PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23173578-5 2012 Increased expression of fibroblast growth factor-21 (FGF21), a putative mammalian starvation master regulator, promotes many of the same beneficial physiological changes seen in DR animals, including decreased glucose levels, increased insulin sensitivity, and improved fatty acid/lipid profiles. Fatty Acids 270-280 fibroblast growth factor 21 Homo sapiens 24-51 23283237-1 2012 Fibroblast growth factor-21 (FGF21) has therapeutic potential for metabolic syndrome due to positive effects on fatty acid metabolism in liver and white adipose tissue. Fatty Acids 112-122 fibroblast growth factor 21 Homo sapiens 0-27 23283237-1 2012 Fibroblast growth factor-21 (FGF21) has therapeutic potential for metabolic syndrome due to positive effects on fatty acid metabolism in liver and white adipose tissue. Fatty Acids 112-122 fibroblast growth factor 21 Homo sapiens 29-34 23283237-8 2012 Consistent with the glucose-stimulated responses being smaller due to continued fatty acid oxidation, mitochondrial membrane potential was increased in FGF21-treated islets by using the fatty acid transport inhibitor etomoxir. Fatty Acids 80-90 fibroblast growth factor 21 Homo sapiens 152-157 23283237-8 2012 Consistent with the glucose-stimulated responses being smaller due to continued fatty acid oxidation, mitochondrial membrane potential was increased in FGF21-treated islets by using the fatty acid transport inhibitor etomoxir. Fatty Acids 186-196 fibroblast growth factor 21 Homo sapiens 152-157 23173578-5 2012 Increased expression of fibroblast growth factor-21 (FGF21), a putative mammalian starvation master regulator, promotes many of the same beneficial physiological changes seen in DR animals, including decreased glucose levels, increased insulin sensitivity, and improved fatty acid/lipid profiles. Fatty Acids 270-280 fibroblast growth factor 21 Homo sapiens 53-58 22740503-9 2012 Adaptive metabolic responses to fasting, including stimulation of ketogenesis and fatty acid oxidation, seem to be partially mediated by FGF21. Fatty Acids 82-92 fibroblast growth factor 21 Homo sapiens 137-142 21505802-1 2011 Fibroblast growth factor-21 (FGF21) is a hepatic hormone that plays a critical role in metabolism, stimulating fatty acid oxidation in the liver and glucose uptake in adipose tissue. Fatty Acids 111-121 fibroblast growth factor 21 Homo sapiens 0-27 21889884-2 2012 Recent evidence has demonstrated that fibroblast growth factor 21 (FGF21) regulates hepatic lipolysis and fatty acid utilization. Fatty Acids 106-116 fibroblast growth factor 21 Homo sapiens 38-65 21889884-2 2012 Recent evidence has demonstrated that fibroblast growth factor 21 (FGF21) regulates hepatic lipolysis and fatty acid utilization. Fatty Acids 106-116 fibroblast growth factor 21 Homo sapiens 67-72 22529197-12 2012 We speculate that increased serum FGF21 levels during HF overfeeding may be a compensatory response to increase fatty acid oxidation and energy expenditure. Fatty Acids 112-122 fibroblast growth factor 21 Homo sapiens 34-39 21505802-1 2011 Fibroblast growth factor-21 (FGF21) is a hepatic hormone that plays a critical role in metabolism, stimulating fatty acid oxidation in the liver and glucose uptake in adipose tissue. Fatty Acids 111-121 fibroblast growth factor 21 Homo sapiens 29-34 21325103-0 2011 Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans. Fatty Acids 93-104 fibroblast growth factor 21 Homo sapiens 32-59 21325103-7 2011 The effects of fatty acids on hepatic production of FGF21 were determined by using real-time PCR. Fatty Acids 15-26 fibroblast growth factor 21 Homo sapiens 52-57 20332535-2 2010 FGF21 expression is induced by peroxisome proliferator-actived receptor alpha in response to physiological conditions requiring increased fatty acid oxidation. Fatty Acids 138-148 fibroblast growth factor 21 Homo sapiens 0-5 20451522-1 2010 BACKGROUND & AIMS: Fibroblast growth factor 21 (FGF21) is an hepatic protein that plays a critical role in metabolism, stimulating fatty acid oxidation in liver and glucose uptake in fat. Fatty Acids 135-145 fibroblast growth factor 21 Homo sapiens 23-50 20451522-1 2010 BACKGROUND & AIMS: Fibroblast growth factor 21 (FGF21) is an hepatic protein that plays a critical role in metabolism, stimulating fatty acid oxidation in liver and glucose uptake in fat. Fatty Acids 135-145 fibroblast growth factor 21 Homo sapiens 52-57 21448070-12 2011 CONCLUSION: Elevated bile acids and FGF21 may be responsible for the higher hepatic fatty acid oxidation in NASH. Fatty Acids 84-94 fibroblast growth factor 21 Homo sapiens 36-41 17623664-1 2007 The fibroblast growth factor (FGF) 19 subfamily of ligands, FGF19, FGF21, and FGF23, function as hormones that regulate bile acid, fatty acid, glucose, and phosphate metabolism in target organs through activating FGF receptors (FGFR1-4). Fatty Acids 131-141 fibroblast growth factor 21 Homo sapiens 67-72 19401423-3 2009 RESEARCH DESIGN AND METHODS: The effect of fatty acids on FGF-21 was investigated in vitro in HepG2 cells. Fatty Acids 43-54 fibroblast growth factor 21 Homo sapiens 58-64 18460341-5 2008 Via reduced release of fatty acids into the circulation, the anti-lipolytic effect could be a mechanism through which FGF21 promotes insulin sensitivity in man. Fatty Acids 23-34 fibroblast growth factor 21 Homo sapiens 118-123 34732847-2 2022 FGF21 signaling requires co-receptor beta-klotho (KLB) co-acting with FGF receptors, which has pleiotropic metabolic effects, including induced hepatic fatty acid oxidation and ketogenesis, in human and animal models of obesity. Fatty Acids 152-162 fibroblast growth factor 21 Homo sapiens 0-5 34732847-2 2022 FGF21 signaling requires co-receptor beta-klotho (KLB) co-acting with FGF receptors, which has pleiotropic metabolic effects, including induced hepatic fatty acid oxidation and ketogenesis, in human and animal models of obesity. Fatty Acids 152-162 fibroblast growth factor 21 Homo sapiens 70-73 35413740-9 2022 FGF21 stimulates hepatic fatty acid oxidation and reduces lipid flux into the liver by increasing peripheral lipoprotein catabolism and reducing adipocyte lipolysis. Fatty Acids 25-35 fibroblast growth factor 21 Homo sapiens 0-5 34659937-4 2021 Peripheral tissues produce fibroblast growth factor 21 (FGF-21), which has anti-inflammatory properties, increases oxidation of fatty acids, and improves insulin sensitivity. Fatty Acids 128-139 fibroblast growth factor 21 Homo sapiens 27-54 34659937-4 2021 Peripheral tissues produce fibroblast growth factor 21 (FGF-21), which has anti-inflammatory properties, increases oxidation of fatty acids, and improves insulin sensitivity. Fatty Acids 128-139 fibroblast growth factor 21 Homo sapiens 56-62 35183545-4 2022 Fibroblast growth factor 21 is dynamically regulated by nutrients derived from food intake and hepatic/adipose release, which in turn act on the central nervous system, liver, and adipose tissues to influence food preference, hepatic glucose, and adipose fatty acid output. Fatty Acids 255-265 fibroblast growth factor 21 Homo sapiens 0-27 34246859-0 2021 Corrigendum to "Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance" (The Journal of Nutritional Biochemistry 57 (2018) 189-196). Fatty Acids 93-103 fibroblast growth factor 21 Homo sapiens 80-85 34019585-3 2021 FGF21 is expressed and secreted primarily in the liver and adipose tissue, promoting oxidation of glucose/fatty acids and insulin sensitivity. Fatty Acids 106-117 fibroblast growth factor 21 Homo sapiens 0-5 34525916-5 2022 Data reported for hydroxytyrosol suggest that the activation of the hepatic PPAR-alpha-FGF21-AMPK-PGC-1alpha signaling cascade is associated with fatty acid oxidation enhancement, de novo lipogenesis diminution and recovery of mitochondrial function, a contention that is supported by the actions of several polyphenols on specific components of this signaling pathway. Fatty Acids 146-156 fibroblast growth factor 21 Homo sapiens 87-92 33693480-5 2022 Mechanistically, FGF21 promoted brown adipose tissue (BAT) activation and white adipose tissue (WAT) browning, thereby enhancing the selective uptake of fatty acids from triglyceride-rich lipoproteins into BAT and into browned WAT, consequently accelerating the clearance of the cholesterol-enriched remnants by the liver. Fatty Acids 153-164 fibroblast growth factor 21 Homo sapiens 17-22 33693480-6 2022 In addition, FGF21 reduced body fat, ameliorated glucose tolerance and markedly reduced hepatic steatosis, related to upregulated hepatic expression of genes involved in fatty acid oxidation and increased hepatic VLDL-triglyceride secretion. Fatty Acids 170-180 fibroblast growth factor 21 Homo sapiens 13-18 29883971-2 2018 FGF19 controls the enterohepatic bile acid/cholesterol system, and FGF21 modulates fatty acid/glucose metabolism. Fatty Acids 83-93 fibroblast growth factor 21 Homo sapiens 67-72 31413360-3 2019 We tested blood samples from 50 patients with AMI and 43 patients with stable angina pectoris (sAP) for FGF21, fatty acid binding protein 4 (FABP4), a protein secreted from adipocytes in response to adrenergic lipolytic signal, and total and individual fatty acids. Fatty Acids 253-264 fibroblast growth factor 21 Homo sapiens 104-109 31413360-4 2019 Compared with sAP patients, AMI patients had higher serum FGF21 levels on admission, which were significantly correlated with peak FABP4 and saturated fatty acids (SFAs) but not with peak levels of cardiac troponin T. In mice, myocardial ischemia rapidly induced FGF21 production by the heart, which accompanied activation of AMP-activated protein kinase (AMPK)-dependent pathway. Fatty Acids 141-162 fibroblast growth factor 21 Homo sapiens 58-63 33264641-4 2021 The convergence of mouse and human studies shows that FGF21 promotes lipid catabolism, including lipolysis, fatty acid oxidation, mitochondrial oxidative activity, and thermogenic energy dissipation, rather than directly regulating insulin and appetite. Fatty Acids 108-118 fibroblast growth factor 21 Homo sapiens 54-59 31175491-9 2019 Here, we review recent progress on the characteristics of FGF21 in its protective role, especially in pathological processes such as suppressing apoptosis in the myocardium, reducing inflammation in cardiomyocytes, reducing oxidative stress, and promoting fatty acid oxidation. Fatty Acids 256-266 fibroblast growth factor 21 Homo sapiens 58-63 28385800-7 2017 This can lead to enhanced FGF21 expression via elevated fatty acid synthesis, consequent to the inhibition of carnitine/palmitoyl-transferase by malonyl-CoA, and via increased glucose-6-phosphate-mediated activation of the carbohydrate response element binding protein, known to regulate FGF21 gene expression. Fatty Acids 56-66 fibroblast growth factor 21 Homo sapiens 26-31 26341481-3 2015 Moreover, FGF21 protects the myocardium and great arteries by attenuating remodeling, inflammation, oxidative stress and also promoting the energy supply to the heart through fatty acid beta-oxidation. Fatty Acids 175-185 fibroblast growth factor 21 Homo sapiens 10-15 28337713-5 2017 FGF21 also increases fatty acid oxidation. Fatty Acids 21-31 fibroblast growth factor 21 Homo sapiens 0-5 27010621-1 2016 Fibroblast growth factor 21 (FGF21) is an endocrine growth factor, a regulator of fatty acids and glucose metabolism. Fatty Acids 82-93 fibroblast growth factor 21 Homo sapiens 0-27 27010621-1 2016 Fibroblast growth factor 21 (FGF21) is an endocrine growth factor, a regulator of fatty acids and glucose metabolism. Fatty Acids 82-93 fibroblast growth factor 21 Homo sapiens 29-34 23736373-14 2014 Treatment of WA with FGF21-induced UCP1 expression and increased oxygen consumption, respiratory uncoupling, norepinephrine-mediated thermogenesis, fatty acid oxidation and heat production, thus recapitulating the association between cold-induced FGF21 secretion and cold-induced thermogenesis in vivo. Fatty Acids 148-158 fibroblast growth factor 21 Homo sapiens 21-26 25355486-7 2014 In addition, FGF21 treatment down-regulated the hepatic expression of fatty acid synthetic key enzyme, activated hepatic AMPK-SIRT1 pathway and significantly down-regulated hepatic oxidative stress protein. Fatty Acids 70-80 fibroblast growth factor 21 Homo sapiens 13-18 25932355-4 2014 Fibroblast growth factor-21 (FGF21) is a regulator of glucose and fatty acid metabolism in the body but little is known about its action in the brain. Fatty Acids 66-76 fibroblast growth factor 21 Homo sapiens 0-27 25932355-4 2014 Fibroblast growth factor-21 (FGF21) is a regulator of glucose and fatty acid metabolism in the body but little is known about its action in the brain. Fatty Acids 66-76 fibroblast growth factor 21 Homo sapiens 29-34