PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34916909-0 2021 Genetic Variants of Fatty Acid Amide Hydrolase Modulate Acute Inflammatory Responses to Colitis in Adult Male Mice. Fatty Acids 20-30 fatty acid amide hydrolase Mus musculus 31-46 34449902-0 2022 The Effects of Systemic and Local Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibitor Treatments on Lung Metabolomic Profile. Fatty Acids 34-44 fatty acid amide hydrolase Mus musculus 45-60 34615374-0 2021 Inhibition of Vascular Growth by Modulation of the Anandamide/Fatty Acid Amide Hydrolase Axis. Fatty Acids 62-72 fatty acid amide hydrolase Mus musculus 73-88 32860981-0 2020 Synthesis and Preliminary Evaluation of a Novel Positron Emission Tomography (PET) Ligand for Imaging Fatty Acid Amide Hydrolase (FAAH). Fatty Acids 102-112 fatty acid amide hydrolase Mus musculus 113-128 34299330-0 2021 Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization. Fatty Acids 0-10 fatty acid amide hydrolase Mus musculus 11-26 34299330-0 2021 Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization. Fatty Acids 0-10 fatty acid amide hydrolase Mus musculus 28-32 32860981-0 2020 Synthesis and Preliminary Evaluation of a Novel Positron Emission Tomography (PET) Ligand for Imaging Fatty Acid Amide Hydrolase (FAAH). Fatty Acids 102-112 fatty acid amide hydrolase Mus musculus 130-134 30526351-0 2019 Therapeutic Effect of a Novel Fatty Acid Amide Hydrolase Inhibitor PF04457845 in the Repetitive Closed Head Injury Mouse Model. Fatty Acids 30-40 fatty acid amide hydrolase Mus musculus 41-56 31775159-2 2020 We investigated a potential interaction between genetically inherited variation in fatty acid amide hydrolase (FAAH, C385A), which metabolizes the cannabis-like endocannabinoid anandamide, and dopaminergic system, measured by dopamine receptor levels and mRNA. Fatty Acids 83-99 fatty acid amide hydrolase Mus musculus 111-115 32038247-13 2019 MZRW decreased oleamide levels in serum, ileum, and colon in normal mice, but increased expression of colonic fatty acid amide hydrolase (FAAH). Fatty Acids 110-126 fatty acid amide hydrolase Mus musculus 138-142 27731508-6 2017 Decidual fatty acid amide hydrolase (FAAH) activity was measured by radioconvertion, total decidual protein nitration by Western blot (WB), and decidual FAAH nitration by immunoprecipitation followed by WB. Fatty Acids 9-19 fatty acid amide hydrolase Mus musculus 37-41 31121907-0 2019 Anti-Inflammatory Effects by Pharmacological Inhibition or Knockdown of Fatty Acid Amide Hydrolase in BV2 Microglial Cells. Fatty Acids 72-82 fatty acid amide hydrolase Mus musculus 83-98 29457656-2 2018 Recently, fatty acid binding proteins (FABPs) have been proposed as intracellular transporters of the endocannabinoid anandamide (AEA) as well as other bioactive lipids to their catabolic enzyme, fatty acid amide hydrolase (FAAH). Fatty Acids 10-20 fatty acid amide hydrolase Mus musculus 196-222 29457656-2 2018 Recently, fatty acid binding proteins (FABPs) have been proposed as intracellular transporters of the endocannabinoid anandamide (AEA) as well as other bioactive lipids to their catabolic enzyme, fatty acid amide hydrolase (FAAH). Fatty Acids 10-20 fatty acid amide hydrolase Mus musculus 224-228 28695708-0 2017 Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT). Fatty Acids 10-20 fatty acid amide hydrolase Mus musculus 21-36 29326169-4 2018 One potential strategy to counter this toxicity is to also inhibit fatty acid amide hydrolase (FAAH), which hydrolyzes bioactive fatty acid ethanolamides (FAEs) into fatty acids and ethanolamine. Fatty Acids 166-177 fatty acid amide hydrolase Mus musculus 78-93 29326169-4 2018 One potential strategy to counter this toxicity is to also inhibit fatty acid amide hydrolase (FAAH), which hydrolyzes bioactive fatty acid ethanolamides (FAEs) into fatty acids and ethanolamine. Fatty Acids 166-177 fatty acid amide hydrolase Mus musculus 95-99 28488728-3 2017 However, at high concentrations of ethanolamines and unesterified fatty acids, FAAH can also catalyze the reverse reaction, producing NAEs. Fatty Acids 66-77 fatty acid amide hydrolase Mus musculus 79-83 27889577-4 2017 This suggested that long chain fatty acid amides radiolabeled in the fatty acid moiety might be useful as ex vivo and in vivo radiotracers for FAAH, since labeled fatty acid released by hydrolysis would be rapidly incorporated into phospholipids with long metabolic turnover periods. Fatty Acids 31-41 fatty acid amide hydrolase Mus musculus 143-147 27889577-4 2017 This suggested that long chain fatty acid amides radiolabeled in the fatty acid moiety might be useful as ex vivo and in vivo radiotracers for FAAH, since labeled fatty acid released by hydrolysis would be rapidly incorporated into phospholipids with long metabolic turnover periods. Fatty Acids 69-79 fatty acid amide hydrolase Mus musculus 143-147 29367955-3 2017 In the present study, we examined whether pharmacological inhibition of fatty acid binding proteins (FABPs) 5 and 7, which blocks the transport of AEA to FAAH, and increase AEA levels in vivo also alters ethanol consumption and preference. Fatty Acids 72-82 fatty acid amide hydrolase Mus musculus 154-158 27318096-8 2016 Together, these results demonstrate an effect of fatty acid amide hydrolase inhibition on the motor symptoms of Parkinson"s disease in two distinct experimental models that is mediated by cannabinoid receptors. Fatty Acids 49-59 fatty acid amide hydrolase Mus musculus 60-75 25711338-0 2015 Simultaneous inhibition of fatty acid amide hydrolase and monoacylglycerol lipase shares discriminative stimulus effects with Delta9-tetrahydrocannabinol in mice. Fatty Acids 27-37 fatty acid amide hydrolase Mus musculus 38-53 27178246-8 2016 When central sensitization was established, FAAH KO mice displayed elevated levels of anandamide, other fatty-acid amides, and endogenous TRPV1 agonists in both paw skin and lumbar spinal cord relative to wild-type mice. Fatty Acids 104-114 fatty acid amide hydrolase Mus musculus 44-48 22442717-1 2012 BACKGROUND: FAAH (fatty acid amide hydrolase), primarily expressed in the liver, hydrolyzes the endocannabinoids fatty acid ethanolamides (FAA). Fatty Acids 18-28 fatty acid amide hydrolase Mus musculus 12-16 22915616-0 2012 Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1. Fatty Acids 16-26 fatty acid amide hydrolase Mus musculus 27-42 23447835-1 2004 FAAH plays a key role in the hydrolysis of a number of primary and secondary fatty acid amides, controlling the levels of the neuromodulatory endocannabinoids in the ECS (3, 4). Fatty Acids 77-87 fatty acid amide hydrolase Mus musculus 0-4 18501510-0 2008 Genetic deletion of Fatty Acid Amide Hydrolase results in improved long-term outcome in chronic autoimmune encephalitis. Fatty Acids 20-30 fatty acid amide hydrolase Mus musculus 31-46 20571484-0 2010 Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. Fatty Acids 20-30 fatty acid amide hydrolase Mus musculus 31-46 19460156-8 2009 Addition of the fatty acid amide (FAAH) inhibitor URB 597 blocked the production of D0NAGly in these cells. Fatty Acids 16-26 fatty acid amide hydrolase Mus musculus 34-38 20714818-4 2010 We found that brain tissue of mice lacking fatty acid amide hydrolase (FAAH (-/-)) had elevated PE and NAPE molecular species in addition to elevated NAEs, suggesting that FAAH activity participates in the overall regulation of this pathway. Fatty Acids 43-53 fatty acid amide hydrolase Mus musculus 54-69 20714818-4 2010 We found that brain tissue of mice lacking fatty acid amide hydrolase (FAAH (-/-)) had elevated PE and NAPE molecular species in addition to elevated NAEs, suggesting that FAAH activity participates in the overall regulation of this pathway. Fatty Acids 43-53 fatty acid amide hydrolase Mus musculus 71-75 20714818-4 2010 We found that brain tissue of mice lacking fatty acid amide hydrolase (FAAH (-/-)) had elevated PE and NAPE molecular species in addition to elevated NAEs, suggesting that FAAH activity participates in the overall regulation of this pathway. Fatty Acids 43-53 fatty acid amide hydrolase Mus musculus 172-176 20029375-1 2010 RATIONALE: Fatty acid amide hydrolase (FAAH) is the main degrading enzyme of the fatty acid ethanolamides anandamide (AEA) and oleoylethanolamide (OEA), which have opposite effects on food intake and energy balance. Fatty Acids 81-91 fatty acid amide hydrolase Mus musculus 11-37 20029375-1 2010 RATIONALE: Fatty acid amide hydrolase (FAAH) is the main degrading enzyme of the fatty acid ethanolamides anandamide (AEA) and oleoylethanolamide (OEA), which have opposite effects on food intake and energy balance. Fatty Acids 81-91 fatty acid amide hydrolase Mus musculus 39-43 19555737-0 2009 Temporal changes in mouse brain fatty acid amide hydrolase activity. Fatty Acids 32-42 fatty acid amide hydrolase Mus musculus 43-58 18501510-1 2008 The enzyme Fatty Acid Amide Hydrolase (FAAH) is a key regulator of the endogenous levels of a family of biologically active lipid mediators, the fatty acid amides. Fatty Acids 145-155 fatty acid amide hydrolase Mus musculus 22-37 18501510-1 2008 The enzyme Fatty Acid Amide Hydrolase (FAAH) is a key regulator of the endogenous levels of a family of biologically active lipid mediators, the fatty acid amides. Fatty Acids 145-155 fatty acid amide hydrolase Mus musculus 39-43 16100529-1 2005 The in vivo effect of inhibitors of fatty acid amide hydrolase (FAAH) upon oedema volume and FAAH activity was evaluated in the carrageenan induced hind paw inflammation model in the mouse. Fatty Acids 36-46 fatty acid amide hydrolase Mus musculus 64-68 17412883-1 2007 Fatty acid amide hydrolase (FAAH) is an intracellular serine hydrolase that catalyzes the cleavage of bioactive fatty acid ethanolamides, such as the endogenous cannabinoid agonist anandamide. Fatty Acids 112-122 fatty acid amide hydrolase Mus musculus 11-26 17412883-1 2007 Fatty acid amide hydrolase (FAAH) is an intracellular serine hydrolase that catalyzes the cleavage of bioactive fatty acid ethanolamides, such as the endogenous cannabinoid agonist anandamide. Fatty Acids 112-122 fatty acid amide hydrolase Mus musculus 28-32 16866345-3 2006 We recently identified a second structural class of fatty acid amides regulated by FAAH in vivo: the N-acyl taurines (NATs). Fatty Acids 52-62 fatty acid amide hydrolase Mus musculus 83-87 16154384-1 2005 Bioactive N-acylethanolamines including the endocannabinoid anandamide are known to be hydrolyzed to fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH). Fatty Acids 101-112 fatty acid amide hydrolase Mus musculus 144-159 16154384-1 2005 Bioactive N-acylethanolamines including the endocannabinoid anandamide are known to be hydrolyzed to fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH). Fatty Acids 101-112 fatty acid amide hydrolase Mus musculus 161-165 17279376-0 2007 Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality. Fatty Acids 14-24 fatty acid amide hydrolase Mus musculus 25-40 16278311-0 2006 Ex vivo imaging of fatty acid amide hydrolase activity and its inhibition in the mouse brain. Fatty Acids 19-29 fatty acid amide hydrolase Mus musculus 30-45 15579492-0 2005 Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3"-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. Fatty Acids 24-34 fatty acid amide hydrolase Mus musculus 35-50 12770562-10 2003 Finally, there are regions of the brain where FAAH-immunoreactive neurons and/or oligodendrocytes occur in the absence of CB(1)-immunoreactive fibers and here FAAH may be involved in regulation of signaling mediated by other endocannabinoid receptors or by receptors for other fatty acid amide signaling molecules. Fatty Acids 277-287 fatty acid amide hydrolase Mus musculus 159-163 12736361-3 2003 Mice lacking the enzyme fatty acid amide hydrolase [FAAH (-/-) mice] are severely impaired in their ability to degrade the endocannabinoid anandamide and therefore represent a unique animal model in which to examine the function of this signaling lipid in vivo. Fatty Acids 24-34 fatty acid amide hydrolase Mus musculus 35-50 12736361-3 2003 Mice lacking the enzyme fatty acid amide hydrolase [FAAH (-/-) mice] are severely impaired in their ability to degrade the endocannabinoid anandamide and therefore represent a unique animal model in which to examine the function of this signaling lipid in vivo. Fatty Acids 24-34 fatty acid amide hydrolase Mus musculus 52-56 12052036-3 2002 The conserved regions of FAAH are described in terms of sequence and function, including the domains that contains the serine catalytic nucleophile, the hydrophobic domain important for self-association, the proline rich domain region which may be important for subcellular localization and the fatty acid chain binding domain. Fatty Acids 295-305 fatty acid amide hydrolase Mus musculus 25-29