PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9593830-4 1998 The increase depended upon the release of fatty acids from Lp(a) by PLA2. Fatty Acids 42-53 phospholipase A2 group IB Homo sapiens 68-72 9692961-11 1998 Furthermore, increased temperature and ionization of the fatty acid tended to cause segregation of bound phospholipase A2 into domains poor in phospholipid content which presumably impeded bilayer hydrolysis. Fatty Acids 57-67 phospholipase A2 group IB Homo sapiens 105-121 9538254-10 1998 Among the phospholipase A2 hydrolysis products of phospholipids, unsaturated fatty acids (oleate, linoleate, and arachidonate) and lysophospholipid (lysophosphatidylcholine) by themselves broke lysosomes down directly, whereas saturated fatty acids (palmitate and stearate) had little effect. Fatty Acids 67-88 phospholipase A2 group IB Homo sapiens 10-26 9526092-2 1998 LPC is produced as a result of PC hydrolysis by several isoforms of phospholipase A2 (PLA2) and in the reaction mediated by lecithin-cholesterol acyltransferase that transfers the fatty acid residue from PC to cholesterol. Fatty Acids 180-190 phospholipase A2 group IB Homo sapiens 68-84 9202883-2 1997 PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGa) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF) when the sn-1 position of the phosphatidylcholine contains an alkyl ether linkage and some bioactive lysophospholipids, such as lysophosphatidic acid (lysoPA). Fatty Acids 126-136 phospholipase A2 group IB Homo sapiens 0-4 9323323-1 1997 Biochemical studies have shown that a proportion of schizophrenics have an abnormal fatty acid composition in their red blood-cell membrane phospholipids and it has been suggested that this might be due to altered levels of the enzyme phospholipase A2 (PLA2). Fatty Acids 84-94 phospholipase A2 group IB Homo sapiens 235-251 9235913-7 1997 We now find that this apparent increase in activity is accounted for, in part, by glycerol acting as an alternative acceptor for the cleaved fatty acid, as is the case for this enzyme"s phospholipase A2 (PLA2) activity. Fatty Acids 141-151 phospholipase A2 group IB Homo sapiens 186-202 9235913-7 1997 We now find that this apparent increase in activity is accounted for, in part, by glycerol acting as an alternative acceptor for the cleaved fatty acid, as is the case for this enzyme"s phospholipase A2 (PLA2) activity. Fatty Acids 141-151 phospholipase A2 group IB Homo sapiens 204-208 9234904-3 1997 Secretory PLA2 readily hydrolyzed 1-palmitoyl-2-[3H]-oleoyl-sn-glycero-3-phosphoglycerol coated on styrene-divinylbenzene beads which could be easily monitored by measuring the radioactivity of fatty acid released to solution in the presence of bovine serum albumin. Fatty Acids 194-204 phospholipase A2 group IB Homo sapiens 10-14 9250613-3 1997 Incorporation of arachidonic acid into phospholipids (reacylation) and liberation of this fatty acid from the phospholipid pool (deacylation) are controlled by a set of finely tuned enzymes, including lysophospholipid acyltransferase and phospholipase A2. Fatty Acids 90-100 phospholipase A2 group IB Homo sapiens 238-254 9450323-1 1997 The action of phospholipase A2 (PLA2) on bilayer substrates causes the accumulation of reaction products, lyso-phospholipid and fatty acid. Fatty Acids 128-138 phospholipase A2 group IB Homo sapiens 14-30 9450323-1 1997 The action of phospholipase A2 (PLA2) on bilayer substrates causes the accumulation of reaction products, lyso-phospholipid and fatty acid. Fatty Acids 128-138 phospholipase A2 group IB Homo sapiens 32-36 9330351-18 1997 In addition, gallbladder inflammation is associated with raised phospholipase A2 activity, leading to formation of fatty acids and lysophospholipid which causes membrane damage. Fatty Acids 115-126 phospholipase A2 group IB Homo sapiens 64-80 9239738-12 1997 These data support the conclusion that cytosolic PLA2 is the principal PLA2 isozyme mediating phospholipid metabolism and the liberation of fatty acid substrate (i.e. arachidonic acid) in term amnion, while secretory PLA2 isozymes, and in particular, Type II PLA2 play a major role in phospholipid metabolism in term placenta. Fatty Acids 140-150 phospholipase A2 group IB Homo sapiens 49-53 9239738-12 1997 These data support the conclusion that cytosolic PLA2 is the principal PLA2 isozyme mediating phospholipid metabolism and the liberation of fatty acid substrate (i.e. arachidonic acid) in term amnion, while secretory PLA2 isozymes, and in particular, Type II PLA2 play a major role in phospholipid metabolism in term placenta. Fatty Acids 140-150 phospholipase A2 group IB Homo sapiens 71-75 9239738-12 1997 These data support the conclusion that cytosolic PLA2 is the principal PLA2 isozyme mediating phospholipid metabolism and the liberation of fatty acid substrate (i.e. arachidonic acid) in term amnion, while secretory PLA2 isozymes, and in particular, Type II PLA2 play a major role in phospholipid metabolism in term placenta. Fatty Acids 140-150 phospholipase A2 group IB Homo sapiens 71-75 9239738-12 1997 These data support the conclusion that cytosolic PLA2 is the principal PLA2 isozyme mediating phospholipid metabolism and the liberation of fatty acid substrate (i.e. arachidonic acid) in term amnion, while secretory PLA2 isozymes, and in particular, Type II PLA2 play a major role in phospholipid metabolism in term placenta. Fatty Acids 140-150 phospholipase A2 group IB Homo sapiens 71-75 8952891-6 1996 More specifically, PLA2 provides the precursor for the eicosanoids, when the cleaved fatty acid is arachidonic acid, or for PAF, when the sn-1 position of the phospholipid is an alkyl ether linkage. Fatty Acids 85-95 phospholipase A2 group IB Homo sapiens 19-23 9066294-1 1997 Phospholipase A2 (PLA2) catalyzes the release of free fatty acids from membrane phospholipids, and its products derived from these fatty acids, such as prostaglandins and leukotrienes, significantly up-regulate the key melanogenic enzyme, tyrosinase, in melanocytes. Fatty Acids 54-65 phospholipase A2 group IB Homo sapiens 0-16 9066294-1 1997 Phospholipase A2 (PLA2) catalyzes the release of free fatty acids from membrane phospholipids, and its products derived from these fatty acids, such as prostaglandins and leukotrienes, significantly up-regulate the key melanogenic enzyme, tyrosinase, in melanocytes. Fatty Acids 54-65 phospholipase A2 group IB Homo sapiens 18-22 7666017-0 1995 A simple technique for the analysis of positional distribution of fatty acids on di- and triacylglycerols using lipase and phospholipase A2. Fatty Acids 66-77 phospholipase A2 group IB Homo sapiens 123-139 7548176-5 1995 To investigate the role of fatty acids released by hydrolysis of cellular phospholipids, exogenously-added group I, II or III PLA2"s were used to mobilize fatty acids from cellular membranes. Fatty Acids 155-166 phospholipase A2 group IB Homo sapiens 126-130 7666017-1 1995 A simple technique is described for the analysis of positional distribution of fatty acids on di- and triacylglycerols using lipase and phospholipase A2 that de-esterify fatty acids from specific sn positions. Fatty Acids 79-90 phospholipase A2 group IB Homo sapiens 136-152 7666017-1 1995 A simple technique is described for the analysis of positional distribution of fatty acids on di- and triacylglycerols using lipase and phospholipase A2 that de-esterify fatty acids from specific sn positions. Fatty Acids 170-181 phospholipase A2 group IB Homo sapiens 136-152 7857976-1 1995 The rate of hydrolysis of phosphatidylcholine bilayers by soluble phospholipase A2 (PLA2) is greatly enhanced by the presence in the bilayer of a threshold mole fraction of the reaction products: fatty acid and lysophosphatidylcholine (lyso-PC). Fatty Acids 196-206 phospholipase A2 group IB Homo sapiens 66-82 7857976-1 1995 The rate of hydrolysis of phosphatidylcholine bilayers by soluble phospholipase A2 (PLA2) is greatly enhanced by the presence in the bilayer of a threshold mole fraction of the reaction products: fatty acid and lysophosphatidylcholine (lyso-PC). Fatty Acids 196-206 phospholipase A2 group IB Homo sapiens 84-88 8482720-5 1993 Incorporation of [3H]palmitate and [3H]myristate into the GPI-lipid peaked after 8 h and 24 h of labelling, respectively, and both fatty acids were partially released after PLA2 treatment of the dual labelled ([3H]glucosamine/[14C]palmitate or [3H]glucosamine/[14C]myristate) GPI. Fatty Acids 131-142 phospholipase A2 group IB Homo sapiens 173-177 8490032-1 1993 Cleavage of oxidized fatty acids by phospholipase A2 has been implicated as the first step in the repair mechanism for oxidative damage to membrane phospholipids. Fatty Acids 21-32 phospholipase A2 group IB Homo sapiens 36-52 7825047-3 1994 PLA2 releases fatty acids from lipid membranes. Fatty Acids 14-25 phospholipase A2 group IB Homo sapiens 0-4 8053897-0 1994 Fatty acid and phospholipid selectivity of different phospholipase A2 enzymes studied by using a mammalian membrane as substrate. Fatty Acids 0-10 phospholipase A2 group IB Homo sapiens 53-69 8053897-1 1994 Previous studies using phospholipid mixed vesicles have demonstrated that several types of phospholipase A2 (PLA2) enzymes exhibit different selectivity for fatty acids at the sn-2 position, for the type of chemical bond at the sn-1 position or for the phosphobase moiety at the sn-3 position of phospholipids. Fatty Acids 157-168 phospholipase A2 group IB Homo sapiens 91-107 8053897-1 1994 Previous studies using phospholipid mixed vesicles have demonstrated that several types of phospholipase A2 (PLA2) enzymes exhibit different selectivity for fatty acids at the sn-2 position, for the type of chemical bond at the sn-1 position or for the phosphobase moiety at the sn-3 position of phospholipids. Fatty Acids 157-168 phospholipase A2 group IB Homo sapiens 109-113 8264152-2 1993 In the kidney, Ang II at nanomolar concentration binds to proximal tubular cells and stimulates phospholipase A2 (PLA2), which in turn catalyzes the hydrolysis of phosphatidylcholine into lysophosphatidylcholine (LPC) and fatty acid. Fatty Acids 222-232 phospholipase A2 group IB Homo sapiens 96-112 8264152-2 1993 In the kidney, Ang II at nanomolar concentration binds to proximal tubular cells and stimulates phospholipase A2 (PLA2), which in turn catalyzes the hydrolysis of phosphatidylcholine into lysophosphatidylcholine (LPC) and fatty acid. Fatty Acids 222-232 phospholipase A2 group IB Homo sapiens 114-118 8384573-5 1993 The inhibitory effect of phospholipase A2 was the consequence of fatty acid release. Fatty Acids 65-75 phospholipase A2 group IB Homo sapiens 25-41 8472353-5 1993 Fatty acids released by PLA2 activity were eluted from an aminopropyl solid-phase column directly into scintillation vials, where the radioactivity was counted. Fatty Acids 0-11 phospholipase A2 group IB Homo sapiens 24-28 8444905-6 1993 Activation of endogenous phospholipase A2 by mellitin in vivo or hydrolysis of phosphatidylcholine by purified phospholipase A2 in vitro inhibited PDGF receptor autophosphorylation similar to that of purified fatty acids. Fatty Acids 209-220 phospholipase A2 group IB Homo sapiens 111-127 1321625-1 1992 Phospholipase A2 (PLA2) treatment of synaptosomal membranes, which causes the release of fatty acids, particularly unsaturated fatty acids, inhibits the flux of chloride ions through the gamma-aminobutyric acid (GABA) benzodiazepine receptor ion channel in response to activation by agonists. Fatty Acids 89-100 phospholipase A2 group IB Homo sapiens 0-16 8274032-3 1993 The isolated fractions of phosphatidylcholine (PC), phosphatidylinositol (PI) and phosphatidyl-ethanolamine (PE) were treated with phospholipase A2 to release fatty acids in the sn-2 position. Fatty Acids 159-170 phospholipase A2 group IB Homo sapiens 131-147 1321625-1 1992 Phospholipase A2 (PLA2) treatment of synaptosomal membranes, which causes the release of fatty acids, particularly unsaturated fatty acids, inhibits the flux of chloride ions through the gamma-aminobutyric acid (GABA) benzodiazepine receptor ion channel in response to activation by agonists. Fatty Acids 89-100 phospholipase A2 group IB Homo sapiens 18-22 2033260-1 1991 Phospholipase A2 (PLA2) enzymes hydrolyze membrane phospholipids liberating fatty acid and lysophospholipid. Fatty Acids 76-86 phospholipase A2 group IB Homo sapiens 0-16 1319251-6 1992 PA2 activity is required for fatty acid turnover and is the rate-limiting step in prostaglandin production. Fatty Acids 29-39 phospholipase A2 group IB Homo sapiens 0-3 1917756-5 1991 This surfactant inactivation was predominantly related to the effect of lysophosphatidylcholine on the surface film, although the fatty acids released with higher PLA2 concentrations also had a detrimental effect on surfactant function. Fatty Acids 130-141 phospholipase A2 group IB Homo sapiens 163-167 1864851-5 1991 In marked contact to the NADH-ferricyanide oxidoreductase of the plasma membrane, the NADH oxidase is activated by lysophospholipids and fatty acids, products of phospholipase A2 action, in a time-dependent manner suggestive of stabilization of an activated form of the enzyme. Fatty Acids 137-148 phospholipase A2 group IB Homo sapiens 162-178 1581331-0 1992 Spontaneous domain formation of phospholipase A2 at interfaces: fluorescence microscopy of the interaction of phospholipase A2 with mixed monolayers of lecithin, lysolecithin and fatty acid. Fatty Acids 179-189 phospholipase A2 group IB Homo sapiens 32-48 1581331-0 1992 Spontaneous domain formation of phospholipase A2 at interfaces: fluorescence microscopy of the interaction of phospholipase A2 with mixed monolayers of lecithin, lysolecithin and fatty acid. Fatty Acids 179-189 phospholipase A2 group IB Homo sapiens 110-126 1533163-1 1992 The selectivity of phospholipase A2 from serum was evaluated using radioassays and mass analyses of fatty acids liberated from phosphatidylcholine and phosphatidylethanolamine. Fatty Acids 100-111 phospholipase A2 group IB Homo sapiens 19-35 1576162-3 1992 However, it is a complicated and non-trivial task for several reasons including the critical dependence of PLA2 activity on the physical state of the lipid substrate, the complex kinetics of its action, the low activity of most intercellular and membrane-bound enzymes and the metabolism of the fatty acid products, when applied to intact cell. Fatty Acids 295-305 phospholipase A2 group IB Homo sapiens 107-111 1819458-6 1991 The fatty acid release increased after pretreatment of VLDL with phospholipase A2. Fatty Acids 4-14 phospholipase A2 group IB Homo sapiens 65-81 2033260-1 1991 Phospholipase A2 (PLA2) enzymes hydrolyze membrane phospholipids liberating fatty acid and lysophospholipid. Fatty Acids 76-86 phospholipase A2 group IB Homo sapiens 18-22 1901939-7 1991 This concentration- and time-dependent effect of Et3PbCl might be due to a stimulated liberation of fatty acids via phospholipase A2, because this stimulation could be totally prevented by the phospholipase inhibitors quinacrine and p-bromophenacylbromide. Fatty Acids 100-111 phospholipase A2 group IB Homo sapiens 116-132 1910734-12 1991 Phospholipase A2 is present in serum likely as a consequence of blood coagulation and may release fatty acids from cellular membranes following hemorrhage. Fatty Acids 98-109 phospholipase A2 group IB Homo sapiens 0-16 1650878-8 1991 The results suggest that increased fatty acid incorporation into phospholipids in LTB4-activated neutrophils reflects activation of phospholipase A2 and acyltransferases as well as of de novo phospholipid synthesis. Fatty Acids 35-45 phospholipase A2 group IB Homo sapiens 132-148 2123404-9 1990 These findings indicate that differences in substrate specificity found in vitro among the phospholipase A2 activities located in distinct subcellular particulates might be a reflection of the distinct phospholipid and fatty acid composition in these particulates. Fatty Acids 219-229 phospholipase A2 group IB Homo sapiens 91-107 1901228-6 1991 Phospholipase A2 (PLA2) and the calcium ionophore, A23187, stimulated the release of 3H from theca cells prelabeled with [3H]arachidonic acid, and both PLA2 and the closely related fatty acid, eicosatrienoic acid (C20:3), could replicate the inhibitory effects of arachidonic acid on LH-stimulated androstenedione production. Fatty Acids 181-191 phospholipase A2 group IB Homo sapiens 0-16 1901228-6 1991 Phospholipase A2 (PLA2) and the calcium ionophore, A23187, stimulated the release of 3H from theca cells prelabeled with [3H]arachidonic acid, and both PLA2 and the closely related fatty acid, eicosatrienoic acid (C20:3), could replicate the inhibitory effects of arachidonic acid on LH-stimulated androstenedione production. Fatty Acids 181-191 phospholipase A2 group IB Homo sapiens 18-22 2217203-3 1990 This additional phospholipase A2 selectively hydrolyzes fatty acid at the sn-2 position of the glycerol and favors phospholipids containing arachidonic acid, which is the rate-limiting precursor for prostaglandin and leukotriene production. Fatty Acids 56-66 phospholipase A2 group IB Homo sapiens 16-32 1965768-12 1990 Phospholipase A2 (PLA2) hydrolyzes fatty acid from the sn-2 position of a wide variety of phospholipids. Fatty Acids 35-45 phospholipase A2 group IB Homo sapiens 0-16 2129000-9 1990 These results illustrate that oxidative reactions of cis-unsaturated fatty acids relieve their natural inhibitory activity, and polymerization of an inactive fatty acid metabolite yields a potent inhibitor of in vitro and in situ phospholipase A2 activity. Fatty Acids 69-79 phospholipase A2 group IB Homo sapiens 230-246 2163589-0 1990 AT32P-dependent estimation of nanomoles of fatty acids: its use in the assay of phospholipase A2 activity. Fatty Acids 43-54 phospholipase A2 group IB Homo sapiens 80-96 2163589-5 1990 As little as 1 to 3 nmol of fatty acids hydrolyzed from any phospholipid using nanogram amounts of phospholipase A2 can be estimated with reliability. Fatty Acids 28-39 phospholipase A2 group IB Homo sapiens 99-115 1965768-12 1990 Phospholipase A2 (PLA2) hydrolyzes fatty acid from the sn-2 position of a wide variety of phospholipids. Fatty Acids 35-45 phospholipase A2 group IB Homo sapiens 18-22 34944707-4 2021 Members of the family of phospholipase A2, which hydrolyze the fatty acid present at the sn-2 position of phospholipids, have recently emerged as key controllers of lipid droplet homeostasis, regulating their formation and the availability of fatty acids for lipid mediator production. Fatty Acids 63-73 phospholipase A2 group IB Homo sapiens 25-41 2402761-8 1990 Fatty acid release was decreased by 75% when the melittin fraction was pretreated with p-BPB to reduce contaminating venom PLA2 activity. Fatty Acids 0-10 phospholipase A2 group IB Homo sapiens 123-127 34944707-4 2021 Members of the family of phospholipase A2, which hydrolyze the fatty acid present at the sn-2 position of phospholipids, have recently emerged as key controllers of lipid droplet homeostasis, regulating their formation and the availability of fatty acids for lipid mediator production. Fatty Acids 243-254 phospholipase A2 group IB Homo sapiens 25-41 35358512-3 2022 For example, phospholipase A2 (PLA2) enzymes constitute a superfamily of degradative, biosynthetic, and signaling enzymes that all act stereospecifically to hydrolyze and release the fatty acids of membrane phospholipids. Fatty Acids 183-194 phospholipase A2 group IB Homo sapiens 13-29 35358512-3 2022 For example, phospholipase A2 (PLA2) enzymes constitute a superfamily of degradative, biosynthetic, and signaling enzymes that all act stereospecifically to hydrolyze and release the fatty acids of membrane phospholipids. Fatty Acids 183-194 phospholipase A2 group IB Homo sapiens 31-35 2631109-1 1989 A spectrophotometric method is proposed for determining phospholipase A2 activity, which is based on the conversion of hemoglobin into hemichrome under the fatty acid action. Fatty Acids 156-166 phospholipase A2 group IB Homo sapiens 56-72 3433293-1 1987 We have set up an assay of phospholipase A2 by a spectrophotometric method, based on the pH change due to the liberation of fatty acids. Fatty Acids 124-135 phospholipase A2 group IB Homo sapiens 27-43 2694965-5 1989 First of all, the analysis is focused in the phospholipid transmethylation reactions possibly occurring at plasma membrane level during capacitation and the AR; it is suggested too, that this pathway could provide the substrate for a sperm head membrane bound phospholipase A2 which is able to produce a lysophospholipid (a fusogen) and fatty acids; both of them, very likely involved in the late steps of the AR. Fatty Acids 337-348 phospholipase A2 group IB Homo sapiens 260-276 3114260-3 1987 Treatment of the intact phospholipid with phospholipase A2 resulted in the release of 88% of the radiolabel into the acidified aqueous phase of the extraction mixture, indicating the moiety in the sn-2 position remained as acetate and had not been elongated to fatty acid. Fatty Acids 261-271 phospholipase A2 group IB Homo sapiens 42-58 2606905-7 1989 Melittin and Ca2+, which activate phospholipase A2, increased the rate of state 4 respiration and the liberation of fatty acids. Fatty Acids 116-127 phospholipase A2 group IB Homo sapiens 34-50 2469472-14 1989 The inhibitory effect at high albumin concentrations is probably the result of removal of free fatty acids from the micelle: fatty acids are known to cause stimulation of phospholipase A2 by providing a negative charge to the lipid/water interface. Fatty Acids 95-106 phospholipase A2 group IB Homo sapiens 171-187 2923895-16 1989 The kinetics of segregation of fatty acids during the course of hydrolysis of bilayers of zwitterionic phospholipids by phospholipase A2 exhibits an unequivocal correlation with a variety of phenomena that are observed during the transition from the pre-steady-state phase to the steady-state phase of hydrolysis in the reaction progress curves as a function of temperature and in the presence of lipophilic additives. Fatty Acids 31-42 phospholipase A2 group IB Homo sapiens 120-136 3117829-6 1987 The finding of decreased free and phospholipase A2-releasable arachidonic acid of the total lipid extract of the amnion of women with dysfunctional labor could suggest further metabolic exhaustion of the substrate or failure of liberation of this fatty acid from glycerophospholipids by enzymes other than phospholipase A2, such as phospholipase C or diacyl and monoacylglycerolipases. Fatty Acids 247-257 phospholipase A2 group IB Homo sapiens 34-50 3435543-4 1987 Using this method, the fatty acid produced is fully recovered and its amount, as measured by its fluorescence intensity, is a direct measure of the cell membrane PLA2 activity. Fatty Acids 23-33 phospholipase A2 group IB Homo sapiens 162-166 6675717-3 1983 The present study reports the effect of fatty acid peroxidation on the organization of PS and PE in human red cells using a nonpermeable Bee Venom phospholipase-A2 which specifically hydrolyzes outer bilayer lipids. Fatty Acids 40-50 phospholipase A2 group IB Homo sapiens 147-163 3080542-5 1986 This stimulation-induced incorporation of fatty acids into cellular phospholipids was directed exlusively into position 2 of the lipid and probably reflects the reacylation of lysophospholipids after the release of arachidonic acid by phospholipase A2. Fatty Acids 42-53 phospholipase A2 group IB Homo sapiens 235-251 3000470-1 1985 Phospholipase A2-induced changes in the affinity of benzodiazepine receptors are due to accumulation of monoacylglycerol phosphatides, and not fatty acids, in the membranes. Fatty Acids 143-154 phospholipase A2 group IB Homo sapiens 0-16 3836246-0 1985 Phospholipase A2 dependent release of fatty acids from peroxidized membranes. Fatty Acids 38-49 phospholipase A2 group IB Homo sapiens 0-16 3855556-4 1985 Incubation of PLA2 with phospholipids or various neutral lipids, including saturated fatty acids, had little or no effect on enzymatic activity. Fatty Acids 75-96 phospholipase A2 group IB Homo sapiens 14-18 4062974-9 1985 The effects of all of the drugs employed in this study on the action of PLA2 on a bilayer substrate (fatty acid-containing ternary lipid mixture) are hypothesized to be a result of the drug-mediated shift in phase equilibria away from the optimally active phase distribution. Fatty Acids 101-111 phospholipase A2 group IB Homo sapiens 72-76 3893547-1 1985 Assay methods for bee venom phospholipase A2 are presented which respond to different aspects of enzymic behaviour and which allow basal activity, fatty acid activation and acyl-group activation to be distinguished. Fatty Acids 147-157 phospholipase A2 group IB Homo sapiens 28-44 6441309-7 1984 These results suggest that endogenous phospholipase A2 may break membrane phosphatidyl choline into lysophosphatidyl choline and fatty acid, when the acrosome reaction occurs. Fatty Acids 129-139 phospholipase A2 group IB Homo sapiens 38-54 6818991-3 1982 In both cases, free 3H-labelled fatty acids were generated during the labelling procedure, indicating phospholipase A2 hydrolysis. Fatty Acids 32-43 phospholipase A2 group IB Homo sapiens 102-118 6319862-2 1983 Phospholipase A2 inhibited etorphine binding, suggesting either that phospholipids are essential for ligand binding or that products of the phospholipase A2 reaction, either lysophospholipids or fatty acids, disrupt the membrane integrity because of their detergent like properties. Fatty Acids 195-206 phospholipase A2 group IB Homo sapiens 0-16 6319862-2 1983 Phospholipase A2 inhibited etorphine binding, suggesting either that phospholipids are essential for ligand binding or that products of the phospholipase A2 reaction, either lysophospholipids or fatty acids, disrupt the membrane integrity because of their detergent like properties. Fatty Acids 195-206 phospholipase A2 group IB Homo sapiens 140-156 7104380-0 1982 Stimulation of fatty acid methylation in human red cell membranes by phospholipase A2 activation. Fatty Acids 15-25 phospholipase A2 group IB Homo sapiens 69-85 7104380-9 1982 Fatty acid methylation appears to be one of the consequences of phospholipase A2 action in plasma membranes. Fatty Acids 0-10 phospholipase A2 group IB Homo sapiens 64-80 7380202-11 1980 Fatty acid present in the oil phase or produced from it by a limited hydrolysis of phospholipid by phospholipase A2 or triglyceride by lipase, changes the properties of the interface so that colipase can bind and thereby lipase via its binding to colipase. Fatty Acids 0-10 phospholipase A2 group IB Homo sapiens 99-115 7315970-8 1981 Full reversal of inhibition occurred in the presence of phospholipase A2, which hydrolyzed the phospholipids to lysolecithin and fatty acids. Fatty Acids 129-140 phospholipase A2 group IB Homo sapiens 56-72 7241575-7 1981 Exogenous oleic and linoleic acid, at intramembrane concentrations equal to those produced by phospholipase A2, inhibit lactate and arabinose transfer, while accelerating oxalate and erythritol movements, in agreement with effects of endogenous fatty acids. Fatty Acids 245-256 phospholipase A2 group IB Homo sapiens 94-110 6120752-4 1981 Low concentrations of phospholipase A2 (1-2 international units) also activated the solubilized enzyme, at least in part by releasing free fatty acids, as the activation was mimicked by oleic acid (1-2 mumol/mg protein) and was abolished by fatty acid depleted bovine serum albumin. Fatty Acids 139-149 phospholipase A2 group IB Homo sapiens 22-38 156639-2 1979 The calcium-dependent ATPase activity of phospholipase-A2-digested sarcoplasmic vesicles decreases concomitantly with the contents of residual lysophospholipids and fatty acids when increasing albumin concentrations are applied. Fatty Acids 165-176 phospholipase A2 group IB Homo sapiens 41-57 7360285-2 1980 In vivo lysophospholipids are invariably produced with fatty acids as the product of hydrolysis by phospholipase A2 (ref. Fatty Acids 55-66 phospholipase A2 group IB Homo sapiens 99-115 1252506-3 1976 Hydrolysis by phospholipase A2 was controlled by addition of fatty acid-free bovine serum albumin. Fatty Acids 61-71 phospholipase A2 group IB Homo sapiens 14-30 413264-2 1977 Impairment of mitochondria and accumulation of fatty acids were prevented by inhibitors of phospholipase A2 from mitochondria. Fatty Acids 47-58 phospholipase A2 group IB Homo sapiens 91-107 1259964-6 1976 Judging from mild alkaline hydrolysis and exzymatic treatment with phospholipase A2, C and D, the unidentified phosphoglycolipid possessing Pi, glycerol, fatty acids and glucose in a molar ratio of 1 : 2 : 2 : 1, appeared likely to be a glucosyl derivative of phosphatidylglycerol. Fatty Acids 154-165 phospholipase A2 group IB Homo sapiens 67-92 933913-4 1976 Fatty acids may restrict the availability of chemical energy within cancer cells in at least two ways, either by modulating the activity of the mitochondrial adenine nucleotide translocase through the agency of their coenzyme A derivatives (LCFACoAs), or by uncoupling oxidative phosphorylation through the activation of phospholipase A2. Fatty Acids 0-11 phospholipase A2 group IB Homo sapiens 321-337 4673665-0 1972 The effect of fatty acids and of albumin on the action of a purified phospholipase A 2 from cobra venom on synthetic lecithins. Fatty Acids 14-25 phospholipase A2 group IB Homo sapiens 69-86 127477-4 1975 After incubation with phospholipase-A2 the lecithin and cephalin streaks were reduced and in addition lysophosphatide and fatty acid streaks were detected. Fatty Acids 122-132 phospholipase A2 group IB Homo sapiens 22-38 803261-0 1975 Activation of bee venom phospholipase A2 by fatty acids, aliphatic anhydrides and glutaraldehyde. Fatty Acids 44-55 phospholipase A2 group IB Homo sapiens 24-40 33086624-2 2020 In principle, PLA2 has the capacity to hydrolyze the sn-2 position of glycerophospholipids to release fatty acids and lysophospholipids, yet several enzymes in this superfamily catalyze other reactions rather than or in addition to the PLA2 reaction. Fatty Acids 102-113 phospholipase A2 group IB Homo sapiens 14-18 33002451-2 2021 Two sites are involved in manifestation of PLA2 enzymatic activity: catalytic site responsible for substrate binding and fatty acid cleavage from the sn-2 position of a glycerophospholipid, and interface binding site (IBS) responsible for the protein binding to lipid membrane. Fatty Acids 121-131 phospholipase A2 group IB Homo sapiens 43-47 33580989-1 2021 Phospholipase A2 (PLA2 ) is responsible for the release of fatty acids from glycerophospholipids. Fatty Acids 59-70 phospholipase A2 group IB Homo sapiens 0-16 33580989-1 2021 Phospholipase A2 (PLA2 ) is responsible for the release of fatty acids from glycerophospholipids. Fatty Acids 59-70 phospholipase A2 group IB Homo sapiens 18-22 31838071-2 2020 PLA2 enzymes catalyze the Ca2+ dependent hydrolysis of 2-acyl ester bonds of 3-sn-phospholipids, releasing fatty acids and lysophospholipids. Fatty Acids 107-118 phospholipase A2 group IB Homo sapiens 0-4 31957789-4 2020 PLA2 mediates the hydrolysis of membrane phospholipids into lysophospholipids and free fatty acids. Fatty Acids 87-98 phospholipase A2 group IB Homo sapiens 0-4 30010011-1 2019 Phospholipase A2s are enzymes that hydrolyze the fatty acid at the sn-2 position of the glycerol backbone of membrane glycerophospholipids. Fatty Acids 49-59 phospholipase A2 group IB Homo sapiens 0-16 31717968-8 2019 Among the members of the fatty acid uptake complex, the calcium-independent membrane phospholipase A2 (iPLA2beta) abandoned DRM-PM most rapidly. Fatty Acids 25-35 phospholipase A2 group IB Homo sapiens 85-101 30830399-8 2018 Phosphatidylcholines, lyso-phosphatidylcholines and fatty acids were significantly changed among pathological samples suggesting changes in phospholipase A2 and arachidonic acid metabolic pathways. Fatty Acids 52-63 phospholipase A2 group IB Homo sapiens 140-156 30769093-1 2019 The phospholipase A2 (PLA2) family comprises a group of lipolytic enzymes that typically hydrolyze the sn-2 position of (glycerol) phospholipids to give rise to fatty acids and lysophospholipids. Fatty Acids 161-172 phospholipase A2 group IB Homo sapiens 4-20 30769093-1 2019 The phospholipase A2 (PLA2) family comprises a group of lipolytic enzymes that typically hydrolyze the sn-2 position of (glycerol) phospholipids to give rise to fatty acids and lysophospholipids. Fatty Acids 161-172 phospholipase A2 group IB Homo sapiens 22-26 29577851-7 2018 The release of free fatty acids from PC/PS liposomes by bee venom phospholipase A2 was measured with the fluorescent probe acrylodated intestinal fatty acid-binding protein (ADIFAB) and radioactive labelling by preparing liposomes in the presence of L- 3-phosphatidylcholine, 1-stearyl-2[1-14C] arachidonoyl. Fatty Acids 20-31 phospholipase A2 group IB Homo sapiens 66-82 29077970-6 2018 We support the notion that bluntness in niacin skin test might reflect abnormalities in membrane fatty acid composition, which could be induced by increased PLA2 enzyme activity, in vivo oxidative stress or lipid metabolism imbalance in SZ. Fatty Acids 97-107 phospholipase A2 group IB Homo sapiens 157-161 29342349-5 2018 Molecular dynamics simulations revealed the optimal phospholipid binding mode leading to a detailed understanding of the preference of cytosolic phospholipase A2 for cleavage of proinflammatory arachidonic acid, calcium-independent phospholipase A2, which is involved in membrane remodeling for cleavage of linoleic acid and for antibacterial secreted phospholipase A2 favoring linoleic acid, saturated fatty acids, and phosphatidylglycerol. Fatty Acids 393-414 phospholipase A2 group IB Homo sapiens 145-161 29577851-7 2018 The release of free fatty acids from PC/PS liposomes by bee venom phospholipase A2 was measured with the fluorescent probe acrylodated intestinal fatty acid-binding protein (ADIFAB) and radioactive labelling by preparing liposomes in the presence of L- 3-phosphatidylcholine, 1-stearyl-2[1-14C] arachidonoyl. Fatty Acids 20-30 phospholipase A2 group IB Homo sapiens 66-82 26335363-6 2015 The primary structure was determined by EDMAN degradation method and the PLA2 activity by titration of fatty acids released from the egg yolk phospholipids. Fatty Acids 103-114 phospholipase A2 group IB Homo sapiens 73-77 29138276-3 2017 Specifically, we found that survival of cancer cells was critically dependent on phospholipase A2 (PLA2) to mobilize lysophospholipids and free fatty acids to sustain fatty acid oxidation and oxidative phosphorylation. Fatty Acids 144-154 phospholipase A2 group IB Homo sapiens 99-103 28602806-5 2017 Here we showed that influx of fatty acids is mediated by an apical heterotetrameric plasma membrane protein complex of which the calcium-independent membrane phospholipase A2 (iPLA2ss) is one constituent. Fatty Acids 30-41 phospholipase A2 group IB Homo sapiens 158-174 29129849-1 2017 The phospholipase A2 (PLA2) family comprises a group of lipolytic enzymes that typically hydrolyze the sn-2 position of glycerophospholipids to give rise to fatty acids and lysophospholipids. Fatty Acids 157-168 phospholipase A2 group IB Homo sapiens 4-20 29129849-1 2017 The phospholipase A2 (PLA2) family comprises a group of lipolytic enzymes that typically hydrolyze the sn-2 position of glycerophospholipids to give rise to fatty acids and lysophospholipids. Fatty Acids 157-168 phospholipase A2 group IB Homo sapiens 22-26 29129849-3 2017 From a general viewpoint, the PLA2 family has mainly been implicated in signal transduction, producing bioactive lipid mediators derived from fatty acids and lysophospholipids. Fatty Acids 142-153 phospholipase A2 group IB Homo sapiens 30-34 29773019-2 2017 PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGs) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF) when the sn-1 position of the phosphatidylcholine contains an alkyl ether linkage and some bioactive lysophospholipids, such as lysophosphatidic acid (lysoPA). Fatty Acids 126-136 phospholipase A2 group IB Homo sapiens 0-4 27218880-1 2016 Phospholipase A2 (PLA2) is a peripheral membrane protein that can hydrolyze phospholipids to produce lysolipids and fatty acids. Fatty Acids 116-127 phospholipase A2 group IB Homo sapiens 0-16 27218880-1 2016 Phospholipase A2 (PLA2) is a peripheral membrane protein that can hydrolyze phospholipids to produce lysolipids and fatty acids. Fatty Acids 116-127 phospholipase A2 group IB Homo sapiens 18-22 25152418-1 2014 The catalytic potential of phospholipase A2 (PLA2) for the synthesis of phospholipids with defined fatty acid structure in the sn-2 position has been underestimated hitherto because of very low conversion in most organic solvents. Fatty Acids 99-109 phospholipase A2 group IB Homo sapiens 27-43 25450448-3 2014 Hence, the importance of unraveling the cell mechanisms controlling lipid droplet biosynthesis, homeostasis and degradation seems evident Phospholipase A2s, a family of enzymes whose common feature is to hydrolyze the fatty acid present at the sn-2 position of phospholipids, play pivotal roles in cell signaling and inflammation. Fatty Acids 218-228 phospholipase A2 group IB Homo sapiens 138-154 25152418-1 2014 The catalytic potential of phospholipase A2 (PLA2) for the synthesis of phospholipids with defined fatty acid structure in the sn-2 position has been underestimated hitherto because of very low conversion in most organic solvents. Fatty Acids 99-109 phospholipase A2 group IB Homo sapiens 45-49 23727005-1 2013 Phospholipase A2 (PLA2) enzymes catalyze the hydrolysis of the sn-2 ester linkage of glycerophospholipids to produce fatty acids and lysophospholipids. Fatty Acids 117-128 phospholipase A2 group IB Homo sapiens 0-16 23478748-0 2014 Omega-3 fatty acid supplementation changes intracellular phospholipase A2 activity and membrane fatty acid profiles in individuals at ultra-high risk for psychosis. Fatty Acids 8-18 phospholipase A2 group IB Homo sapiens 57-73 24046806-1 2013 Pancreatic phospholipase A2, product of PLA2G1B, catalyzes the release of fatty acids from dietary phospholipids.Diet is the ultimate source of arachidonic acid in cellular phospholipids, precursor of eicosanoid signaling molecules, linked to inflammation, cell proliferation and colorectal carcinogenesis. Fatty Acids 74-85 phospholipase A2 group IB Homo sapiens 40-47 24719358-0 2014 Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis. Fatty Acids 57-67 phospholipase A2 group IB Homo sapiens 16-32 24719358-3 2014 Using the human hepatocyte-derived tumor cell line HepG2, we found that fatty acid influx is mediated by a heterotetrameric plasma membrane protein complex consisting of plasma membrane fatty acid-binding protein, caveolin-1, CD36, and calcium-independent membrane phospholipase A2 (iPLA2beta). Fatty Acids 72-82 phospholipase A2 group IB Homo sapiens 265-281 23727005-1 2013 Phospholipase A2 (PLA2) enzymes catalyze the hydrolysis of the sn-2 ester linkage of glycerophospholipids to produce fatty acids and lysophospholipids. Fatty Acids 117-128 phospholipase A2 group IB Homo sapiens 18-22 17531957-1 2007 Phospholipase A(2) (PLA(2)) are esterases that cleave glycerophospholipids to release fatty acids and lysophospholipids. Fatty Acids 86-97 phospholipase A2 group IB Homo sapiens 0-18 23704812-2 2013 Here, 9-oxononanoic acid (9-ONA), one of the major products of peroxidized fatty acids, was found to stimulate the activity of phospholipase A2 (PLA2), the key enzyme to initiate arachidonate cascade and eicosanoid production. Fatty Acids 75-86 phospholipase A2 group IB Homo sapiens 127-143 23704812-2 2013 Here, 9-oxononanoic acid (9-ONA), one of the major products of peroxidized fatty acids, was found to stimulate the activity of phospholipase A2 (PLA2), the key enzyme to initiate arachidonate cascade and eicosanoid production. Fatty Acids 75-86 phospholipase A2 group IB Homo sapiens 145-149 22414059-6 2012 Group VIA Phospholipase A2 (iPLA2beta) appears to be a component of a mechanism for repairing mitochondrial phospholipids that contain oxidized fatty acid substituents, and genetic or acquired iPLA2beta-deficiency increases beta-cell mitochondrial susceptibility to injury from ROS and predisposes to development of T2D. Fatty Acids 144-154 phospholipase A2 group IB Homo sapiens 10-26 22110477-7 2012 Group VIA phospholipase A2 (iPLA2beta) appears to be a component of a mechanism for repairing mitochondrial phospholipids that contain oxidized fatty acid substituents, and genetic or acquired iPLA2beta-deficiency increases beta-cell mitochondrial susceptibility to injury from ROS and predisposes to developing T2DM. Fatty Acids 144-154 phospholipase A2 group IB Homo sapiens 10-26 18775417-1 2008 Phospholipase A(2) (PLA(2)) are esterases that cleave glycerophospholipids to release fatty acids and lysophospholipids. Fatty Acids 86-97 phospholipase A2 group IB Homo sapiens 0-18 18775417-1 2008 Phospholipase A(2) (PLA(2)) are esterases that cleave glycerophospholipids to release fatty acids and lysophospholipids. Fatty Acids 86-97 phospholipase A2 group IB Homo sapiens 20-26 22642495-1 2012 Ester bond hydrolysis of membrane phospholipids by Phospholipase A(2) and consequent release of fatty acids are the initiating steps of inflammation. Fatty Acids 96-107 phospholipase A2 group IB Homo sapiens 51-69 22642495-9 2012 It may be concluded from the structural and kinetics studies that the fatty acid, n-hexadecanoic acid, is an inhibitor of phospholipase A(2), hence, an anti-inflammatory compound. Fatty Acids 70-80 phospholipase A2 group IB Homo sapiens 122-140 22327613-3 2012 RECENT FINDINGS: The group 1B PLA2 digestion of phospholipids in the intestinal lumen facilitates postprandial lysophospholipid absorption, which suppresses hepatic fatty acid oxidation leading to increased VLDL synthesis, decreased glucose tolerance, and promotion of tissue lipid deposition to accentuate diet-induced hyperlipidemia, diabetes, and obesity. Fatty Acids 165-175 phospholipase A2 group IB Homo sapiens 30-34 21435339-2 2011 In the current work, the hydrolysis of phospholipids by PLA(2) was monitored with acrylodan-labelled intestinal fatty acid binding protein (ADIFAB) and this fluorescence based technique was also used to access the enzymatic inhibitory effect of non-steroidal anti-inflammatory drugs (NSAIDs). Fatty Acids 112-122 phospholipase A2 group IB Homo sapiens 56-62 20969853-1 2011 Phospholipase A(2) releases the fatty acid arachidonic acid from membrane phospholipids. Fatty Acids 32-42 phospholipase A2 group IB Homo sapiens 0-18 19800928-5 2010 In this paper we examined the possible role of arachidonic acid (AA), a fatty acid that is generated by the activity of phospholipase A2 (PLA2). Fatty Acids 72-82 phospholipase A2 group IB Homo sapiens 120-136 19800928-5 2010 In this paper we examined the possible role of arachidonic acid (AA), a fatty acid that is generated by the activity of phospholipase A2 (PLA2). Fatty Acids 72-82 phospholipase A2 group IB Homo sapiens 138-142 20362028-1 2010 Phospholipase A(2) (PLA(2)) enzymes (EC3.1.4.4) regulate the release of biologically active fatty acids and lysophospholipids from membrane phospholipid pools. Fatty Acids 92-103 phospholipase A2 group IB Homo sapiens 0-18 20362028-1 2010 Phospholipase A(2) (PLA(2)) enzymes (EC3.1.4.4) regulate the release of biologically active fatty acids and lysophospholipids from membrane phospholipid pools. Fatty Acids 92-103 phospholipase A2 group IB Homo sapiens 20-26 20513971-4 2010 When LPL and the fatty acids were reacted in glycerol in the presence of porcine pancreas PLA(2), the reaction was not very effective. Fatty Acids 17-28 phospholipase A2 group IB Homo sapiens 90-96 17531957-1 2007 Phospholipase A(2) (PLA(2)) are esterases that cleave glycerophospholipids to release fatty acids and lysophospholipids. Fatty Acids 86-97 phospholipase A2 group IB Homo sapiens 20-26 17311918-1 2007 Snake presynaptic phospholipase A2 neurotoxins (SPANs) bind to the presynaptic membrane and hydrolyze phosphatidylcholine with generation of lysophosphatidylcholine (LysoPC) and fatty acid (FA). Fatty Acids 178-188 phospholipase A2 group IB Homo sapiens 18-34 16967904-1 2006 Phospholipase A2s (PLA2) are a class of enzymes, which catalyze the hydrolysis of membrane phospholipids at the sn-2 position to release fatty acids and lysophospholipids. Fatty Acids 137-148 phospholipase A2 group IB Homo sapiens 0-16 16805767-4 2006 Snake presynaptic PLA2 neurotoxins block nerve terminals by binding to the nerve membrane and catalyzing phospholipid hydrolysis with production of lysophospholipids and fatty acids. Fatty Acids 170-181 phospholipase A2 group IB Homo sapiens 18-22 21690738-2 2005 These lipases are interfacially activated enzymes and in the specific case of phospholipase A(2) (PLA(2)) the enzyme catalyses the hydrolysis of di-acyl phospholipids into products of lysolipids and fatty acids, that dramatically change the physical properties of lipid membrane substrates. Fatty Acids 199-210 phospholipase A2 group IB Homo sapiens 78-96 21690738-2 2005 These lipases are interfacially activated enzymes and in the specific case of phospholipase A(2) (PLA(2)) the enzyme catalyses the hydrolysis of di-acyl phospholipids into products of lysolipids and fatty acids, that dramatically change the physical properties of lipid membrane substrates. Fatty Acids 199-210 phospholipase A2 group IB Homo sapiens 98-104 15906145-5 2005 We propose that the mechanism for pore opening, in addition to the oxidative stress, involves the uncoupling effect of fatty acids providing activation of phospholipase A2, lipid peroxidation, and the oxidation of membrane thiols. Fatty Acids 119-130 phospholipase A2 group IB Homo sapiens 155-171 12240034-1 2001 Phosphatidylethanolamine and -choline derivatives equipped with fluorescent donor-acceptor pairs of dyes connected to the tips of the fatty acids were synthesised and shown to be suitable substrates for phospholipase A2. Fatty Acids 134-145 phospholipase A2 group IB Homo sapiens 203-219 14557275-5 2003 The incorporation of [14C]DAG and [14C]fatty acids released from plasma membrane by additions of either phospholipase C or phospholipase A2 into triacylglycerol was increased by 6.2- and 2.8-fold, respectively, in DGAT cells compared with control cells, indicating that DGAT can attenuate signaling lipids. Fatty Acids 39-50 phospholipase A2 group IB Homo sapiens 123-139 12728744-8 2003 Phospholipase A2 (PLA2) hydrolyzes fatty acids from membrane phospholipids: liberated omega-6 PUFAs are metabolized to prostaglandins with a higher inflammatory potential, compared with those generated from the omega-3 family. Fatty Acids 35-46 phospholipase A2 group IB Homo sapiens 0-16 12728744-8 2003 Phospholipase A2 (PLA2) hydrolyzes fatty acids from membrane phospholipids: liberated omega-6 PUFAs are metabolized to prostaglandins with a higher inflammatory potential, compared with those generated from the omega-3 family. Fatty Acids 35-46 phospholipase A2 group IB Homo sapiens 18-22 12728744-9 2003 Thus the activity of PLA2 coupled with membrane fatty acid composition may play a central role in the development of neuronal dysfunction. Fatty Acids 48-58 phospholipase A2 group IB Homo sapiens 21-25 12562826-8 2003 A structural model for NAE-lipid interactions is proposed in order to explain the differences in PLA2 activity modulation by these fatty acid derivatives. Fatty Acids 131-141 phospholipase A2 group IB Homo sapiens 97-101 12475227-0 2002 Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive. Fatty Acids 129-139 phospholipase A2 group IB Homo sapiens 21-37 12167600-1 2002 Phospholipase A(2) (PLA(2)) hydrolyzes the sn-2 ester bond in phospholipids, releasing a fatty acid and a lysophospholipid. Fatty Acids 89-99 phospholipase A2 group IB Homo sapiens 0-18 12167600-1 2002 Phospholipase A(2) (PLA(2)) hydrolyzes the sn-2 ester bond in phospholipids, releasing a fatty acid and a lysophospholipid. Fatty Acids 89-99 phospholipase A2 group IB Homo sapiens 20-26 14657205-1 2004 Phospholipase A2 (PLA2) belongs to a family of enzymes that catalyze the cleavage of fatty acids from the sn-2 position of phospholipids. Fatty Acids 85-96 phospholipase A2 group IB Homo sapiens 0-16 14657205-1 2004 Phospholipase A2 (PLA2) belongs to a family of enzymes that catalyze the cleavage of fatty acids from the sn-2 position of phospholipids. Fatty Acids 85-96 phospholipase A2 group IB Homo sapiens 18-22 14992263-5 2004 Using Ehrlich ascites tumor cells, NIH3T3 mouse fibroblasts and HeLa cells as biological systems, it is revealed that phospholipase A2-mediated mobilization of arachidonic acid from phospholipids and subsequent oxidation of the fatty acid via lipoxygenase systems to potent eicosanoids are essential elements in the signaling cascade that is activated by cell swelling and leads to release of osmolytes. Fatty Acids 228-238 phospholipase A2 group IB Homo sapiens 118-134 12895207-1 2003 OBJECTIVES: In vivo studies demonstrating that lithium is a powerful phospholipase A2 (PLA2) inhibitor suggest that PLA2 activation, and subsequent cell signaling overactivation by increased fatty acid release may be the primary abnormality in bipolar affective disorder (BPAD), thus making PLA2 genes attractive candidates for the susceptibility to BPAD. Fatty Acids 191-201 phospholipase A2 group IB Homo sapiens 69-85 12895207-1 2003 OBJECTIVES: In vivo studies demonstrating that lithium is a powerful phospholipase A2 (PLA2) inhibitor suggest that PLA2 activation, and subsequent cell signaling overactivation by increased fatty acid release may be the primary abnormality in bipolar affective disorder (BPAD), thus making PLA2 genes attractive candidates for the susceptibility to BPAD. Fatty Acids 191-201 phospholipase A2 group IB Homo sapiens 87-91 11757031-2 2002 Among those phospholipases, phospholipase A2 cleaves one of the acyl chains from phospholipids, thereby producing fatty acids and lysophospholipids such as LPC, LPS, and LPE. Fatty Acids 114-125 phospholipase A2 group IB Homo sapiens 28-44 11129952-6 2000 The mechanism for the reduction in radiolabelled fatty acid incorporation into phosphatidylcholine was a 64% (p < 0.05) reduction in membrane phospholipase A2 activity. Fatty Acids 49-59 phospholipase A2 group IB Homo sapiens 145-161 11159446-5 2001 Phospholipid hydrolysis by PLA2 is followed by preferential removal of the liberated lysolipid and accumulation of the fatty acid in the membrane that may predominantly modulate PLA2 activity by affecting membrane electrostatics and/or morphology. Fatty Acids 119-129 phospholipase A2 group IB Homo sapiens 27-31 11159446-5 2001 Phospholipid hydrolysis by PLA2 is followed by preferential removal of the liberated lysolipid and accumulation of the fatty acid in the membrane that may predominantly modulate PLA2 activity by affecting membrane electrostatics and/or morphology. Fatty Acids 119-129 phospholipase A2 group IB Homo sapiens 178-182 11080676-7 2000 The release of fatty acids and lysophospholipids from the cell surfaces induces the translocation and activation of cytosolic PLA(2) and 5-lipoxygenase, resulting in the leukotriene synthesis. Fatty Acids 15-26 phospholipase A2 group IB Homo sapiens 126-132 10972869-4 2000 This rapid PLA2 activation occurred before the accumulation of 12-oxophytodienoic and jasmonic acids, two fatty acid-derived defence signals. Fatty Acids 106-116 phospholipase A2 group IB Homo sapiens 11-15 10961723-6 2000 These results indicate that the effect of phospholipase A2 on bile lithogenecity is modulated by the fatty acid species in bile phospholipids, and therefore, that the role of phospholipase A2 in cholesterol gallstone formation is dependent, in part, on biliary phospholipid species selection at the site of hepatic excretion. Fatty Acids 101-111 phospholipase A2 group IB Homo sapiens 42-58 11028854-1 2000 Various cell stimuli act through activation of phospholipase A2, which hydrolyses fatty acids from membrane phospholipids, resulting in the formation of fatty acids and lysophospholipids. Fatty Acids 82-93 phospholipase A2 group IB Homo sapiens 47-63 11028854-1 2000 Various cell stimuli act through activation of phospholipase A2, which hydrolyses fatty acids from membrane phospholipids, resulting in the formation of fatty acids and lysophospholipids. Fatty Acids 153-164 phospholipase A2 group IB Homo sapiens 47-63 10491743-2 1999 Long-chain fatty acid metabolic products produced by phospholipase A2 activation accumulate during ischemia as a result of the inhibition of fatty acid beta-oxidation on the mitochondria and peroxisomes. Fatty Acids 11-21 phospholipase A2 group IB Homo sapiens 53-69 10692455-6 2000 Moreover, treatment of dimers with PL-A2 increased the free level of this fatty acid specific to PG compared with untreated dimers. Fatty Acids 74-84 phospholipase A2 group IB Homo sapiens 35-40 10555781-3 1999 To do this, it is necessary to determine a "dilution factor" lambda, which estimates the contribution to the brain precursor acyl-CoA pool of fatty acids released from phospholipids through the action of PLA1 or PLA2. Fatty Acids 142-153 phospholipase A2 group IB Homo sapiens 212-216 10747887-0 2000 Distinct roles of two intracellular phospholipase A2s in fatty acid release in the cell death pathway. Fatty Acids 57-67 phospholipase A2 group IB Homo sapiens 36-52 10888232-5 2000 Since phosphatidylcholine is metabolized mainly by the action of phospholipase A2, with the release of arachidonic acid and other fatty acids, the effect of phosphocholine on arachidonic acid release in endothelial cells was also examined. Fatty Acids 130-141 phospholipase A2 group IB Homo sapiens 65-81 10555781-6 1999 For example, a reduced brain turnover of arachidonate by chronic lithium, demonstrated in rats by the fatty acid method, suggests that this agent, which is used to treat bipolar disorder, has for its target an arachidonate-specific PLA2. Fatty Acids 102-112 phospholipase A2 group IB Homo sapiens 232-236 10555781-7 1999 In another context, when combined with in vivo imaging by quantitative autoradiography in rodents or positron emission tomography in macaques or humans, the fatty acid method can localize and quantify normal and modified PLA2-mediated signal transduction in brain. Fatty Acids 157-167 phospholipase A2 group IB Homo sapiens 221-225 10591080-1 1999 Phospholipase A2 (PLA2) enzymes cleave esterified fatty acids from membrane glycerophospholipids. Fatty Acids 39-61 phospholipase A2 group IB Homo sapiens 0-16 10591080-1 1999 Phospholipase A2 (PLA2) enzymes cleave esterified fatty acids from membrane glycerophospholipids. Fatty Acids 39-61 phospholipase A2 group IB Homo sapiens 18-22 10323780-3 1999 Recently, secretory phospholipase A2 (PLA2), an enzyme capable of hydrolyzing LDL PC into fatty acid and lysoPC molecules, has been found in atherosclerotic arteries. Fatty Acids 90-100 phospholipase A2 group IB Homo sapiens 38-42 10391868-3 1999 To elucidate the biochemical mechanism, we have examined PMN phospholipase A2 (PLA2) activity and its relationship to cellular and circulating fatty acids in pregnant women (30 to 34 weeks) and nonpregnant controls. Fatty Acids 143-154 phospholipase A2 group IB Homo sapiens 79-83 10323780-3 1999 Recently, secretory phospholipase A2 (PLA2), an enzyme capable of hydrolyzing LDL PC into fatty acid and lysoPC molecules, has been found in atherosclerotic arteries. Fatty Acids 90-100 phospholipase A2 group IB Homo sapiens 20-36 10192509-9 1999 LPC, oxLDL and CL thus display a common antigenic site, which could be formed by removal of a fatty acid at the sn-2 position, possibly due to the activity to phospholipase A2 and/or oxidation. Fatty Acids 94-104 phospholipase A2 group IB Homo sapiens 159-175 10749996-5 1999 The products of PLA(2) catabolism are a fatty acid (often arachidonic acid) and a lysophospholipid. Fatty Acids 40-50 phospholipase A2 group IB Homo sapiens 16-22 9792902-5 1998 Phospholipase A2 action serves to release fatty acids and to generate lysophospholipids that, either directly or serving as substrates for the generation of other metabolites, have and essential role in the final stages of membrane fusion. Fatty Acids 42-53 phospholipase A2 group IB Homo sapiens 0-16