PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31020545-5 2019 Treatment of C2C12 myotubes with camptothecin increased phosphorylation of AMP-dependent kinase (AMPK) and acetyl-coenzyme A carboxylase, caused nuclear translocation and deacetylation of forkhead box O1 (FoxO1), increased transcription and protein expression of adipose triglyceride lipase (ATGL), decreased the amount of intracellular oil droplets, and significantly increased beta-oxidation of fatty acids. Fatty Acids 397-408 forkhead box O1 Mus musculus 188-203 29300910-6 2018 Mice with deletion of both insulin receptor and FoxO1 showed a much more modest phenotype, with normal or near-normal glucose levels, growth, leptin levels, hepatic diglycerides, and fatty acid oxidation gene expression; however, lipogenic gene expression remained low. Fatty Acids 183-193 forkhead box O1 Mus musculus 48-53 26984405-0 2016 FoxO1 Deacetylation Decreases Fatty Acid Oxidation in beta-Cells and Sustains Insulin Secretion in Diabetes. Fatty Acids 30-40 forkhead box O1 Mus musculus 0-5 26984405-7 2016 Islets expressing 6KR mutant FoxO1 have enhanced insulin secretion in vivo and ex vivo and decreased fatty acid oxidation ex vivo Remarkably, the gene expression signature associated with FoxO1 deacetylation differs from wild type by only ~2% of the >4000 genes regulated in response to re-feeding. Fatty Acids 101-111 forkhead box O1 Mus musculus 29-34 26984405-9 2016 The data support the notion that deacetylated FoxO1 protects beta-cell function by limiting mitochondrial lipid utilization and raise the possibility that inhibition of fatty acid oxidation in beta-cells is beneficial to diabetes treatment. Fatty Acids 169-179 forkhead box O1 Mus musculus 46-51 22800886-0 2012 LRP16 gene protects mouse insulinoma MIN6 cells against fatty acid-induced apoptosis through Akt/FoxO1 signaling. Fatty Acids 56-66 forkhead box O1 Mus musculus 97-102 19585174-3 2009 The incorporation of fluorescent-labeled glucose and fatty acid was significantly inhibited in cells deficient in Foxo1. Fatty Acids 53-63 forkhead box O1 Mus musculus 114-119 21194380-0 2011 Role of SIRT1-FoxO1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice. Fatty Acids 41-54 forkhead box O1 Mus musculus 14-19 19944124-3 2010 The transcription regulator Foxo1 is a prominent effector of PI3K/Akt; when it is inhibited, pancreatic beta-cells are protected against fatty-acid-induced apoptosis. Fatty Acids 137-147 forkhead box O1 Mus musculus 28-33 18174526-0 2008 Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Fatty Acids 65-75 forkhead box O1 Mus musculus 14-19 19046567-4 2008 These metabolic effects of SRT1720 are mediated by the induction of a genetic network controlling fatty acid oxidation through a multifaceted mechanism that involves the direct deacetylation of PGC-1alpha, FOXO1, and p53 and the indirect stimulation of AMPK signaling through a global metabolic adaptation mimicking low energy levels. Fatty Acids 98-108 forkhead box O1 Mus musculus 206-211 18325999-8 2008 Furthermore, we observed that beta2-AR agonist administration in mouse skeletal muscle induced the expression of genes that activate fatty acid oxidation and modulate pyruvate use, including PGC-1alpha, lipin-1alpha, FOXO1, and PDK4. Fatty Acids 133-143 forkhead box O1 Mus musculus 217-222 18174526-5 2008 Foxo1 activity was increased with fatty acid administration and by pharmacological inducers of ER stress, and this increase was prevented by JNK inhibition. Fatty Acids 34-44 forkhead box O1 Mus musculus 0-5 18174526-6 2008 Fatty acids induced nuclear localization of Foxo1 at 4 h when Akt activity was increased, indicating that FoxO1 activation was not mediated by JNK inhibition of Akt. Fatty Acids 0-11 forkhead box O1 Mus musculus 44-49 18174526-6 2008 Fatty acids induced nuclear localization of Foxo1 at 4 h when Akt activity was increased, indicating that FoxO1 activation was not mediated by JNK inhibition of Akt. Fatty Acids 0-11 forkhead box O1 Mus musculus 106-111 18174526-8 2008 A dominant-negative Foxo1 adenovirus (Adv-DNFoxo) conferred cells with protection from ER stress and fatty acid-mediated apoptosis. Fatty Acids 101-111 forkhead box O1 Mus musculus 20-25 18174526-10 2008 CONCLUSIONS: Early induction of JNK and Foxo1 activation plays an important role in fatty acid-induced apoptosis. Fatty Acids 84-94 forkhead box O1 Mus musculus 40-45 18174526-11 2008 Expressing a dominant-negative allele of Foxo1 reduces expression of apoptotic and ER stress markers and promotes beta-cell survival from fatty acid and ER stress, identifying a potential therapeutic target for preserving beta-cells in type 2 diabetes. Fatty Acids 138-148 forkhead box O1 Mus musculus 41-46 17374693-8 2007 Together these results indicate that the insulin-resistant adipocyte produced by the exposure to a high concentration of fatty acids is characterized by decreased levels of FoxO1. Fatty Acids 121-132 forkhead box O1 Mus musculus 173-178 15691844-0 2005 FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms. Fatty Acids 17-27 forkhead box O1 Mus musculus 0-5 16906224-4 2006 Here we show that adenoviral delivery of constitutively nuclear forkhead box O1 (FoxO1) to mouse liver results in steatosis arising from increased triglyceride accumulation and decreased fatty acid oxidation. Fatty Acids 187-197 forkhead box O1 Mus musculus 64-79 16906224-4 2006 Here we show that adenoviral delivery of constitutively nuclear forkhead box O1 (FoxO1) to mouse liver results in steatosis arising from increased triglyceride accumulation and decreased fatty acid oxidation. Fatty Acids 187-197 forkhead box O1 Mus musculus 81-86 15691844-2 2005 Here, we investigate the role of FoxO1 in the regulation of fatty acid (FA) metabolism in muscle cells. Fatty Acids 60-70 forkhead box O1 Mus musculus 33-38 15691844-8 2005 The enhanced FA utilization induced by FoxO1 was mediated by a severalfold increase in plasma membrane level of the fatty acid translocase FAT/CD36 and eliminated by cell treatment with the CD36 inhibitor sulfo-N-succinimidyl-oleate. Fatty Acids 116-126 forkhead box O1 Mus musculus 39-44 34539243-12 2021 In Huh-6 cells and mouse tumor tissues, FoxO1 knockdown resulted in increased cell proliferation, migration, and invasion and active fatty acid metabolism. Fatty Acids 133-143 forkhead box O1 Mus musculus 40-45 34539243-17 2021 Conclusion: FoxO1 and SREBP-1c inhibited each other in HB, leading to the increase of intracellular fatty acid metabolism, and ultimately facilitated the development of HB. Fatty Acids 100-110 forkhead box O1 Mus musculus 12-17 33054209-0 2020 FoxO1 Knockdown Promotes Fatty Acid Synthesis via Modulating SREBP1 Activities in the Dairy Goat Mammary Epithelial Cells. Fatty Acids 25-35 forkhead box O1 Mus musculus 0-5