PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19460454-1 2009 Free fatty acids (FFAs) have been demonstrated to act as ligands of several G-protein-coupled receptors (GPCRs) (FFAR1, FFAR2, FFAR3, GPR84, and GPR120). Fatty Acids 5-16 free fatty acid receptor 2 Homo sapiens 120-125 27607913-3 2016 In addition, fatty acids GPCRs are thought to have an increasing role in regulating peptide secretions namely short fatty acids GPCR (GPR41, GPR43), medium chain fatty acid GPCR (GPR84), long chain fatty acid GPCR (GPR40, GPR120) and cannabinoid-like GPCR (GPR55, GPR119). Fatty Acids 13-24 free fatty acid receptor 2 Homo sapiens 141-146 24304723-8 2013 Fatty acids can act as a ligand of G protein-coupled receptors, such as GPR41 and GPR43, and nuclear receptor PPARalpha, which bear crucial roles in the regulation of energy expenditure. Fatty Acids 0-11 free fatty acid receptor 2 Homo sapiens 82-87 23060857-1 2012 The deorphanization of the free fatty acid (FFA) receptors FFA1 (GPR40), FFA2 (GPR43), FFA3 (GPR41), GPR84, and GPR120 has made clear that the body is capable of recognizing and responding directly to nonesterified fatty acid of virtually any chain length. Fatty Acids 32-42 free fatty acid receptor 2 Homo sapiens 79-84 20336586-2 2010 GPR43 is a GPCR that has been implicated in the regulation of fatty-acid and glucose homeostasis in adipose tissue and the intestines, thus having potential therapeutic relevance in the treatment of type 2 diabetes, insulin resistance and obesity. Fatty Acids 62-72 free fatty acid receptor 2 Homo sapiens 0-5 34681211-0 2021 The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A. Fatty Acids 73-83 free fatty acid receptor 2 Homo sapiens 114-119 19009545-6 2008 However, the receptors through which these fatty acids and lipids act were unknown, until the identification of fatty acid binding receptors: GPR40, GPR41, GPR43, and GPR119. Fatty Acids 43-54 free fatty acid receptor 2 Homo sapiens 156-161 34675921-0 2021 Short Chain Fatty Acids Prevent Glyoxylate-Induced Calcium Oxalate Stones by GPR43-Dependent Immunomodulatory Mechanism. Fatty Acids 12-23 free fatty acid receptor 2 Homo sapiens 77-82 33913592-0 2021 Short chain fatty acids released by Fusobacterium nucleatum are neutrophil chemoattractants acting via free fatty acid receptor 2 (FFAR2). Fatty Acids 12-23 free fatty acid receptor 2 Homo sapiens 103-129 34112743-0 2021 The Short-Chain Fatty Acid Receptor GPR43 Modulates YAP/TAZ via RhoA. Fatty Acids 16-26 free fatty acid receptor 2 Homo sapiens 36-41 33913592-0 2021 Short chain fatty acids released by Fusobacterium nucleatum are neutrophil chemoattractants acting via free fatty acid receptor 2 (FFAR2). Fatty Acids 12-23 free fatty acid receptor 2 Homo sapiens 131-136 33495605-3 2021 Among them are GPCRs specific for free fatty acid ligands (lipid GPCRs), including free fatty acid receptor 1 (FFA1, otherwise known as GPR40), FFA2 (GPR43), FFA3 (GPR41) and FFA4 (GPR120), as well as the lipid metabolite binding glucose-dependent insulinotropic receptor (GPR119). Fatty Acids 39-49 free fatty acid receptor 2 Homo sapiens 150-155 33897464-3 2021 Short-chain (<6 carbon) fatty acids target FFAR2/GPR43 and FFAR3/GPR41. Fatty Acids 24-35 free fatty acid receptor 2 Homo sapiens 43-48 33897464-3 2021 Short-chain (<6 carbon) fatty acids target FFAR2/GPR43 and FFAR3/GPR41. Fatty Acids 24-35 free fatty acid receptor 2 Homo sapiens 49-54 33842404-6 2021 In addition, knocking-down FFAR2 in the human colon cancer cell lines (SW480 and HT29) resulted in increased expression of several key enzymes in fatty acid oxidation, such as carnitine palmitoyltransferase 2, acyl-CoA dehydrogenase, long-chain acyl-CoA dehydrogenase, C-2 to C-3 short chain, and hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, alpha subunit. Fatty Acids 146-156 free fatty acid receptor 2 Homo sapiens 27-32 33842404-7 2021 Collectively, these results demonstrated that Ffar2 deficiency significantly altered profiles of fatty acid metabolites and gut microbiome, which might promote colorectal cancer development. Fatty Acids 97-107 free fatty acid receptor 2 Homo sapiens 46-51 32958255-0 2020 Microbiota-derived short chain fatty acid promotion of Amphiregulin expression by dendritic cells is regulated by GPR43 and Blimp-1. Fatty Acids 31-41 free fatty acid receptor 2 Homo sapiens 114-119 31747578-3 2019 show that short-chain fatty acids sensed through the G protein-coupled receptor Ffar2 promote ILC3 function in the colon. Fatty Acids 22-33 free fatty acid receptor 2 Homo sapiens 80-85 31694949-2 2020 Here, we identified free fatty acid receptor 2 (FFAR2) as a cofactor for IAV entry into host cells. Fatty Acids 25-35 free fatty acid receptor 2 Homo sapiens 48-53 31310579-7 2019 Furthermore, several GPCRs have been implicated in fatty acid sensing: GPR40 and GPR120 respond to medium- and long-chain fatty acids, GPR41 and GPR43 to short-chain fatty acids, and GPR119 to endogenous lipid derivatives. Fatty Acids 51-61 free fatty acid receptor 2 Homo sapiens 145-150