PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26220174-2	2015	This metabolic switch activates mechanistic target of rapamycin complex 1 (mTORC1), which initiates growth by increasing protein and RNA synthesis and fatty acid metabolism, while decreasing autophagy.	Fatty Acids	151-161	CREB regulated transcription coactivator 1	Mus musculus	75-81	
34685712-0	2021	Activation of mTORC1 by Free Fatty Acids Suppresses LAMP2 and Autophagy Function via ER Stress in Alcohol-Related Liver Disease.	Fatty Acids	29-40	CREB regulated transcription coactivator 1	Mus musculus	14-20	
34267188-8	2021	The pathological effect of sustained mTORC1 activity in ALD may be attributed to the suppression of peroxisome proliferator activated receptor alpha (PPARalpha), the master regulator of fatty acid oxidation in hepatocytes, because fenofibrate (PPARalpha agonist) treatment reverses ethanol-induced liver steatosis and inflammation in Depdc5-LKO mice.	Fatty Acids	186-196	CREB regulated transcription coactivator 1	Mus musculus	37-43	
34146544-6	2021	Further, we examined whether the activation of the anabolic program mediated by mTORC1 complex activation in the fasted state could suppress the robust catabolic programming and enhanced PPARalpha transcriptional response of mice with a liver-specific defect in mitochondrial long-chain fatty acid oxidation using Cpt2L-/- mice.	Fatty Acids	287-297	CREB regulated transcription coactivator 1	Mus musculus	80-86	
33401933-14	2021	Conclusions: TSC2-S1365 phosphorylation status regulates myocardial substrate utilization, and its decline activates mTORC1 biasing metabolism away from fatty acid oxidation to glycolysis to confer protection against IR.	Fatty Acids	153-163	CREB regulated transcription coactivator 1	Mus musculus	117-123	
33303821-0	2020	Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKbeta and mTORC1.	Fatty Acids	0-21	CREB regulated transcription coactivator 1	Mus musculus	123-129	
31673045-10	2019	In addition, the activation of mTORC1 by SCD1 deficiency reveals an important function of fatty acids in regulating different cellular processes through mTORC1 signaling.	Fatty Acids	90-101	CREB regulated transcription coactivator 1	Mus musculus	31-37	
33219129-7	2021	Interestingly, ABHD5-dependent suppression of mTORC1 was abrogated by pharmacological inhibition of DGAT1 or DGAT2, isoenzymes that re-esterify fatty acids in a process that consumes ATP.	Fatty Acids	144-155	CREB regulated transcription coactivator 1	Mus musculus	46-52	
31394165-5	2019	The investigation of molecular mechanisms responsible for the sexual dimorphisms delineated the selective activation of the ERK/mTORc1 signaling pathway leading to an increased biosynthesis and elongation of fatty acids in VLCAD-/- females.	Fatty Acids	208-219	CREB regulated transcription coactivator 1	Mus musculus	128-134	
31673045-10	2019	In addition, the activation of mTORC1 by SCD1 deficiency reveals an important function of fatty acids in regulating different cellular processes through mTORC1 signaling.	Fatty Acids	90-101	CREB regulated transcription coactivator 1	Mus musculus	153-159	
29457836-8	2018	DEPTOR-dependent inhibition of mTORC1 also attenuated alcohol-induced cytoplasmic accumulation of the lipogenic regulator lipin 1 and prevented alcohol-mediated inhibition of fatty acid oxidation.	Fatty Acids	175-185	CREB regulated transcription coactivator 1	Mus musculus	31-37	
31338091-5	2019	These enhanced TORC1 pathway activities may culminate in increased expression of the nuclear receptor peroxisome proliferator-activated receptor gamma (Ppargamma) that regulates fatty acid storage, and the transcription factor sterol regulatory element-binding transcription factor 1 (Srebf1).	Fatty Acids	178-188	CREB regulated transcription coactivator 1	Mus musculus	15-20	
30909319-7	2019	Decreased mTORC1 activity in turn mediates an elevation of fatty acid oxidation (FAO) by indirectly upregulating the expression of carnitine palmitoyltransferase 1a (Cpt1a) that mediates the rate-limiting step of beta-oxidation.	Fatty Acids	59-69	CREB regulated transcription coactivator 1	Mus musculus	10-16	
30298052-7	2018	Here, we show that under the physiological condition of acute lipogenesis, lobeglitazone inhibits hepatic lipid synthesis, the subsequent ER stress, and omega-oxidation of fatty acids by inhibiting the mTORC1 pathway.	Fatty Acids	172-183	CREB regulated transcription coactivator 1	Mus musculus	202-208	
27901044-3	2016	Here, we show that the mTORC1-PPARgamma pathway is crucial for the fatty acid uptake programme in activated CD4+ T cells.	Fatty Acids	67-77	CREB regulated transcription coactivator 1	Mus musculus	23-29	
28223357-3	2017	We report here that mTORC1 and mTORC2 are activated in response to exogenously supplied fatty acids via the de novo synthesis of PA, a central metabolite for membrane phospholipid biosynthesis.	Fatty Acids	88-99	CREB regulated transcription coactivator 1	Mus musculus	20-26	
26204830-0	2015	Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Downregulates ELOVL1 Gene Expression and Fatty Acid Synthesis in Goat Fetal Fibroblasts.	Fatty Acids	104-114	CREB regulated transcription coactivator 1	Mus musculus	55-61	
26204830-2	2015	Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of cell metabolism and is associated with fatty acids synthesis.	Fatty Acids	114-125	CREB regulated transcription coactivator 1	Mus musculus	41-47	
26204830-5	2015	Inhibition of mTORC1 by rapamycin decreased ELOVL1 expression and fatty acids synthesis in Cashmere goat fetal fibroblasts.	Fatty Acids	66-77	CREB regulated transcription coactivator 1	Mus musculus	14-20	
26204830-6	2015	These data show that ELOVL1 expression is regulated by mTORC1 and that mTORC1 has significant function in fatty acids synthesis in Cashmere goat.	Fatty Acids	106-117	CREB regulated transcription coactivator 1	Mus musculus	71-77	
25985629-3	2015	mTOR complex 1 (mTORC1) controls multiple cellular processes, including protein synthesis, glucose metabolism, fatty acid and sterol synthesis, mitochondrial biogenesis, and autophagy.	Fatty Acids	111-121	CREB regulated transcription coactivator 1	Mus musculus	16-22	
26112996-7	2015	CONCLUSION: High levels of AAs up-regulate hepatic fatty acid biosynthetic gene expression through an mTORC1-dependent manner, while attenuate insulin-mediated repression of gluconeogenesis through elevating IRS-1 Ser(302) phosphorylation, which in turn impairs Akt activation and thereby weakening insulin action.	Fatty Acids	51-61	CREB regulated transcription coactivator 1	Mus musculus	102-108	
22877732-4	2012	More particularly, it aims at providing an overview of the status of knowledge regarding the mechanisms underlying the ability of certain amino acids, glucose and fatty acids, to affect mTORC1 activity and in turn illustrates how the mTORC1 pathway couples nutrient sensing to the hypothalamic regulation of the organisms" energy homoeostasis and to the control of intracellular metabolic processes, such as glucose uptake, protein and lipid biosynthesis.	Fatty Acids	163-174	CREB regulated transcription coactivator 1	Mus musculus	186-192	
24726883-0	2014	Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes.	Fatty Acids	0-11	CREB regulated transcription coactivator 1	Mus musculus	51-57	
22877732-4	2012	More particularly, it aims at providing an overview of the status of knowledge regarding the mechanisms underlying the ability of certain amino acids, glucose and fatty acids, to affect mTORC1 activity and in turn illustrates how the mTORC1 pathway couples nutrient sensing to the hypothalamic regulation of the organisms" energy homoeostasis and to the control of intracellular metabolic processes, such as glucose uptake, protein and lipid biosynthesis.	Fatty Acids	163-174	CREB regulated transcription coactivator 1	Mus musculus	234-240	
19305497-0	2009	Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.	Fatty Acids	18-28	CREB regulated transcription coactivator 1	Mus musculus	109-115	
19305497-14	2009	Moreover, in stressed beta-cells mTORC1 inhibition decreases IRE1alpha protein expression and JNK activity without affecting ER protein load, suggesting that mTORC1 regulates the beta-cell stress response to glucose and fatty acids by modulating the synthesis and activity of specific proteins involved in the execution of the ER stress response.	Fatty Acids	220-231	CREB regulated transcription coactivator 1	Mus musculus	33-39	
19305497-14	2009	Moreover, in stressed beta-cells mTORC1 inhibition decreases IRE1alpha protein expression and JNK activity without affecting ER protein load, suggesting that mTORC1 regulates the beta-cell stress response to glucose and fatty acids by modulating the synthesis and activity of specific proteins involved in the execution of the ER stress response.	Fatty Acids	220-231	CREB regulated transcription coactivator 1	Mus musculus	158-164