain family member 1 Homo sapiens 150-154 18601897-2 2008 As expected, fatty acid transport protein (FATP)1 and long-chain acyl CoA synthetase (Acsl)1 were the predominant isoforms expressed in adipocytes consistent with their roles in the transport and activation of exogenous fatty acids destined for storage in the form of triglycerides. Fatty Acids 13-23 acyl-CoA synthetase long chain family member 1 Homo sapiens 86-92 18601897-2 2008 As expected, fatty acid transport protein (FATP)1 and long-chain acyl CoA synthetase (Acsl)1 were the predominant isoforms expressed in adipocytes consistent with their roles in the transport and activation of exogenous fatty acids destined for storage in the form of triglycerides. Fatty Acids 220-231 acyl-CoA synthetase long chain family member 1 Homo sapiens 86-92 17690180-4 2007 To seek whether the GPL signature was associated with long-chain acyl-CoA synthetase (LACS), a potential modulator of fatty acid profiles in de novo GPL synthesis, we analyzed gene expression, catabolic activity, substrate selectivity, and inhibitor sensitivity of diverse LACSs. Fatty Acids 118-128 acyl-CoA synthetase long chain family member 1 Homo sapiens 54-84 17690180-4 2007 To seek whether the GPL signature was associated with long-chain acyl-CoA synthetase (LACS), a potential modulator of fatty acid profiles in de novo GPL synthesis, we analyzed gene expression, catabolic activity, substrate selectivity, and inhibitor sensitivity of diverse LACSs. Fatty Acids 118-128 acyl-CoA synthetase long chain family member 1 Homo sapiens 86-90 16705061-6 2006 Furthermore, ACSL1 overexpression produced a 60% increase in cellular LCA-CoA content (160 +/- 6 vs. 100 +/- 6 nmol/g protein in controls, P < 0.05) and increased [(14)C]oleate incorporation into TG without significantly altering fatty acid oxidation. Fatty Acids 233-243 acyl-CoA synthetase long chain family member 1 Homo sapiens 13-18 16705061-2 2006 Storage of fatty acid as triglyceride (TG) requires the activation of fatty acids to long-chain acyl-CoAs (LC-CoA) by the enzyme acyl-CoA synthetase (ACSL). Fatty Acids 70-81 acyl-CoA synthetase long chain family member 1 Homo sapiens 150-154 16705061-3 2006 There are five known isoforms of ACSL (ACSL1, -3, -4, -5, -6), which vary in their tissue specificity and affinity for fatty acid substrates. Fatty Acids 119-129 acyl-CoA synthetase long chain family member 1 Homo sapiens 33-37 16705061-3 2006 There are five known isoforms of ACSL (ACSL1, -3, -4, -5, -6), which vary in their tissue specificity and affinity for fatty acid substrates. Fatty Acids 119-129 acyl-CoA synthetase long chain family member 1 Homo sapiens 39-44 11751901-4 2002 When incubated with exogenous fatty acids, ACS1/FATP1 cells accumulated 5 times more triacylglycerol (TG) as compared with NIH 3T3 fibroblasts. Fatty Acids 30-41 acyl-CoA synthetase long chain family member 1 Homo sapiens 43-47 16357361-6 2006 Moreover, inhibition of ACSL1 activity in adipocytes impairs fatty acid uptake, suggesting that esterification is essential for fatty acid transport. Fatty Acids 61-71 acyl-CoA synthetase long chain family member 1 Homo sapiens 24-29 16357361-6 2006 Moreover, inhibition of ACSL1 activity in adipocytes impairs fatty acid uptake, suggesting that esterification is essential for fatty acid transport. Fatty Acids 128-138 acyl-CoA synthetase long chain family member 1 Homo sapiens 24-29 12163649-1 2002 Recent studies suggest that the long-chain acyl-CoA synthetases (ACS) may play a role in channeling fatty acids either toward complex lipid synthesis and storage or toward oxidation. Fatty Acids 100-111 acyl-CoA synthetase long chain family member 1 Homo sapiens 65-68 31166619-7 2019 Rather, ACSL1 was associated with mitochondria where it modulated fatty acid metabolism. Fatty Acids 66-76 acyl-CoA synthetase long chain family member 1 Homo sapiens 8-13 34511469-0 2021 An Essential Role of the N-Terminal Region of ACSL1 in Linking Free Fatty Acids to Mitochondrial beta-Oxidation in C2C12 Myotubes. Fatty Acids 68-79 acyl-CoA synthetase long chain family member 1 Homo sapiens 46-51 34511469-3 2021 Several reports have shown that ACSL1, among the ACSLs, is located in mitochondria and mainly leads fatty acids to the beta-oxidation pathway in various cell types. Fatty Acids 100-111 acyl-CoA synthetase long chain family member 1 Homo sapiens 32-37 33564069-7 2021 Our study implicates ACSL1 as playing an important role in prostate tumor progression, and provides a therapeutic strategy of targeting fatty acid metabolism for the treatment of prostate cancer. Fatty Acids 136-146 acyl-CoA synthetase long chain family member 1 Homo sapiens 21-26 33813326-6 2021 Among these 97 DEG, some representative genes were related to lipolysis and fatty acid utilization (PPARG, LPL, PLIN2, ACOX1, ACSL1, FABP3, and FABP4). Fatty Acids 76-86 acyl-CoA synthetase long chain family member 1 Homo sapiens 126-131 32218693-12 2020 In summary, high expression of ACSL1 reduced fatty acid beta-oxidation through the PPARgamma pathway, thereby increasing triglyceride levels. Fatty Acids 45-55 acyl-CoA synthetase long chain family member 1 Homo sapiens 31-36 28507299-6 2017 Interestingly, several proteins involved in the fatty acid beta-oxidation pathway, including ACSL1, ACADS, and ACOX1, were up-regulated by Leu deprivation. Fatty Acids 48-58 acyl-CoA synthetase long chain family member 1 Homo sapiens 93-98 30559328-2 2019 Increasing the size of acyl-CoA pool by enhancing LACS activity appears to be a useful approach to improve the production and modify the composition of fatty acid-derived compounds, such as triacylglycerol. Fatty Acids 152-162 acyl-CoA synthetase long chain family member 1 Homo sapiens 50-54 30504065-7 2019 In the functional study, we find that the expression of ACSL1, CPT1, CACT, and HADHB, the genes related to fatty acid beta-oxidation, increases after PA stimulation. Fatty Acids 107-117 acyl-CoA synthetase long chain family member 1 Homo sapiens 56-61 27644403-6 2016 We then found that the expression levels of three enzymes involved in fatty acid degradation, including long-chain acyl-CoA synthetase (LACS), were increased in a PPARalpha-dependent manner. Fatty Acids 70-80 acyl-CoA synthetase long chain family member 1 Homo sapiens 104-134 27644403-6 2016 We then found that the expression levels of three enzymes involved in fatty acid degradation, including long-chain acyl-CoA synthetase (LACS), were increased in a PPARalpha-dependent manner. Fatty Acids 70-80 acyl-CoA synthetase long chain family member 1 Homo sapiens 136-140 27644403-7 2016 This increased expression of LACS might enhance the fatty acyl-CoA supply to fatty acid degradation and sulfatide synthesis pathways. Fatty Acids 77-87 acyl-CoA synthetase long chain family member 1 Homo sapiens 29-33 27992526-7 2016 Thus, we have identified a "risk genotype" of ACSL1 gene that confers constitutive high levels of the enzyme, which is involved in the activation of fatty acids through conversion to acyl-CoA and has been recently related to increased invasiveness of tumor cells. Fatty Acids 149-160 acyl-CoA synthetase long chain family member 1 Homo sapiens 46-51