PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29605434-0 2018 ACSL5 genotype influence on fatty acid metabolism: a cellular, tissue, and whole-body study. Fatty Acids 28-38 acyl-CoA synthetase long chain family member 5 Homo sapiens 0-5 30935113-2 2019 The purpose of these studies was to define the role of ACSL-5 in mitochondrial fatty acid metabolism and the potential effects on insulin action in human skeletal muscle cells (HSKMC). Fatty Acids 79-89 acyl-CoA synthetase long chain family member 5 Homo sapiens 55-61 30935113-9 2019 We concluded that ACSL-5 in human skeletal muscle functions to increase mitochondrial fatty acid oxidation, but contrary to conventional wisdom, is associated with increased free radical production and reduced insulin signaling. Fatty Acids 86-96 acyl-CoA synthetase long chain family member 5 Homo sapiens 18-24 29605434-3 2018 Study objectives were to investigate the effect of rs2419621 genotype and ACSL5 human protein isoforms on fatty acid oxidation and respiration. Fatty Acids 106-116 acyl-CoA synthetase long chain family member 5 Homo sapiens 74-79 29605434-8 2018 RESULTS: In comparison to rs2419621 non-carriers, T allele carriers displayed higher levels of i) 683aa ACSL5 isoform, localized mainly in the mitochondria, playing a greater role in fatty acid oxidation in comparison to the 739aa protein isoform ii) in vitro CO2 production in rectus abdominis primary myotubes iii) in vivo fatty acid oxidation and lower carbohydrate oxidation post-intervention iv) ex vivo complex I and II tissue respiration in vastus lateralis muscle. Fatty Acids 183-193 acyl-CoA synthetase long chain family member 5 Homo sapiens 104-109 29605434-8 2018 RESULTS: In comparison to rs2419621 non-carriers, T allele carriers displayed higher levels of i) 683aa ACSL5 isoform, localized mainly in the mitochondria, playing a greater role in fatty acid oxidation in comparison to the 739aa protein isoform ii) in vitro CO2 production in rectus abdominis primary myotubes iii) in vivo fatty acid oxidation and lower carbohydrate oxidation post-intervention iv) ex vivo complex I and II tissue respiration in vastus lateralis muscle. Fatty Acids 325-335 acyl-CoA synthetase long chain family member 5 Homo sapiens 104-109 29605434-9 2018 CONCLUSIONS: These results support the conclusion that rs2419621 T allele carriers, are more responsive to lifestyle interventions partly due to an increase in the short ACSL5 protein isoform, increasing cellular, tissue and whole-body fatty acid utilization. Fatty Acids 236-246 acyl-CoA synthetase long chain family member 5 Homo sapiens 170-175 18806831-3 2009 Acyl-CoA synthetase 5 (ACSL5) is a member of the ACS family, which converts fatty acid to acyl-CoA. Fatty Acids 76-86 acyl-CoA synthetase long chain family member 5 Homo sapiens 23-28 27189022-0 2016 A splice variant in the ACSL5 gene relates migraine with fatty acid activation in mitochondria. Fatty Acids 57-67 acyl-CoA synthetase long chain family member 5 Homo sapiens 24-29 27539148-11 2016 ACSL5 encodes ACSL5, an enzyme with known roles in fatty acid metabolism. Fatty Acids 51-61 acyl-CoA synthetase long chain family member 5 Homo sapiens 0-5 27539148-11 2016 ACSL5 encodes ACSL5, an enzyme with known roles in fatty acid metabolism. Fatty Acids 51-61 acyl-CoA synthetase long chain family member 5 Homo sapiens 14-19 27124483-6 2016 Syncytializing cells suppress previously active genes that regulate fatty-acid uptake (SLC27A2/FATP2, FABP4, ACSL5) and lipid metabolism (GPAT3, LPCAT3). Fatty Acids 68-78 acyl-CoA synthetase long chain family member 5 Homo sapiens 109-114 20470896-8 2010 We propose that ACSL5 could play a role in promoting fatty acid-induced lipoapoptosis in hepatocytes as important mechanism in fatty liver-related disorders. Fatty Acids 53-63 acyl-CoA synthetase long chain family member 5 Homo sapiens 16-21 18806831-3 2009 Acyl-CoA synthetase 5 (ACSL5) is a member of the ACS family, which converts fatty acid to acyl-CoA. Fatty Acids 76-86 acyl-CoA synthetase long chain family member 5 Homo sapiens 23-26 17761945-6 2007 We further show that overexpression of ACSL3 or ACSL5 alone in the absence of OM led to fatty acid partitioning into beta-oxidation. Fatty Acids 88-98 acyl-CoA synthetase long chain family member 5 Homo sapiens 48-53 17761945-7 2007 Importantly, we demonstrate that transfection of siRNAs targeted to ACSL3 and ACSL5 abrogated the enhancing effect of OM on fatty acid oxidation in HepG2 cells. Fatty Acids 124-134 acyl-CoA synthetase long chain family member 5 Homo sapiens 78-83 17761945-8 2007 CONCLUSIONS: These new findings identify ACSL3 and ACSL5 as OM-regulated genes that function in fatty acid metabolism and suggest a novel cellular mechanism by which OM directly lowers the plasma TG in hyperlipidemic animals through stimulating the transcription of ACSL specific isoforms in the liver. Fatty Acids 96-106 acyl-CoA synthetase long chain family member 5 Homo sapiens 51-56 15285911-3 2004 Long-chain-fatty-acid-CoA ligase 5 (LACS 5) utilizes a wide range of saturated fatty acids with a substrate preference for C16-C18 unsaturated fatty acids. Fatty Acids 69-90 acyl-CoA synthetase long chain family member 5 Homo sapiens 0-34 15285911-3 2004 Long-chain-fatty-acid-CoA ligase 5 (LACS 5) utilizes a wide range of saturated fatty acids with a substrate preference for C16-C18 unsaturated fatty acids. Fatty Acids 69-90 acyl-CoA synthetase long chain family member 5 Homo sapiens 36-42 11127823-9 2000 These results demonstrate a novel fatty acid-induced glioma cell growth mediated by ACS5. Fatty Acids 34-44 acyl-CoA synthetase long chain family member 5 Homo sapiens 84-88 17495181-1 2007 Peroxisome proliferator-activated receptor gamma (PPARgamma) and its response gene, Acyl CoA synthetase 5 (ACSL5), which has an important role in fatty acid metabolism, may affect weight loss in response to caloric restriction. Fatty Acids 146-156 acyl-CoA synthetase long chain family member 5 Homo sapiens 107-112 16263710-2 2006 Of the five mammalian ACSL isoforms cloned and characterized, ACSL5 is the only isoform found to be located, in part, on mitochondria and thus was hypothesized to be involved in fatty acid oxidation. Fatty Acids 178-188 acyl-CoA synthetase long chain family member 5 Homo sapiens 62-67 16241998-2 2005 The enzyme acyl-CoA synthetase 5 (ACS5) plays a crucial role in fatty acid metabolism, mainly through the generation of multifunctional long-chain-fatty-acid-CoA esters. Fatty Acids 64-74 acyl-CoA synthetase long chain family member 5 Homo sapiens 11-32 16241998-2 2005 The enzyme acyl-CoA synthetase 5 (ACS5) plays a crucial role in fatty acid metabolism, mainly through the generation of multifunctional long-chain-fatty-acid-CoA esters. Fatty Acids 64-74 acyl-CoA synthetase long chain family member 5 Homo sapiens 34-38