PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22498046-2 2012 The release of fatty acids and lysophospholipids by PLA(2) activates several intra-cellular second messenger cascades that regulate a wide variety of physiological responses. Fatty Acids 15-26 phospholipase A2 group VI Homo sapiens 52-58 22414059-6 2012 Group VIA Phospholipase A2 (iPLA2beta) appears to be a component of a mechanism for repairing mitochondrial phospholipids that contain oxidized fatty acid substituents, and genetic or acquired iPLA2beta-deficiency increases beta-cell mitochondrial susceptibility to injury from ROS and predisposes to development of T2D. Fatty Acids 144-154 phospholipase A2 group VI Homo sapiens 28-37 22110477-7 2012 Group VIA phospholipase A2 (iPLA2beta) appears to be a component of a mechanism for repairing mitochondrial phospholipids that contain oxidized fatty acid substituents, and genetic or acquired iPLA2beta-deficiency increases beta-cell mitochondrial susceptibility to injury from ROS and predisposes to developing T2DM. Fatty Acids 144-154 phospholipase A2 group VI Homo sapiens 28-37 20886109-12 2010 INAD/NBIA is caused by loss of the ability of PLA2G6 to catalyze fatty acid release from phospholipids, which predicts accumulation of PLA2G6 phospholipid substrates and provides a mechanistic explanation for the accumulation of membranes in neuroaxonal spheroids previously observed in histopathological studies of INAD/NBIA. Fatty Acids 65-75 phospholipase A2 group VI Homo sapiens 46-52 20886109-12 2010 INAD/NBIA is caused by loss of the ability of PLA2G6 to catalyze fatty acid release from phospholipids, which predicts accumulation of PLA2G6 phospholipid substrates and provides a mechanistic explanation for the accumulation of membranes in neuroaxonal spheroids previously observed in histopathological studies of INAD/NBIA. Fatty Acids 65-75 phospholipase A2 group VI Homo sapiens 135-141 19577642-1 2009 Phospholipases A2 (PLA2) catalyse the cleavage of fatty acids esterified at the sn-2 position of glycerophospholipids. Fatty Acids 50-61 phospholipase A2 group VI Homo sapiens 19-23 12181317-6 2002 In support of this view, not only AA, but also other fatty acids, were found to be liberated in an iPLA(2)-dependent manner in the H(2)O(2)-treated cells. Fatty Acids 53-64 phospholipase A2 group VI Homo sapiens 99-106 18467085-1 2008 Phospholipases A(2) (PLA(2)) are ubiquitous enzymes involved in membrane fatty acid metabolism and intracellular signalling. Fatty Acids 73-83 phospholipase A2 group VI Homo sapiens 21-27 12181317-7 2002 Collectively, these studies underscore the importance of the iPLA(2) in modulating homeostatic fatty acid deacylation reactions and document a potentially important route under pathophysiological conditions for increasing free fatty acid levels during oxidative stress. Fatty Acids 95-105 phospholipase A2 group VI Homo sapiens 61-68 11525380-8 2001 iPLA2beta prefers to hydrolyze fatty acid at the sn-2 fatty acid substituent but also exhibits phospholipase A1, lysophospholipase, PAF acetylhydrolase, and transacylase activities. Fatty Acids 31-41 phospholipase A2 group VI Homo sapiens 0-9 9603953-10 1998 iPLA2 increased the spontaneous release of fatty acids, and this was further augmented by serum but not by IL-1. Fatty Acids 43-54 phospholipase A2 group VI Homo sapiens 0-5 10964913-3 2000 Release of fatty acids such as arachidonic acid requires sn-2-deacylation catalyzed by a class of enzymes known as phospholipases A(2) (PLA(2), EC ). Fatty Acids 11-22 phospholipase A2 group VI Homo sapiens 136-142 10747887-5 2000 Pharmacological and transfection studies revealed that Ca(2+)-independent PLA(2) (iPLA(2); type VI), a phospholipid remodeling PLA(2), contributes to the cell death-associated increase in fatty acid release. Fatty Acids 188-198 phospholipase A2 group VI Homo sapiens 82-89 34131139-2 2021 The calcium-independent phospholipase iPLA2beta is known to cleave acyl tails from the glycerol backbone of lipids and release oxidized fatty acids from phospholipids. Fatty Acids 136-147 phospholipase A2 group VI Homo sapiens 38-47 9593733-9 1998 Therefore, we conclude that iPLA2-mediated fatty acid release is facilitated in Fas-stimulated cells and plays a modifying although not essential role in the apoptotic cell death process. Fatty Acids 43-53 phospholipase A2 group VI Homo sapiens 28-33 33087576-5 2020 Importantly, we uncovered a role for the phospholipase PLA2G6 (PNPLA9, iPLA2beta), known to metabolize Hp-PE to lyso-PE and oxidized fatty acid, in mitigating ferroptosis induced by GPX4 inhibition in vitro or by hypoxia/reoxygenation injury in vivo. Fatty Acids 133-143 phospholipase A2 group VI Homo sapiens 63-69 33414430-13 2021 Fatty acids released from PLs by iPLA2 and cPLA2 action were esterified into TAGs, thus promoting a biological response to alpha-syn overexpression with uncompromised cell viability. Fatty Acids 0-11 phospholipase A2 group VI Homo sapiens 33-38 33087576-5 2020 Importantly, we uncovered a role for the phospholipase PLA2G6 (PNPLA9, iPLA2beta), known to metabolize Hp-PE to lyso-PE and oxidized fatty acid, in mitigating ferroptosis induced by GPX4 inhibition in vitro or by hypoxia/reoxygenation injury in vivo. Fatty Acids 133-143 phospholipase A2 group VI Homo sapiens 71-80 28602806-6 2017 The newly synthesized bile acid-phospholipid conjugate ursodeoxycholate-lysophosphatidylethanolamide (UDCA-LPE) blocked iPLA2ss, which structurally disrupted the fatty acid-uptake complex. Fatty Acids 162-172 phospholipase A2 group VI Homo sapiens 120-125 31717968-8 2019 Among the members of the fatty acid uptake complex, the calcium-independent membrane phospholipase A2 (iPLA2beta) abandoned DRM-PM most rapidly. Fatty Acids 25-35 phospholipase A2 group VI Homo sapiens 103-112 28602806-5 2017 Here we showed that influx of fatty acids is mediated by an apical heterotetrameric plasma membrane protein complex of which the calcium-independent membrane phospholipase A2 (iPLA2ss) is one constituent. Fatty Acids 30-41 phospholipase A2 group VI Homo sapiens 176-181 24719358-3 2014 Using the human hepatocyte-derived tumor cell line HepG2, we found that fatty acid influx is mediated by a heterotetrameric plasma membrane protein complex consisting of plasma membrane fatty acid-binding protein, caveolin-1, CD36, and calcium-independent membrane phospholipase A2 (iPLA2beta). Fatty Acids 72-82 phospholipase A2 group VI Homo sapiens 283-292 24719358-4 2014 Blocking iPLA2beta with the bile acid-phospholipid conjugate ursodeoxycholate-lysophosphatidylethanolamide (UDCA-LPE) caused the dissociation of the complex, thereby inhibiting fatty acid influx (IC50 47 muM), and suppressed the synthesis of all subunits through a reduction in lysophosphatidylcholine from 8.0 to 3.5 mumol/mg of protein and corresponding depletion of phosphorylated c-Jun N-terminal kinase. Fatty Acids 177-187 phospholipase A2 group VI Homo sapiens 9-18 24719358-7 2014 Thus, iPLA2beta acts as an upstream checkpoint for mechanisms that regulate fatty acid uptake, and its inhibition by UDCA-LPE qualifies this nontoxic compound as a therapeutic candidate for the treatment of NASH.-Stremmel, W., Staffer, S., Wannhoff, A., Pathil, A., Chamulitrat, W. Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis. Fatty Acids 76-86 phospholipase A2 group VI Homo sapiens 6-15 24719358-7 2014 Thus, iPLA2beta acts as an upstream checkpoint for mechanisms that regulate fatty acid uptake, and its inhibition by UDCA-LPE qualifies this nontoxic compound as a therapeutic candidate for the treatment of NASH.-Stremmel, W., Staffer, S., Wannhoff, A., Pathil, A., Chamulitrat, W. Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis. Fatty Acids 339-349 phospholipase A2 group VI Homo sapiens 6-15 27141409-1 2016 The PLA2G6 gene encodes a group VIA calcium independent phospholipase A2 (iPLA2beta), which hydrolyses glycerophospholipids to release fatty acids and lysophospholipids. Fatty Acids 135-146 phospholipase A2 group VI Homo sapiens 4-10