PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2472294-1 1989 The interaction of fatty acids with rat alpha-fetoprotein and albumin was measured using a partition equilibrium method. Fatty Acids 19-30 alpha-fetoprotein Rattus norvegicus 40-57 2472294-2 1989 alpha-Fetoprotein (AFP) displays one high-affinity binding site for fatty acids and albumin near two binding sites. Fatty Acids 68-79 alpha-fetoprotein Rattus norvegicus 0-17 2451542-0 1988 Fatty acids bound to alpha-fetoprotein and albumin during rat development. Fatty Acids 0-11 alpha-fetoprotein Rattus norvegicus 21-38 2472294-2 1989 alpha-Fetoprotein (AFP) displays one high-affinity binding site for fatty acids and albumin near two binding sites. Fatty Acids 68-79 alpha-fetoprotein Rattus norvegicus 19-22 2472294-3 1989 The AFP association constants for most fatty acids were similar to those of albumin (in the 10(7) M-1 range) whereas for docosahexaenoic acid it was 9.7 x 10(8) M-1, about 50-fold higher than that corresponding to albumin. Fatty Acids 39-50 alpha-fetoprotein Rattus norvegicus 4-7 2472294-4 1989 This difference justifies docosahexaenoic acid in fetal or neonatal serum being mainly bound to AFP and can indicate a highly specific role of AFP in the transport of this fatty acid. Fatty Acids 172-182 alpha-fetoprotein Rattus norvegicus 96-99 2472294-4 1989 This difference justifies docosahexaenoic acid in fetal or neonatal serum being mainly bound to AFP and can indicate a highly specific role of AFP in the transport of this fatty acid. Fatty Acids 172-182 alpha-fetoprotein Rattus norvegicus 143-146 2917144-7 1989 The reciprocally declining alpha-fetoprotein content of both tissues may partially account for the complementary fraction of the fatty acid-binding capacity. Fatty Acids 129-139 alpha-fetoprotein Rattus norvegicus 27-44 2451542-1 1988 The time-course levels and composition of the fatty acids bound to rat alpha-fetoprotein (AFP) and albumin from several sources, were determined throughout development, and related to the intake of lipids from milk and the compositional changes in brain and liver fatty acids. Fatty Acids 46-57 alpha-fetoprotein Rattus norvegicus 71-88 2451542-1 1988 The time-course levels and composition of the fatty acids bound to rat alpha-fetoprotein (AFP) and albumin from several sources, were determined throughout development, and related to the intake of lipids from milk and the compositional changes in brain and liver fatty acids. Fatty Acids 46-57 alpha-fetoprotein Rattus norvegicus 90-93 2451542-2 1988 The major fatty acids bound to AFP were acids bound to AFP were polyunsaturated and mainly docosahexaenoic acid (22:6(n-3], either from fetal serum (23.1%) or whole fetuses (21.6%), whereas palmitic (34.1%) and oleic (29.9%) acids were the main acids bound to albumin from the same sources. Fatty Acids 10-21 alpha-fetoprotein Rattus norvegicus 31-34 2451542-2 1988 The major fatty acids bound to AFP were acids bound to AFP were polyunsaturated and mainly docosahexaenoic acid (22:6(n-3], either from fetal serum (23.1%) or whole fetuses (21.6%), whereas palmitic (34.1%) and oleic (29.9%) acids were the main acids bound to albumin from the same sources. Fatty Acids 10-21 alpha-fetoprotein Rattus norvegicus 55-58 2451542-3 1988 Amniotic fluid AFP contained less fatty acids (0.8 mol/mol protein) than that of fetal serum (1.4 mol/mol protein), and especially noticeable was a reduced amount of 22:6 (9.6%). Fatty Acids 34-45 alpha-fetoprotein Rattus norvegicus 15-18 2451542-4 1988 Both AFP-concanavalin A microforms showed identical fatty acid composition. Fatty Acids 52-62 alpha-fetoprotein Rattus norvegicus 5-8 2412659-5 1985 This finding supports the hypothesis that AFP may serve as a carrier protein to deliver bound molecules, such as non-esterified fatty acids, to brain cells at a specific time during development. Fatty Acids 128-139 alpha-fetoprotein Rattus norvegicus 42-45 2434503-5 1987 On the contrary, saturable binding and uptake of fatty acid and protein were evidenced when the molar ratio of arachidonic to AFP was fixed at 0.5, and the concentration of both increased simultaneously. Fatty Acids 49-59 alpha-fetoprotein Rattus norvegicus 126-129 2434503-7 1987 Fatty acid distribution in cell lipids after 2 and 24 h of culture at 37 degrees C, in the presence of arachidonic acid bound to AFP, revealed that this fatty acid was mainly incorporated in cell phospholipids. Fatty Acids 0-10 alpha-fetoprotein Rattus norvegicus 129-132 2434503-7 1987 Fatty acid distribution in cell lipids after 2 and 24 h of culture at 37 degrees C, in the presence of arachidonic acid bound to AFP, revealed that this fatty acid was mainly incorporated in cell phospholipids. Fatty Acids 153-163 alpha-fetoprotein Rattus norvegicus 129-132 2434503-12 1987 The AFP binds to an AFP receptor and the fatty acid is then removed and transported inside the cell by a specific fatty acid-binding protein. Fatty Acids 41-51 alpha-fetoprotein Rattus norvegicus 4-7 2434503-12 1987 The AFP binds to an AFP receptor and the fatty acid is then removed and transported inside the cell by a specific fatty acid-binding protein. Fatty Acids 41-51 alpha-fetoprotein Rattus norvegicus 20-23 2434503-12 1987 The AFP binds to an AFP receptor and the fatty acid is then removed and transported inside the cell by a specific fatty acid-binding protein. Fatty Acids 114-124 alpha-fetoprotein Rattus norvegicus 4-7 2434503-12 1987 The AFP binds to an AFP receptor and the fatty acid is then removed and transported inside the cell by a specific fatty acid-binding protein. Fatty Acids 114-124 alpha-fetoprotein Rattus norvegicus 20-23 2434503-2 1987 The purpose of the present work was to study the mechanism by which fatty acids bound to AFP are transferred to living cells. Fatty Acids 68-79 alpha-fetoprotein Rattus norvegicus 89-92 6183647-0 1982 The fatty acid levels of rat alpha-fetoprotein derived from fetuses, pregnancy and hepatoma sera. Fatty Acids 4-14 alpha-fetoprotein Rattus norvegicus 29-46 2578598-2 1985 This study shows that the developing brain accumulates the estrogen but not the fatty acid, suggesting that the uptake of AFP by the developing brain is a mechanism for transporting estrogens, but not fatty acids. Fatty Acids 201-212 alpha-fetoprotein Rattus norvegicus 122-125 6197732-4 1983 Estrogenic hormones compete with fatty acids bound to the high affinity binding site of rat AFP but remained unable to displace arachidonic acid bound to the human one. Fatty Acids 33-44 alpha-fetoprotein Rattus norvegicus 92-95 6190512-0 1983 On rat alpha-fetoprotein as a fatty acid carrier. Fatty Acids 30-40 alpha-fetoprotein Rattus norvegicus 7-24 6190512-2 1983 Fatty acids interfere with rat alpha-fetoprotein-estrogen interaction. Fatty Acids 0-11 alpha-fetoprotein Rattus norvegicus 31-48 6190512-3 1983 We present here a quantitative study of the association constants for the binding to alpha-fetoprotein of different fatty acids. Fatty Acids 116-127 alpha-fetoprotein Rattus norvegicus 85-102 6183647-1 1982 The fatty acid levels of alpha-fetoprotein (AFP) isolated from term rat fetuses is about half that of similar human preparations. Fatty Acids 4-14 alpha-fetoprotein Rattus norvegicus 25-42 6183647-1 1982 The fatty acid levels of alpha-fetoprotein (AFP) isolated from term rat fetuses is about half that of similar human preparations. Fatty Acids 4-14 alpha-fetoprotein Rattus norvegicus 44-47 6183647-2 1982 Arachidonic and docosahexaenoic acids constitute about 33% of the total fatty acids in the rat AFP isolates. Fatty Acids 72-83 alpha-fetoprotein Rattus norvegicus 95-98 6183647-3 1982 The AFP isolated from rat maternal and hepatoma sera have relatively low levels of these fatty acids. Fatty Acids 89-100 alpha-fetoprotein Rattus norvegicus 4-7 94192-0 1979 Ligand properties of diethylstilbestrol: studies with purified native and fatty acid-free rat alpha 1-fetoprotein and albumin. Fatty Acids 74-84 alpha-fetoprotein Rattus norvegicus 94-113 6169054-2 1980 We present here a quantitative study of the association constants for the binding to AFP of these different fatty acids. Fatty Acids 108-119 alpha-fetoprotein Rattus norvegicus 85-88 6169054-4 1980 Moreover, though all the fatty acids identified in rat serum or rat AFP extract are more or less tightly bound by rodent AFP, only some of them can compete for exogeneous estrogens complexed to this highly estrophilic macromolecule. Fatty Acids 25-36 alpha-fetoprotein Rattus norvegicus 68-71 6169054-4 1980 Moreover, though all the fatty acids identified in rat serum or rat AFP extract are more or less tightly bound by rodent AFP, only some of them can compete for exogeneous estrogens complexed to this highly estrophilic macromolecule. Fatty Acids 25-36 alpha-fetoprotein Rattus norvegicus 121-124 94192-3 1979 The removal of fatty acids from pure AFP causes a reversible 3 fold increase of the number of DES binding sites; the same delipidation procedure applied to albumin slightly diminishes its DES binding parameters. Fatty Acids 15-26 alpha-fetoprotein Rattus norvegicus 37-40 10471121-0 1999 Regulation of alpha-foetoprotein gene expression by fatty acids and fibrates. Fatty Acids 52-63 alpha-fetoprotein Rattus norvegicus 14-32 10471121-3 1999 We investigated the effects of fatty acids and fibrates on expression of the AFP gene using two complementary approaches. Fatty Acids 31-42 alpha-fetoprotein Rattus norvegicus 77-80 1373954-0 1992 In vivo transient rise in plasma free fatty acids alters the functional properties of alpha-fetoprotein. Fatty Acids 38-49 alpha-fetoprotein Rattus norvegicus 86-103 95001-2 1979 Quantitative data are presented on the fatty acid composition of rat alpha-fetoprotein (AFP) and serum albumin, (SA), and of brain extracts of suckling rats. Fatty Acids 39-49 alpha-fetoprotein Rattus norvegicus 69-86 95001-2 1979 Quantitative data are presented on the fatty acid composition of rat alpha-fetoprotein (AFP) and serum albumin, (SA), and of brain extracts of suckling rats. Fatty Acids 39-49 alpha-fetoprotein Rattus norvegicus 88-91 95001-3 1979 In AFP and SA preparations, 40% and 13%, respectively, of total fatty acids present are polyenoic acids. Fatty Acids 64-75 alpha-fetoprotein Rattus norvegicus 3-6