PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17382463-4 2007 Knock-down of PGC-1alpha is accompanied by diminished protein concentration and decreased expression level of PGC-1alpha target genes, among them key enzymes involved in gluconeogenesis, mitochondrial biogenesis and fatty acid oxidation. Fatty Acids 216-226 PPARG coactivator 1 alpha Rattus norvegicus 14-24 17382463-4 2007 Knock-down of PGC-1alpha is accompanied by diminished protein concentration and decreased expression level of PGC-1alpha target genes, among them key enzymes involved in gluconeogenesis, mitochondrial biogenesis and fatty acid oxidation. Fatty Acids 216-226 PPARG coactivator 1 alpha Rattus norvegicus 110-120 12807885-1 2003 Peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) is a transcriptional coactivator that regulates multiple aspects of cellular energy metabolism, including mitochondrial biogenesis, hepatic gluconeogenesis, and beta-oxidation of fatty acids. Fatty Acids 260-271 PPARG coactivator 1 alpha Rattus norvegicus 0-67 15967803-5 2005 The peroxisome proliferator-activated receptor gamma coactivator (PGC-1alpha) stimulates the expression of genes involved in hepatic gluconeogenesis and mitochondrial fatty acid oxidation. Fatty Acids 167-177 PPARG coactivator 1 alpha Rattus norvegicus 66-76 15469941-4 2004 The peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) is a coactivator that promotes mitochondrial biogenesis, mitochondrial fatty acid oxidation, and hepatic gluconeogenesis. Fatty Acids 159-169 PPARG coactivator 1 alpha Rattus norvegicus 75-86 16223979-3 2006 Therefore, we have examined the relationship between PGC-1alpha protein expression and the intramuscular fatty acid accumulation in hindlimb muscles of animals in which the capacity for fatty acid accumulation in muscle is increased (Zucker obese rat) or reduced [FAT/CD36 null (KO) mice]. Fatty Acids 105-115 PPARG coactivator 1 alpha Rattus norvegicus 53-63 12807885-1 2003 Peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) is a transcriptional coactivator that regulates multiple aspects of cellular energy metabolism, including mitochondrial biogenesis, hepatic gluconeogenesis, and beta-oxidation of fatty acids. Fatty Acids 260-271 PPARG coactivator 1 alpha Rattus norvegicus 69-79 34923497-7 2022 The exercise upregulated the renal expressions of both medium-chain acyl-CoA dehydrogenase and peroxisome proliferator-activated receptor gamma coactivator-1alpha related to fatty acid metabolism. Fatty Acids 174-184 PPARG coactivator 1 alpha Rattus norvegicus 95-162 31368276-12 2019 CONCLUSION: Both EA and treadmill exercise can significantly increase the expression of PGC-1alpha, FNDC5 and p-AMPK in skeletal muscle of DIO rats, suggesting their efficacy in restoring fatty acid oxidation in skeletal muscle cells and improving mitochondrial function, which may contribute to their function in body reduction. Fatty Acids 188-198 PPARG coactivator 1 alpha Rattus norvegicus 88-98 33991387-8 2021 The increased expression of GLUT4 and decreased expression of PGC1alpha and PPARalpha may reflect a shift from fatty acid oxidation to glycolysis. Fatty Acids 111-121 PPARG coactivator 1 alpha Rattus norvegicus 62-71 33486096-7 2021 Quantitative real-time PCR analysis revealed a downregulation of PGC-1alpha with concomitant suppression of fatty acid oxidation/mitochondrial genes. Fatty Acids 108-118 PPARG coactivator 1 alpha Rattus norvegicus 65-75 31815823-4 2020 Acute exposure to ET1 (4 hours) in the presence of palmitate as primary energy substrate induced mitochondrial membrane depolarization and decreased mitochondrial bioenergetics and expression of genes related to fatty acid oxidation (ie, peroxisome proliferator-activated receptor-gamma coactivator-1alpha, a driver of mitochondrial biogenesis, and carnitine palmitoyltransferase-1beta, facilitator of fatty acid uptake). Fatty Acids 212-222 PPARG coactivator 1 alpha Rattus norvegicus 238-305 24462915-7 2014 After either treatment PGC1alpha gene expression was down regulated in skeletal muscle, an important player in fatty acid oxidation. Fatty Acids 111-121 PPARG coactivator 1 alpha Rattus norvegicus 23-32 28074114-4 2016 They also prevented the downregulation of hepatic Sirtuin 1 (SIRT1) and PGC1alpha and their target fatty acid oxidation pathway genes and attenuated the upregulation of hepatic PGC1beta and sterol regulatory element-binding protein 1c (SREBP1c) and their target lipogenic pathway genes via the phosphorylation of 5" adenosine monophosphate-activated protein kinase (AMPK). Fatty Acids 99-109 PPARG coactivator 1 alpha Rattus norvegicus 72-81 25516653-6 2014 Accordingly, AMPK targets acetyl-CoA carboxylase and cyclic AMP response element binding protein are phosphorylated, with the concomitant carnitine palmitoyltransferase-1alpha (CPT-1alpha) activation and higher expression of peroxisome proliferator-activated receptor-gamma co-activator-1alpha and that of the fatty acid oxidation (FAO)-related enzymes CPT-1alpha, acyl-CoA oxidase 1, and acyl-CoA thioesterase 2. Fatty Acids 310-320 PPARG coactivator 1 alpha Rattus norvegicus 225-293 29901150-3 2018 The present study aimed to investigate the role of NT-PGC-1alpha in mitochondrial fatty acid metabolism and its possible regulatory mechanism in NRCMs. Fatty Acids 82-92 PPARG coactivator 1 alpha Rattus norvegicus 54-64 29901150-9 2018 Furthermore, NT-PGC-1alpha overexpression alleviated the PE-induced suppression of fatty acid metabolism-associated protein expression, increased extracellular oxygen consumption and decreased lipid droplet accumulation in NRCMs. Fatty Acids 83-93 PPARG coactivator 1 alpha Rattus norvegicus 16-26 24013029-6 2014 Additionally, the genistein-mediated induction of fatty acid oxidation genes involved PGC1alpha and PPARdelta. Fatty Acids 50-60 PPARG coactivator 1 alpha Rattus norvegicus 86-95 23515531-1 2013 The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) is a key determinant of cardiac metabolic function by regulating genes governing fatty acid oxidation and mitochondrial biogenesis. Fatty Acids 194-204 PPARG coactivator 1 alpha Rattus norvegicus 101-111 23415654-7 2013 We found also an epigenomic deregulation of energy metabolism and fatty acids beta-oxidation in myocardium and liver, through imbalanced methylation/acetylation of PGC-1alpha and decreased expression of SIRT1. Fatty Acids 66-77 PPARG coactivator 1 alpha Rattus norvegicus 164-174 22899824-0 2012 PGC-1alpha overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion. Fatty Acids 55-65 PPARG coactivator 1 alpha Rattus norvegicus 0-10 23152488-6 2013 The expression of multiple peroxisome proliferator-activated receptor-gamma coactivator-1alpha target genes required for fatty acid oxidation was similarly decreased. Fatty Acids 121-131 PPARG coactivator 1 alpha Rattus norvegicus 27-94 22899824-2 2012 We examined whether peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) overexpression and a subsequent increase in mitochondrial content and function in rat primary hepatocytes (in vitro) and Sprague-Dawley rats (in vivo) would comprehensively alter mitochondrial lipid metabolism, including complete (CO(2)) and incomplete (acid-soluble metabolites) fatty acid oxidation (FAO), tricarboxylic acid cycle flux, and triacylglycerol (TAG) storage and export. Fatty Acids 381-391 PPARG coactivator 1 alpha Rattus norvegicus 89-99 20490453-10 2010 CONCLUSIONS/INTERPRETATIONS: Increases in PGC-1alpha levels, similar to those that can be induced by physiological stimuli, altered intramuscular lipids and improved fatty acid oxidation, insulin signalling and insulin-stimulated glucose transport, albeit to different extents in lean and insulin-resistant muscle. Fatty Acids 166-176 PPARG coactivator 1 alpha Rattus norvegicus 42-52 18509063-4 2008 This adaptation appears to be mediated by activation of peroxisome proliferator-activated receptor (PPAR)delta by fatty acids, which results in a gradual, posttranscriptionally regulated increase in PPAR gamma coactivator 1alpha (PGC-1alpha) protein expression. Fatty Acids 114-125 PPARG coactivator 1 alpha Rattus norvegicus 199-228 18509063-4 2008 This adaptation appears to be mediated by activation of peroxisome proliferator-activated receptor (PPAR)delta by fatty acids, which results in a gradual, posttranscriptionally regulated increase in PPAR gamma coactivator 1alpha (PGC-1alpha) protein expression. Fatty Acids 114-125 PPARG coactivator 1 alpha Rattus norvegicus 230-240 18079123-10 2008 Thus, in skeletal muscle in vivo, a modest PGC-1alpha overexpression up-regulated selected plasmalemmal and mitochondrial fuel-handling proteins, increased SS (not IMF) mitochondrial fatty acid oxidation, and improved insulin sensitivity. Fatty Acids 183-193 PPARG coactivator 1 alpha Rattus norvegicus 43-53 17987121-4 2007 PRINCIPAL FINDINGS: Oleate and palmitate, the most abundant monounsaturated fatty acid and saturated fatty acid in plasma, respectively, differently affect the mRNA and protein levels of PGC-1alpha in VSMCs. Fatty Acids 66-86 PPARG coactivator 1 alpha Rattus norvegicus 187-197 17987121-5 2007 OA treatment resulted in a reduction of PGC-1alpha expression, which may be responsible for the increase in VSMC proliferation and migration caused by this fatty acid. Fatty Acids 156-166 PPARG coactivator 1 alpha Rattus norvegicus 40-50 17987121-8 2007 This saturated fatty acid induced PGC-1alpha expression and prevented OA-induced VSMC proliferation and migration. Fatty Acids 5-25 PPARG coactivator 1 alpha Rattus norvegicus 34-44