PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25685286-6 2015 There are several mechanisms through which adiponectin may decrease the risk of type 2 diabetes, including suppression of hepatic gluconeogenesis, stimulation of fatty acid oxidation in the liver, stimulation of fatty acid oxidation and glucose uptake in skeletal muscle, and stimulation of insulin secretion. Fatty Acids 162-172 adiponectin, C1Q and collagen domain containing Homo sapiens 43-54 25685286-6 2015 There are several mechanisms through which adiponectin may decrease the risk of type 2 diabetes, including suppression of hepatic gluconeogenesis, stimulation of fatty acid oxidation in the liver, stimulation of fatty acid oxidation and glucose uptake in skeletal muscle, and stimulation of insulin secretion. Fatty Acids 212-222 adiponectin, C1Q and collagen domain containing Homo sapiens 43-54 25078899-2 2014 Adiponectin is an insulin-sensitizing hormone produced in adipose tissue, directly suppressing hepatic gluconeogenesis, stimulating fatty acid oxidation and glucose uptake in skeletal muscle and insulin secretion. Fatty Acids 132-142 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 25880054-0 2015 Effects of administration of omega-3 fatty acids with or without vitamin E supplementation on adiponectin gene expression in PBMCs and serum adiponectin and adipocyte fatty acid-binding protein levels in male patients with CAD. Fatty Acids 37-47 adiponectin, C1Q and collagen domain containing Homo sapiens 94-105 25232450-10 2014 Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-alpha. Fatty Acids 52-62 adiponectin, C1Q and collagen domain containing Homo sapiens 11-22 25150074-8 2014 There was a significant negative relationship between adiponectin levels and saturated fatty acid intakes in both groups, but the relationship between adiponectin and mono-unsaturated fatty acid intakes was positive and significant only in asthmatic group. Fatty Acids 77-97 adiponectin, C1Q and collagen domain containing Homo sapiens 54-65 24646889-7 2014 Supplementation with palmitic acid, the preliminary end product of fatty acid synthesis, rescues MM cells from adiponectin-induced apoptosis. Fatty Acids 67-77 adiponectin, C1Q and collagen domain containing Homo sapiens 111-122 25108566-1 2014 OBJECTIVE: Adiponectin is known to confer its cardioprotective effects in obesity and type 2 diabetes, mainly by regulating glucose and fatty acid metabolism in cardiomyocytes. Fatty Acids 136-146 adiponectin, C1Q and collagen domain containing Homo sapiens 11-22 25087591-0 2014 Associations of erythrocyte membrane fatty acids with the concentrations of C-reactive protein, interleukin 1 receptor antagonist and adiponectin in 1373 men. Fatty Acids 37-48 adiponectin, C1Q and collagen domain containing Homo sapiens 134-145 25380880-3 2014 Adiponectin modulates certain metabolic processes, including glucose regulation and fatty acid oxidation, and exerts some weight-reduction effects. Fatty Acids 84-94 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 24828613-6 2014 Adiponectin treatment decreased the mRNA and protein levels of enzymes related to hepatic lipogenesis (ACC) and increased those related to fatty acid oxidation (ACOX and CPTI). Fatty Acids 139-149 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 24828613-9 2014 Furthermore, adiponectin-induced upregulation of SHBG production via HNF-4alpha overexpression was abrogated by the inhibition of fatty acid oxidation or by the induction of lipogenesis with a 30mM glucose treatment in HepG2 cells. Fatty Acids 130-140 adiponectin, C1Q and collagen domain containing Homo sapiens 13-24 22668831-0 2012 Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin. Fatty Acids 89-100 adiponectin, C1Q and collagen domain containing Homo sapiens 116-127 24990535-1 2014 Adiponectin is a protein hormone that modulates glucose metabolism and fatty acid oxidation. Fatty Acids 71-81 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 24322911-3 2014 Adiponectin has insulin-sensitizing action and leads to down-regulation of hepatic gluconeogenesis and an increase of fatty acid oxidation. Fatty Acids 118-128 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 24642786-0 2014 Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations. Fatty Acids 0-11 adiponectin, C1Q and collagen domain containing Homo sapiens 112-123 24642786-1 2014 BACKGROUND/OBJECTIVES: Evidence on the association between fatty acids and adiponectin and leptin concentrations is scarce and inconsistent, which may in part be due to limitations of dietary reporting methods. Fatty Acids 59-70 adiponectin, C1Q and collagen domain containing Homo sapiens 75-86 24642786-2 2014 We aimed to estimate the association of fatty acids, derived from a food frequency questionnaire (FFQ) and measured in the erythrocyte membrane, with adiponectin and leptin concentrations. Fatty Acids 40-51 adiponectin, C1Q and collagen domain containing Homo sapiens 150-161 24916550-10 2014 Correlations with specific liver enzymes may indicate that adiponectin levels are tied to fatty acid deposition in the liver; however, liver/kidney damage though further mechanistic clarification is required. Fatty Acids 90-100 adiponectin, C1Q and collagen domain containing Homo sapiens 59-70 24740426-1 2014 BACKGROUND: Adiponectin plays an important role in regulating glucose levels and fatty acid oxidation. Fatty Acids 81-91 adiponectin, C1Q and collagen domain containing Homo sapiens 12-23 24417944-2 2014 Skeletal muscle is an important target tissue for adiponectin where it regulates glucose and fatty acid metabolism directly and via insulin sensitizing effects. Fatty Acids 93-103 adiponectin, C1Q and collagen domain containing Homo sapiens 50-61 23440352-6 2013 In contrast, g-adiponectin significantly increased oleate oxidation (n = 5, p < 0.05), and the effect of g-adiponectin (p < 0.001) on insulin secretion by INS-1E was significantly reduced in the presence of etomoxir (1 mumol/l), an inhibitor of fatty acid beta oxidation. Fatty Acids 251-261 adiponectin, C1Q and collagen domain containing Homo sapiens 15-26 24386594-2 2013 Adiponectin regulates the sensitivity of insulin, fatty acid catabolism, glucose homeostasis and anti-inflammatory system through various mechanisms. Fatty Acids 50-60 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 23594583-0 2013 Saturated fatty acids intake in relation to C-reactive protein, adiponectin, and leptin: a population-based study. Fatty Acids 0-21 adiponectin, C1Q and collagen domain containing Homo sapiens 64-75 23192392-3 2013 Adiponectin, a cytokine secreted from adipose tissue, participates in a number of metabolic processes, including glucose regulation and fatty acid metabolism and involves in a series of complicated diseases from head to toe. Fatty Acids 136-146 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 23317789-6 2013 Adiponectin receptors mediate a wide spectrum of metabolic reactions, including gluconeogenesis and fatty-acid oxidation. Fatty Acids 100-110 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 23168281-3 2012 Some hormones like insulin, thyroid hormones and adipokines (e.g., leptin, adiponectin) have positive effects on muscle mitochondrial bioenergetics through their direct or indirect effects on mitochondrial biogenesis, mitochondrial protein expression, mitochondrial enzyme activities and/or AMPK pathway activation--all of which can improve fatty acid oxidation. Fatty Acids 341-351 adiponectin, C1Q and collagen domain containing Homo sapiens 75-86 22314192-3 2012 Adiponectin"s effects in both liver and muscle are believed to be due in large part to AMP-activated protein kinase (AMPK) activation, resulting in a reduction in hepatic gluconeogenic enzymes and increased fatty acid oxidation and reduced ectopic lipid deposition in muscle. Fatty Acids 207-217 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 22761459-0 2012 Effects of acute and one-week fatty acid lowering on cardiac function and insulin sensitivity in relation with myocardial and muscle fat and adiponectin levels. Fatty Acids 30-40 adiponectin, C1Q and collagen domain containing Homo sapiens 141-152 21931325-1 2012 OBJECTIVE: Adipocytokine genes encoding adiponectin (ADIPOQ) and the leptin receptor (LEPR) affect glucose and fatty acid metabolism. Fatty Acids 111-121 adiponectin, C1Q and collagen domain containing Homo sapiens 40-51 21931325-1 2012 OBJECTIVE: Adipocytokine genes encoding adiponectin (ADIPOQ) and the leptin receptor (LEPR) affect glucose and fatty acid metabolism. Fatty Acids 111-121 adiponectin, C1Q and collagen domain containing Homo sapiens 53-59 22040870-1 2012 Unsaturated fatty acids are ligands of PPAR-gamma, which up-regulates genes involved in fatty acid transport and TAG synthesis and the insulin-sensitising adipokine adiponectin, which activates fatty acid beta-oxidation via PPAR-alpha action in liver. Fatty Acids 12-22 adiponectin, C1Q and collagen domain containing Homo sapiens 165-176 22450341-8 2012 Adiponectin increases fatty acids oxidation, which lowers circulating free fatty acids and prevents insulin resistance. Fatty Acids 22-33 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 22876922-2 2012 The main insulin-sensitizing action of adiponectin results from decrease in hepatic gluconeogenesis and increase in muscle glucose transport and, secondly from enhancement of energy consumption and fatty acid oxidation in peripheral tissues with the aim of increasing ATP production. Fatty Acids 198-208 adiponectin, C1Q and collagen domain containing Homo sapiens 39-50 23017712-4 2012 Adiponectin expression and serum levels are associated with the amount and type of fatty acids and carbohydrate consumed. Fatty Acids 83-94 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 23017722-5 2012 Adiponectin is the most abundantly secreted protein from adipose tissue and has been shown to decrease hepatic glucose production, increase fatty acid oxidation in liver and skeletal muscle, and decrease vascular inflammation. Fatty Acids 140-150 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 21852205-2 2011 Adiponectin, an adipokine secreted from adipose tissue, plays an important role in fatty acid and glucose metabolism. Fatty Acids 83-93 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 21284979-1 2011 Adiponectin and its receptors, AdipoR1 and AdipoR2, regulate glucose and fatty acid metabolism partly via activation of AMP-activated protein kinase (AMPK). Fatty Acids 73-83 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 20876611-1 2010 Adiponectin is an adipocyte-secreted protein involved in a variety of metabolic processes, including glucose regulation and fatty acid catabolism. Fatty Acids 124-134 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 20435456-9 2011 Adiponectin-mediated adenosine monophosphate (AMP) kinase phosphorylation, peroxisome proliferator-activator receptor-alpha expression and the expression of genes involved in fatty acid oxidation were elevated in both liver and muscle (P<.05). Fatty Acids 175-185 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 20814411-1 2011 Adiponectin, an anti-inflammatory and insulin-sensitizing protein secreted from adipose tissue, may be modulated by dietary fatty acids, although the mechanism is not fully known. Fatty Acids 124-135 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 20945960-1 2011 Adiponectin is an adipokine increasing glucose and fatty acid metabolism and improving insulin sensitivity. Fatty Acids 51-61 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 20802503-4 2010 Adiponectin (APN) is an insulin-sensitizing adipokine known to stimulate skeletal muscle fatty acid (FA) oxidation and reduce lipid accumulation. Fatty Acids 89-99 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 20960377-6 2010 Fatty acid oxidation, through effects on AMP-activated protein kinase (AMPK), adiponectin, peroxisome proliferator-activated receptors (PPARs), and mitochondrial function is predominantly altered in alcoholic liver disease, although studies suggest that activation of this pathway may improve nonalcoholic fatty liver disease. Fatty Acids 0-10 adiponectin, C1Q and collagen domain containing Homo sapiens 78-89 20802503-4 2010 Adiponectin (APN) is an insulin-sensitizing adipokine known to stimulate skeletal muscle fatty acid (FA) oxidation and reduce lipid accumulation. Fatty Acids 89-99 adiponectin, C1Q and collagen domain containing Homo sapiens 13-16 20519115-1 2010 Adiponectin and its receptors, AdipoR1 and AdipoR2, regulate glucose and fatty acid metabolism via activation of AMP-activated protein kinase. Fatty Acids 73-83 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 19716279-1 2009 Adiponectin regulates energy homeostasis through the modulation of glucose and fatty acid metabolism in peripheral tissues. Fatty Acids 79-89 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 20237168-0 2010 Plasma fatty acids and desaturase activity are associated with circulating adiponectin in healthy adolescent girls. Fatty Acids 7-18 adiponectin, C1Q and collagen domain containing Homo sapiens 75-86 20237168-2 2010 OBJECTIVE: The objective of the study was to evaluate the association of adiponectin concentrations with plasma fatty acids and indices of endogenous fatty acid metabolism. Fatty Acids 112-123 adiponectin, C1Q and collagen domain containing Homo sapiens 73-84 20237168-2 2010 OBJECTIVE: The objective of the study was to evaluate the association of adiponectin concentrations with plasma fatty acids and indices of endogenous fatty acid metabolism. Fatty Acids 112-122 adiponectin, C1Q and collagen domain containing Homo sapiens 73-84 20237168-10 2010 CONCLUSIONS: Adiponectin, an inverse marker of metabolic derangements, was associated with desaturase activity, indicating that possible functional alterations in fatty acid metabolism may already be present in young healthy adolescent females. Fatty Acids 163-173 adiponectin, C1Q and collagen domain containing Homo sapiens 13-24 19723556-6 2010 Adiponectin acts to increase insulin sensitivity, fatty acid oxidation, as well as energy expenditure and reduces the production of glucose by the liver. Fatty Acids 50-60 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 20032495-0 2010 Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Fatty Acids 129-150 adiponectin, C1Q and collagen domain containing Homo sapiens 89-95 20032495-3 2010 OBJECTIVE: Gene-nutrient interactions were examined in MetS subjects to determine interactions between single nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and its receptors (ADIPOR1 and ADIPOR2) and plasma fatty acid composition and their effects on MetS characteristics. Fatty Acids 226-236 adiponectin, C1Q and collagen domain containing Homo sapiens 149-160 20032495-3 2010 OBJECTIVE: Gene-nutrient interactions were examined in MetS subjects to determine interactions between single nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and its receptors (ADIPOR1 and ADIPOR2) and plasma fatty acid composition and their effects on MetS characteristics. Fatty Acids 226-236 adiponectin, C1Q and collagen domain containing Homo sapiens 167-173 20356535-0 2010 [Relationship of adipocyte fatty acid-binding protein to adiponectin ratio with femoral intima-media thickness and endothelium-dependent vasodilation in patients with newly-diagnosed type 2 diabetes mellitus]. Fatty Acids 27-37 adiponectin, C1Q and collagen domain containing Homo sapiens 57-68 19448705-4 2009 Leptin and adiponectin have each been shown to increase fatty acid (FA) oxidation and decrease triglyceride storage in muscle, which may explain, in part, the insulin-sensitizing effect of these cytokines. Fatty Acids 56-66 adiponectin, C1Q and collagen domain containing Homo sapiens 11-22 19874712-7 2009 Further experiments demonstrated that adiponectin can suppress lipid accumulation by increasing fatty acid oxidation during C2C12 myogenesis. Fatty Acids 96-106 adiponectin, C1Q and collagen domain containing Homo sapiens 38-49 31569855-5 2009 The review illustrates the involvement of main adipokines in pathogenesis of DM2 and provides a detailed description of such factors as impaired adiponectin and stimulation of cytokine production responsible for metabolic disorders, activation of lipolysis, in adipocytes, increased fatty acid and triglyceride levels, suppression of insulin activity at the receptor and intracellular levels. Fatty Acids 283-293 adiponectin, C1Q and collagen domain containing Homo sapiens 145-156 19722015-4 2009 However, the long-term or short-term high fat diets, especially rich in saturated fatty acids, probably by activation of toll-like receptors, stimulated the expression of proinflammatory adipokines and inhibited adiponectin expression. Fatty Acids 72-93 adiponectin, C1Q and collagen domain containing Homo sapiens 212-223 19886515-1 2009 Adiponectin one of the cytokines secreted by the adipose tissue that regulates the energetic metabolism through glucose and insulin interactions, stimulates the oxidation of fatty acids, reduces the plasmatic triglycerides and improves glucose metabolism by increasing insulin sensibility. Fatty Acids 174-185 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 19290887-3 2009 The present study examined adiponectin-mediated protection against saturated fatty acid-induced apoptosis in the human hepatoma cell line, HepG2. Fatty Acids 67-87 adiponectin, C1Q and collagen domain containing Homo sapiens 27-38 19290887-11 2009 These data suggest that adiponectin is an important determinant of saturated fatty acid-induced apoptosis in liver cells and may have implications for fatty acid-mediated liver cell injury in adiponectin-deficient individuals. Fatty Acids 67-87 adiponectin, C1Q and collagen domain containing Homo sapiens 24-35 19290887-11 2009 These data suggest that adiponectin is an important determinant of saturated fatty acid-induced apoptosis in liver cells and may have implications for fatty acid-mediated liver cell injury in adiponectin-deficient individuals. Fatty Acids 77-87 adiponectin, C1Q and collagen domain containing Homo sapiens 24-35 19217762-0 2009 Fatty acid uptake by breast cancer cells (MDA-MB-231): effects of insulin, leptin, adiponectin, and TNFalpha. Fatty Acids 0-10 adiponectin, C1Q and collagen domain containing Homo sapiens 83-94 21694920-3 2009 Insulin resistance from excess fatty acids is exacerbated by decreased secretion of high molecular weight adiponectin from adipose cells in the obese state. Fatty Acids 31-42 adiponectin, C1Q and collagen domain containing Homo sapiens 106-117 18472252-12 2009 A reduction in insulin sensitivity and its impact on adiponectin concentration could be linked to high non-esterified fatty acid levels, increased triglyceride synthesis in the liver and impaired catabolism of triglyceride-rich lipoproteins. Fatty Acids 118-128 adiponectin, C1Q and collagen domain containing Homo sapiens 53-64 21694920-10 2009 Fatty acid accumulation and resistin inhibit insulin and adiponectin. Fatty Acids 0-10 adiponectin, C1Q and collagen domain containing Homo sapiens 57-68 17700650-0 2008 Nutritional intervention to reduce the n-6/n-3 fatty acid ratio increases adiponectin concentration and fatty acid oxidation in healthy subjects. Fatty Acids 47-57 adiponectin, C1Q and collagen domain containing Homo sapiens 74-85 19702116-6 2009 Lipid metabolism alterations in liver and peripheral tissues are addressed, with particular reference to adipose and muscle tissues, and the mechanisms by which some adipokines, namely leptin and adiponectin, mediate the regulation of fatty acid oxidation in those tissues. Fatty Acids 235-245 adiponectin, C1Q and collagen domain containing Homo sapiens 196-207 18163210-2 2008 In addition to its effects on glucose and fatty acid metabolism, it has been reported that adiponectin has a direct growth-inhibitory effect on breast cancer cells. Fatty Acids 42-52 adiponectin, C1Q and collagen domain containing Homo sapiens 91-102 19227810-6 2008 In the liver, adiponectin modulates lipid and energy metabolism, stimulating fatty acid catabolism and reducing gluconeogenesis. Fatty Acids 77-87 adiponectin, C1Q and collagen domain containing Homo sapiens 14-25 18054196-2 2008 Its functions in regulating glucose utilization and fatty acid metabolism in mammals are mediated by two subtypes of adiponectin receptors (AdipoR1 and AdipoR2). Fatty Acids 52-62 adiponectin, C1Q and collagen domain containing Homo sapiens 117-128 18239552-1 2008 OBJECTIVE: Little is known about the effects of alterations in fatty acid classes on adiponectin, a hormone secreted by the adipocyte known to be important in the development of diabetes and cardiovascular disease (CVD). Fatty Acids 63-73 adiponectin, C1Q and collagen domain containing Homo sapiens 85-96 19046738-2 2008 The adipocyte-derived cytokine, adiponectin, has been shown to improve insulin sensitivity, increase rates of fatty acid oxidation, decrease muscle lipid content, and reduce inflammation and vascular injury. Fatty Acids 110-120 adiponectin, C1Q and collagen domain containing Homo sapiens 32-43 18262390-3 2008 We investigated acute effects of a high-fat load and changes in fatty acid saturation on circulating adiponectin and associated mediators of inflammation including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP). Fatty Acids 64-74 adiponectin, C1Q and collagen domain containing Homo sapiens 101-112 17803698-8 2008 Delta-total adiponectin levels correlated positively with the rate of Delta-insulin-stimulated glucose disposal (R(d)) (r = 0.89) and Delta-oxidative glucose metabolism (r = 0.71) and inversely with Delta-fasting free fatty acid (FFA) levels (r = -0.69) and Delta-lipid oxidation (r = -0.73) during insulin stimulation (all P < 0.01). Fatty Acids 218-228 adiponectin, C1Q and collagen domain containing Homo sapiens 12-23 18184112-4 2008 Lipid metabolism alterations in liver and peripheral tissues are addressed, with particular reference to adipose and muscle tissues, and the mechanisms by which some adipokines, namely leptin and adiponectin, mediate the regulation of fatty acid oxidation in those tissues. Fatty Acids 235-245 adiponectin, C1Q and collagen domain containing Homo sapiens 196-207 17940701-1 2007 Adiponectin, derived mainly from white adipose tissue, regulates glucose and fatty acid metabolism and has anti-inflammatory and anti-atherosclerotic properties. Fatty Acids 77-87 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 17966120-4 2007 Interestingly, the insulin-sensitizing effects of exercise have similar metabolic effects as adiponectin in that exercise also promotes glucose uptake into muscle and increases rates of fatty acid oxidation. Fatty Acids 186-196 adiponectin, C1Q and collagen domain containing Homo sapiens 93-104 17940701-5 2007 Adiponectin activates AMPK phosphorylation and then promotes ATP-generating pathways in heart, including glucose transport, glycolysis, and fatty acid oxidation. Fatty Acids 140-150 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 17909707-1 2007 Adiponectin is known to play a role in fatty acid and glucose metabolism through a change in insulin sensitivity and activation of fuel oxidation by AMP-activated protein kinase. Fatty Acids 39-49 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 18059213-4 2007 Low adiponectin secretion is a hallmark of impaired adipocyte function; its secretion is inhibited by cytokines such as tumor necrosis factor alpha, interleukin 6 and plasminogen activator inhibitor 1 and by high oxidative stress induced by increased fatty acids that activate nicotinamide adenine dinucleotide phosphate-oxidase. Fatty Acids 251-262 adiponectin, C1Q and collagen domain containing Homo sapiens 4-15 17356008-2 2007 Adiponectin (Ad) stimulates fatty acid (FA) oxidation and improves insulin sensitivity in humans and rodents, due in part to the activation of AMP-activated protein kinase (AMPK) and subsequent deactivation of acetyl coenzyme A carboxylase (ACC). Fatty Acids 28-38 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 17577393-8 2007 Preventing abnormal hepatic methionine metabolism by supplementing ethanol diets with SAM reduces liver triglyceride levels by up-regulation of adiponectin-mediated pathways to decrease fatty acid and triglyceride synthesis. Fatty Acids 186-196 adiponectin, C1Q and collagen domain containing Homo sapiens 144-155 17499232-0 2007 Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes. Fatty Acids 86-96 adiponectin, C1Q and collagen domain containing Homo sapiens 34-45 17499232-1 2007 OBJECTIVE: Our aim was to investigate the regulation of glucose and fatty acid metabolism in cardiomyocytes by the globular (gAd) and full-length (fAd) forms of adiponectin. Fatty Acids 68-78 adiponectin, C1Q and collagen domain containing Homo sapiens 161-172 17201694-1 2007 Adiponectin is involved in the regulation of glucose and fatty acid metabolism, influences whole-body insulin sensitivity and protects arterial walls against the development of atherosclerosis. Fatty Acids 57-67 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 17786081-2 2007 Acting through 2 distinct membrane receptors, adiponectin receptors 1 and 2 (which utilize 5"-adenosine monophosphate-activated protein kinase phosphorylation, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha as key cell signaling elements), adiponectin increases hepatic and skeletal muscle sensitivity to insulin, enhances fatty acid oxidation, suppresses monocyte-endothelial interaction, supports endothelial cell growth, lowers blood pressure, and moderates adipose tissue growth. Fatty Acids 367-377 adiponectin, C1Q and collagen domain containing Homo sapiens 46-57 17598332-10 2007 (2) Indian T2DM patients with normal or low BMI have increased UCP2 and UCP3 expession in their muscle, as well as increased high molecular weight adiponectin which promote fatty acid oxidation and prevent obesity. Fatty Acids 173-183 adiponectin, C1Q and collagen domain containing Homo sapiens 147-158 17608265-1 2007 BACKGROUND: The aim of this study was to examine the relationship between adiponectin plasma circulating levels and its gene expression in two abdominal fat depots (subcutaneous and visceral) with the fatty acid composition of plasma and adipose tissue in morbidly obese subjects. Fatty Acids 201-211 adiponectin, C1Q and collagen domain containing Homo sapiens 74-85 17608265-8 2007 The visceral depot showed greater statistical associations between adiponectin gene expression and fatty acids profile, being saturated fatty acids associated with a decrease (r=-0.68, P=0.015), whereas monounsaturated were related to an increase in this adipose region (r=0.67, P=0.017). Fatty Acids 99-110 adiponectin, C1Q and collagen domain containing Homo sapiens 67-78 17608265-8 2007 The visceral depot showed greater statistical associations between adiponectin gene expression and fatty acids profile, being saturated fatty acids associated with a decrease (r=-0.68, P=0.015), whereas monounsaturated were related to an increase in this adipose region (r=0.67, P=0.017). Fatty Acids 126-147 adiponectin, C1Q and collagen domain containing Homo sapiens 67-78 17608265-9 2007 CONCLUSIONS: We demonstrated significant associations between adipose tissue adiponectin gene expression and fatty acid composition. Fatty Acids 109-119 adiponectin, C1Q and collagen domain containing Homo sapiens 77-88 18333368-7 2007 It was recently shown that adipocyte synthesized adiponectin reduces the release of fatty acids from the adipose tissue and would also enhance their uptake and oxidation in the muscle, thereby limiting their uptake in the liver. Fatty Acids 84-95 adiponectin, C1Q and collagen domain containing Homo sapiens 49-60 17209173-1 2007 BACKGROUND: Despite adiponectin"s presumed role in fatty acid oxidation and energy homeostasis, little is known about the effect of gene variants on substrate oxidation, energy expenditure, and adiposity-related phenotypes. Fatty Acids 51-61 adiponectin, C1Q and collagen domain containing Homo sapiens 20-31 16584505-5 2006 Other adipokines like adiponectin and leptin, at least in physiological concentrations, are insulin sparing as they stimulate beta oxidation of fatty acids in skeletal muscle. Fatty Acids 144-155 adiponectin, C1Q and collagen domain containing Homo sapiens 22-33 17130638-6 2006 Adiponectin enhances fatty acid oxidation and insulin sensitivity, in part by stimulating AMP-activated protein kinase phosphorylation and activity in liver and muscle. Fatty Acids 21-31 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 17016629-9 2006 This process is associated with a lower concentration of adiponectin that in turn regulates the catabolism of VLDL and HDL; consequently increasing the flow of fatty acids from the adipose tissue to the liver and muscles. Fatty Acids 160-171 adiponectin, C1Q and collagen domain containing Homo sapiens 57-68 17228091-1 2006 Adiponectin, an adipocyte-derived plasma protein, has been shown to play an important role in the regulation of fatty acid and glucose metabolism. Fatty Acids 112-122 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 17228091-2 2006 Adiponectin enhances fatty acid oxidation both in skeletal and cardiac muscle as well as in the liver, thus reducing triglyceride content in these tissues. Fatty Acids 21-31 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 16936205-0 2006 Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Fatty Acids 22-32 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 16936205-2 2006 One of the mechanisms through which adiponectin exerts such effects involves an increase in fatty acid oxidation in muscle and liver. Fatty Acids 92-102 adiponectin, C1Q and collagen domain containing Homo sapiens 36-47 16936205-8 2006 Taken together, these results suggest that adiponectin stimulates fatty acid oxidation in muscle cells by the sequential activation of AMPK, p38 MAPK, and PPARalpha. Fatty Acids 66-76 adiponectin, C1Q and collagen domain containing Homo sapiens 43-54 17021375-10 2006 Administration of adiponectin in the brain recapitulates the peripheral actions to increase fatty acid oxidation and insulin sensitivity and reduce glucose. Fatty Acids 92-102 adiponectin, C1Q and collagen domain containing Homo sapiens 18-29 17021375-13 2006 Furthermore, adiponectin stimulates fatty acid oxidation and reduces glucose and lipids, at least in part, by activating AMPK in muscle and liver. Fatty Acids 36-46 adiponectin, C1Q and collagen domain containing Homo sapiens 13-24 16463046-8 2006 CONCLUSIONS/INTERPRETATION: We propose that the metabolic effect of insulin resistance, partly mediated by depressed plasma adiponectin levels, increases fatty acid flux from adipose tissue to the liver and induces the accumulation of fat in the liver. Fatty Acids 154-164 adiponectin, C1Q and collagen domain containing Homo sapiens 124-135 16613757-18 2006 Adiponectin inhibits liver neoglucogenesis and promotes fatty acid oxidation in skeletal muscle. Fatty Acids 56-66 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 19804051-6 2005 It is known that adiponectin is an important regulator of hepatic and muscle fatty acid oxidation. Fatty Acids 77-87 adiponectin, C1Q and collagen domain containing Homo sapiens 17-28 16055297-2 2006 Adiponectin receptors (adipoR1 and adipoR2) are recently found in mice which act as receptors for globular and full-length adiponectin to mediate the fatty-acid oxidation and glucose uptake in muscle and liver. Fatty Acids 150-160 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 16497175-4 2006 Adiponectin and leptin have each been demonstrated to increase rates of fatty acid (FA) oxidation and decrease muscle lipid content, which may in part be the underlying mechanism to their insulin sensitizing effect. Fatty Acids 72-82 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 15769985-0 2005 Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics. Fatty Acids 38-48 adiponectin, C1Q and collagen domain containing Homo sapiens 71-82 16249439-0 2005 The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects. Fatty Acids 88-98 adiponectin, C1Q and collagen domain containing Homo sapiens 35-46 16249439-3 2005 Therefore, we examined whether the globular head of adiponectin, gAcrp30, acutely activates fatty acid oxidation and glucose uptake in isolated human skeletal muscle. Fatty Acids 92-102 adiponectin, C1Q and collagen domain containing Homo sapiens 52-63 16140297-5 2005 Exogenous adiponectin enhanced glucose and fatty acid uptake and induced AMPK phosphorylation in cultured cardiomyocytes. Fatty Acids 43-53 adiponectin, C1Q and collagen domain containing Homo sapiens 10-21 15769985-2 2005 In rodent skeletal muscle, globular adiponectin (gAD) activates AMP-kinase (AMPK) and stimulates fatty acid oxidation effects mediated through the adiponectin receptors, AdipoR1 and AdipoR2. Fatty Acids 97-107 adiponectin, C1Q and collagen domain containing Homo sapiens 36-47 15949695-5 2005 Fatty acids may influence the expression of adipokines like leptin, resistin or adiponectin directly by interaction with transcription factors, or indirectly via unknown mechanisms possibly linked to fatty acid oxidation, synthesis or storage. Fatty Acids 0-11 adiponectin, C1Q and collagen domain containing Homo sapiens 80-91 15637134-4 2005 RESULTS: The proportion of saturated fatty acids in plasma was significantly associated with circulating adiponectin concentration (r = -0.24; P = 0.01). Fatty Acids 27-48 adiponectin, C1Q and collagen domain containing Homo sapiens 105-116 15766512-2 2005 Adiponectin stimulates fatty acids oxidation, reduces plasma triglycerides, and improves glucose metabolism by increasing the insulin sensitivity. Fatty Acids 23-34 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 15637134-12 2005 CONCLUSIONS: Saturated and omega-3 fatty acids of dietary origin (as inferred from plasma fatty acid concentration) are associated with circulating adiponectin concentrations in healthy humans. Fatty Acids 35-45 adiponectin, C1Q and collagen domain containing Homo sapiens 148-159 15650029-7 2005 In multivariate regression including HOMA, age, nonesterified fatty acids, and adipose tissue compartment, adiponectin was an independent predictor of plasma apoB-48 (beta coefficient = -0.354; P = 0.048), apoC-III (beta coefficient = -0.406; P = 0.012), RLP-cholesterol (beta coefficient = -0.377; P = 0.016), and triglycerides (beta coefficient = -0.374; P = 0.013). Fatty Acids 62-73 adiponectin, C1Q and collagen domain containing Homo sapiens 107-118 15826474-1 2005 BACKGROUND: The authors evaluated whether adipose adiponectin expression is related to adipose tissue lipolytic activity and fatty acid oxidation rate in lean and obese women. Fatty Acids 125-135 adiponectin, C1Q and collagen domain containing Homo sapiens 50-61 15826474-13 2005 CONCLUSIONS: Low adipose tissue adiponectin expression observed in obese people may contribute to the progression of obesity and its co-morbidities by modulating hormone-sensitive lipase activity and fatty acid oxidation. Fatty Acids 200-210 adiponectin, C1Q and collagen domain containing Homo sapiens 32-43 15127202-0 2004 Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of Type 2 diabetic patients. Fatty Acids 27-37 adiponectin, C1Q and collagen domain containing Homo sapiens 59-70 15655035-8 2005 The primary mechanisms by which adiponectin enhance insulin sensitivity appears to be through increased fatty acid oxidation and inhibition of hepatic glucose production. Fatty Acids 104-114 adiponectin, C1Q and collagen domain containing Homo sapiens 32-43 16232373-4 2005 Adiponectin accelerates the oxidation process of fatty acids in muscle cells, reduces triglycerides plasma concentration. Fatty Acids 49-60 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 15544426-2 2005 Adiponectin, abundantly present in the plasma increases insulin sensitivity by stimulating fatty acid oxidation, decreases plasma triglycerides and improves glucose metabolism. Fatty Acids 91-101 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 15380884-4 2004 The aim of this study is to provide an overview of the metabolic alterations occurring in insulin resistance as well as to review the biological roles of adiponectin, particularly in the regulation of fatty acid oxidation and insulin action. Fatty Acids 201-211 adiponectin, C1Q and collagen domain containing Homo sapiens 154-165 15380884-7 2004 Low levels of adiponectin decreases fatty acid oxidation in muscle. Fatty Acids 36-46 adiponectin, C1Q and collagen domain containing Homo sapiens 14-25 15380884-8 2004 Recent data have demonstrated that adiponectin effects are mediated by the interaction with muscle and hepatic receptors through activation of AMP kinase, the cellular "fuel gauge", which in turn inhibits acetyl CoA carboxylase and increases fatty acid beta-oxidation. Fatty Acids 242-252 adiponectin, C1Q and collagen domain containing Homo sapiens 35-46 15277397-1 2004 Considerable data support adiponectin as an important adipose-derived insulin sensitizer that enhances fatty acid oxidation and alters hepatic gluconeogenesis. Fatty Acids 103-113 adiponectin, C1Q and collagen domain containing Homo sapiens 26-37 15379417-1 2004 Adiponectin is an adipocyte secreted protein that has been reported to increase fatty acid oxidation and improve insulin sensitivity. Fatty Acids 80-90 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 15163922-5 2004 Adiponectin improves insulin sensitivity in skeletal muscle and liver, through a stimulation of fatty acid oxidation and glucose utilization. Fatty Acids 96-106 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 15294059-3 2004 Among the hormones it releases are adiponectin and leptin, both of which can activate AMP-activated protein kinase and increase fatty acid oxidation in skeletal muscle and probably other tissues. Fatty Acids 128-138 adiponectin, C1Q and collagen domain containing Homo sapiens 35-46 15029093-5 2004 Conversely, leptin and adiponectin both exert an insulin-sensitizing effect, at least in part, by favoring tIssue fatty-acId oxIdation through activation of AMP-activated kinase. Fatty Acids 114-124 adiponectin, C1Q and collagen domain containing Homo sapiens 23-34 15599338-1 2004 Adiponectin, an adipocyte-secreted protein encoded by the ACDC gene (also known as APM1), has been shown to play an important role in the regulation of fatty acid and glucose metabolism in liver and muscle, where it modulates insulin sensitivity. Fatty Acids 152-162 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 15599338-1 2004 Adiponectin, an adipocyte-secreted protein encoded by the ACDC gene (also known as APM1), has been shown to play an important role in the regulation of fatty acid and glucose metabolism in liver and muscle, where it modulates insulin sensitivity. Fatty Acids 152-162 adiponectin, C1Q and collagen domain containing Homo sapiens 58-62 15599338-1 2004 Adiponectin, an adipocyte-secreted protein encoded by the ACDC gene (also known as APM1), has been shown to play an important role in the regulation of fatty acid and glucose metabolism in liver and muscle, where it modulates insulin sensitivity. Fatty Acids 152-162 adiponectin, C1Q and collagen domain containing Homo sapiens 83-87 15599338-2 2004 Adiponectin enhances fatty acid oxidation in liver and muscle, thus reducing triglyceride content in these tissues. Fatty Acids 21-31 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 14641017-5 2003 Conversely, leptin and adiponectin exert an insulin-sensitizing effect, at least in part by favouring tissue fatty-acid oxidation through AMP-activated kinase activation. Fatty Acids 109-119 adiponectin, C1Q and collagen domain containing Homo sapiens 23-34 12833108-1 2003 OBJECTIVE: Adiponectin is an adipose-specific protein with short-term effects in vivo on glucose and fatty acid levels. Fatty Acids 101-111 adiponectin, C1Q and collagen domain containing Homo sapiens 11-22 12769732-2 2003 Administration of recombinant adiponectin in rodents increases glucose uptake and increases fat oxidation in muscle, reduces fatty acid uptake and hepatic glucose production in liver, and improves whole body insulin resistance. Fatty Acids 125-135 adiponectin, C1Q and collagen domain containing Homo sapiens 30-41 12611609-11 2003 Adiponectin increases insulin sensitivity by increasing tIssue fat oxidation, resulting in reduced circulating fatty acid levels and reduced intracellular triglyceride contents in liver and muscle. Fatty Acids 111-121 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 12368907-0 2002 Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Fatty Acids 47-57 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 12601307-4 2003 Adiponectin stimulates fatty acids oxidation, decreases plasma triglycerides, and improves glucose metabolism by increasing insulin sensitivity. Fatty Acids 23-34 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 11790963-10 2002 Adiponectin increases insulin sensitivity, perhaps by increasing tissue fat oxidation resulting in reduced circulating fatty acid levels and reduced intramyocellular or liver triglyceride content. Fatty Acids 119-129 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 34113999-11 2021 Feature ratios of several fatty acids-myristic acid (m/z 227.2018, retention time (RT) 229), heptadecanoic acid (m/z 269.2491, RT 276), linoleic acid (m/z 280.2358, RT 236)-were negatively correlated with fasting plasma concentrations of leptin (nanograms per milliliter) and adiponectin (micrograms per milliliter), respectively (all P < 0.05). Fatty Acids 26-37 adiponectin, C1Q and collagen domain containing Homo sapiens 276-287 25831109-14 2015 The ratios suggest a minor proportion of adiponectin and resistin in relation to the fatty acids in patients with generalized chronic periodontitis. Fatty Acids 85-96 adiponectin, C1Q and collagen domain containing Homo sapiens 41-52 34423393-4 2021 We aimed to investigate whether adiponectin overexpression in skeletal muscle might be a local protective mechanism, favoring fatty acid utilization. Fatty Acids 126-136 adiponectin, C1Q and collagen domain containing Homo sapiens 32-43 34423393-7 2021 Adiponectin overexpression remarkably upregulated the mRNA level of myogenic regulatory factors as well as genes implicated in lipolysis (HSL, ATGL) and cellular and mitochondrial fatty acid transport (LPL, CD36, CPT1B). Fatty Acids 180-190 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 34471717-3 2021 Adiponectin is an adipocyte derived protein hormone that enhances insulin sensitivity and ameliorates diabetes by enhancing fatty acid oxidation and glucose uptake in skeletal muscle and reducing glucose production in the liver. Fatty Acids 124-134 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 35056647-4 2022 Leptin and adiponectin increase fatty acid oxidation, prevent foam cell formation, and improve lipid metabolism, while visfatin, fetuin-A, PAI-1, and resistin have pro-atherogenic properties. Fatty Acids 32-42 adiponectin, C1Q and collagen domain containing Homo sapiens 11-22 34981470-6 2021 Adiponectin directly increases insulin sensitivity and reduces obesity-related insulin resistance by down-regulating hepatic glucose production and increasing fatty acid (FA) oxidation in skeletal muscle. Fatty Acids 159-169 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 35024685-3 2022 Emerging evidence highlights that hypertrophied adipocytes and infiltrated immune cells secrete a variety of molecules, including fatty acids and adipokines, such as leptin, adiponectin, and a panel of cytokines/chemokines that modulate our immune system. Fatty Acids 130-141 adiponectin, C1Q and collagen domain containing Homo sapiens 174-185 33543406-3 2021 The protein, adiponectin, is actively involved in regulating glucose levels as well as fatty acid breakdown playing crucial role in dyslipidemia and vascular complications. Fatty Acids 87-97 adiponectin, C1Q and collagen domain containing Homo sapiens 13-24 33271223-1 2021 Adiponectin is one of the most abundant circulating hormones, which through adenosine monophosphate-activated protein kinase (AMPK), enhances fatty acid and glucose oxidation, and exerts a cardioprotective effect. Fatty Acids 142-152 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 33528867-8 2021 In addition, coculture-induced glycolysis increased in cancer cells while fatty acid catabolism decreased with lower adiponectin levels. Fatty Acids 74-84 adiponectin, C1Q and collagen domain containing Homo sapiens 117-128 33919141-7 2021 Conversely, dietary ingredients which have a negative effect on the concentration of adiponectin are typical components of the Western diet: saturated fatty acids, trans fatty acids, monosaccharides and disaccharides, and red meat. Fatty Acids 141-162 adiponectin, C1Q and collagen domain containing Homo sapiens 85-96 33557390-6 2021 Adiponectin enhanced glucose uptake, glycolytic processes and fatty acid oxidation in cultured primary hypothalamic astrocytes. Fatty Acids 62-72 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 32686381-0 2020 Increased adiponectin gene expression in adipose tissue may be related to an abnormal serum fatty acid profile in patients with chronic kidney disease. Fatty Acids 92-102 adiponectin, C1Q and collagen domain containing Homo sapiens 10-21 33317050-1 2020 Adiponectin is the adipokine associated with insulin sensitization, reducing liver gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. Fatty Acids 115-125 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 31731705-4 2019 Additionally, we show that adiponectin induces anti-inflammatory effects in the microglial cell line subjected to an exogenous treatment with a saturated free fatty acid. Fatty Acids 159-169 adiponectin, C1Q and collagen domain containing Homo sapiens 27-38 31731705-5 2019 In conclusion, the current study suggests that adiponectin suppresses the saturated free fatty acid-triggered the hypothalamic inflammation by modulating the microglial activation and thus maintains energy homeostasis. Fatty Acids 89-99 adiponectin, C1Q and collagen domain containing Homo sapiens 47-58 30857216-4 2019 Adiponectin-induced improvement of insulin resistance and adiponectin itself reduce hepatic glucose production and increase the utilization of glucose and fatty acids by skeletal muscles, lowering blood glucose levels. Fatty Acids 155-166 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 31807045-5 2019 Adiponectin influences fatty acid oxidation and glucose intake in muscle. Fatty Acids 23-33 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 31592400-2 2019 Our research efforts have led to the identification of adiponectin receptors, AdipoR1 and AdipoR2, with the former shown to activate AMP kinase in the liver and the latter shown to activate peroxisome proliferator-activated receptor-alpha signaling thereby increasing fatty acid oxidation. Fatty Acids 268-278 adiponectin, C1Q and collagen domain containing Homo sapiens 55-66 30934678-1 2019 Adiponectin regulates metabolism through blood glucose control and fatty acid oxidation, partly mediated by downstream effects of adiponectin signaling in skeletal muscle. Fatty Acids 67-77 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 30857216-4 2019 Adiponectin-induced improvement of insulin resistance and adiponectin itself reduce hepatic glucose production and increase the utilization of glucose and fatty acids by skeletal muscles, lowering blood glucose levels. Fatty Acids 155-166 adiponectin, C1Q and collagen domain containing Homo sapiens 58-69 29669464-3 2018 Adiponectin is one of the adipocyte-specific protein with novel applications pertaining to metabolism by promoting insulin sensitivity and regulating glucose and fatty acid catabolism, while chemerin is considered as an inhibitor of insulin signaling and glucose catabolism. Fatty Acids 162-172 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 30203461-2 2019 Adiponectin is a protein hormone that enhances insulin sensitivity through increased fatty acid oxidation and inhibition of hepatic glucose production. Fatty Acids 85-95 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 29912982-1 2018 Activation of adiponectin receptors (AdipoRs) by its natural ligand, adiponectin has been known to be involved in modulating critical metabolic processes such as glucose metabolism and fatty acid oxidation as demonstrated by a number of in vitro and in vivo studies over last two decades. Fatty Acids 185-195 adiponectin, C1Q and collagen domain containing Homo sapiens 14-25 29978896-7 2018 Adiponectin stimulates fatty acid oxidation in skeletal muscle and inhibits glucose production in the liver, resulting in an improvement in whole-body energy homeostasis. Fatty Acids 23-33 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 29912982-1 2018 Activation of adiponectin receptors (AdipoRs) by its natural ligand, adiponectin has been known to be involved in modulating critical metabolic processes such as glucose metabolism and fatty acid oxidation as demonstrated by a number of in vitro and in vivo studies over last two decades. Fatty Acids 185-195 adiponectin, C1Q and collagen domain containing Homo sapiens 69-80 29655459-2 2018 High molecular weight (HMW) adiponectin is thought to be most biologically active and promotes glucose uptake, insulin sensitivity, and fatty acid oxidation. Fatty Acids 136-146 adiponectin, C1Q and collagen domain containing Homo sapiens 28-39 29794781-1 2018 Adiponectin secreted by adipocytes plays an important role in the regulation of glucose and fatty acid metabolism. Fatty Acids 92-102 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 28552966-10 2017 Higher levels of even-chain saturated fatty acids (14:0 myristic, 16:0 palmitic, and 18:0 stearic acids) were associated with higher levels of resistin (P for trend = 0.048) and lower levels of adiponectin (P for trend = 0.003). Fatty Acids 28-49 adiponectin, C1Q and collagen domain containing Homo sapiens 194-205 29750183-0 2018 Serum adiponectin and TNFalpha concentrations are closely associated with epicardial adipose tissue fatty acid profiles in patients undergoing cardiovascular surgery. Fatty Acids 100-110 adiponectin, C1Q and collagen domain containing Homo sapiens 6-17 28544341-7 2017 Furthermore, these fatty acids recovered the suppression of beta-adrenergic receptor-stimulated uncoupling protein 1 expression and secretion of adiponectin in C3H10T1/2 and 3T3-L1 adipocytes, respectively, under inflammatory conditions, suggesting that enone fatty acids can ameliorate dysfunctions of adipocytes induced by inflammation. Fatty Acids 19-30 adiponectin, C1Q and collagen domain containing Homo sapiens 145-156 28139377-5 2017 We have identified a positive association (regression coefficient +- SE = 0.01 +- 0.001, P = 3.4 x 10-13) between plasma adiponectin levels and methylation of a CpG site in CPT1A, a key player in fatty acid metabolism. Fatty Acids 196-206 adiponectin, C1Q and collagen domain containing Homo sapiens 121-132 27740628-7 2017 PTHrP couples adiponectin actions to activate the AMPK pathway in the skeletal muscles and liver, respectively, for fatty acid oxidation. Fatty Acids 116-126 adiponectin, C1Q and collagen domain containing Homo sapiens 14-25 27036610-0 2016 Serum saturated fatty acid decreases plasma adiponectin and increases leptin throughout pregnancy independently of BMI. Fatty Acids 6-26 adiponectin, C1Q and collagen domain containing Homo sapiens 44-55 28585210-11 2017 Actually, adiponectin resistance occurs very rapidly after saturated fatty acid feeding, this metabolic disturbance is not due to a decrease in AdipoR1 protein content. Fatty Acids 59-79 adiponectin, C1Q and collagen domain containing Homo sapiens 10-21 28555711-7 2017 In particular, FABP4, PLIN1, and ADIPOQ were related to fatty acid and lipid metabolism. Fatty Acids 56-66 adiponectin, C1Q and collagen domain containing Homo sapiens 33-39 27723672-0 2016 Effects of administration of omega-3 fatty acids with or without vitamin E supplementation on adiponectin gene expression in PBMCs and serum adiponectin and adipocyte fatty acid-binding protein levels in male patients with CAD. Fatty Acids 37-47 adiponectin, C1Q and collagen domain containing Homo sapiens 94-105 27348122-2 2016 Adiponectin is an adipose tissue-secreted protein known for its effects on the stimulation of fatty acid oxidation. Fatty Acids 94-104 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 27036610-9 2016 In the multiple longitudinal models, total SFA (beta = -41.039; P = 0.008) and 16:0 were negatively associated with plasma adiponectin (16:0, beta = -0.511; P = 0.001). Fatty Acids 43-46 adiponectin, C1Q and collagen domain containing Homo sapiens 123-134 27321337-0 2016 Saturated fatty acid intake decreases serum adiponectin levels in subjects with type 1 diabetes. Fatty Acids 0-20 adiponectin, C1Q and collagen domain containing Homo sapiens 44-55 27296394-1 2016 INTRODUCTION: Adiponectin (ADIPOQ), involved in regulating glucose levels and fatty acid oxidation, plays key roles in metabolic derangements such as gestational diabetes mellitus (GDM). Fatty Acids 78-88 adiponectin, C1Q and collagen domain containing Homo sapiens 14-25 27296394-1 2016 INTRODUCTION: Adiponectin (ADIPOQ), involved in regulating glucose levels and fatty acid oxidation, plays key roles in metabolic derangements such as gestational diabetes mellitus (GDM). Fatty Acids 78-88 adiponectin, C1Q and collagen domain containing Homo sapiens 27-33 27003122-3 2016 Adiponectin supports fatty acid utilization and triglyceride-content reduction in cells and increases both the mitochondrial biogenesis and the oxidative metabolism in muscle cells. Fatty Acids 21-31 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 27321337-4 2016 Different dietary interventions, especially those altering fatty acid intake, have been reported as possible mediators of adiponectin levels. Fatty Acids 59-69 adiponectin, C1Q and collagen domain containing Homo sapiens 122-133 27321337-12 2016 CONCLUSIONS: The present study suggests that high SFA intake may be associated with lower adiponectin levels in patients with T1DM. Fatty Acids 50-53 adiponectin, C1Q and collagen domain containing Homo sapiens 90-101 27003399-4 2016 Similarly, adiponectin, leptin and IL-6 enhance glucose uptake and increase fatty acid oxidation in skeletal muscle. Fatty Acids 76-86 adiponectin, C1Q and collagen domain containing Homo sapiens 11-22 26993047-3 2016 Adiponectin, elicited through cognate receptors, suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, which together contribute to a beneficial metabolic action in whole body energy homeostasis. Fatty Acids 105-115 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 26419856-1 2016 SCOPE: Interactions between adiponectin genetic variants and plasma fatty acid profile can modulate plasma inflammatory biomarker concentration and the risk for metabolic diseases. Fatty Acids 68-78 adiponectin, C1Q and collagen domain containing Homo sapiens 28-39 26419856-8 2016 CONCLUSION: Plasma fatty acid profile can interact with adiponectin gene variants to modulate the risk for systemic inflammatory state. Fatty Acids 19-29 adiponectin, C1Q and collagen domain containing Homo sapiens 56-67 25900100-0 2015 Fatty acids increase adiponectin secretion through both classical and exosome pathways. Fatty Acids 0-11 adiponectin, C1Q and collagen domain containing Homo sapiens 21-32 25471552-3 2015 Adiponectin, a protein derived from adipocytes, is primarily involved in regulating glucose levels and fatty acid break down. Fatty Acids 103-113 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 25900100-1 2015 Little is known about the effects of fatty acids on adiponectin oligomer assembly and trafficking. Fatty Acids 37-48 adiponectin, C1Q and collagen domain containing Homo sapiens 52-63 25900100-2 2015 The aim of this study was to examine the effects of different fatty acids on adiponectin transport and secretion in differentiated 3T3-L1 adipocytes. Fatty Acids 62-73 adiponectin, C1Q and collagen domain containing Homo sapiens 77-88 25900100-4 2015 Adiponectin secretion was increased by treatment with fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and several fatty acids changed the cellular localization of adiponectin. Fatty Acids 54-65 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 25900100-4 2015 Adiponectin secretion was increased by treatment with fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and several fatty acids changed the cellular localization of adiponectin. Fatty Acids 54-65 adiponectin, C1Q and collagen domain containing Homo sapiens 198-209 25900100-4 2015 Adiponectin secretion was increased by treatment with fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and several fatty acids changed the cellular localization of adiponectin. Fatty Acids 149-160 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 25900100-4 2015 Adiponectin secretion was increased by treatment with fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and several fatty acids changed the cellular localization of adiponectin. Fatty Acids 149-160 adiponectin, C1Q and collagen domain containing Homo sapiens 198-209 26306152-1 2015 BACKGROUND: The human ADIPOQ gene encodes adiponectin protein hormone, which is involved in regulating glucose levels as well as fatty acid breakdown. Fatty Acids 129-139 adiponectin, C1Q and collagen domain containing Homo sapiens 22-28 26306152-1 2015 BACKGROUND: The human ADIPOQ gene encodes adiponectin protein hormone, which is involved in regulating glucose levels as well as fatty acid breakdown. Fatty Acids 129-139 adiponectin, C1Q and collagen domain containing Homo sapiens 42-53