PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33758172-6 2021 Mobilized adipocyte fatty acids are oxidized, leading to increased peroxisome proliferator-activated receptor alpha (PPARalpha)-dependent adiponectin secretion, which in turn increases hepatic fatty acid oxidation to ameliorate obesity-induced fatty liver. Fatty Acids 20-31 adiponectin, C1Q and collagen domain containing Mus musculus 138-149 34268878-2 2021 The objective of this study was focused on the ADPN to investigate the functional mechanisms of pectin oligosaccharide (POS) from hawthorn fruit in the improvement of hepatic fatty acid oxidation. Fatty Acids 175-185 adiponectin, C1Q and collagen domain containing Mus musculus 47-51 34986886-0 2022 Adiponectin triggers breast cancer cell death via fatty acid metabolic reprogramming. Fatty Acids 50-60 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 34859390-0 2022 Adiponectin ameliorates placental injury in gestational diabetes mice by correcting fatty acid oxidation/peroxide imbalance-induced ferroptosis via restoration of CPT-1 activity. Fatty Acids 84-94 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 34859390-19 2022 CONCLUSIONS: ADPN ameliorated placental injury in GDM by correcting fatty acid oxidation/peroxide imbalance-induced ferroptosis via restoration of CPT-1 activity. Fatty Acids 68-78 adiponectin, C1Q and collagen domain containing Mus musculus 13-17 35563332-7 2022 Wildtype dams on a HF/HS diet protected the fetuses from fatty acid overload as judged by increased liver TGs in dams and normal serum and liver TG levels in fetuses, while low adiponectin was associated with increased fetal liver TGs. Fatty Acids 57-67 adiponectin, C1Q and collagen domain containing Mus musculus 177-188 35563332-8 2022 Low maternal adiponectin increased the expression of genes involved in fatty acid transport; Lpl and Cd36 in the placenta. Fatty Acids 71-81 adiponectin, C1Q and collagen domain containing Mus musculus 13-24 34986886-5 2022 METHODS: The effects of adiponectin on fatty acid metabolism were evaluated by measuring the cellular neutral lipid pool, free fatty acid level, and fatty acid oxidation (FAO). Fatty Acids 39-49 adiponectin, C1Q and collagen domain containing Mus musculus 24-35 34986886-5 2022 METHODS: The effects of adiponectin on fatty acid metabolism were evaluated by measuring the cellular neutral lipid pool, free fatty acid level, and fatty acid oxidation (FAO). Fatty Acids 127-137 adiponectin, C1Q and collagen domain containing Mus musculus 24-35 34986886-5 2022 METHODS: The effects of adiponectin on fatty acid metabolism were evaluated by measuring the cellular neutral lipid pool, free fatty acid level, and fatty acid oxidation (FAO). Fatty Acids 149-159 adiponectin, C1Q and collagen domain containing Mus musculus 24-35 34986886-14 2022 Mechanistically, dysregulated cellular lipid homeostasis by adiponectin was induced by two concerted actions: 1) suppression of fatty acid synthesis (FAS) through downregulation of SREBP-1 and FAS-related enzymes, and 2) stimulation of lipophagy-mediated lipolysis and FAO. Fatty Acids 128-138 adiponectin, C1Q and collagen domain containing Mus musculus 60-71 34986886-16 2022 Finally, fatty acid metabolic remodeling by adiponectin and the key role of SIRT-1 were confirmed in nude mice bearing breast tumor xenografts. Fatty Acids 9-19 adiponectin, C1Q and collagen domain containing Mus musculus 44-55 34986886-17 2022 CONCLUSION: This study elucidates the multifaceted role of adiponectin in tumor fatty acid metabolic reprogramming and provides evidence for the connection between its metabolic actions and suppression of breast cancer. Fatty Acids 80-90 adiponectin, C1Q and collagen domain containing Mus musculus 59-70 33758172-6 2021 Mobilized adipocyte fatty acids are oxidized, leading to increased peroxisome proliferator-activated receptor alpha (PPARalpha)-dependent adiponectin secretion, which in turn increases hepatic fatty acid oxidation to ameliorate obesity-induced fatty liver. Fatty Acids 20-30 adiponectin, C1Q and collagen domain containing Mus musculus 138-149 33199780-2 2020 Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors AdipoR1 and AdipoR2, and AdipoRs signaling is reported to enhance fatty acid oxidation and glucose uptake. Fatty Acids 171-181 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 33293421-5 2020 Both gAcrp30 and full-length adiponectin (Acrp30) treatment increased eNOS/AMPK activation in muscle and muscle fatty acid oxidation. Fatty Acids 112-122 adiponectin, C1Q and collagen domain containing Mus musculus 29-40 33293421-5 2020 Both gAcrp30 and full-length adiponectin (Acrp30) treatment increased eNOS/AMPK activation in muscle and muscle fatty acid oxidation. Fatty Acids 112-122 adiponectin, C1Q and collagen domain containing Mus musculus 6-12 31250564-4 2019 Moreover, the interactions between Mstn and adiponectin in regulating gene expression critical for fatty acid metabolism and insulin action in hepatocytes have not been investigated. Fatty Acids 99-109 adiponectin, C1Q and collagen domain containing Mus musculus 44-55 32586265-12 2020 CONCLUSION: Alteration of gut microbiota induced by antibiotic use may affect the expression of adiponectin and resistin in mice fed the high-fat diet by modifying promoter DNA methylation, thus leading to increased fatty acid oxidation and less body weight gain. Fatty Acids 216-226 adiponectin, C1Q and collagen domain containing Mus musculus 96-107 31554925-6 2019 Notably, adiponectin is an important adipokine and an essential regulator of glucose and fatty acid homeostasis. Fatty Acids 89-99 adiponectin, C1Q and collagen domain containing Mus musculus 9-20 31629112-0 2020 An adiponectin receptor agonist antibody stimulates glucose uptake and fatty-acid oxidation by activating AMP-activated protein kinase. Fatty Acids 71-81 adiponectin, C1Q and collagen domain containing Mus musculus 3-14 26700221-5 2017 Gene expression and methylation degree of CpG sites in promoter sequences of genes involved in fatty acid metabolism, including adiponectin (Adipoq), stearoyl-CoA desaturase (Scd1) and fatty acid synthase (Fasn), were determined by bisulphite sequencing in liver and epididymal white adipose tissue. Fatty Acids 95-105 adiponectin, C1Q and collagen domain containing Mus musculus 128-139 31125082-1 2019 The metabolic hormone adiponectin is secreted into the circulation by adipocytes and mediates key biological functions, including insulin sensitivity, adipocyte development, and fatty acid oxidation. Fatty Acids 178-188 adiponectin, C1Q and collagen domain containing Mus musculus 22-33 28805698-4 2017 These beneficial effects were accompanied by the activation of adiponectin-adenosine monophosphate-activated protein kinase (AMPK) mediated signaling cascades in the liver, which downregulated molecules involved in lipogenesis and concurrently upregulated molecules related to fatty acid oxidation. Fatty Acids 277-287 adiponectin, C1Q and collagen domain containing Mus musculus 63-74 30891787-2 2019 T3 and adiponectin play important roles in controlling normal metabolic functions such as stimulation of fatty acid oxidation and increase in thermogenesis. Fatty Acids 105-115 adiponectin, C1Q and collagen domain containing Mus musculus 7-18 29991592-0 2018 A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms. Fatty Acids 121-131 adiponectin, C1Q and collagen domain containing Mus musculus 32-43 29991592-13 2018 To our knowledge, this is the first report on identification of a short peptide from adiponectin with positive effects on glucose or fatty acid metabolism. Fatty Acids 133-143 adiponectin, C1Q and collagen domain containing Mus musculus 85-96 22904186-3 2012 Compared with WT mice, adiponectin KO mice fed a chow diet exhibited decreased mRNA expression of rate-limiting enzymes in several important glucose and lipid metabolic pathways, including glycolysis, tricarboxylic acid cycle, fatty-acid activation and synthesis, triglyceride synthesis, and cholesterol synthesis. Fatty Acids 227-237 adiponectin, C1Q and collagen domain containing Mus musculus 23-34 25915851-7 2015 Our data also indicate that stimulation of omega-oxidation of fatty acids by the HFD is enhanced by adiponectin. Fatty Acids 62-73 adiponectin, C1Q and collagen domain containing Mus musculus 100-111 25915851-8 2015 In conclusion, this metabolomic profiling approach in AdKO mice identified important targets of adiponectin action, including PLA2, to regulate lysophospholipid metabolism and omega-oxidation of fatty acids. Fatty Acids 195-206 adiponectin, C1Q and collagen domain containing Mus musculus 96-107 25243869-6 2015 GGEx18 significantly increased the expression of fatty acid oxidation genes, including adiponectin, AMPKs, PPARalpha and its target enzymes, and CPT-1, in both mesenteric adipose tissues and 3T3-L1 cells. Fatty Acids 49-59 adiponectin, C1Q and collagen domain containing Mus musculus 87-98 24381003-1 2014 The adipocyte-derived hormone adiponectin promotes fatty acid oxidation and improves insulin sensitivity and thus plays a key role in the regulation of lipid and glucose metabolism and energy homeostasis. Fatty Acids 51-61 adiponectin, C1Q and collagen domain containing Mus musculus 30-41 24381003-8 2014 The adiponectin-dependent, antisteatotic effect of rimonabant was mediated by reduced uptake and increased beta-oxidation of fatty acids in the liver. Fatty Acids 125-136 adiponectin, C1Q and collagen domain containing Mus musculus 4-15 23023478-1 2013 Adiponectin is secreted from adipose tissue and functions as a protein hormone in regulating glucose metabolism and fatty acid catabolism. Fatty Acids 116-126 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 22367091-9 2012 Adiponectin attenuates alcoholic liver injury by the complex network of multiple signaling pathways in the liver, leading to enhanced fatty acid oxidation and reduced steatosis. Fatty Acids 134-144 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 23238294-5 2013 Adiponectin corrected the altered branched-chain amino acid metabolism caused by HFD and corrected increases across a range of glycerolipids, fatty acids, and various lysolipids. Fatty Acids 142-153 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 21889885-10 2012 These findings suggest that tiliroside enhances fatty acid oxidation via the enhancement adiponectin signaling associated with the activation of both AMP-activated protein kinase and peroxisome proliferator-activated receptor alpha and ameliorates obesity-induced metabolic disorders, such as hyperinsulinemia and hyperlipidemia, although it does not suppress body weight gain and visceral fat accumulation in obese-diabetic model mice. Fatty Acids 48-58 adiponectin, C1Q and collagen domain containing Mus musculus 89-100 23155424-1 2012 BACKGROUND: Adiponectin regulates glucose and fatty-acid metabolism but its role in chronic graft rejection mediated by Th2 cytokines remains ill-defined. Fatty Acids 46-56 adiponectin, C1Q and collagen domain containing Mus musculus 12-23 22030618-9 2012 Overall results suggest that (-)-secoisolariciresinol exerts a suppressive effect on the gain of body weight of mice fed a high-fat diet by inducing gene expression of adiponectin, resulting in the altered expression of various genes related to the synthesis and beta-oxidation of fatty acids. Fatty Acids 281-292 adiponectin, C1Q and collagen domain containing Mus musculus 168-179 22127231-5 2012 Soymorphin-5 increased plasma adiponectin concentration and liver mRNA expression of AdipoR2, a subtype of adiponectin receptor that is involved in stimulating the peroxisome proliferator-activated receptor (PPAR)alpha pathway and fatty acid beta-oxidation. Fatty Acids 231-241 adiponectin, C1Q and collagen domain containing Mus musculus 107-118 22045665-0 2012 Enhanced fatty acid flux triggered by adiponectin overexpression. Fatty Acids 9-19 adiponectin, C1Q and collagen domain containing Mus musculus 38-49 22108800-5 2012 Consequently, both the circulating adiponectin levels and the activity of hepatic AMP-activated protein kinase were significantly increased, subsequently enhancing whole-body insulin sensitivity and energy expenditure with increased hepatic fatty acid oxidation in VEPDK1KO mice. Fatty Acids 241-251 adiponectin, C1Q and collagen domain containing Mus musculus 35-46 22140527-0 2011 The multi-level action of fatty acids on adiponectin production by fat cells. Fatty Acids 26-37 adiponectin, C1Q and collagen domain containing Mus musculus 41-52 21332406-6 2011 At the same time expression of the adiponectin gene/protein and its receptor, AdipoR2, increased in adipose tissue and/or plasma, accompanied by increased activation of hepatic AMP-activated protein kinase, a marker of fatty acid oxidation. Fatty Acids 219-229 adiponectin, C1Q and collagen domain containing Mus musculus 35-46 22140527-3 2011 Here, we investigated the effect of a major dietary saturated fatty acid, palmitate, on the insulin-sensitizing adipokine adiponectin produced by cultured adipocytes. Fatty Acids 52-72 adiponectin, C1Q and collagen domain containing Mus musculus 122-133 19690401-8 2010 The elevation of liver insulin sensitivity by the hormone adiponectin in CR and long-lived dwarf mice can lower endogenous glucose production and raise fatty acid oxidation. Fatty Acids 152-162 adiponectin, C1Q and collagen domain containing Mus musculus 58-69 20093494-4 2010 In parallel, adiponectin-overexpressing mice also display enhanced clearance of circulating fatty acids and increased expansion of subcutaneous adipose tissue with chronic high fat diet (HFD) feeding. Fatty Acids 92-103 adiponectin, C1Q and collagen domain containing Mus musculus 13-24 20667975-2 2010 Here we tested the hypothesis that AMP, generated in activating fatty acids to their CoA derivatives, catalyzed by acyl-CoA synthetases, is involved in AMPK activation by adiponectin. Fatty Acids 64-75 adiponectin, C1Q and collagen domain containing Mus musculus 171-182 19254698-1 2009 Adiponectin, one of the insulin-sensitizing adipokines, has been shown to activate fatty acid oxidation in liver and skeletal muscle, thus maintaining insulin sensitivity. Fatty Acids 83-93 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 19564844-3 2009 Adiponectin has direct actions in the liver with prominent roles to improve hepatic insulin sensitivity, increase fatty acid oxidation, and decrease inflammation. Fatty Acids 114-124 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 19254698-2 2009 However, the precise roles of adiponectin in fatty acid synthesis are poorly understood. Fatty Acids 45-55 adiponectin, C1Q and collagen domain containing Mus musculus 30-41 19254698-3 2009 Here we show that adiponectin administration acutely suppresses expression of sterol regulatory element-binding protein (SREBP) 1c, the master regulator which controls and upregulates the enzymes involved in fatty acid synthesis, in the liver of +Lepr(db)/+Lepr(db) (db/db) mouse as well as in cultured hepatocytes. Fatty Acids 208-218 adiponectin, C1Q and collagen domain containing Mus musculus 18-29 17717684-0 2008 Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. Fatty Acids 21-32 adiponectin, C1Q and collagen domain containing Mus musculus 55-66 19013135-7 2009 The expression levels of peroxisome proliferator-activated receptor (PPAR) alpha and carnitine palmitoyltransferase-1 (CPT-1), a key enzyme in mitochondrial fatty acid oxidation, were decreased in adiponectin KO mice, suggesting possible contribution of altered fat metabolism to these phenomena. Fatty Acids 157-167 adiponectin, C1Q and collagen domain containing Mus musculus 197-208 18946183-1 2008 Adiponectin, which is expressed exclusively in adipose tissue, has been shown to increase fatty acid oxidation via activation of AMP-activated kinase (AMPK) and phosphorylation of acetyl CoA carboxylase (ACC). Fatty Acids 90-100 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 18446001-1 2008 Adiponectin has been proposed to act as an antidiabetic adipokine, suppressing gluconeogenesis and stimulating fatty acid oxidation in the liver and skeletal muscle. Fatty Acids 111-121 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 17768423-2 2008 Neuropeptide Y (NPY) and cholecystokinin play critical roles in the regulation of food intake and energy homeostasis, while adiponectin and carnitine palmitoyltransferase (CPT) are important for insulin sensitivity and fatty acid oxidation. Fatty Acids 219-229 adiponectin, C1Q and collagen domain containing Mus musculus 124-135 17717684-8 2008 These results indicate that the intake of certain fatty acids may affect serum adiponectin levels in mice and adiponectin gene expression in mouse WAT and 3T3-L1 adipocytes. Fatty Acids 50-61 adiponectin, C1Q and collagen domain containing Mus musculus 79-90 17717684-8 2008 These results indicate that the intake of certain fatty acids may affect serum adiponectin levels in mice and adiponectin gene expression in mouse WAT and 3T3-L1 adipocytes. Fatty Acids 50-61 adiponectin, C1Q and collagen domain containing Mus musculus 110-121 17905742-9 2007 The suppression of glucose production by adiponectin in vitro depended on AMP-activated protein kinase, a cell mediator of fatty acid oxidation. Fatty Acids 123-133 adiponectin, C1Q and collagen domain containing Mus musculus 41-52 16507604-2 2006 Adiponectin treatment improves the metabolic phenotype by increasing fatty acid oxidation in skeletal muscle and suppressing hepatic glucose production. Fatty Acids 69-79 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 17618856-1 2007 Adiponectin has been shown to stimulate fatty acid oxidation and enhance insulin sensitivity through the activation of AMP-activated protein kinase (AMPK) in the peripheral tissues. Fatty Acids 40-50 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 15210937-3 2004 In muscle and liver, adiponectin stimulates AMP-activated protein kinase activation and fatty acid oxidation. Fatty Acids 88-98 adiponectin, C1Q and collagen domain containing Mus musculus 21-32 16595853-3 2006 One such factor, adiponectin, increases fatty acid oxidation and enhances insulin sensitivity. Fatty Acids 40-50 adiponectin, C1Q and collagen domain containing Mus musculus 17-28 16055297-2 2006 Adiponectin receptors (adipoR1 and adipoR2) are recently found in mice which act as receptors for globular and full-length adiponectin to mediate the fatty-acid oxidation and glucose uptake in muscle and liver. Fatty Acids 150-160 adiponectin, C1Q and collagen domain containing Mus musculus 123-134 16108051-0 2005 Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Fatty Acids 56-69 adiponectin, C1Q and collagen domain containing Mus musculus 8-19 16108051-3 2005 Circulating adiponectin levels were significantly elevated by chronic ethanol administration to mice consuming a diet high in saturated fat. Fatty Acids 126-139 adiponectin, C1Q and collagen domain containing Mus musculus 12-23 16108051-4 2005 The increase in circulating adiponectin was associated with the activation a set of hepatic signaling pathways mediated through AMP-activated protein kinase, PPAR-alpha, and PPAR-gamma coactivator alpha, which in turn led to markedly increased rates of fatty acid oxidation, prevention of hepatic steatosis, and alleviation of liver enzyme changes. Fatty Acids 253-263 adiponectin, C1Q and collagen domain containing Mus musculus 28-39 16108051-5 2005 Furthermore, treatment of rat 3T3-L1 adipocytes with saturated fatty acids (palmitic or stearic acids) in the presence of ethanol increased secretion of adiponectin and enhanced activity of a mouse adiponectin promoter. Fatty Acids 53-74 adiponectin, C1Q and collagen domain containing Mus musculus 198-209 16108051-6 2005 In conclusion, the protective action of saturated fat against the development of alcoholic fatty liver in mice is partially mediated through induction of adiponectin. Fatty Acids 40-53 adiponectin, C1Q and collagen domain containing Mus musculus 154-165 15897298-9 2005 We showed that AdipoR1 and AdipoR2 serve as receptors for globular and full-length adiponectin and mediate increased AMP-activated protein kinase, peroxisome proliferator-activated receptor-alpha ligand activities, and glucose uptake and fatty-acid oxidation by adiponectin. Fatty Acids 238-248 adiponectin, C1Q and collagen domain containing Mus musculus 83-94 15542462-1 2004 In mice, adiponectin receptors (AdipoR) have been found to mediate the effect of adiponectin in muscle and liver in regulation of glucose and fatty acid metabolism. Fatty Acids 142-152 adiponectin, C1Q and collagen domain containing Mus musculus 81-92 15231994-1 2004 Biochemical, genetic, and animal studies in recent years have established a critical role for the adipokine Acrp30/adiponectin in controlling whole-body metabolism, particularly by enhancing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. Fatty Acids 250-260 adiponectin, C1Q and collagen domain containing Mus musculus 108-114 15231994-1 2004 Biochemical, genetic, and animal studies in recent years have established a critical role for the adipokine Acrp30/adiponectin in controlling whole-body metabolism, particularly by enhancing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. Fatty Acids 250-260 adiponectin, C1Q and collagen domain containing Mus musculus 115-126 15893773-1 2005 The adipocyte-derived hormone adiponectin was recently shown to stimulate glucose-utilization and to increase fatty acid oxidation in liver and muscle. Fatty Acids 110-120 adiponectin, C1Q and collagen domain containing Mus musculus 30-41 15599400-5 2004 In cultured adipocytes, elevated levels of fatty acids increased oxidative stress via NADPH oxidase activation, and oxidative stress caused dysregulated production of adipocytokines (fat-derived hormones), including adiponectin, plasminogen activator inhibitor-1, IL-6, and monocyte chemotactic protein-1. Fatty Acids 43-54 adiponectin, C1Q and collagen domain containing Mus musculus 216-227 14592951-7 2004 These beneficial effects of adiponectin are partly due to its ability to decrease ritonavir-induced synthesis of fatty acids and triglyceride, and to increase fatty acid combustion in the liver tissue. Fatty Acids 113-124 adiponectin, C1Q and collagen domain containing Mus musculus 28-39 14592951-7 2004 These beneficial effects of adiponectin are partly due to its ability to decrease ritonavir-induced synthesis of fatty acids and triglyceride, and to increase fatty acid combustion in the liver tissue. Fatty Acids 113-123 adiponectin, C1Q and collagen domain containing Mus musculus 28-39 12660873-7 2002 Among the genes related to glucose and fatty acid metabolism, adiponectin mRNA levels in adipose tissue and adiponectin plasma concentrations were elevated in mice on a calorie-restricted diet, although there were no significant differences between soy protein and casein protein groups. Fatty Acids 39-49 adiponectin, C1Q and collagen domain containing Mus musculus 62-73 12840063-6 2003 These therapeutic effects resulted partly from the ability of adiponectin to increase carnitine palmitoyltransferase I activity and enhance hepatic fatty acid oxidation, while it decreased the activities of two key enzymes involved in fatty acid synthesis, including acetyl-CoA carboxylase and fatty acid synthase. Fatty Acids 148-158 adiponectin, C1Q and collagen domain containing Mus musculus 62-73 12782674-5 2003 Analysis of DGAT1-deficient WAT revealed a twofold increase in the expression of adiponectin, a molecule that enhances fatty acid oxidation and insulin sensitivity, and this increase may account in part for the transplantation-induced metabolic changes. Fatty Acids 119-129 adiponectin, C1Q and collagen domain containing Mus musculus 81-92 12802337-5 2003 This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR-alpha. Fatty Acids 86-96 adiponectin, C1Q and collagen domain containing Mus musculus 35-46 12833108-13 2003 CONCLUSIONS: Levels of circulating adiponectin do not alter in response to a fat meal, despite evidence in mice that acute changes in adiponectin significantly affect postprandial fatty acid flux. Fatty Acids 180-190 adiponectin, C1Q and collagen domain containing Mus musculus 134-145 11729635-6 2001 These inhibitors potentiate leptin"s effects and stimulated adiponectin levels, which increases fatty acid combustion and energy dissipation, thereby ameliorating HF diet-induced obesity and insulin resistance. Fatty Acids 96-106 adiponectin, C1Q and collagen domain containing Mus musculus 60-71