PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33513366-6 2021 We validated our findings by directly manipulating the regulator SREBP1, the target gene ADCY5, and the variant rs56371916, which together imply a novel link between fatty acid oxidation and osteoblast differentiation. Fatty Acids 166-176 sterol regulatory element binding transcription factor 1 Homo sapiens 65-71 34019961-0 2021 E2F1 promotes proliferation and metastasis of clear cell renal cell carcinoma via activation of SREBP1-dependent fatty acid biosynthesis. Fatty Acids 113-123 sterol regulatory element binding transcription factor 1 Homo sapiens 96-102 34019961-6 2021 E2F1 knockdown or SREBP1 suppression attenuated fatty acid (FA) de novo synthesis, cell proliferation and epithelial-mesenchymal transition (EMT) in ccRCC cells. Fatty Acids 48-58 sterol regulatory element binding transcription factor 1 Homo sapiens 18-24 33742461-4 2021 Recently, variants in SREBF1, a gene coding for a transcription factor related to cholesterol and fatty acid synthesis, have been associated with the disease. Fatty Acids 98-108 sterol regulatory element binding transcription factor 1 Homo sapiens 22-28 33975883-0 2021 Suppression of ACADM-mediated fatty acid oxidation promotes hepatocellular carcinoma via aberrant Cav1/SREBP-1 signaling. Fatty Acids 30-40 sterol regulatory element binding transcription factor 1 Homo sapiens 103-110 33975883-10 2021 These findings indicate that deregulation of fatty acid oxidation mediated by the Cav1/SREBP-1/ACADM axis results in HCC progression, which implicates targeting fatty acid metabolism to improve HCC treatment. Fatty Acids 45-55 sterol regulatory element binding transcription factor 1 Homo sapiens 87-94 33975883-10 2021 These findings indicate that deregulation of fatty acid oxidation mediated by the Cav1/SREBP-1/ACADM axis results in HCC progression, which implicates targeting fatty acid metabolism to improve HCC treatment. Fatty Acids 161-171 sterol regulatory element binding transcription factor 1 Homo sapiens 87-94 33414447-5 2021 MIEF2 enhanced de novo fatty acid synthesis through up-regulating the expression of sterol regulatory element binding protein 1 (SREBP1) and its transcriptional target lipogenic genes ACC1, FASN and SCD1. Fatty Acids 23-33 sterol regulatory element binding transcription factor 1 Homo sapiens 84-127 33414447-5 2021 MIEF2 enhanced de novo fatty acid synthesis through up-regulating the expression of sterol regulatory element binding protein 1 (SREBP1) and its transcriptional target lipogenic genes ACC1, FASN and SCD1. Fatty Acids 23-33 sterol regulatory element binding transcription factor 1 Homo sapiens 129-135 33209199-6 2020 AA inhibited the expression of SREBP-1 and its target genes that encode enzymes involved in fatty acid synthesis. Fatty Acids 92-102 sterol regulatory element binding transcription factor 1 Homo sapiens 31-38 31932581-5 2020 On the one hand, SIK2 enhanced fatty acid synthesis through upregulating the expression of sterol regulatory element binding protein 1c (SREBP1c) and thus the transcription of major lipogenic enzyme FASN. Fatty Acids 31-41 sterol regulatory element binding transcription factor 1 Homo sapiens 91-135 32497488-4 2020 SREBF1 encodes sterol regulatory element-binding protein 1 (SREBP1), which promotes the transcription of lipogenes involved in the biosynthesis of fatty acids and cholesterols. Fatty Acids 147-158 sterol regulatory element binding transcription factor 1 Homo sapiens 0-6 32497488-4 2020 SREBF1 encodes sterol regulatory element-binding protein 1 (SREBP1), which promotes the transcription of lipogenes involved in the biosynthesis of fatty acids and cholesterols. Fatty Acids 147-158 sterol regulatory element binding transcription factor 1 Homo sapiens 15-58 32497488-4 2020 SREBF1 encodes sterol regulatory element-binding protein 1 (SREBP1), which promotes the transcription of lipogenes involved in the biosynthesis of fatty acids and cholesterols. Fatty Acids 147-158 sterol regulatory element binding transcription factor 1 Homo sapiens 60-66 32218693-10 2020 The expression level of fatty acid oxidation pathway PPARgamma was significantly down-regulated compared with the control group, as were genes associated with fatty acid synthesis pathways: SREBP1, ACC, FAS, and SCD1. Fatty Acids 24-34 sterol regulatory element binding transcription factor 1 Homo sapiens 190-196 32218693-10 2020 The expression level of fatty acid oxidation pathway PPARgamma was significantly down-regulated compared with the control group, as were genes associated with fatty acid synthesis pathways: SREBP1, ACC, FAS, and SCD1. Fatty Acids 159-169 sterol regulatory element binding transcription factor 1 Homo sapiens 190-196 32464305-5 2020 Moreover, sterol regulatory element-binding protein 1 (SREBP-1c) was activated in human gastric cancer tissues, and it promoted the expression of a series of genes associated with the synthesis of fatty acids, such as SCD1 and FASN. Fatty Acids 197-208 sterol regulatory element binding transcription factor 1 Homo sapiens 10-53 32464305-5 2020 Moreover, sterol regulatory element-binding protein 1 (SREBP-1c) was activated in human gastric cancer tissues, and it promoted the expression of a series of genes associated with the synthesis of fatty acids, such as SCD1 and FASN. Fatty Acids 197-208 sterol regulatory element binding transcription factor 1 Homo sapiens 55-63 32160325-15 2020 Inductions of CYPs with suppression of SREBP-1a and SREBP-1c might contribute to an increased risk of fatty acid accumulation. Fatty Acids 102-112 sterol regulatory element binding transcription factor 1 Homo sapiens 39-47 32160325-15 2020 Inductions of CYPs with suppression of SREBP-1a and SREBP-1c might contribute to an increased risk of fatty acid accumulation. Fatty Acids 102-112 sterol regulatory element binding transcription factor 1 Homo sapiens 52-60 31932581-5 2020 On the one hand, SIK2 enhanced fatty acid synthesis through upregulating the expression of sterol regulatory element binding protein 1c (SREBP1c) and thus the transcription of major lipogenic enzyme FASN. Fatty Acids 31-41 sterol regulatory element binding transcription factor 1 Homo sapiens 137-144 31542428-10 2019 Deepening the molecular mechanism, we found that Que decreased the expression of SREBP-1 and SREBP-2, transcriptional factors representing the main regulators of de novo fatty acid and cholesterol synthesis, respectively. Fatty Acids 170-180 sterol regulatory element binding transcription factor 1 Homo sapiens 81-88 30985894-4 2019 Further study in porcine mammary epithelial cells (PMECs) confirmed that valine upregulated the phosphorylation levels of AKT-activated MTOR and subsequently induced the nuclear accumulation of sterol regulatory element binding protein 1 (SREBP1), thus increasing the expression of proteins related to fatty acids synthesis and intracellular triacylglycerol content. Fatty Acids 302-313 sterol regulatory element binding transcription factor 1 Homo sapiens 194-237 31379107-0 2019 Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1. Fatty Acids 23-33 sterol regulatory element binding transcription factor 1 Homo sapiens 78-85 31379107-2 2019 Here, we show that both human homologs of Lin28 accelerate de novo fatty acid synthesis and promote the conversion from saturated to unsaturated fatty acids via the regulation of SREBP-1. Fatty Acids 67-77 sterol regulatory element binding transcription factor 1 Homo sapiens 179-186 31379107-5 2019 Collectively, our findings uncover that post-transcriptional regulation by Lin28A/B enhances de novo fatty acid synthesis and metabolic conversion of saturated and unsaturated fatty acids via SREBP-1, which is critical for cancer progression. Fatty Acids 101-111 sterol regulatory element binding transcription factor 1 Homo sapiens 192-199 31395683-9 2019 In conclusion, these results indicate that LLM is a novel inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Fatty Acids 88-98 sterol regulatory element binding transcription factor 1 Homo sapiens 71-77 31316083-0 2019 SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait. Fatty Acids 25-35 sterol regulatory element binding transcription factor 1 Homo sapiens 0-6 31511501-2 2019 The transcription factor Sterol Regulatory Element Binding Protein 1 (SREBP-1), a regulator of fatty acid synthesis, has been shown to pivotally regulate the proliferation and metastasis of HCC cells. Fatty Acids 95-105 sterol regulatory element binding transcription factor 1 Homo sapiens 25-68 31511501-2 2019 The transcription factor Sterol Regulatory Element Binding Protein 1 (SREBP-1), a regulator of fatty acid synthesis, has been shown to pivotally regulate the proliferation and metastasis of HCC cells. Fatty Acids 95-105 sterol regulatory element binding transcription factor 1 Homo sapiens 70-77 30985894-5 2019 Inhibition of AKT/MTOR signaling or silencing of SREBP1 in PMECs downregulates the expression of proteins related to fatty acids synthesis and intracellular triacylglycerol content. Fatty Acids 117-128 sterol regulatory element binding transcription factor 1 Homo sapiens 49-55 31223033-7 2019 SREBP1c activates genes involved in fatty acid and triglyceride synthesis while PPARalpha activates CPT1, a rate limiting enzyme for controlling entry and oxidation of fatty acids into mitochondria. Fatty Acids 36-46 sterol regulatory element binding transcription factor 1 Homo sapiens 0-7 31223033-7 2019 SREBP1c activates genes involved in fatty acid and triglyceride synthesis while PPARalpha activates CPT1, a rate limiting enzyme for controlling entry and oxidation of fatty acids into mitochondria. Fatty Acids 168-179 sterol regulatory element binding transcription factor 1 Homo sapiens 0-7 31297058-11 2019 Furthermore, the expression level of messenger RNA (mRNA) and protein of sterol regulatory element binding protein 1 (SREBP1) as well as its downstream signaling pathway and the synthesis and the desaturation of fatty acid metabolism-associated proteins (adenosine triphosphate citrate lyase, acetyl-CoA carboxylase alpha, fatty acid synthase (FASN), and stearoyl-CoA desaturase D) were also decreased. Fatty Acids 212-222 sterol regulatory element binding transcription factor 1 Homo sapiens 73-116 31297058-11 2019 Furthermore, the expression level of messenger RNA (mRNA) and protein of sterol regulatory element binding protein 1 (SREBP1) as well as its downstream signaling pathway and the synthesis and the desaturation of fatty acid metabolism-associated proteins (adenosine triphosphate citrate lyase, acetyl-CoA carboxylase alpha, fatty acid synthase (FASN), and stearoyl-CoA desaturase D) were also decreased. Fatty Acids 212-222 sterol regulatory element binding transcription factor 1 Homo sapiens 118-124 30545108-4 2018 Further study of the hypolipidemic mechanism showed that oleiferasaponin A2 inhibited fatty acid synthesis by significantly down-regulating the expression of SREBP-1c, FAS and FAS protein, while dramatically promoting fatty acid beta-oxidation by up-regulating the expression of ACOX-1, CPT-1 and ACOX-1 protein. Fatty Acids 86-96 sterol regulatory element binding transcription factor 1 Homo sapiens 158-166 30928092-5 2019 Then RA-XII effectively reduced fatty acids levels by decreasing the expression of SREBP-1 and inhibiting the expressions of de novo fatty acid synthesis proteins FASN and SCD. Fatty Acids 32-43 sterol regulatory element binding transcription factor 1 Homo sapiens 83-90 30928092-5 2019 Then RA-XII effectively reduced fatty acids levels by decreasing the expression of SREBP-1 and inhibiting the expressions of de novo fatty acid synthesis proteins FASN and SCD. Fatty Acids 32-42 sterol regulatory element binding transcription factor 1 Homo sapiens 83-90 30954075-6 2019 CONCLUSIONS: SREBP-1c silencing further augmented glucose production of HepG2 cells treated by FFA significantly, genes responsible for fatty acid synthesis and gluconeogenesis played an important role in this process. Fatty Acids 136-146 sterol regulatory element binding transcription factor 1 Homo sapiens 13-21 28827664-7 2017 This could be explained by the decreased and mis-localized expression of the transcription factor SREBP1 and the down-regulation of enzymes involved in the beta-oxidation and degradation of fatty acids. Fatty Acids 190-201 sterol regulatory element binding transcription factor 1 Homo sapiens 98-104 30180878-9 2018 In contrast, MM134 LTED cells displayed a high expression of the sterol regulatory element-binding protein 1 (SREBP1), a regulator of fatty acid and cholesterol synthesis, and were hypersensitive to genetic or pharmacological inhibition of SREBPs. Fatty Acids 134-144 sterol regulatory element binding transcription factor 1 Homo sapiens 65-108 30180878-9 2018 In contrast, MM134 LTED cells displayed a high expression of the sterol regulatory element-binding protein 1 (SREBP1), a regulator of fatty acid and cholesterol synthesis, and were hypersensitive to genetic or pharmacological inhibition of SREBPs. Fatty Acids 134-144 sterol regulatory element binding transcription factor 1 Homo sapiens 110-116 30180878-10 2018 Several SREBP1 downstream targets involved in fatty acid synthesis, including FASN, were induced, and MM134 LTED cells were more sensitive to etomoxir, an inhibitor of the rate-limiting enzyme in beta-oxidation, than their respective parental control cells. Fatty Acids 46-56 sterol regulatory element binding transcription factor 1 Homo sapiens 8-14 30015961-2 2018 SREBP-1c activates the transcription of multiple genes encoding for enzymes involved in the synthesis of triglycerides (TG) and fatty acids (FA) and accelerates lipid synthesis. Fatty Acids 128-139 sterol regulatory element binding transcription factor 1 Homo sapiens 0-8 29323924-0 2018 Akt Serine/Threonine Kinase 1 Regulates de Novo Fatty Acid Synthesis through the Mammalian Target of Rapamycin/Sterol Regulatory Element Binding Protein 1 Axis in Dairy Goat Mammary Epithelial Cells. Fatty Acids 48-58 sterol regulatory element binding transcription factor 1 Homo sapiens 111-154 29449559-5 2018 Knockdown of either SREBP1 or SREBP2 decreased levels of fatty acids as a result of decreased expression of SREBP target genes required for lipid biosynthesis in colon cancer cells. Fatty Acids 57-68 sterol regulatory element binding transcription factor 1 Homo sapiens 20-26 29449559-6 2018 Bioenergetic analysis revealed that silencing SREBP1 or SREBP2 expression reduced the mitochondrial respiration, glycolysis, as well as fatty acid oxidation indicating an alteration in cellular metabolism. Fatty Acids 136-146 sterol regulatory element binding transcription factor 1 Homo sapiens 46-52 29174379-4 2018 published in Cell Metabolism (2016;24(6):863-874) addresses this issue and reveals that rescuing de novo fatty acid synthesis (lipogenesis) through the activation of the transcription factor SREBP-1c can prevent lethality as well as severe lipotoxicity caused by a combined deficiency in lipogenesis and beta-oxidation. Fatty Acids 105-115 sterol regulatory element binding transcription factor 1 Homo sapiens 191-199 29174379-5 2018 Altogether, this study reveals that optimizing lipid signals generated by lipogenesis through SREBP-1c can help redirect fatty acids toward beneficial actions, by buffering lipotoxic lipid intermediates even in the setting of lipid overload. Fatty Acids 121-132 sterol regulatory element binding transcription factor 1 Homo sapiens 94-102 28604762-6 2017 Small interfering RNAs targeting SREBP1 could reverse fatty acid synthesis induced by TIP30 deficiency. Fatty Acids 54-64 sterol regulatory element binding transcription factor 1 Homo sapiens 33-39 28587208-0 2017 Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models. Fatty Acids 23-33 sterol regulatory element binding transcription factor 1 Homo sapiens 69-77 28594405-6 2017 We found that HIF1alpha upregulated adipophilin, fatty acid synthase and sterol regulatory element-binding protein 1, and downregulated carnitine palmitoyltransferase 1 (CPT1), resulting in the promoted lipid uptake and transport, increased de novo fatty acid synthesis and suppressed fatty acid oxidation. Fatty Acids 249-259 sterol regulatory element binding transcription factor 1 Homo sapiens 73-116 28256090-5 2017 Sterol regulatory element-binding protein-1c (Srebp-1c), a master transcription factor of fatty acid (FA) biosynthesis, is responsible for the pathogenesis of fatty liver (steatosis). Fatty Acids 90-100 sterol regulatory element binding transcription factor 1 Homo sapiens 0-44 28256090-5 2017 Sterol regulatory element-binding protein-1c (Srebp-1c), a master transcription factor of fatty acid (FA) biosynthesis, is responsible for the pathogenesis of fatty liver (steatosis). Fatty Acids 90-100 sterol regulatory element binding transcription factor 1 Homo sapiens 46-54 28062356-8 2017 These changes were associated with a lowered expression of the fatty acid biosynthesis regulators PPAR-gamma and SREBP-1c, and with an increased enzymatic catabolism of vitamin E. Fatty Acids 63-73 sterol regulatory element binding transcription factor 1 Homo sapiens 113-121 28443075-9 2017 GRIM-19 overexpression abrogated fatty acid-induced upregulation of sterol regulatory element-binding transcription factor-1 (SREBP-1c), resulting in attenuated expression of its target genes such as fatty acid synthase (FAS) and acetyl CoA carboxylase (ACC). Fatty Acids 33-43 sterol regulatory element binding transcription factor 1 Homo sapiens 68-124 28443075-9 2017 GRIM-19 overexpression abrogated fatty acid-induced upregulation of sterol regulatory element-binding transcription factor-1 (SREBP-1c), resulting in attenuated expression of its target genes such as fatty acid synthase (FAS) and acetyl CoA carboxylase (ACC). Fatty Acids 33-43 sterol regulatory element binding transcription factor 1 Homo sapiens 126-134 27492885-5 2017 The biosynthesis of fatty acids and cholesterol is regulated by the sterol regulatory element binding protein (SREBP) transcription factors SREBP1 and SREBP2, which are encoded by the SREBF1 and SREBF2 genes on chromosome 17p11.2 and 22q13.2, respectively. Fatty Acids 20-31 sterol regulatory element binding transcription factor 1 Homo sapiens 140-146 27492885-5 2017 The biosynthesis of fatty acids and cholesterol is regulated by the sterol regulatory element binding protein (SREBP) transcription factors SREBP1 and SREBP2, which are encoded by the SREBF1 and SREBF2 genes on chromosome 17p11.2 and 22q13.2, respectively. Fatty Acids 20-31 sterol regulatory element binding transcription factor 1 Homo sapiens 184-190 28027934-3 2017 Sterol regulatory element-binding transcription factor 1c (SREBP-1c) and carbohydrate responsive-element binding protein (ChREBP) are the major regulators of fatty acid synthase (FASN), a key enzyme of de novo fatty acid synthesis. Fatty Acids 158-168 sterol regulatory element binding transcription factor 1 Homo sapiens 0-57 28041958-0 2017 SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Fatty Acids 85-95 sterol regulatory element binding transcription factor 1 Homo sapiens 0-6 28041958-4 2017 Unexpectedly, rather than requiring LXRs, this late program of anti-inflammatory fatty acid biosynthesis is dependent on SREBP1 and results in the uncoupling of NFkappaB binding from gene activation. Fatty Acids 81-91 sterol regulatory element binding transcription factor 1 Homo sapiens 121-127 28027934-3 2017 Sterol regulatory element-binding transcription factor 1c (SREBP-1c) and carbohydrate responsive-element binding protein (ChREBP) are the major regulators of fatty acid synthase (FASN), a key enzyme of de novo fatty acid synthesis. Fatty Acids 158-168 sterol regulatory element binding transcription factor 1 Homo sapiens 59-67 27076879-2 2016 Sterol regulatory element-binding transcription factor 1 (SREBF-1) induces the expression of a family of genes involved in fatty acid synthesis. Fatty Acids 123-133 sterol regulatory element binding transcription factor 1 Homo sapiens 58-65 27452504-8 2016 Thus, our data indicate that ATF4 regulates SREBP1c expression to control fatty acids synthesis. Fatty Acids 74-85 sterol regulatory element binding transcription factor 1 Homo sapiens 44-51 26776965-10 2016 Taken together, betulin alleviates alcoholic liver injury possibly through blocking the regulation of SREBP-1 on fatty acid synthesis and activating SIRT1-LKB1-AMPK signaling pathway. Fatty Acids 113-123 sterol regulatory element binding transcription factor 1 Homo sapiens 102-109 27452504-0 2016 ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation. Fatty Acids 45-56 sterol regulatory element binding transcription factor 1 Homo sapiens 15-22 27076879-2 2016 Sterol regulatory element-binding transcription factor 1 (SREBF-1) induces the expression of a family of genes involved in fatty acid synthesis. Fatty Acids 123-133 sterol regulatory element binding transcription factor 1 Homo sapiens 0-56 27076879-3 2016 Moreover, dysregulation of miR-33b, which is located within the intron 17 of the SREBF-1 gene, disrupts fatty acid oxidation and insulin signaling, thus leading to MetS. Fatty Acids 104-114 sterol regulatory element binding transcription factor 1 Homo sapiens 81-88 26830228-2 2016 The intronic microRNAs miR-33a and miR-33b, located within the genes encoding sterol regulatory element-binding protein 2 (SREBP-2) and SREBP-1, respectively, are transcribed in concert with their host genes and function alongside them to regulate cholesterol, fatty acid, and glucose metabolism. Fatty Acids 261-271 sterol regulatory element binding transcription factor 1 Homo sapiens 136-143 24493696-2 2014 Sterol regulatory element-binding proteins (SREBP; SREBP-1 and SREBP-2) are key transcription factors controlling lipogenesis and cholesterogenesis via the regulation of genes related to fatty acid and cholesterol biosynthesis. Fatty Acids 187-197 sterol regulatory element binding transcription factor 1 Homo sapiens 51-58 26399511-6 2015 These fatty acids also downregulated the mRNA expression of lipogenic genes by suppressing LXRalpha activity and inhibiting SREBP-1 maturation. Fatty Acids 6-17 sterol regulatory element binding transcription factor 1 Homo sapiens 124-131 25270091-3 2014 Increased lipogenesis has been found in cancer cells, sterol regulatory element binding protein 1 (SREBP1) are nuclear lipogenic transcription factors, which mainly regulate lipogenic processes by activating genes involved in fatty acid and triglyceride biosynthesis. Fatty Acids 226-236 sterol regulatory element binding transcription factor 1 Homo sapiens 54-97 25270091-3 2014 Increased lipogenesis has been found in cancer cells, sterol regulatory element binding protein 1 (SREBP1) are nuclear lipogenic transcription factors, which mainly regulate lipogenic processes by activating genes involved in fatty acid and triglyceride biosynthesis. Fatty Acids 226-236 sterol regulatory element binding transcription factor 1 Homo sapiens 99-105 25180873-12 2014 CONCLUSION: Under intermittent hypoxic conditions, ROS may regulate the expression of hypoxia-inducible factors and the adipose differentiation-related protein,as well as influence fatty acid metabolism via a HIF-1 a-SREBP-1 c-FAS signal and upregulation of the ADFP protein, in liver cells. Fatty Acids 181-191 sterol regulatory element binding transcription factor 1 Homo sapiens 217-226 24704425-1 2014 Sterol regulatory element binding proteins (SREBP), encoded by the Srebf1 and Srebf2 genes, are important regulators of genes involved in cholesterol and fatty acid metabolism. Fatty Acids 154-164 sterol regulatory element binding transcription factor 1 Homo sapiens 67-73 24603540-6 2014 Our results suggest that TAM can induce hepatocyte steatosis in vitro and that the enhancement of fatty acid synthesis through the upregulations of SREBP-1c and its downstream target genes (FAS, ACC and SCD) may be the key mechanism of TAM-induced hepatocyte steatosis. Fatty Acids 98-108 sterol regulatory element binding transcription factor 1 Homo sapiens 148-156 23546614-7 2014 Fatty acid supplementation/n3 PUFA supplementation was associated with a downregulated expression of the genes encoding PPARgamma and PGC-1alpha (P < 0.001), and an upregulated expression of the genes encoding PPARalpha (P < 0.007) and SREBP1 (P < 0.021). Fatty Acids 0-10 sterol regulatory element binding transcription factor 1 Homo sapiens 242-248 23403193-8 2013 In conclusion, genetic polymorphisms in SREBF1 can be used to develop genetic tools for the selection of animals producing milk with healthier fatty acid composition. Fatty Acids 143-153 sterol regulatory element binding transcription factor 1 Homo sapiens 40-46 23732667-2 2013 SREBP-1 can maintain lipids dynamic equilibrium by regulating the expression of enzymes required for synthesis of endogenous cholesterol, fatty acids, triglycerides and phospholipids. Fatty Acids 138-149 sterol regulatory element binding transcription factor 1 Homo sapiens 0-7 23859617-4 2014 We recently demonstrated that SREBP-1 is required for the survival of mutant EGFR-containing glioblastoma, and that this pro-survival metabolic pathway is mediated, in part, by SREBP-1-dependent upregulation of the fatty acid synthesis and low density lipoprotein (LDL) receptor (LDLR). Fatty Acids 215-225 sterol regulatory element binding transcription factor 1 Homo sapiens 30-37 23859617-4 2014 We recently demonstrated that SREBP-1 is required for the survival of mutant EGFR-containing glioblastoma, and that this pro-survival metabolic pathway is mediated, in part, by SREBP-1-dependent upregulation of the fatty acid synthesis and low density lipoprotein (LDL) receptor (LDLR). Fatty Acids 215-225 sterol regulatory element binding transcription factor 1 Homo sapiens 177-184 23951060-3 2013 We recently demonstrated that a key transcription factor for lipogenesis, sterol regulatory element-binding protein-1 (SREBP-1), induced fatty acid and lipid accumulation and androgen receptor (AR) transcriptional activity, and also promoted prostate cancer cell growth and castration resistance. Fatty Acids 137-147 sterol regulatory element binding transcription factor 1 Homo sapiens 74-117 23951060-3 2013 We recently demonstrated that a key transcription factor for lipogenesis, sterol regulatory element-binding protein-1 (SREBP-1), induced fatty acid and lipid accumulation and androgen receptor (AR) transcriptional activity, and also promoted prostate cancer cell growth and castration resistance. Fatty Acids 137-147 sterol regulatory element binding transcription factor 1 Homo sapiens 119-126 23515281-0 2013 A novel JNK2/SREBP-1c pathway involved in insulin-induced fatty acid synthesis in human adipocytes. Fatty Acids 58-68 sterol regulatory element binding transcription factor 1 Homo sapiens 13-21 23515281-9 2013 Furthermore, depletion of JNK2 attenuated insulin-induced upregulation of SREBP-1c target lipogenic enzymes, leading to reduced de novo fatty acid synthesis. Fatty Acids 136-146 sterol regulatory element binding transcription factor 1 Homo sapiens 74-82 23515281-11 2013 These results suggest that SREBP-1c is a novel insulin/JNK2-regulated gene and that the JNK2/SREBP-1c pathway mediates insulin-induced fatty acid synthesis, which may lead to enlargement of LDs in human adipocytes. Fatty Acids 135-145 sterol regulatory element binding transcription factor 1 Homo sapiens 27-35 23515281-11 2013 These results suggest that SREBP-1c is a novel insulin/JNK2-regulated gene and that the JNK2/SREBP-1c pathway mediates insulin-induced fatty acid synthesis, which may lead to enlargement of LDs in human adipocytes. Fatty Acids 135-145 sterol regulatory element binding transcription factor 1 Homo sapiens 93-101 22690737-1 2013 The aim of this study was to evaluate the effect of genetic variants on candidate genes corresponding to the sterol recognition element-binding protein-1 (SREBP-1) signaling pathway and stearoyl-CoA desaturases (SCD1 and SCD5) on muscle fatty acid (FA) composition of Brangus steers fattened on grass. Fatty Acids 237-247 sterol regulatory element binding transcription factor 1 Homo sapiens 109-153 22690737-1 2013 The aim of this study was to evaluate the effect of genetic variants on candidate genes corresponding to the sterol recognition element-binding protein-1 (SREBP-1) signaling pathway and stearoyl-CoA desaturases (SCD1 and SCD5) on muscle fatty acid (FA) composition of Brangus steers fattened on grass. Fatty Acids 237-247 sterol regulatory element binding transcription factor 1 Homo sapiens 155-162 23422505-2 2013 Sterol regulatory element binding protein-1a (SREBP-1a) is a key transcriptional factor for modulating fatty acid and cholesterol synthesis. Fatty Acids 103-113 sterol regulatory element binding transcription factor 1 Homo sapiens 46-54 22994399-5 2013 The downstream effects of SREBP-1c leading to increased fatty acid synthesis and decreased fatty acid oxidation are also described. Fatty Acids 56-66 sterol regulatory element binding transcription factor 1 Homo sapiens 26-34 22994399-5 2013 The downstream effects of SREBP-1c leading to increased fatty acid synthesis and decreased fatty acid oxidation are also described. Fatty Acids 91-101 sterol regulatory element binding transcription factor 1 Homo sapiens 26-34 22064655-3 2012 We have shown that (i) expression of SREBP-1 protein is positively associated with the clinical Gleason grades in human prostate cancer; (ii) genetic overexpression or knockdown of SREBP-1 in prostate cancer cells resulted in corresponding increased or decreased AR, FASN and Nox5 expression, fatty acid and lipid droplet accumulation, and ROS generation; and (iii) SREBP-1 induces and promotes the growth, migration, invasion, and castration-resistant progression of prostate cancer cells in vitro and in vivo. Fatty Acids 293-303 sterol regulatory element binding transcription factor 1 Homo sapiens 181-188 22969728-7 2012 Transcriptome data enabled the generation of a regulatory network based on the transcription factor SREBF1, linked to a metabolic network of glycerolipid, and fatty acid biosynthesis including the downstream transcriptional targets of SREBF1 which include LIPIN1 (LPIN) and low density lipoprotein receptor. Fatty Acids 159-169 sterol regulatory element binding transcription factor 1 Homo sapiens 235-241 22274626-3 2012 These intronic microRNAs are embedded in the sterol response element binding protein genes, SREBF2 and SREBF1, which code for transcription factors that coordinate cholesterol and fatty acid synthesis. Fatty Acids 183-193 sterol regulatory element binding transcription factor 1 Homo sapiens 106-112 22279139-6 2012 This reduction was due to the decreased expression of SREBP-1c and its responsive genes in fatty acid synthesis, including FAS, SCD1, and ACC1. Fatty Acids 91-101 sterol regulatory element binding transcription factor 1 Homo sapiens 54-62 21924277-4 2012 First, clozapine, haloperidol, olanzapine and risperidone activated, at different levels, SREBP-1 activity reflected by an increased expression of SREBP-1 target genes involved in fatty acid biosynthesis (SREBP-1, FAS and/or SCD1) resulting in an accumulation of intracellular lipids. Fatty Acids 180-190 sterol regulatory element binding transcription factor 1 Homo sapiens 90-97 21924277-4 2012 First, clozapine, haloperidol, olanzapine and risperidone activated, at different levels, SREBP-1 activity reflected by an increased expression of SREBP-1 target genes involved in fatty acid biosynthesis (SREBP-1, FAS and/or SCD1) resulting in an accumulation of intracellular lipids. Fatty Acids 180-190 sterol regulatory element binding transcription factor 1 Homo sapiens 147-154 21924277-4 2012 First, clozapine, haloperidol, olanzapine and risperidone activated, at different levels, SREBP-1 activity reflected by an increased expression of SREBP-1 target genes involved in fatty acid biosynthesis (SREBP-1, FAS and/or SCD1) resulting in an accumulation of intracellular lipids. Fatty Acids 180-190 sterol regulatory element binding transcription factor 1 Homo sapiens 147-154 22064655-1 2012 We previously reported that sterol regulatory element-binding protein-1 (SREBP-1) is involved in the transcriptional regulation of androgen receptor (AR) and formation of fatty acid through altered expression of fatty acid synthase (FASN). Fatty Acids 171-181 sterol regulatory element binding transcription factor 1 Homo sapiens 28-71 22064655-1 2012 We previously reported that sterol regulatory element-binding protein-1 (SREBP-1) is involved in the transcriptional regulation of androgen receptor (AR) and formation of fatty acid through altered expression of fatty acid synthase (FASN). Fatty Acids 171-181 sterol regulatory element binding transcription factor 1 Homo sapiens 73-80 22531971-4 2012 The sterol regulatory element-binding protein 1c (SREBP-1c) and peroxisome proliferator-activated receptor alpha (PPARalpha) are two key transcription factors involved, respectively, in fatty acid synthesis and degradation in liver. Fatty Acids 186-196 sterol regulatory element binding transcription factor 1 Homo sapiens 4-48 22531971-4 2012 The sterol regulatory element-binding protein 1c (SREBP-1c) and peroxisome proliferator-activated receptor alpha (PPARalpha) are two key transcription factors involved, respectively, in fatty acid synthesis and degradation in liver. Fatty Acids 186-196 sterol regulatory element binding transcription factor 1 Homo sapiens 50-58 22531971-10 2012 These results suggest that the hepatotoxicity induced by divalproex sodium may be related with fatty acid synthesis and degradation mediated by SREBP-1c and PPARalpha in hepatocytes. Fatty Acids 95-105 sterol regulatory element binding transcription factor 1 Homo sapiens 144-152 22707265-5 2012 In hepatocytes, taurine significantly induced Insig-2a levels and delayed nuclear translocation of the sterol regulatory element-binding protein 1 (SREBP-1) protein, resulting in a dose-dependent reduction in the cellular lipid levels without inducing the expression of fatty acid synthesis genes. Fatty Acids 270-280 sterol regulatory element binding transcription factor 1 Homo sapiens 148-155 22064655-3 2012 We have shown that (i) expression of SREBP-1 protein is positively associated with the clinical Gleason grades in human prostate cancer; (ii) genetic overexpression or knockdown of SREBP-1 in prostate cancer cells resulted in corresponding increased or decreased AR, FASN and Nox5 expression, fatty acid and lipid droplet accumulation, and ROS generation; and (iii) SREBP-1 induces and promotes the growth, migration, invasion, and castration-resistant progression of prostate cancer cells in vitro and in vivo. Fatty Acids 293-303 sterol regulatory element binding transcription factor 1 Homo sapiens 181-188 23226416-1 2012 SREBP-1 are ubiquitously expressed transcription factors, strongly expressed in lipogenic tissues where they regulate several metabolic processes like fatty acid synthesis. Fatty Acids 151-161 sterol regulatory element binding transcription factor 1 Homo sapiens 0-7 22012398-8 2011 Notably, miR-33 antagonism in this non-human primate model also increased the expression of miR-33 target genes involved in fatty acid oxidation (CROT, CPT1A, HADHB and PRKAA1) and reduced the expression of genes involved in fatty acid synthesis (SREBF1, FASN, ACLY and ACACA), resulting in a marked suppression of the plasma levels of very-low-density lipoprotein (VLDL)-associated triglycerides, a finding that has not previously been observed in mice. Fatty Acids 124-134 sterol regulatory element binding transcription factor 1 Homo sapiens 247-253 20071336-5 2010 By inhibition of SREBP-1, beta2M mAb reduced fatty acid and lipid levels, an integral component of cell membrane, cell signaling mediators, and energy metabolism. Fatty Acids 45-55 sterol regulatory element binding transcription factor 1 Homo sapiens 17-24 20416812-3 2010 The Sterol Regulatory Element Binding Protein-1 (SREBF1) is a transcription factor involved in the regulation of fatty acid synthesis in muscle and adipose tissues. Fatty Acids 113-123 sterol regulatory element binding transcription factor 1 Homo sapiens 4-47 20416812-3 2010 The Sterol Regulatory Element Binding Protein-1 (SREBF1) is a transcription factor involved in the regulation of fatty acid synthesis in muscle and adipose tissues. Fatty Acids 113-123 sterol regulatory element binding transcription factor 1 Homo sapiens 49-55 20124555-3 2010 Transfection of HepG2 cells with sense or antisense miR-370 or miR-122 upregulated and downregulated, respectively, the transcription factor sterol-regulatory element binding protein 1c (SREBP-1c) and the enzymes diacylglycerol acyltransferase-2 (DGAT2), fatty acid synthase (FAS), and acyl-CoA carboxylase 1 (ACC1) that regulate fatty acid and triglyceride biosynthesis. Fatty Acids 255-265 sterol regulatory element binding transcription factor 1 Homo sapiens 141-185 20124555-3 2010 Transfection of HepG2 cells with sense or antisense miR-370 or miR-122 upregulated and downregulated, respectively, the transcription factor sterol-regulatory element binding protein 1c (SREBP-1c) and the enzymes diacylglycerol acyltransferase-2 (DGAT2), fatty acid synthase (FAS), and acyl-CoA carboxylase 1 (ACC1) that regulate fatty acid and triglyceride biosynthesis. Fatty Acids 255-265 sterol regulatory element binding transcription factor 1 Homo sapiens 187-195 18936756-3 2010 Previously, we demonstrated in glial cell lines that antipsychotic drugs induce the expression of genes involved in cholesterol and fatty acids biosynthesis through activation of the sterol regulatory element binding protein (SREBP) transcription factors, encoded by the sterol regulatory element binding transcription factor 1 (SREBF1) and sterol regulatory element binding transcription factor 2 (SREBF2) genes. Fatty Acids 132-143 sterol regulatory element binding transcription factor 1 Homo sapiens 271-327 18936756-3 2010 Previously, we demonstrated in glial cell lines that antipsychotic drugs induce the expression of genes involved in cholesterol and fatty acids biosynthesis through activation of the sterol regulatory element binding protein (SREBP) transcription factors, encoded by the sterol regulatory element binding transcription factor 1 (SREBF1) and sterol regulatory element binding transcription factor 2 (SREBF2) genes. Fatty Acids 132-143 sterol regulatory element binding transcription factor 1 Homo sapiens 329-335 21388747-2 2011 Docosahexaenoic acid (DHA) reduces, whereas insulin augments, nuclear abundance of sterol-regulatory-element-binding-protein-1 (SREBP-1), which promotes DNL, stearoyl-CoA-desaturase (SCD, also Delta9-desaturase), fatty acid-(FA)-elongation (Elovl) and FA-desaturation (FADS). Fatty Acids 213-223 sterol regulatory element binding transcription factor 1 Homo sapiens 83-126 21388747-2 2011 Docosahexaenoic acid (DHA) reduces, whereas insulin augments, nuclear abundance of sterol-regulatory-element-binding-protein-1 (SREBP-1), which promotes DNL, stearoyl-CoA-desaturase (SCD, also Delta9-desaturase), fatty acid-(FA)-elongation (Elovl) and FA-desaturation (FADS). Fatty Acids 213-223 sterol regulatory element binding transcription factor 1 Homo sapiens 128-135 21406729-3 2011 From this screen, we identified the Sterol-Regulatory Element-Binding Protein 1 (SREBP1), a transcription factor, which regulates genes involved in cholesterol and fatty acid synthesis including fatty acid synthase. Fatty Acids 164-174 sterol regulatory element binding transcription factor 1 Homo sapiens 36-79 21406729-3 2011 From this screen, we identified the Sterol-Regulatory Element-Binding Protein 1 (SREBP1), a transcription factor, which regulates genes involved in cholesterol and fatty acid synthesis including fatty acid synthase. Fatty Acids 164-174 sterol regulatory element binding transcription factor 1 Homo sapiens 81-87 20889723-6 2010 SREBP1c-induced loss of the primary cilium could be confirmed in mammalian Madin-Darby canine kidney (MDCK) cells and was mediated by changes in the supply of fatty acids. Fatty Acids 159-170 sterol regulatory element binding transcription factor 1 Homo sapiens 0-7 20385813-7 2010 SREBP-1c also promotes fatty acid synthesis by activating several genes encoding enzymes in the biosynthetic pathway. Fatty Acids 23-33 sterol regulatory element binding transcription factor 1 Homo sapiens 0-8 20385813-10 2010 Oleate (400 muM) treatment prolonged the half-life of PNPLA3 from 2.4 to 6.7 h. These findings are consistent with nutritional control of PNPLA3 being effected by a feed-forward loop; SREBP-1c promotes accumulation of PNPLA3 directly by activating Pnpla3 transcription and indirectly by inhibiting PNPLA3 degradation through the stimulation of fatty acid synthesis. Fatty Acids 344-354 sterol regulatory element binding transcription factor 1 Homo sapiens 184-192 20385828-2 2010 Here we demonstrate that macrophage colony-stimulating factor (M-CSF)-dependent differentiation of primary human monocytes from healthy volunteers induces transcription of SREBP-1c target genes required for fatty acid (FA) biosynthesis and impairs transcription of SREBP-2 target genes required for cholesterol synthesis. Fatty Acids 207-217 sterol regulatory element binding transcription factor 1 Homo sapiens 172-180 20028734-1 2010 The role of the transcription factors sterol regulatory element binding protein 1a (SREBP-1a) and SREBP-1c in the regulation of cholesterol and fatty acid metabolism has been well studied; however, little is known about their specific function in muscle. Fatty Acids 144-154 sterol regulatory element binding transcription factor 1 Homo sapiens 84-92 20017192-2 2010 This protection is intrinsic, not due to changes in complement regulatory proteins, and requires activation of Akt and sterol receptor element binding protein-1 (SREBP-1), which regulates fatty acid and phospholipid synthesis. Fatty Acids 188-198 sterol regulatory element binding transcription factor 1 Homo sapiens 119-160 20017192-2 2010 This protection is intrinsic, not due to changes in complement regulatory proteins, and requires activation of Akt and sterol receptor element binding protein-1 (SREBP-1), which regulates fatty acid and phospholipid synthesis. Fatty Acids 188-198 sterol regulatory element binding transcription factor 1 Homo sapiens 162-169 20028734-1 2010 The role of the transcription factors sterol regulatory element binding protein 1a (SREBP-1a) and SREBP-1c in the regulation of cholesterol and fatty acid metabolism has been well studied; however, little is known about their specific function in muscle. Fatty Acids 144-154 sterol regulatory element binding transcription factor 1 Homo sapiens 98-106 19360318-1 2009 We previously studied fatty acid metabolism in the liver of nonalcoholic fatty liver disease (NAFLD) and reported the activation of the LXRalpha-SREBP-1c pathway in hepatocytes. Fatty Acids 22-32 sterol regulatory element binding transcription factor 1 Homo sapiens 145-153 20847591-1 2009 The transcription factor sterol regulatory element-binding protein 1c (SREBP1c) plays an important role in the regulation of fatty acid metabolism in the liver. Fatty Acids 125-135 sterol regulatory element binding transcription factor 1 Homo sapiens 25-69 20847591-1 2009 The transcription factor sterol regulatory element-binding protein 1c (SREBP1c) plays an important role in the regulation of fatty acid metabolism in the liver. Fatty Acids 125-135 sterol regulatory element binding transcription factor 1 Homo sapiens 71-78 19323650-7 2009 25, 9621-9631], caspase 7 may also be induced by statins and is under the positive control of SREBP (sterol-regulatory-element-binding protein)-1 and -2, major activators of cholesterol and fatty acid synthesis genes, in HGT-1 cells. Fatty Acids 190-200 sterol regulatory element binding transcription factor 1 Homo sapiens 101-152 18727921-1 2008 SREBP1c (sterol regulatory element-binding protein 1c) is a metabolic-syndrome-associated transcription factor that controls fatty acid biosynthesis under glucose/insulin stimulation. Fatty Acids 125-135 sterol regulatory element binding transcription factor 1 Homo sapiens 0-7 18835813-7 2008 Unsaturated fatty acid-mediated stabilization of Insig-1 enhances the ability of sterols to inhibit proteolytic activation of SREBP-1, which activates transcription of genes involved in fatty acid synthesis. Fatty Acids 12-22 sterol regulatory element binding transcription factor 1 Homo sapiens 126-133 19292868-1 2009 Sterol regulatory element-binding proteins 1 and 2 (SREBP-1 and SREBP-2) are important regulators of genes involved in cholesterol and fatty acid metabolism, but have also been implicated in the regulation of the cell cycle and have been associated with the pathogenesis of type 2 diabetes, atherosclerosis and obesity, among others. Fatty Acids 135-145 sterol regulatory element binding transcription factor 1 Homo sapiens 0-50 19292868-1 2009 Sterol regulatory element-binding proteins 1 and 2 (SREBP-1 and SREBP-2) are important regulators of genes involved in cholesterol and fatty acid metabolism, but have also been implicated in the regulation of the cell cycle and have been associated with the pathogenesis of type 2 diabetes, atherosclerosis and obesity, among others. Fatty Acids 135-145 sterol regulatory element binding transcription factor 1 Homo sapiens 52-59 18195716-5 2009 We therefore hypothesized that the major genes involved in the SREBP activation of fatty acids and cholesterol production (SREBF1, SREBF2, SCAP, INSIG1 and INSIG2) would be strong candidate genes for interindividual variation in drug-induced weight gain. Fatty Acids 83-94 sterol regulatory element binding transcription factor 1 Homo sapiens 123-129 19041341-6 2009 Fatty acid activated transcription factors (PPARs, LXR, RXR, and SREBP-1) have been demonstrated to regulate these fatty acid transport/binding proteins, and placental functions. Fatty Acids 0-10 sterol regulatory element binding transcription factor 1 Homo sapiens 65-72 19041341-6 2009 Fatty acid activated transcription factors (PPARs, LXR, RXR, and SREBP-1) have been demonstrated to regulate these fatty acid transport/binding proteins, and placental functions. Fatty Acids 115-125 sterol regulatory element binding transcription factor 1 Homo sapiens 65-72 18727921-1 2008 SREBP1c (sterol regulatory element-binding protein 1c) is a metabolic-syndrome-associated transcription factor that controls fatty acid biosynthesis under glucose/insulin stimulation. Fatty Acids 125-135 sterol regulatory element binding transcription factor 1 Homo sapiens 9-53 18654640-1 2008 The sterol regulatory element-binding protein (SREBP) family member SREBP1 is a critical transcriptional regulator of cholesterol and fatty acid metabolism and has been implicated in insulin resistance, diabetes, and other diet-related diseases. Fatty Acids 134-144 sterol regulatory element binding transcription factor 1 Homo sapiens 68-74 18922461-2 2008 (2008) demonstrate that fatty acid biosynthesis, under the transcriptional control of SREBP1, is regulated by the rapamycin-sensitive mTOR signaling network, thus expanding the scope of biosynthetic processes integrated by mTOR. Fatty Acids 24-34 sterol regulatory element binding transcription factor 1 Homo sapiens 86-92 19035881-5 2008 In addition, LXR agonists activate fatty acid synthesis by stimulating the expression of a lipogenic transcription factor, sterol regulatory element-binding protein-1c (SREBP-1c), leading to the elevation of plasma triglycerides and liver steatosis. Fatty Acids 35-45 sterol regulatory element binding transcription factor 1 Homo sapiens 123-167 18343222-8 2008 SREBP-1 is a major transcription factor that controls the expression of multiple genes involved fatty acid synthesis and desaturation. Fatty Acids 96-106 sterol regulatory element binding transcription factor 1 Homo sapiens 0-7 18360697-4 2008 A major regulator of fatty acids synthesis is sterol regulatory element-binding protein-1c (SREBP-1c). Fatty Acids 21-32 sterol regulatory element binding transcription factor 1 Homo sapiens 46-90 18360697-4 2008 A major regulator of fatty acids synthesis is sterol regulatory element-binding protein-1c (SREBP-1c). Fatty Acids 21-32 sterol regulatory element binding transcription factor 1 Homo sapiens 92-100 18360697-12 2008 These data indicate that, in NAFLD, insulin signaling via IRS-1 causes the up-regulation of SREBP1-c, leading to the increased synthesis of fatty acids by the hepatocytes; negative feedback regulation via AMPK does not occur and the activation of Foxa2, following a decrease of IRS-2, up-regulates fatty acid oxidation. Fatty Acids 140-151 sterol regulatory element binding transcription factor 1 Homo sapiens 92-100 18360697-12 2008 These data indicate that, in NAFLD, insulin signaling via IRS-1 causes the up-regulation of SREBP1-c, leading to the increased synthesis of fatty acids by the hepatocytes; negative feedback regulation via AMPK does not occur and the activation of Foxa2, following a decrease of IRS-2, up-regulates fatty acid oxidation. Fatty Acids 140-150 sterol regulatory element binding transcription factor 1 Homo sapiens 92-100 18460914-7 2008 In contrast to peroxisome proliferator-activated receptor alpha, 22:6,n-3 is the most potent fatty acid regulator of hepatic sterol regulatory element binding protein-1. Fatty Acids 93-103 sterol regulatory element binding transcription factor 1 Homo sapiens 125-168 18374150-5 2008 The transcription factor SREBP-1, which regulates fatty acid synthesis, was found to be activated in extracts of ECs incubated with IL-4 for 6 hours. Fatty Acids 50-60 sterol regulatory element binding transcription factor 1 Homo sapiens 25-32 19035881-5 2008 In addition, LXR agonists activate fatty acid synthesis by stimulating the expression of a lipogenic transcription factor, sterol regulatory element-binding protein-1c (SREBP-1c), leading to the elevation of plasma triglycerides and liver steatosis. Fatty Acids 35-45 sterol regulatory element binding transcription factor 1 Homo sapiens 169-177 18684130-4 2008 SREBP-1c and ChREBP are transactivated by liver X receptor (LXR), a nuclear receptor that regulates the metabolism of cholesterol and fatty acids. Fatty Acids 134-145 sterol regulatory element binding transcription factor 1 Homo sapiens 0-8 18751906-3 2008 Two transcription factors, namely SREBP1-c and PPARalpha, appear to be the main players controlling synthesis and degradation of fatty acids respectively. Fatty Acids 129-140 sterol regulatory element binding transcription factor 1 Homo sapiens 34-42 18751906-5 2008 The first part focuses on SREBP1-c contribution to the control of gene expression relevant to fatty acid synthesis and the main mechanisms of activation for this transcriptional program. Fatty Acids 94-104 sterol regulatory element binding transcription factor 1 Homo sapiens 26-34 18063918-6 2007 In addition, LXR agonists activate de novo fatty acid synthesis by stimulating the expression of a lipogenic transcription factor, sterol regulatory element-binding protein-1c (SREBP-1c), leading to the elevation of plasma triglycerides and liver steatosis. Fatty Acids 43-53 sterol regulatory element binding transcription factor 1 Homo sapiens 131-175 18063918-6 2007 In addition, LXR agonists activate de novo fatty acid synthesis by stimulating the expression of a lipogenic transcription factor, sterol regulatory element-binding protein-1c (SREBP-1c), leading to the elevation of plasma triglycerides and liver steatosis. Fatty Acids 43-53 sterol regulatory element binding transcription factor 1 Homo sapiens 177-185 17884995-8 2007 The effect on FASN was shown to be mediated by sterol regulatory element binding protein-1, an important transcription factor involved in fatty acid synthesis. Fatty Acids 138-148 sterol regulatory element binding transcription factor 1 Homo sapiens 47-90 17956338-1 2007 SREBP-1c (sterol-regulatory-element-binding protein 1c) is a transcription factor that regulates genes associated with glucose and fatty acid metabolism and exhibits responsiveness to insulin and exercise. Fatty Acids 131-141 sterol regulatory element binding transcription factor 1 Homo sapiens 0-8 17956338-1 2007 SREBP-1c (sterol-regulatory-element-binding protein 1c) is a transcription factor that regulates genes associated with glucose and fatty acid metabolism and exhibits responsiveness to insulin and exercise. Fatty Acids 131-141 sterol regulatory element binding transcription factor 1 Homo sapiens 10-54 17633477-4 2007 LXRs also play an important role in fatty acid metabolism by activating the sterol regulatory element-bing protein 1c gene (SREBP1c). Fatty Acids 36-46 sterol regulatory element binding transcription factor 1 Homo sapiens 124-131 17671740-10 2007 Further studies will be needed to clarify how fatty acid synthesis is increased by SREBP-1c, which is under the control of insulin and AMP-activated protein kinase. Fatty Acids 46-56 sterol regulatory element binding transcription factor 1 Homo sapiens 83-91 17279346-2 2007 SREBP-1c is a bHLH transcription factor that controls lipogenesis and is induced during overnutrition to facilitate the conversion of glucose to fatty acids and triglycerides for the storage of the excess energy. Fatty Acids 145-156 sterol regulatory element binding transcription factor 1 Homo sapiens 0-8 17236119-3 2007 Increasing activation of transcription factors, such as carbohydrate responsive element binding protein (ChREBP), sterol response element binding protein-1c (SREBP-1c), or forkhead box 01 (Fox01), may contribute to fatty acid synthesis. Fatty Acids 215-225 sterol regulatory element binding transcription factor 1 Homo sapiens 158-166 17186944-9 2007 OSCi and TO-901317 increased the mRNA and precursor form of SREBP-1c, a major regulator of fatty acid and triglyceride synthesis. Fatty Acids 91-101 sterol regulatory element binding transcription factor 1 Homo sapiens 60-68 17344645-5 2007 SREBP-1c induces the expression of a family of genes involved in glucose utilization and fatty acid synthesis and can be considered as a thrifty gene. Fatty Acids 89-99 sterol regulatory element binding transcription factor 1 Homo sapiens 0-8 17236119-3 2007 Increasing activation of transcription factors, such as carbohydrate responsive element binding protein (ChREBP), sterol response element binding protein-1c (SREBP-1c), or forkhead box 01 (Fox01), may contribute to fatty acid synthesis. Fatty Acids 215-225 sterol regulatory element binding transcription factor 1 Homo sapiens 114-156 16251601-2 2005 In vitro binding and cell culture studies have identified many transcription factors as prospective targets for fatty acid regulation, including peroxisome proliferator-activated receptors (PPARalpha, beta, gamma1, and gamma2), sterol regulatory element binding protein-1c (SREBP-1c), hepatic nuclear factors (HNF-4alpha and gamma), retinoid X receptor (RXRalpha), liver X receptor (LXRalpha), and others. Fatty Acids 112-122 sterol regulatory element binding transcription factor 1 Homo sapiens 274-282 16403800-8 2006 SREBP-1, a lipid-sensing sterol regulatory element-binding protein, is a critical regulator of fatty acid homeostasis in the placenta. Fatty Acids 95-105 sterol regulatory element binding transcription factor 1 Homo sapiens 0-7 16221687-1 2005 Fatty acid biosynthesis is transcriptionally regulated by liver X receptor (LXR) and its gene target, sterol regulatory element binding protein-1c (SREBP-1c). Fatty Acids 0-10 sterol regulatory element binding transcription factor 1 Homo sapiens 102-146 16221687-1 2005 Fatty acid biosynthesis is transcriptionally regulated by liver X receptor (LXR) and its gene target, sterol regulatory element binding protein-1c (SREBP-1c). Fatty Acids 0-10 sterol regulatory element binding transcription factor 1 Homo sapiens 148-156 16154299-5 2005 A variety of other proteins, including PTEN, MAPK1, SREBP1, SREBP2 and PI are also involved in the regulation of fatty acid biosynthesis. Fatty Acids 113-123 sterol regulatory element binding transcription factor 1 Homo sapiens 52-58 16387548-4 2005 Remarkably, this site is uniquely responsive to SREBP-1c that is mainly involved in fatty acids synthesis. Fatty Acids 84-95 sterol regulatory element binding transcription factor 1 Homo sapiens 48-56 15794649-9 2005 In SREBP-1a (+) cells, several enzymes involved in lipid metabolism were significantly altered, suggesting that cellular lipid metabolism is triggered by accumulation of fatty acids rather than by its degradation. Fatty Acids 170-181 sterol regulatory element binding transcription factor 1 Homo sapiens 3-11 15769984-9 2005 The expression of mRNA for fatty acid synthase, a target gene for SREBP-1c, was increased by hCG (24-fold, P = 0.006) and insulin (19-fold, P = 0.024), which also increased the level of cellular, total fatty acid (1.34-fold; P = 0.03). Fatty Acids 27-37 sterol regulatory element binding transcription factor 1 Homo sapiens 66-74 15769984-10 2005 Thus, hCG and insulin cause a switch toward expression of the SREBP-1c isoform with consequent effects on fatty acid synthesis. Fatty Acids 106-116 sterol regulatory element binding transcription factor 1 Homo sapiens 62-70 15881188-2 2005 While SREBP-2 regulates expression of genes involved in cholesterol biosynthesis and LDL receptor, SREBP-1c controls fatty acid synthesis. Fatty Acids 117-127 sterol regulatory element binding transcription factor 1 Homo sapiens 99-107 16002205-4 2005 Using adenoviral expression of SREBP-1c and a SREBP-mutant we show that lipogenic gene expression, de novo fatty acid synthesis and lipid accumulation are induced primarily through sterol-regulatory elements (SREs) and not E-Boxes. Fatty Acids 107-117 sterol regulatory element binding transcription factor 1 Homo sapiens 31-39 15333740-5 2004 The effects of fatty acids are mediated either directly owing to their specific binding to various nuclear receptors (PPAR, LXR, HNF-4alpha) leading to changes in the trans-activating activity of these transcription factors, or indirectly as the result of changes in the abundance of regulatory transcription factors (SREBP-1c, ChREBP, etc.). Fatty Acids 15-26 sterol regulatory element binding transcription factor 1 Homo sapiens 318-326 12865412-0 2003 Keratinocyte growth factor and the transcription factors C/EBP alpha, C/EBP delta, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells. Fatty Acids 105-115 sterol regulatory element binding transcription factor 1 Homo sapiens 87-95 15573522-8 2004 In fact, involvement of several nuclear transcription factors (PPARgamma, LXR, RXR, and SREBP-1) is critical in the expression of genes responsible for fatty acids uptake, placental trophoblast differentiation and hCG production. Fatty Acids 152-163 sterol regulatory element binding transcription factor 1 Homo sapiens 88-95 14748724-1 2004 Sterol-regulatory-element-binding protein 1c (SREBP-1c) is one member of the family of transcription factors that stimulate sterol and fatty-acid biosynthesis in animal cells. Fatty Acids 135-145 sterol regulatory element binding transcription factor 1 Homo sapiens 0-44 14748724-1 2004 Sterol-regulatory-element-binding protein 1c (SREBP-1c) is one member of the family of transcription factors that stimulate sterol and fatty-acid biosynthesis in animal cells. Fatty Acids 135-145 sterol regulatory element binding transcription factor 1 Homo sapiens 46-54 14654692-1 2003 Adipocyte determination and differentiation dependent factor 1 (ADD1)/sterol regulatory element binding protein isoform (SREBP1c) is a key transcription factor in fatty acid metabolism and insulin- dependent gene expression. Fatty Acids 163-173 sterol regulatory element binding transcription factor 1 Homo sapiens 121-128 15350011-11 2004 The key enzyme activities of the energy-consuming process of glycogen and fatty acid synthesis as well as lipoprotein metabolism were accelerated by insulin through the IRS-2 / SREBP-1c pathway. Fatty Acids 74-84 sterol regulatory element binding transcription factor 1 Homo sapiens 177-185 15123650-2 2004 Herein, we report that the human SHP promoter (hSHP) is activated by sterol regulatory element-binding protein-1 (SREBP-1), which regulates the expression of various genes involved in cholesterol and fatty acid synthesis. Fatty Acids 200-210 sterol regulatory element binding transcription factor 1 Homo sapiens 69-112 15123650-2 2004 Herein, we report that the human SHP promoter (hSHP) is activated by sterol regulatory element-binding protein-1 (SREBP-1), which regulates the expression of various genes involved in cholesterol and fatty acid synthesis. Fatty Acids 200-210 sterol regulatory element binding transcription factor 1 Homo sapiens 114-121 12730331-3 2003 These nuclear receptors play crucial roles in the regulation of fatty acid metabolism: LXRs activate expression of sterol regulatory element-binding protein 1c (SREBP-1c), a dominant lipogenic gene regulator, whereas PPARalpha promotes fatty acid beta-oxidation genes. Fatty Acids 64-74 sterol regulatory element binding transcription factor 1 Homo sapiens 115-159 12730331-3 2003 These nuclear receptors play crucial roles in the regulation of fatty acid metabolism: LXRs activate expression of sterol regulatory element-binding protein 1c (SREBP-1c), a dominant lipogenic gene regulator, whereas PPARalpha promotes fatty acid beta-oxidation genes. Fatty Acids 64-74 sterol regulatory element binding transcription factor 1 Homo sapiens 161-169 12538078-4 2003 Sterol regulatory element binding protein-1c (SREBP-1c) is a key transcription factor that activates transcription of genes involved with fatty acid synthesis. Fatty Acids 138-148 sterol regulatory element binding transcription factor 1 Homo sapiens 0-44 12538078-4 2003 Sterol regulatory element binding protein-1c (SREBP-1c) is a key transcription factor that activates transcription of genes involved with fatty acid synthesis. Fatty Acids 138-148 sterol regulatory element binding transcription factor 1 Homo sapiens 46-54 12531699-4 2003 In contrast, upregulation of fatty acid metabolism during in vitro transformation of human mammary epithelial cells and in breast cancer cells was driven by increased MAP kinase and PI 3-kinase signaling, which increased SREBP-1 levels. Fatty Acids 29-39 sterol regulatory element binding transcription factor 1 Homo sapiens 221-228 12147235-8 2002 Because HUFA are primarily incorporated into phospholipids (PL), our results suggest that the primary role of SREBP-1c in liver is the regulation of fatty acid supply for PL rather than for triglycerides. Fatty Acids 149-159 sterol regulatory element binding transcription factor 1 Homo sapiens 110-118 12213084-0 2002 Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport. Fatty Acids 16-26 sterol regulatory element binding transcription factor 1 Homo sapiens 55-98 12213084-4 2002 18:2, 20:4, 20:5 and 22:6 fatty acids decreased the amount of mature SREBP-1 and mRNA levels of SREBP-1c, SREBP-1a, FAS and acetyl-CoA carboxylase. Fatty Acids 26-37 sterol regulatory element binding transcription factor 1 Homo sapiens 69-76 12213084-4 2002 18:2, 20:4, 20:5 and 22:6 fatty acids decreased the amount of mature SREBP-1 and mRNA levels of SREBP-1c, SREBP-1a, FAS and acetyl-CoA carboxylase. Fatty Acids 26-37 sterol regulatory element binding transcription factor 1 Homo sapiens 96-104 12213084-4 2002 18:2, 20:4, 20:5 and 22:6 fatty acids decreased the amount of mature SREBP-1 and mRNA levels of SREBP-1c, SREBP-1a, FAS and acetyl-CoA carboxylase. Fatty Acids 26-37 sterol regulatory element binding transcription factor 1 Homo sapiens 106-114 12440976-5 2002 Because HUFAs are poorly incorporated into TAGs, the primary role of SREBP-1c in liver may be monitoring and regulating fatty acid composition in PLs rather than the regulation of TAG synthesis. Fatty Acids 120-130 sterol regulatory element binding transcription factor 1 Homo sapiens 69-77 12079833-7 2002 The decrease in SREBP-1 mature protein paralleled the decrease in mRNAs for genes of fatty acid and cholesterol biosynthesis, such as HMG-CoA synthase and fatty acid synthase, but interestingly gene expression of stearoyl-CoA desaturase 1 (SCD1) was instead induced. Fatty Acids 85-95 sterol regulatory element binding transcription factor 1 Homo sapiens 16-23 11916923-1 2002 Sterol regulatory element binding protein (SREBP)-1 is a transcription factor with important roles in the control of fatty acid metabolism and adipogenesis. Fatty Acids 117-127 sterol regulatory element binding transcription factor 1 Homo sapiens 43-51 12079833-1 2002 Cellular cholesterol and fatty acid metabolism in mammals is controlled by a family of transcription factors called sterol regulatory element-binding protein isoforms, three of which (SREBP-1a, 1c, and 2) are well characterized. Fatty Acids 25-35 sterol regulatory element binding transcription factor 1 Homo sapiens 184-203 11694526-7 2002 These data suggest that PUFAs could be deeply involved in nutritional regulation of cellular fatty acid levels by inhibiting an LXR-SREBP-1c system crucial for lipogenesis. Fatty Acids 93-103 sterol regulatory element binding transcription factor 1 Homo sapiens 132-140 14993353-4 2002 LXRs are also involved in fatty acid metabolism by their ability to increase the expression of sterol regulatory element-binding protein 1c (SREBP-1c). Fatty Acids 26-36 sterol regulatory element binding transcription factor 1 Homo sapiens 95-139 14993353-4 2002 LXRs are also involved in fatty acid metabolism by their ability to increase the expression of sterol regulatory element-binding protein 1c (SREBP-1c). Fatty Acids 26-36 sterol regulatory element binding transcription factor 1 Homo sapiens 141-149 11738387-7 2001 First, we hypothesize that upregulation and/or increase in the mature form of SREBP-1 caused by HAART may lead to perturbations in synergistic regulation of genes involved in maintenance of cholesterol homeostasis and synthesis of fatty acids, that may explain the accumulation of fat which is a hallmark of this syndrome. Fatty Acids 231-242 sterol regulatory element binding transcription factor 1 Homo sapiens 78-85 11724468-13 2001 Another likely mechanism is that HUFA suppress genes for fatty acid synthesis by reducing both mRNA and protein maturation of sterol regulatory element binding protein-1. Fatty Acids 57-67 sterol regulatory element binding transcription factor 1 Homo sapiens 126-169 7739539-3 1995 The ADD1/SREBP1 consensus E-box site is similar to a regulatory sequence designated the carbohydrate response element, defined by its ability to regulate transcription in response to carbohydrate in genes involved in fatty acid and triglyceride metabolism in liver and fat. Fatty Acids 217-227 sterol regulatory element binding transcription factor 1 Homo sapiens 9-15 11082286-4 2000 This study sought to determine whether SREBP-1 participates in the regulation of proliferation-associated fatty acid synthesis in colorectal neoplasia. Fatty Acids 106-116 sterol regulatory element binding transcription factor 1 Homo sapiens 39-46 11082286-7 2000 Cerulenin and TOFA each inhibited the endogenous synthesis of fatty acids in a dose-dependent manner and each induced increases in both precursor and mature forms of SREBP-1. Fatty Acids 62-73 sterol regulatory element binding transcription factor 1 Homo sapiens 166-173 11082286-9 2000 These results demonstrate that tumor cells recognize and respond to a deficiency in endogenous fatty acid synthesis by upregulating both SREBP-1 and FAS expression and support the model that SREBP-1 participates in the transcriptional regulation of lipogenic genes in colorectal neoplasia. Fatty Acids 95-105 sterol regulatory element binding transcription factor 1 Homo sapiens 137-144 11082286-9 2000 These results demonstrate that tumor cells recognize and respond to a deficiency in endogenous fatty acid synthesis by upregulating both SREBP-1 and FAS expression and support the model that SREBP-1 participates in the transcriptional regulation of lipogenic genes in colorectal neoplasia. Fatty Acids 95-105 sterol regulatory element binding transcription factor 1 Homo sapiens 191-198 9070916-1 1997 Sterol-regulatory element binding protein (SREBP) 1 and SREBP2 are ubiquitously expressed transcription factors that play key roles in the regulation of cholesterol and fatty acid metabolism. Fatty Acids 169-179 sterol regulatory element binding transcription factor 1 Homo sapiens 0-51 11160371-10 2001 Furthermore, they establish that differential expression of ADD-1/SREBP-1 is a key determinant of the site of fatty acid synthesis in the body.-Gondret, F., P. Ferre, and I. Dugail. Fatty Acids 110-120 sterol regulatory element binding transcription factor 1 Homo sapiens 66-73 8577712-1 1996 Transcription from the housekeeping promoter for the acetyl coenzyme A carboxylase (ACC) gene, which encodes the rate-controlling enzyme of fatty acid biosynthesis, is shown to be regulated by cellular sterol levels through novel binding sites for the sterol-sensitive sterol regulatory element binding protein (SREBP)-1 transcription factor. Fatty Acids 140-150 sterol regulatory element binding transcription factor 1 Homo sapiens 312-320 34884968-4 2021 We observed that 5-CQA improved OA-induced intracellular lipid accumulation by downregulating sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FASN) expression, which regulates the fatty acid synthesis, as well as SREBP2 and HMG-CoA reductases (HMG-CoR) expressions, which regulate cholesterol synthesis. Fatty Acids 210-220 sterol regulatory element binding transcription factor 1 Homo sapiens 94-137 23304111-2 2012 Liver PPAR-alpha downregulation with parallel PPAR-gamma and SREBP-1c up-regulation may trigger major metabolic disturbances between de novo lipogenesis and fatty acid oxidation favouring the former, in association with the onset of steatosis in obesity-induced oxidative stress and related long-chain polyunsaturated fatty acid n-3 (LCPUFA n-3) depletion, insulin resistance, hypoadiponectinemia, and endoplasmic reticulum stress. Fatty Acids 157-167 sterol regulatory element binding transcription factor 1 Homo sapiens 61-69 34942305-10 2022 Mechanistically, SETD8, which was posttranslationally stabilized by USP17, could transcriptionally modulate sterol regulatory element-binding protein 1 (SREBP1), a key transcription factor in fatty acid biosynthesis and lipogenesis, by monomethylating the 20th lysine of the H4 histone, elevating lipid biosynthesis and accumulation in RCC and further promoting cancer progression and metastasis. Fatty Acids 192-202 sterol regulatory element binding transcription factor 1 Homo sapiens 108-151 34942305-10 2022 Mechanistically, SETD8, which was posttranslationally stabilized by USP17, could transcriptionally modulate sterol regulatory element-binding protein 1 (SREBP1), a key transcription factor in fatty acid biosynthesis and lipogenesis, by monomethylating the 20th lysine of the H4 histone, elevating lipid biosynthesis and accumulation in RCC and further promoting cancer progression and metastasis. Fatty Acids 192-202 sterol regulatory element binding transcription factor 1 Homo sapiens 153-159 33232284-7 2020 Moreover, the content of phospholipids, triglycerides, neutral lipids and the protein expression levels of fatty acid metabolism related FASN, ACC1 and SREBP1C proteins were significantly increased following down-regulation of FBP1. Fatty Acids 107-117 sterol regulatory element binding transcription factor 1 Homo sapiens 152-159 18068676-1 2008 Sterol regulatory element binding protein (SREBP)-1a is a transcription factor that is highly expressed in actively growing cells, and is involved in the biosynthesis of cholesterol, fatty acids and phospholipids. Fatty Acids 183-194 sterol regulatory element binding transcription factor 1 Homo sapiens 43-52 34884968-4 2021 We observed that 5-CQA improved OA-induced intracellular lipid accumulation by downregulating sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FASN) expression, which regulates the fatty acid synthesis, as well as SREBP2 and HMG-CoA reductases (HMG-CoR) expressions, which regulate cholesterol synthesis. Fatty Acids 210-220 sterol regulatory element binding transcription factor 1 Homo sapiens 139-145 34648812-3 2021 The HIF-1alpha protein upregulated the expression of adipose differentiation-related protein (ADRP), fatty acid synthase (FASN), and sterol regulatory element binding protein 1(SREBP1), while simultaneously downregulating carnitine palmitoyltransferase 1 (CPT1), thereby leading to a more pronounced uptake of lipids and reduced oxidation of fatty acids. Fatty Acids 342-353 sterol regulatory element binding transcription factor 1 Homo sapiens 177-183 34272396-4 2021 Further studies identify sterol regulatory element binding transcription factor 1 (SREBF1) as a central mediator linking TP63 with fatty-acid metabolism, which regulates the biosynthesis of fatty-acids, sphingolipids (SL), and glycerophospholipids (GPL), as revealed by liquid chromatography tandem mass spectrometry (LC-MS/MS)-based lipidomics. Fatty Acids 131-141 sterol regulatory element binding transcription factor 1 Homo sapiens 25-81 34272396-4 2021 Further studies identify sterol regulatory element binding transcription factor 1 (SREBF1) as a central mediator linking TP63 with fatty-acid metabolism, which regulates the biosynthesis of fatty-acids, sphingolipids (SL), and glycerophospholipids (GPL), as revealed by liquid chromatography tandem mass spectrometry (LC-MS/MS)-based lipidomics. Fatty Acids 131-141 sterol regulatory element binding transcription factor 1 Homo sapiens 83-89 34272396-4 2021 Further studies identify sterol regulatory element binding transcription factor 1 (SREBF1) as a central mediator linking TP63 with fatty-acid metabolism, which regulates the biosynthesis of fatty-acids, sphingolipids (SL), and glycerophospholipids (GPL), as revealed by liquid chromatography tandem mass spectrometry (LC-MS/MS)-based lipidomics. Fatty Acids 190-201 sterol regulatory element binding transcription factor 1 Homo sapiens 25-81 34272396-4 2021 Further studies identify sterol regulatory element binding transcription factor 1 (SREBF1) as a central mediator linking TP63 with fatty-acid metabolism, which regulates the biosynthesis of fatty-acids, sphingolipids (SL), and glycerophospholipids (GPL), as revealed by liquid chromatography tandem mass spectrometry (LC-MS/MS)-based lipidomics. Fatty Acids 190-201 sterol regulatory element binding transcription factor 1 Homo sapiens 83-89 35046516-9 2022 The symmetric dimethylation of SREBP1a increases the levels of cholesterol, fatty acid, and triglyceride biogenesis in the cells, escaping degradation through the ubiquitin-proteasome pathway. Fatty Acids 76-86 sterol regulatory element binding transcription factor 1 Homo sapiens 31-38 35634673-20 2022 Conclusion: Hypoxia promotes migration of lung adenocarcinoma A549 cells by regulating fatty acid metabolism through HIF-1alpha/SREBP-1/ACC1 pathway. Fatty Acids 87-97 sterol regulatory element binding transcription factor 1 Homo sapiens 128-135 34900747-3 2021 The transcription factor sterol regulatory element binding protein 1 (SREBP)-1 regulates fatty-acid synthesis but also promotes the proliferation or metastasis of HCC cells. Fatty Acids 89-99 sterol regulatory element binding transcription factor 1 Homo sapiens 25-68 34900747-3 2021 The transcription factor sterol regulatory element binding protein 1 (SREBP)-1 regulates fatty-acid synthesis but also promotes the proliferation or metastasis of HCC cells. Fatty Acids 89-99 sterol regulatory element binding transcription factor 1 Homo sapiens 70-78 34539243-0 2021 The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism. Fatty Acids 102-112 sterol regulatory element binding transcription factor 1 Homo sapiens 35-43 34539243-13 2021 On the contrary, after the knockdown of SREBP-1c, cell proliferation, migration, and invasion were weakened, and fatty acid metabolism was significantly reduced. Fatty Acids 113-123 sterol regulatory element binding transcription factor 1 Homo sapiens 40-48 34539243-17 2021 Conclusion: FoxO1 and SREBP-1c inhibited each other in HB, leading to the increase of intracellular fatty acid metabolism, and ultimately facilitated the development of HB. Fatty Acids 100-110 sterol regulatory element binding transcription factor 1 Homo sapiens 22-30 34531575-0 2021 SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation. Fatty Acids 15-25 sterol regulatory element binding transcription factor 1 Homo sapiens 0-6 34158007-12 2021 Multiple genes in the fatty acid synthesis signaling pathway, including FASN and SREBP1c, were downregulated in PC-knockdown TC cells compared to control cells. Fatty Acids 22-32 sterol regulatory element binding transcription factor 1 Homo sapiens 81-88 35005107-3 2022 FTO overexpression in the liver promotes lipogenesis and lipid droplet (LD) enlargement and suppresses CPT-1-mediated fatty acid oxidation via the SREBP1c pathway, promoting excessive lipid storage and nonalcoholic fatty liver diseases (NAFLD). Fatty Acids 118-128 sterol regulatory element binding transcription factor 1 Homo sapiens 147-154