PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35075215-1 2022 BACKGROUND: The antiprostate cancer effects of dietary omega-3 fatty acids (FAs) were previously found to be dependent on host G-protein coupled receptor 120 (GPR120). Fatty Acids 76-79 free fatty acid receptor 4 Mus musculus 127-157 34444876-10 2021 This is the first evaluation of the anti-inflammatory activity of selective FFAR agonists, showing that pharmacological intervention targeting FFAR4, which is a sensor of medium and long chain fatty acids, attenuates intestinal inflammation. Fatty Acids 193-204 free fatty acid receptor 4 Mus musculus 143-148 35516426-9 2022 Furthermore, the colonic expression of the free fatty acid receptors 4 (Ffar4) gene was significantly upregulated after Rb1 treatment, in response to a notable increase of LCFA in feces. Fatty Acids 48-58 free fatty acid receptor 4 Mus musculus 72-77 35075215-1 2022 BACKGROUND: The antiprostate cancer effects of dietary omega-3 fatty acids (FAs) were previously found to be dependent on host G-protein coupled receptor 120 (GPR120). Fatty Acids 76-79 free fatty acid receptor 4 Mus musculus 159-165 35189618-0 2022 Docosahexaenoic Acid Attenuates the Progression of Nonalcoholic Steatohepatitis by Suppressing the Adipocyte Inflammation via the G Protein-Coupled Receptor 120/Free Fatty Acid Receptor 4 Pathway. Fatty Acids 166-176 free fatty acid receptor 4 Mus musculus 130-160 31361546-7 2019 Deficiency in GPR120 did not modify brown adipocyte morphology or the anatomical architecture of BAT, as assessed by electron microscopy, but instead impaired the expression of UCP1 and the fatty acid oxidation capacity of neonatal BAT. Fatty Acids 190-200 free fatty acid receptor 4 Mus musculus 14-20 33752243-0 2022 Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload. Fatty Acids 50-61 free fatty acid receptor 4 Mus musculus 0-26 33752243-1 2022 AIMS: Free fatty acid receptor 4 (Ffar4) is a G-protein coupled receptor for endogenous medium/long-chain fatty acids that attenuates metabolic disease and inflammation. Fatty Acids 106-117 free fatty acid receptor 4 Mus musculus 6-32 33752243-1 2022 AIMS: Free fatty acid receptor 4 (Ffar4) is a G-protein coupled receptor for endogenous medium/long-chain fatty acids that attenuates metabolic disease and inflammation. Fatty Acids 106-117 free fatty acid receptor 4 Mus musculus 34-39 33752243-11 2022 CONCLUSIONS: Our data indicate that Ffar4 in cardiac myocytes responds to endogenous fatty acids, reducing oxidative injury, and protecting the heart from pathologic stress, with significant translational implications for targeting Ffar4 in cardiovascular disease. Fatty Acids 85-96 free fatty acid receptor 4 Mus musculus 36-41 33752243-11 2022 CONCLUSIONS: Our data indicate that Ffar4 in cardiac myocytes responds to endogenous fatty acids, reducing oxidative injury, and protecting the heart from pathologic stress, with significant translational implications for targeting Ffar4 in cardiovascular disease. Fatty Acids 85-96 free fatty acid receptor 4 Mus musculus 232-237 32877513-1 2020 Free fatty acid receptor GPR120 expresses in pancreatic islets, but its specific cell distribution and function are not fully established yet. Fatty Acids 5-15 free fatty acid receptor 4 Mus musculus 25-31 32728158-4 2020 We report that PBI-4547 is a fatty acid mimetic, acting concomitantly as a GPR84 antagonist and GPR40/GPR120 agonist. Fatty Acids 29-39 free fatty acid receptor 4 Mus musculus 102-108 34043793-3 2021 Free fatty acid receptor 4 (FFAR4), also known as G protein-coupled receptor 120 (GPR120), is a long-chain fatty acid receptor highly expressed in adipocytes, endothelial cells, and macrophages. Fatty Acids 5-15 free fatty acid receptor 4 Mus musculus 28-33 34043793-3 2021 Free fatty acid receptor 4 (FFAR4), also known as G protein-coupled receptor 120 (GPR120), is a long-chain fatty acid receptor highly expressed in adipocytes, endothelial cells, and macrophages. Fatty Acids 5-15 free fatty acid receptor 4 Mus musculus 50-80 34043793-3 2021 Free fatty acid receptor 4 (FFAR4), also known as G protein-coupled receptor 120 (GPR120), is a long-chain fatty acid receptor highly expressed in adipocytes, endothelial cells, and macrophages. Fatty Acids 5-15 free fatty acid receptor 4 Mus musculus 82-88 33268480-7 2021 Leptin receptor and free fatty acid (FFA) receptor, GPR120, are upregulated only in macrophages derived from male mice when cultured in the presence of FFA to mimic hyperlipidemia of obesity. Fatty Acids 25-35 free fatty acid receptor 4 Mus musculus 52-58 31740001-1 2020 We examined whether the acetylenic fatty acids 6-octadecynoic acid (6-ODA) and 9-octadecynoic acid (9-ODA) perform as ligands for free fatty acid receptors of medium- and long-chain fatty acids FFAR1 and FFAR4, previously called GPR40 and GPR120, respectively. Fatty Acids 35-45 free fatty acid receptor 4 Mus musculus 204-209 31740001-1 2020 We examined whether the acetylenic fatty acids 6-octadecynoic acid (6-ODA) and 9-octadecynoic acid (9-ODA) perform as ligands for free fatty acid receptors of medium- and long-chain fatty acids FFAR1 and FFAR4, previously called GPR40 and GPR120, respectively. Fatty Acids 35-45 free fatty acid receptor 4 Mus musculus 239-245 30202902-1 2019 Background: GPR120, a G protein-coupled receptor for long-chain polyunsaturated fatty acids (FAs), mediates the anti-inflammatory effects of omega-3 (omega-3) FAs. Fatty Acids 93-96 free fatty acid receptor 4 Mus musculus 12-18 30375738-0 2019 Fatty acid taste quality information via GPR120 in the anterior tongue of mice. Fatty Acids 0-10 free fatty acid receptor 4 Mus musculus 41-47 30375738-9 2019 GPR120 plays roles in distinguishing fatty acid taste from other primary tastes and the detection of low linoleic acid concentrations. Fatty Acids 37-47 free fatty acid receptor 4 Mus musculus 0-6 31002464-0 2019 Free fatty acid receptors, G protein-coupled receptor 120 and G protein-coupled receptor 40, are essential for oil-induced gastric inhibitory polypeptide secretion. Fatty Acids 5-15 free fatty acid receptor 4 Mus musculus 27-57 31002464-3 2019 G protein-coupled receptor (GPR)120 and GPR40 are two major receptors for long chain fatty acids, and are expressed in enteroendocrine K cells. Fatty Acids 85-96 free fatty acid receptor 4 Mus musculus 28-35 30202902-1 2019 Background: GPR120, a G protein-coupled receptor for long-chain polyunsaturated fatty acids (FAs), mediates the anti-inflammatory effects of omega-3 (omega-3) FAs. Fatty Acids 159-162 free fatty acid receptor 4 Mus musculus 12-18 28847514-6 2017 Our results demonstrated that endogenous and exogenous n-3 PUFA enrichment ameliorates ethanol-stimulated adipose lipolysis by increasing PDE3B activity and reducing cAMP accumulation in adipocyte, which was associated with activation of GPR120 and regulation of Ca2+/CaMKKbeta/AMPK signaling, resultantly blocking fatty acid trafficking from adipose tissue to the liver, which contributing to ameliorating ethanol-induced adipose dysfunction and liver injury. Fatty Acids 315-325 free fatty acid receptor 4 Mus musculus 238-244 24997608-3 2014 We reported that Gpr120 is the functional receptor for these fatty acids and that omega-3-FAs produce robust anti-inflammatory, insulin-sensitizing effects, both in vivo and in vitro, in a Gpr120-dependent manner. Fatty Acids 61-72 free fatty acid receptor 4 Mus musculus 17-23 28183801-0 2017 Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance. Fatty Acids 0-10 free fatty acid receptor 4 Mus musculus 34-40 23831422-3 2013 GPR40 and GPR120, two fatty acid responsive G-protein-coupled receptors (GPCRs), are expressed in taste bud cells, and knockout mice lacking either of those receptors have blunted taste nerve responses to and reduced preference for fatty acids. Fatty Acids 22-32 free fatty acid receptor 4 Mus musculus 10-16 25743342-0 2014 Behavioral palatability of dietary fatty acids correlates with the intracellular calcium ion levels induced by the fatty acids in GPR120-expressing cells. Fatty Acids 35-46 free fatty acid receptor 4 Mus musculus 130-136 24154510-0 2013 GPR40 and GPR120 fatty acid sensors are critical for postoral but not oral mediation of fat preferences in the mouse. Fatty Acids 17-27 free fatty acid receptor 4 Mus musculus 10-16 23831422-3 2013 GPR40 and GPR120, two fatty acid responsive G-protein-coupled receptors (GPCRs), are expressed in taste bud cells, and knockout mice lacking either of those receptors have blunted taste nerve responses to and reduced preference for fatty acids. Fatty Acids 232-243 free fatty acid receptor 4 Mus musculus 10-16 23831422-5 2013 Five non-fatty acid agonists of GPR40 and two non-fatty acid agonists of GPR120 activated the glossopharyngeal nerve of wild-type mice but not of knockout mice lacking the cognate receptor. Fatty Acids 50-60 free fatty acid receptor 4 Mus musculus 73-79 20573884-0 2010 Taste preference for fatty acids is mediated by GPR40 and GPR120. Fatty Acids 21-32 free fatty acid receptor 4 Mus musculus 58-64 20573884-4 2010 Compared with wild-type mice, male and female GPR120 knock-out and GPR40 knock-out mice show a diminished preference for linoleic acid and oleic acid, and diminished taste nerve responses to several fatty acids. Fatty Acids 199-210 free fatty acid receptor 4 Mus musculus 46-52 20573884-5 2010 These results show that GPR40 and GPR120 mediate the taste of fatty acids. Fatty Acids 62-73 free fatty acid receptor 4 Mus musculus 34-40 18617622-10 2008 However, receptors known to bind fatty acids were found to be expressed in osteoblastic (GPR120) and osteoclastic (GPR40, 41, 43, 120) cells. Fatty Acids 33-44 free fatty acid receptor 4 Mus musculus 89-95