PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33239171-1 2021 We previously demonstrated that angiopoietin-like 8 (ANGPTL8) forms a localized complex with ANGPTL4 to reduce its lipoprotein lipase (LPL)-inhibitory activity and enable increased postprandial uptake of fatty acids (FA) into adipose tissue. Fatty Acids 204-215 angiopoietin like 4 Homo sapiens 93-100 35063423-9 2022 Time-dependent effects of A1AT and A1AT conjugated fatty acids on IL-I b, PPAR-g and Angptl4 showed statistically significant P=0.07, P=0.001, and P=0.02 respectively, compared to those of the former study subjects. Fatty Acids 51-62 angiopoietin like 4 Homo sapiens 85-92 31707478-11 2020 CONCLUSIONS: The present data suggest that increase in plasma FFA during mountain ultra-marathon run may be involved in plasma ANGPTL4 release and that increase in ANGPTL4 secretion may be a compensatory mechanism against fatty acid-induced oxidative stress. Fatty Acids 222-232 angiopoietin like 4 Homo sapiens 164-171 32487544-0 2020 Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids. Fatty Acids 109-120 angiopoietin like 4 Homo sapiens 65-72 32368403-0 2020 Erratum: Angiopoietin-like 4 deficiency upregulates macrophage function through the dysregulation of cell-intrinsic fatty acid metabolism. Fatty Acids 116-126 angiopoietin like 4 Homo sapiens 9-28 32120190-5 2020 Long-chain fatty acids stimulate angiogenesis in these cells via vascular endothelium growth factor (VEGF), angiopoietin-like protein 4 (ANGPTL4), fatty acid-binding proteins (FABPs), or eicosanoids. Fatty Acids 11-21 angiopoietin like 4 Homo sapiens 108-135 32120190-5 2020 Long-chain fatty acids stimulate angiogenesis in these cells via vascular endothelium growth factor (VEGF), angiopoietin-like protein 4 (ANGPTL4), fatty acid-binding proteins (FABPs), or eicosanoids. Fatty Acids 11-21 angiopoietin like 4 Homo sapiens 137-144 32195030-0 2020 Angiopoietin-like 4 deficiency upregulates macrophage function through the dysregulation of cell-intrinsic fatty acid metabolism. Fatty Acids 107-117 angiopoietin like 4 Homo sapiens 0-19 32195030-10 2020 Thus, ANGPTL4 deficiency in macrophages results in ER stress due to the cell-intrinsic reprogramming of fatty-acid metabolism. Fatty Acids 104-114 angiopoietin like 4 Homo sapiens 6-13 29339422-5 2019 Moreover, significantly reduced fatty acid oxidation, as featured by decreased CPT-1 levels, was observed in hypertrophic cardiomyocytes following ANGPTL4 down-regulation. Fatty Acids 32-42 angiopoietin like 4 Homo sapiens 147-154 32507396-13 2020 These data signify the critical role of FTO variants and adipose ANGPTL4 in fatty acid metabolism and bariatric outcomes in humans. Fatty Acids 76-86 angiopoietin like 4 Homo sapiens 65-72 26363050-2 2015 In this study, we demonstrate that A1AT (Prolastin), a potent inducer of Angptl4, contains significant quantities of the fatty acids (FA) linoleic acid (C18:2) and oleic acid (C18:1). Fatty Acids 121-132 angiopoietin like 4 Homo sapiens 73-80 26476336-5 2015 Here, we demonstrate that ANGPTL4 is part of a shuttling mechanism that directs fatty acids derived from circulating triglyceride-rich lipoproteins to BAT during cold. Fatty Acids 80-91 angiopoietin like 4 Homo sapiens 26-33 32421966-6 2019 Fasting-induced adipose factor (FIAF) is suppressed by gut microbiota and results in the increased storage of fatty acids in the adipose tissues and liver. Fatty Acids 110-121 angiopoietin like 4 Homo sapiens 0-30 32421966-6 2019 Fasting-induced adipose factor (FIAF) is suppressed by gut microbiota and results in the increased storage of fatty acids in the adipose tissues and liver. Fatty Acids 110-121 angiopoietin like 4 Homo sapiens 32-36 29587751-5 2018 RESULTS: Plasma ANGPTL4 and PLTP activity were increased in T2DM (p < 0.001 for each), coinciding with elevated hsCRP, triglycerides and non-esterified fatty acids (NEFA) (p = 0.031 to 0.001). Fatty Acids 155-166 angiopoietin like 4 Homo sapiens 16-23 27023631-5 2016 Overall, ANGPTL4 is the central component of a fatty acid-driven feedback mechanism that regulates plasma triglyceride hydrolysis and subsequent tissue fatty acid uptake in response to changes in lipid availability and cellular fuel demand. Fatty Acids 47-57 angiopoietin like 4 Homo sapiens 9-16 27023631-5 2016 Overall, ANGPTL4 is the central component of a fatty acid-driven feedback mechanism that regulates plasma triglyceride hydrolysis and subsequent tissue fatty acid uptake in response to changes in lipid availability and cellular fuel demand. Fatty Acids 152-162 angiopoietin like 4 Homo sapiens 9-16 24324678-1 2013 BACKGROUND: Ligands of peroxisome-proliferator activated receptors (PPARs), such as non-esterified fatty acids (NEFAs), induce expression of angiopoietin-like protein 4 (ANGPTL4). Fatty Acids 88-110 angiopoietin like 4 Homo sapiens 141-168 24591600-0 2014 Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise. Fatty Acids 0-10 angiopoietin like 4 Homo sapiens 21-28 24173241-10 2014 The use of Angptl4-modulating agents such as certain drugs, food constituents (such as fatty acids), nuclear factor (such as PPARalpha), and bacteria may treat associated diseases such as tumor metastasis, ischemic-reperfusion injury, inflammation, and chronic low-grade inflammation. Fatty Acids 87-98 angiopoietin like 4 Homo sapiens 11-18 24720597-8 2014 Maternal plasma ANGPTL-4 is decreased in GDM, and it has been proposed to be responsible for an increase in placental LPL activity, which would facilitate a greater fatty acid placental transfer, contributing to the higher fetal fat accumulation. Fatty Acids 165-175 angiopoietin like 4 Homo sapiens 16-24 24324678-1 2013 BACKGROUND: Ligands of peroxisome-proliferator activated receptors (PPARs), such as non-esterified fatty acids (NEFAs), induce expression of angiopoietin-like protein 4 (ANGPTL4). Fatty Acids 88-110 angiopoietin like 4 Homo sapiens 170-177 23153451-7 2013 Angiogenic effect of these fatty acids (AA, EPA, OA) was significantly decreased in ANGPTL4 knocked down cells, indicating ANGPTL4 may be involved at least in part in fatty acid induced angiogenesis. Fatty Acids 27-38 angiopoietin like 4 Homo sapiens 84-91 23319744-2 2013 In this study we examined whether different fatty acids have a differential effect on plasma ANGPTL4 levels during hyperinsulinemia in healthy lean males. Fatty Acids 44-55 angiopoietin like 4 Homo sapiens 93-100 23319744-10 2013 These results suggest that ANGPTL4 is strongly regulated by fatty acids in humans, and is also dependent on the type of fatty acid. Fatty Acids 60-71 angiopoietin like 4 Homo sapiens 27-34 23319744-10 2013 These results suggest that ANGPTL4 is strongly regulated by fatty acids in humans, and is also dependent on the type of fatty acid. Fatty Acids 60-70 angiopoietin like 4 Homo sapiens 27-34 23153451-7 2013 Angiogenic effect of these fatty acids (AA, EPA, OA) was significantly decreased in ANGPTL4 knocked down cells, indicating ANGPTL4 may be involved at least in part in fatty acid induced angiogenesis. Fatty Acids 27-38 angiopoietin like 4 Homo sapiens 123-130 23153451-7 2013 Angiogenic effect of these fatty acids (AA, EPA, OA) was significantly decreased in ANGPTL4 knocked down cells, indicating ANGPTL4 may be involved at least in part in fatty acid induced angiogenesis. Fatty Acids 27-37 angiopoietin like 4 Homo sapiens 84-91 23153451-7 2013 Angiogenic effect of these fatty acids (AA, EPA, OA) was significantly decreased in ANGPTL4 knocked down cells, indicating ANGPTL4 may be involved at least in part in fatty acid induced angiogenesis. Fatty Acids 27-37 angiopoietin like 4 Homo sapiens 123-130 22773878-0 2012 Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipase. Fatty Acids 0-11 angiopoietin like 4 Homo sapiens 53-80 22773878-2 2012 In this study, we demonstrate that fatty acids reduce the inactivation of LPL by Angptl4. Fatty Acids 35-46 angiopoietin like 4 Homo sapiens 81-88 22773878-5 2012 Surface plasmon resonance, isothermal titration calorimetry, fluorescence, and chromatography measurements revealed that fatty acids bind with high affinity to ccd-Angptl4. Fatty Acids 121-132 angiopoietin like 4 Homo sapiens 164-171 22773878-10 2012 On binding of fatty acids, ccd-Angptl4 underwent conformational changes resulting in a decreased helical content, weakened structural stability, dissociation of oligomers, and altered fluorescence properties of the Trp-38 residue that is located close to the putative LPL-binding region. Fatty Acids 14-25 angiopoietin like 4 Homo sapiens 31-38 22773878-11 2012 Based on these results, we propose that fatty acids play an important role in modulating the effects of Angptl4. Fatty Acids 40-51 angiopoietin like 4 Homo sapiens 104-111 23056264-0 2012 Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes. Fatty Acids 79-89 angiopoietin like 4 Homo sapiens 0-19 22063269-9 2012 In contrast, ANGPTL4 is expressed ubiquitously and under sensitive control of the Peroxisome proliferator-activated receptor (PPAR) family and fatty acids. Fatty Acids 143-154 angiopoietin like 4 Homo sapiens 13-20 22063269-10 2012 Induction of ANGPTL4 gene expression by fatty acids and via PPARs is part of a feedback mechanism aimed at protecting cells against lipotoxicity. Fatty Acids 40-51 angiopoietin like 4 Homo sapiens 13-20 19074989-0 2009 Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. Fatty Acids 57-68 angiopoietin like 4 Homo sapiens 15-42 21109185-3 2010 (2010) show that by inhibiting lipoprotein lipase (LPL) activity in mesenteric lymph nodes, Angiopoietin-like protein 4 (Angptl4) protects resident macrophages from dietary saturated fatty acid (SFA)-induced inflammation. Fatty Acids 173-193 angiopoietin like 4 Homo sapiens 92-119 21109185-3 2010 (2010) show that by inhibiting lipoprotein lipase (LPL) activity in mesenteric lymph nodes, Angiopoietin-like protein 4 (Angptl4) protects resident macrophages from dietary saturated fatty acid (SFA)-induced inflammation. Fatty Acids 173-193 angiopoietin like 4 Homo sapiens 121-128 21109185-3 2010 (2010) show that by inhibiting lipoprotein lipase (LPL) activity in mesenteric lymph nodes, Angiopoietin-like protein 4 (Angptl4) protects resident macrophages from dietary saturated fatty acid (SFA)-induced inflammation. Fatty Acids 195-198 angiopoietin like 4 Homo sapiens 92-119 21109185-3 2010 (2010) show that by inhibiting lipoprotein lipase (LPL) activity in mesenteric lymph nodes, Angiopoietin-like protein 4 (Angptl4) protects resident macrophages from dietary saturated fatty acid (SFA)-induced inflammation. Fatty Acids 195-198 angiopoietin like 4 Homo sapiens 121-128 21741084-10 2011 Unlike DHA, other fatty acids (OA, EPA, ARA) stimulated ANGPTL4 mRNA expression and protein secretion in these cells. Fatty Acids 18-29 angiopoietin like 4 Homo sapiens 56-63 21709421-0 2011 Fatty acids and hypoxia stimulate the expression and secretion of the adipokine ANGPTL4 (angiopoietin-like protein 4/ fasting-induced adipose factor) by human adipocytes. Fatty Acids 0-11 angiopoietin like 4 Homo sapiens 80-87 21709421-2 2011 ANGPTL4 (angiopoietin-like protein 4/fasting-induced adipose factor), which is implicated in angiogenesis, lipid metabolism and glucose homeostasis, is a major hypoxia-sensitive gene; recent studies indicate that ANGPTL4 expression is also regulated by fatty acids. Fatty Acids 253-264 angiopoietin like 4 Homo sapiens 0-7 21709421-2 2011 ANGPTL4 (angiopoietin-like protein 4/fasting-induced adipose factor), which is implicated in angiogenesis, lipid metabolism and glucose homeostasis, is a major hypoxia-sensitive gene; recent studies indicate that ANGPTL4 expression is also regulated by fatty acids. Fatty Acids 253-264 angiopoietin like 4 Homo sapiens 213-220 21709421-3 2011 We have examined the effects of hypoxia and fatty acids, alone and together, on the expression and release of ANGPTL4 by human adipocytes. Fatty Acids 44-55 angiopoietin like 4 Homo sapiens 110-117 21709421-9 2011 CONCLUSION: The expression and secretion of ANGPTL4 by human adipocytes is upregulated by both hypoxia and fatty acids. Fatty Acids 107-118 angiopoietin like 4 Homo sapiens 44-51 21709421-10 2011 The stimulatory effect of fatty acids on ANGPTL4 production is augmented under hypoxic conditions. Fatty Acids 26-37 angiopoietin like 4 Homo sapiens 41-48 18466728-4 2008 Secondly, fatty acids flux and storage in the adipose tissue is under the control of the fasting-induced adipocyte factor FIAF, which expression depends on gut microflora. Fatty Acids 10-21 angiopoietin like 4 Homo sapiens 122-126