PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24221358-0 2014 Saturated fatty acids up-regulate COX-2 expression in prostate epithelial cells via toll-like receptor 4/NF-kappaB signaling. Fatty Acids 0-21 prostaglandin-endoperoxide synthase 2 Homo sapiens 34-39 24221358-1 2014 Cyclooxygenase-2 (COX-2) has been implicated in prostate carcinogenesis, and recently it has been confirmed to be a molecular target of saturated fatty acids (SFAs). Fatty Acids 136-157 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-16 24221358-1 2014 Cyclooxygenase-2 (COX-2) has been implicated in prostate carcinogenesis, and recently it has been confirmed to be a molecular target of saturated fatty acids (SFAs). Fatty Acids 136-157 prostaglandin-endoperoxide synthase 2 Homo sapiens 18-23 15340847-8 2004 Factors or events that trigger COX-2 expression include oncogene activation, antioncogene inactivation, cytokines, growth factors, some fatty acids, bile salts, and mucins. Fatty Acids 136-147 prostaglandin-endoperoxide synthase 2 Homo sapiens 31-36 20022932-10 2010 These findings indicate that COX-2 activity, through the production of PGE(2), attenuates the fatty acid-induced inflammatory process and insulin resistance. Fatty Acids 94-104 prostaglandin-endoperoxide synthase 2 Homo sapiens 29-34 19218248-3 2009 Here we show that, during catalysis, fatty acids (FAs) are bound at both COX sites of a PGHS-2 dimer. Fatty Acids 37-48 prostaglandin-endoperoxide synthase 2 Homo sapiens 88-94 19218248-3 2009 Here we show that, during catalysis, fatty acids (FAs) are bound at both COX sites of a PGHS-2 dimer. Fatty Acids 50-53 prostaglandin-endoperoxide synthase 2 Homo sapiens 88-94 19218248-8 2009 When tested with low concentrations of saturated and monounsaturated FAs (e.g. oleic acid), the rates of AA oxygenation are typically 1.5-2 times higher with PGHS-2 than with PGHS-1. Fatty Acids 69-72 prostaglandin-endoperoxide synthase 2 Homo sapiens 158-164 21605700-0 2011 Increased Delta5- and Delta6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fibrosis. Fatty Acids 122-132 prostaglandin-endoperoxide synthase 2 Homo sapiens 41-57 19318492-2 2009 This potential effect may be modified by genetic variation in cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism and inflammation. Fatty Acids 104-114 prostaglandin-endoperoxide synthase 2 Homo sapiens 62-78 19318492-2 2009 This potential effect may be modified by genetic variation in cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism and inflammation. Fatty Acids 104-114 prostaglandin-endoperoxide synthase 2 Homo sapiens 80-85 18296339-7 2008 It is also known that enhanced saturated fatty acid levels can contribute to enhanced cyclooxygenase-2 activity. Fatty Acids 31-51 prostaglandin-endoperoxide synthase 2 Homo sapiens 86-102 11278967-0 2001 Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. Fatty Acids 0-21 prostaglandin-endoperoxide synthase 2 Homo sapiens 81-97 14498827-4 2003 Possible therapeutic targets for such modified fatty acids include: i) Histone deacetylase; ii) nuclear hormone receptors (retinoid receptors), peroxisome proliferator-activated receptors; iii) cyclooxygenase-2; iv) intracellular signalling involving protein farnesylation and Ras activation; and v) various mitochondrial functions. Fatty Acids 47-58 prostaglandin-endoperoxide synthase 2 Homo sapiens 194-210 11726530-0 2001 Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through toll-like receptor 4-derived signaling pathways. Fatty Acids 52-63 prostaglandin-endoperoxide synthase 2 Homo sapiens 32-48 11726530-7 2001 Whether fatty acids also modulate signaling pathways and target gene expression derived from the activation of other Tlrs remains to be determined.-Hwang, D. Modulation of the expression of cyclooxygenase 2 by fatty acids mediated through Toll-like receptor 4-derived signaling pathways. Fatty Acids 8-19 prostaglandin-endoperoxide synthase 2 Homo sapiens 190-206 11726530-7 2001 Whether fatty acids also modulate signaling pathways and target gene expression derived from the activation of other Tlrs remains to be determined.-Hwang, D. Modulation of the expression of cyclooxygenase 2 by fatty acids mediated through Toll-like receptor 4-derived signaling pathways. Fatty Acids 210-221 prostaglandin-endoperoxide synthase 2 Homo sapiens 190-206 15358633-9 2004 Both fatty acids decreased the growth of the tumors obtained by inoculating HT-29 cells in nude mice, microvessel formation and the levels of VEGF, COX-2 and PGE(2) in tumors. Fatty Acids 5-16 prostaglandin-endoperoxide synthase 2 Homo sapiens 148-153 27044314-9 2016 Two genes involved in the fatty acid metabolism (PTGS2 and ALOX5) were also modulated by the n-3 FAs. Fatty Acids 26-36 prostaglandin-endoperoxide synthase 2 Homo sapiens 49-54 7642610-5 1995 Gamma-Linolenate and eicosapentaenoate were poor substrates for both isozymes, but in each case, these two fatty acids were better substrates for hPGHS-2 than hPGHS-1. Fatty Acids 107-118 prostaglandin-endoperoxide synthase 2 Homo sapiens 146-153 30471768-9 2018 This is consistent with biochemical data showing that fatty acids which are not substrates for cyclooxygenases can activate cyclooxygenase-2 allosterically. Fatty Acids 54-65 prostaglandin-endoperoxide synthase 2 Homo sapiens 124-140 27071958-7 2016 Based on the evaluation of inflammatory markers of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2), the fatty acid derivatives of Q3G were found to be effective in lowering the inflammatory response. Fatty Acids 109-119 prostaglandin-endoperoxide synthase 2 Homo sapiens 51-67 27071958-7 2016 Based on the evaluation of inflammatory markers of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2), the fatty acid derivatives of Q3G were found to be effective in lowering the inflammatory response. Fatty Acids 109-119 prostaglandin-endoperoxide synthase 2 Homo sapiens 69-74 30710016-0 2019 Interactions of fatty acids, nonsteroidal anti-inflammatory drugs, and coxibs with the catalytic and allosteric subunits of cyclooxygenases-1 and -2. Fatty Acids 16-27 prostaglandin-endoperoxide synthase 2 Homo sapiens 124-148 29578814-2 2018 Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism, is upregulated during both inflammation and cancer. Fatty Acids 42-52 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-16 29578814-2 2018 Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism, is upregulated during both inflammation and cancer. Fatty Acids 42-52 prostaglandin-endoperoxide synthase 2 Homo sapiens 18-23 28331434-0 2017 Successful reduction of inflammatory responses and arachidonic acid-cyclooxygenase 2 pathway in human pulmonary artery endothelial cells by silencing adipocyte fatty acid-binding protein. Fatty Acids 160-170 prostaglandin-endoperoxide synthase 2 Homo sapiens 68-84 27756840-0 2016 Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit. Fatty Acids 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 48-64 27756840-4 2016 An S121P substitution in both PGHS-2 monomers yields a variant (S121P/S121P PGHS-2) that has 1.7-1.8 times the Vmax of native PGHS-2 and is relatively insensitive to activation by FAs or inhibition by allosteric inhibitors. Fatty Acids 180-183 prostaglandin-endoperoxide synthase 2 Homo sapiens 30-36 27756840-4 2016 An S121P substitution in both PGHS-2 monomers yields a variant (S121P/S121P PGHS-2) that has 1.7-1.8 times the Vmax of native PGHS-2 and is relatively insensitive to activation by FAs or inhibition by allosteric inhibitors. Fatty Acids 180-183 prostaglandin-endoperoxide synthase 2 Homo sapiens 76-82 27756840-4 2016 An S121P substitution in both PGHS-2 monomers yields a variant (S121P/S121P PGHS-2) that has 1.7-1.8 times the Vmax of native PGHS-2 and is relatively insensitive to activation by FAs or inhibition by allosteric inhibitors. Fatty Acids 180-183 prostaglandin-endoperoxide synthase 2 Homo sapiens 76-82 26703471-3 2016 Previous studies suggested that the binding to Eallo of saturated or monounsaturated fatty acids (FAs) that are not COX substrates differentially regulate PGHS-1 versus PGHS-2. Fatty Acids 98-101 prostaglandin-endoperoxide synthase 2 Homo sapiens 169-175 26703471-5 2016 Non-substrate FAs like palmitic acid bind Eallo of PGHSs stimulating human (hu) PGHS-2 but inhibiting huPGHS-1. Fatty Acids 14-17 prostaglandin-endoperoxide synthase 2 Homo sapiens 80-86