PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3662526-3 1987 In this communication, we relate the trapping of fatty acids to the synthesis of PGs and the incorporation of [3H]acetate into platelet-activating factor (PAF). Fatty Acids 49-60 PCNA clamp associated factor Homo sapiens 155-158 2826583-1 1987 Human leukocytes generate platelet-activating factor (PAF-acether), a lipid mediator of inflammation, from membrane alkyl phospholipids through the release of arachidonic acid or other fatty acids at the 2-position and subsequent acetylation. Fatty Acids 185-196 PCNA clamp associated factor Homo sapiens 54-57 2826583-6 1987 The changes in PAF-acether release with each fatty acid added in vitro paralleled those in total PAF-acether generation; the percentage PAF-acether release remained unaffected. Fatty Acids 45-55 PCNA clamp associated factor Homo sapiens 15-18 2826583-6 1987 The changes in PAF-acether release with each fatty acid added in vitro paralleled those in total PAF-acether generation; the percentage PAF-acether release remained unaffected. Fatty Acids 45-55 PCNA clamp associated factor Homo sapiens 97-100 2826583-6 1987 The changes in PAF-acether release with each fatty acid added in vitro paralleled those in total PAF-acether generation; the percentage PAF-acether release remained unaffected. Fatty Acids 45-55 PCNA clamp associated factor Homo sapiens 97-100 10751643-1 2000 Stimulated leukocytes generate platelet-activating factor (PAF) from membrane 1-O-alkyl-2-acyl-sn-glycerophosphocholine through hydrolysis of fatty acid and subsequent acetylation at the sn2 position of glycerol. Fatty Acids 142-152 PCNA clamp associated factor Homo sapiens 31-57 3662526-12 1987 The labeled PAF is not released from the cells in either the presence or absence of the trappers, leading us to conclude that BSA causes an increase in acetate-labeled cellular PAF by trapping released fatty acid. Fatty Acids 202-212 PCNA clamp associated factor Homo sapiens 12-15 3662526-12 1987 The labeled PAF is not released from the cells in either the presence or absence of the trappers, leading us to conclude that BSA causes an increase in acetate-labeled cellular PAF by trapping released fatty acid. Fatty Acids 202-212 PCNA clamp associated factor Homo sapiens 177-180 3006836-9 1986 Analysis of the enhancing properties of lipids structurally related to PAF revealed that the critical moiety was the saturated fatty acid at position 1. Fatty Acids 117-137 PCNA clamp associated factor Homo sapiens 71-74 12573364-8 2002 In contrast to sPLA(2), PAF-AH is calcium-independent and is specific for short acyl groups at the sn-2 position of the phospholipid substrate and with the exception of PAF, can equally hydrolyze oxPL to generate lyso-PC and oxidized fatty acids. Fatty Acids 234-245 PCNA clamp associated factor Homo sapiens 24-27 10751643-1 2000 Stimulated leukocytes generate platelet-activating factor (PAF) from membrane 1-O-alkyl-2-acyl-sn-glycerophosphocholine through hydrolysis of fatty acid and subsequent acetylation at the sn2 position of glycerol. Fatty Acids 142-152 PCNA clamp associated factor Homo sapiens 59-62 10751643-2 2000 Since the enzymes involved in the hydrolysis step of PAF biosynthesis have relative selectivity for arachidonic acid (AA), the fatty acid composition of PAF precursors might modulate PAF production. Fatty Acids 127-137 PCNA clamp associated factor Homo sapiens 53-56 10751643-2 2000 Since the enzymes involved in the hydrolysis step of PAF biosynthesis have relative selectivity for arachidonic acid (AA), the fatty acid composition of PAF precursors might modulate PAF production. Fatty Acids 127-137 PCNA clamp associated factor Homo sapiens 153-156 10751643-2 2000 Since the enzymes involved in the hydrolysis step of PAF biosynthesis have relative selectivity for arachidonic acid (AA), the fatty acid composition of PAF precursors might modulate PAF production. Fatty Acids 127-137 PCNA clamp associated factor Homo sapiens 153-156 8645989-3 1996 Intact human blood neutrophils and eosinophils prepared under sterile conditions specifically bound [3H]PAF in the presence of fatty acid-free serum albumin (0.25% BSA). Fatty Acids 127-137 PCNA clamp associated factor Homo sapiens 104-107 8473016-8 1993 The fatty acid cyclo-oxygenase inhibitor, ibuprofen, abolished both the spontaneous and PAF-stimulated generation of prostanoids by eosinophils. Fatty Acids 4-14 PCNA clamp associated factor Homo sapiens 88-91 1819702-3 1991 Chromatographic fractionation of pooled saliva increased the PAF activity 4-fold, and the observed inhibitory activity was found to co-migrate with the fatty acids. Fatty Acids 152-163 PCNA clamp associated factor Homo sapiens 61-64 2240190-11 1990 The control of PAF metabolism is very complex, but acetylhydrolase, Ca2+, phosphorylation/dephosphorylation of enzymes, and fatty acids (especially polyunsaturates) appear to be important regulatory factors. Fatty Acids 124-135 PCNA clamp associated factor Homo sapiens 15-18 8361018-3 1993 Fetal lung has a capacity to produce PAF and this autacoid is involved in glycogen breakdown to furnish both glycerol backbone, such as dihydroxyacetone phosphate and glycerol-3-phosphate, and the fatty acids utilized to synthesize pulmonary surfactant. Fatty Acids 197-208 PCNA clamp associated factor Homo sapiens 37-40 1511005-0 1992 Albumin and fatty acid effects on the stimulated production of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) by human polymorphonuclear leukocytes. Fatty Acids 12-22 PCNA clamp associated factor Homo sapiens 115-118 1511005-1 1992 Production of platelet-activating factor (PAF) during opsonized zymosan stimulation of human polymorphonuclear leukocytes is dependent on the concentration of extracellular albumin and on the presence of exogenous fatty acids. Fatty Acids 214-225 PCNA clamp associated factor Homo sapiens 14-40 1511005-1 1992 Production of platelet-activating factor (PAF) during opsonized zymosan stimulation of human polymorphonuclear leukocytes is dependent on the concentration of extracellular albumin and on the presence of exogenous fatty acids. Fatty Acids 214-225 PCNA clamp associated factor Homo sapiens 42-45 1511005-2 1992 Fatty acid-free albumin caused a concentration-dependent increase in PAF synthesis up to 5% albumin concentrations (w/v) where the amount of PAF produced was three- to four-fold higher than in controls containing no albumin. Fatty Acids 0-10 PCNA clamp associated factor Homo sapiens 69-72 1511005-2 1992 Fatty acid-free albumin caused a concentration-dependent increase in PAF synthesis up to 5% albumin concentrations (w/v) where the amount of PAF produced was three- to four-fold higher than in controls containing no albumin. Fatty Acids 0-10 PCNA clamp associated factor Homo sapiens 141-144 1511005-3 1992 The addition of free fatty acids, particularly arachidonic acid and palmitic acid, to 5% fatty acid-free albumin media caused a concentration-dependent decrease in PAF synthesis. Fatty Acids 21-31 PCNA clamp associated factor Homo sapiens 164-167 1511005-9 1992 The different inhibitory effects of palmitic acid and stearic acid on PAF production may be related to differences in intracellular utilization of these two fatty acids during cell stimulation. Fatty Acids 157-168 PCNA clamp associated factor Homo sapiens 70-73 1525355-3 1992 The fatty acid (which is released by PAF-challenged cells) may mediate PKC movements and thereby contribute to the many Ca(2+)-independent bioactions of PAF. Fatty Acids 4-14 PCNA clamp associated factor Homo sapiens 37-40 1525355-3 1992 The fatty acid (which is released by PAF-challenged cells) may mediate PKC movements and thereby contribute to the many Ca(2+)-independent bioactions of PAF. Fatty Acids 4-14 PCNA clamp associated factor Homo sapiens 153-156