PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16115757-6 2005 Ubiquitin carboxyl-terminated hydrolase isozyme L1 (UCH-L1) and galectin-3 are overexpressed in the responsive cell line Caco-2, whereas fatty acid-binding protein (E-FABP) and heat shock protein (hsp) 27 are expressed more in the resistant cell lines HRT-18 and HT-29 suggesting a role in non-responsiveness of cells to gefitinib. Fatty Acids 137-147 fatty acid binding protein 5 Homo sapiens 165-171 15922867-0 2005 The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP. Fatty Acids 52-62 fatty acid binding protein 5 Homo sapiens 79-85 15922867-5 2005 The epidermal fatty acid binding protein, E-FABP, was identified as a new EpCAM-regulated protein. Fatty Acids 14-24 fatty acid binding protein 5 Homo sapiens 42-48 8092987-4 1994 Structure-binding relation experiments revealed a high affinity of E-FABP for stearic acid which decreased on reduction of the number of carbon atoms or introduction of double bonds into the fatty acid chain. Fatty Acids 191-201 fatty acid binding protein 5 Homo sapiens 67-73 10191275-3 1999 E-FABP is thought to be involved in cytosolic fatty acid (FA) transport, whereas the role of S100A7 is still unknown. Fatty Acids 46-56 fatty acid binding protein 5 Homo sapiens 0-6 9285630-1 1997 Epidermal fatty acid-binding protein (E-FABP), previously characterized in human keratinocytes, is a cytoplasmic protein of 15 kD that specifically binds fatty acids (FAs). Fatty Acids 154-165 fatty acid binding protein 5 Homo sapiens 0-36 9285630-1 1997 Epidermal fatty acid-binding protein (E-FABP), previously characterized in human keratinocytes, is a cytoplasmic protein of 15 kD that specifically binds fatty acids (FAs). Fatty Acids 154-165 fatty acid binding protein 5 Homo sapiens 38-44 9285630-1 1997 Epidermal fatty acid-binding protein (E-FABP), previously characterized in human keratinocytes, is a cytoplasmic protein of 15 kD that specifically binds fatty acids (FAs). Fatty Acids 167-170 fatty acid binding protein 5 Homo sapiens 0-36 9285630-1 1997 Epidermal fatty acid-binding protein (E-FABP), previously characterized in human keratinocytes, is a cytoplasmic protein of 15 kD that specifically binds fatty acids (FAs). Fatty Acids 167-170 fatty acid binding protein 5 Homo sapiens 38-44 7881766-1 1994 PA-FABP (psoriasis-associated fatty acid-binding protein) is a new member of a group of low-molecular-weight proteins that are highly up-regulated in psoriatic skin and that share similarity to fatty acid-binding proteins. Fatty Acids 30-40 fatty acid binding protein 5 Homo sapiens 0-7 12459653-1 2002 Epidermal-type fatty acid-binding protein (E-FABP), a protein related to the intracellular trafficking of fatty acids, is expressed in melanocytic tumours but not in normal human melanocytes. Fatty Acids 106-117 fatty acid binding protein 5 Homo sapiens 0-41 12459653-1 2002 Epidermal-type fatty acid-binding protein (E-FABP), a protein related to the intracellular trafficking of fatty acids, is expressed in melanocytic tumours but not in normal human melanocytes. Fatty Acids 106-117 fatty acid binding protein 5 Homo sapiens 43-49 12049637-1 2002 Human epidermal-type fatty acid-binding protein (E-FABP) belongs to a family of intracellular 14-15 kDa lipid-binding proteins, whose functions have been associated with fatty acid signalling, cell growth, regulation and differentiation. Fatty Acids 21-31 fatty acid binding protein 5 Homo sapiens 49-55 8726632-1 1996 BACKGROUND: In human keratinocytes, we have recently characterized a low-molecular-weight cytosolic protein of 15 kD that specifically binds fatty acids (FAs) with high affinity, the epidermal FA-binding protein (E-FABP). Fatty Acids 141-152 fatty acid binding protein 5 Homo sapiens 183-211 8726632-1 1996 BACKGROUND: In human keratinocytes, we have recently characterized a low-molecular-weight cytosolic protein of 15 kD that specifically binds fatty acids (FAs) with high affinity, the epidermal FA-binding protein (E-FABP). Fatty Acids 141-152 fatty acid binding protein 5 Homo sapiens 213-219 8726632-1 1996 BACKGROUND: In human keratinocytes, we have recently characterized a low-molecular-weight cytosolic protein of 15 kD that specifically binds fatty acids (FAs) with high affinity, the epidermal FA-binding protein (E-FABP). Fatty Acids 154-157 fatty acid binding protein 5 Homo sapiens 183-211 8726632-1 1996 BACKGROUND: In human keratinocytes, we have recently characterized a low-molecular-weight cytosolic protein of 15 kD that specifically binds fatty acids (FAs) with high affinity, the epidermal FA-binding protein (E-FABP). Fatty Acids 154-157 fatty acid binding protein 5 Homo sapiens 213-219 8726632-10 1996 Since the pattern of E-FABP expression mimics cellular FA transport, our results suggest that lesional psoriatic skin and oral mucosa have a higher metabolism/transport for FAs than normal and non-lesional psoriatic epidermis. Fatty Acids 173-176 fatty acid binding protein 5 Homo sapiens 21-27 8092987-5 1994 Squalene, cholesterol and retinoic acid isomers showed no affinity, suggesting that E-FABP displays high specificity for fatty acids. Fatty Acids 121-132 fatty acid binding protein 5 Homo sapiens 84-90 8092987-10 1994 The presence of E-FABP in tissues other than skin (heart, intestine and adipose tissue) excludes its specific role in fatty acid metabolism in epithelial cells or its involvement in skin lipid-barrier function. Fatty Acids 118-128 fatty acid binding protein 5 Homo sapiens 16-22 34185510-8 2021 Furthermore, desthiobiotin-labeled lysine residues are located close to the fatty acid-binding pocket of FABP5, and the binding affinity varies with the structures of PFASs. Fatty Acids 76-86 fatty acid binding protein 5 Homo sapiens 105-110 8427590-0 1993 Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP). Fatty Acids 49-59 fatty acid binding protein 5 Homo sapiens 97-103 1512466-0 1992 Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. Fatty Acids 87-97 fatty acid binding protein 5 Homo sapiens 115-123 30167092-1 2018 Epidermal or cutaneous fatty acid-binding protein is an intracellular lipid-binding protein, also known as FABP5, and its expression level is closely related to cancer cell proliferation and metastatic activities in various types of carcinoma. Fatty Acids 23-33 fatty acid binding protein 5 Homo sapiens 107-112 34775260-6 2021 The FABP5/HIF-1alpha axis is a promising target for ameliorating fatty acid-triggered cancer progression. Fatty Acids 65-75 fatty acid binding protein 5 Homo sapiens 4-9 35545133-7 2022 MAIN METHODS: By radioactive labeling and metabolite quantification, we studied the function of FABP5 in fatty acid metabolism using genetic/pharmacologic inhibition and overexpression models in LUAD cell lines. Fatty Acids 105-115 fatty acid binding protein 5 Homo sapiens 96-101 35545133-10 2022 FABP5 regulates lipid metabolism, diverting fatty acids towards complex lipid synthesis, whereas it does not affect their catabolism in vitro. Fatty Acids 44-55 fatty acid binding protein 5 Homo sapiens 0-5 35545133-11 2022 Moreover, FABP5 is required for de novo fatty acid synthesis and regulates the expression of enzymes involved in the pathway (including FASN and SCD1). Fatty Acids 40-50 fatty acid binding protein 5 Homo sapiens 10-15 33917805-2 2021 Adipocyte (A-FABP) and epidermal (E-FABP) fatty acid-binding proteins are expressed in adipocytes and are assumed to play an important role in the development of lipid disturbances leading to the onset of metabolic syndrome. Fatty Acids 42-52 fatty acid binding protein 5 Homo sapiens 34-40 33128030-0 2020 Fatty-acid-induced FABP5/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells. Fatty Acids 0-10 fatty acid binding protein 5 Homo sapiens 19-24 33128030-7 2020 Our results indicate that fatty-acid-induced FABP5 upregulation drives HCC progression through HIF-1-driven lipid metabolism reprogramming. Fatty Acids 26-36 fatty acid binding protein 5 Homo sapiens 45-50 32245887-3 2020 It has been shown that TRM cells in the skin rely on the uptake of exogenous fatty acids for their survival and up-regulate fatty acid-binding protein 4 (FABP4) and FABP5 as part of their transcriptional program. Fatty Acids 77-88 fatty acid binding protein 5 Homo sapiens 165-170 33071982-1 2020 Objective: Among fatty acid-binding proteins (FABPs), secreted forms of FABP4 and FABP5, which are expressed in adipocytes and macrophages, act as bioactive molecules. Fatty Acids 17-27 fatty acid binding protein 5 Homo sapiens 82-87 32550890-0 2020 FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism. Fatty Acids 73-83 fatty acid binding protein 5 Homo sapiens 0-5 29914512-15 2018 The increased expression of the key lipase ATGL and intracellular fatty acid trafficking protein FABP5 played crucial roles in this process via fueling or signaling. Fatty Acids 66-76 fatty acid binding protein 5 Homo sapiens 97-102 31831821-2 2019 FASN and MAGL are enzymes that generate cellular fatty acid pools while FABP5 is an intracellular chaperone that delivers fatty acids to nuclear receptors to enhance PCa metastasis. Fatty Acids 122-133 fatty acid binding protein 5 Homo sapiens 72-77 29906613-0 2018 Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-kappaB) signaling in cancer cells. Fatty Acids 83-93 fatty acid binding protein 5 Homo sapiens 0-28 29906613-0 2018 Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-kappaB) signaling in cancer cells. Fatty Acids 83-93 fatty acid binding protein 5 Homo sapiens 30-35 29906613-2 2018 Epidermal fatty acid-binding protein (FABP5) is an intracellular lipid-binding protein that is abundantly expressed in adipocytes and macrophages. Fatty Acids 10-20 fatty acid binding protein 5 Homo sapiens 38-43 31917380-1 2020 Recently, fatty acid binding proteins 5 and 7 (FABP5 and FABP7) have been regarded as the prospective targets for clinically treating multiple diseases related to FABPs. Fatty Acids 10-20 fatty acid binding protein 5 Homo sapiens 47-52 31646566-8 2019 Functional studies have shown that STAT5A-dependent FABP5 expression promoted the proliferation and tumorigenesis of gastric cancer cells by reprogramming intracellular fatty acid metabolism. Fatty Acids 169-179 fatty acid binding protein 5 Homo sapiens 52-57 31646566-9 2019 CONCLUSIONS: Our results indicate that STAT5A-dependent FABP5 expression plays a carcinogenic role in the tumorigenesis of gastric cancer cells via reprogramming intracellular fatty acid metabolism, which establishes a new mechanism for the tumorigenesis of gastric cancer cells. Fatty Acids 176-186 fatty acid binding protein 5 Homo sapiens 56-61 29247738-0 2018 Fatty Acid-Binding Protein 5 Mediates the Uptake of Fatty Acids, but not Drugs, Into Human Brain Endothelial Cells. Fatty Acids 52-63 fatty acid binding protein 5 Homo sapiens 0-28 29247738-1 2018 The purpose of this study was to examine the involvement of fatty acid-binding protein 5 (FABP5), a lipid-binding protein expressed at the blood-brain barrier (BBB), in fatty acid and drug uptake into human brain endothelial cells. Fatty Acids 60-70 fatty acid binding protein 5 Homo sapiens 90-95 29247738-7 2018 Therefore, although FABP5 facilitates brain endothelial cell uptake of fatty acids, it has limited effects on brain endothelial cell uptake and BBB transport of drugs with lower affinity for FABP5. Fatty Acids 71-82 fatty acid binding protein 5 Homo sapiens 20-25 28701570-8 2017 Fatty acid-binding protein 4 was positively associated with age, body mass index (BMI), FABP5, very-low-density lipoprotein cholesterol (VLDLc), non-high-density lipoprote in cholesterol (non-HDLc), Apolipoprotein B 100 (ApoB100), triglycerides, glycerol, glucose, and hsCRP (p < .05), and was negatively associated with HDLc (p < .005) in breast cancer patients. Fatty Acids 0-10 fatty acid binding protein 5 Homo sapiens 88-93 29229603-3 2018 Functional investigations demonstrated that LNMICC promoted lymph node metastasis by reprogramming fatty acid metabolism, by recruiting the nuclear factor NPM1 to the promoter of the fatty acid binding protein FABP5. Fatty Acids 183-193 fatty acid binding protein 5 Homo sapiens 210-215 29215326-8 2018 In particular, FABP5 (2.15-fold increase in fibrotic skin tissues), a transporter of hydrophobic fatty acids, was investigated in greater detail. Fatty Acids 97-108 fatty acid binding protein 5 Homo sapiens 15-20 26814431-1 2016 In previous work, it is suggested that the excessive amount of fatty acids transported by FABP5 may facilitate the malignant progression of prostate cancer cells through a FABP5-PPARgamma-VEGF signal transduction axis to increase angiogenesis. Fatty Acids 63-74 fatty acid binding protein 5 Homo sapiens 90-95 28088613-3 2017 However, the insulin resistance- and dyslipidemia-promoting adipokines adipocyte (AFABP) and epidermal (EFABP) fatty acid-binding protein have not been investigated in non-HIV-associated LD so far. Fatty Acids 111-121 fatty acid binding protein 5 Homo sapiens 104-109 27866222-10 2017 SEPT11 associated with caveolae in mature adipocytes and interacted with both caveolin-1 and the intracellular fatty acid chaperone, fatty acid binding protein 5 (FABP5). Fatty Acids 111-121 fatty acid binding protein 5 Homo sapiens 133-161 27866222-10 2017 SEPT11 associated with caveolae in mature adipocytes and interacted with both caveolin-1 and the intracellular fatty acid chaperone, fatty acid binding protein 5 (FABP5). Fatty Acids 111-121 fatty acid binding protein 5 Homo sapiens 163-168 27552035-10 2016 FABP5 is an intracellular lipid chaperone that plays an essential role in fatty acid metabolism in human skin. Fatty Acids 74-84 fatty acid binding protein 5 Homo sapiens 0-5 27658368-1 2016 Dual inhibition of fatty acid binding proteins 4 and 5 (FABP4 and FABP5) is expected to provide beneficial effects on a number of metabolic parameters such as insulin sensitivity and blood glucose levels and should protect against atherosclerosis. Fatty Acids 19-29 fatty acid binding protein 5 Homo sapiens 66-71 28415688-7 2017 The inhibitor SBFI26 interferes with the FABP5-PPARgamma- signalling pathway at the initial stage of the signal transduction by binding competitively to FABP5 to inhibit cellular fatty acid uptake. Fatty Acids 179-189 fatty acid binding protein 5 Homo sapiens 41-46 28415688-7 2017 The inhibitor SBFI26 interferes with the FABP5-PPARgamma- signalling pathway at the initial stage of the signal transduction by binding competitively to FABP5 to inhibit cellular fatty acid uptake. Fatty Acids 179-189 fatty acid binding protein 5 Homo sapiens 153-158 26814431-1 2016 In previous work, it is suggested that the excessive amount of fatty acids transported by FABP5 may facilitate the malignant progression of prostate cancer cells through a FABP5-PPARgamma-VEGF signal transduction axis to increase angiogenesis. Fatty Acids 63-74 fatty acid binding protein 5 Homo sapiens 172-177 26814431-5 2016 Results in this study combined with some previous results suggested that FABP5 promoted VEGF expression and angiogenesis through PPARgamma which was activated by fatty acids transported by FABP5. Fatty Acids 162-173 fatty acid binding protein 5 Homo sapiens 73-78 26814431-5 2016 Results in this study combined with some previous results suggested that FABP5 promoted VEGF expression and angiogenesis through PPARgamma which was activated by fatty acids transported by FABP5. Fatty Acids 162-173 fatty acid binding protein 5 Homo sapiens 189-194 21395585-5 2011 The major fatty acid transport proteins expressed in human brain microvessel endothelial cells (HBMEC), mouse capillaries and human grey matter were FATP-1, -4 and fatty acid binding protein 5 and fatty acid translocase/CD36. Fatty Acids 10-20 fatty acid binding protein 5 Homo sapiens 164-192 26592976-0 2015 Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5. Fatty Acids 0-21 fatty acid binding protein 5 Homo sapiens 96-124 24713431-0 2014 Fatty acid-binding protein E-FABP restricts tumor growth by promoting IFN-beta responses in tumor-associated macrophages. Fatty Acids 0-10 fatty acid binding protein 5 Homo sapiens 27-33 24692551-0 2014 Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPARbeta/delta) signaling pathway. Fatty Acids 46-56 fatty acid binding protein 5 Homo sapiens 131-136 24692551-6 2014 Furthermore, we show that more saturated, nonactivating fatty acids inhibit nuclear localization signal formation by destabilizing this activation loop, thus implicating FABP5 specifically in cis-bonded, polyunsaturated fatty acid signaling. Fatty Acids 56-67 fatty acid binding protein 5 Homo sapiens 170-175 23722546-0 2013 Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis. Fatty Acids 24-34 fatty acid binding protein 5 Homo sapiens 51-56 23722546-1 2013 The fatty acid-binding protein FABP5 shuttles ligands from the cytosol to the nuclear receptor PPARbeta/delta (encoded for by Ppardelta), thereby enhancing the transcriptional activity of the receptor. Fatty Acids 4-14 fatty acid binding protein 5 Homo sapiens 31-36 23624787-5 2013 We speculate that, as a transporter of fatty acids, FABP5 plays an important protective role against oxidative damage to lipids during infection as well. Fatty Acids 39-50 fatty acid binding protein 5 Homo sapiens 52-57 23349676-3 2013 The airway epithelium constitutes the first line of host defense against infection and our previous study indicated that Fatty Acid Binding Protein 5 (FABP5) is down regulated in airway epithelial cells of smokers with COPD as compared to smokers without COPD. Fatty Acids 121-131 fatty acid binding protein 5 Homo sapiens 151-156 23236415-1 2012 Fatty acid binding proteins (FABPs), in particular FABP5 and FABP7, have recently been identified by us as intracellular transporters for the endocannabinoid anandamide (AEA). Fatty Acids 0-10 fatty acid binding protein 5 Homo sapiens 51-56 23144710-6 2012 Furthermore, members of the fatty acid binding protein family, including FABP3, FABP5 and FABP7, were found to have altered expression in the Npc1 mutant cerebellum relative to control. Fatty Acids 28-38 fatty acid binding protein 5 Homo sapiens 80-85 19623607-1 2010 This study aimed at an analysis of expression of epidermal-type and brain-type fatty acid-binding proteins (E-FABP and B-FABP, also called FABP5 and FABP7, respectively) in adult hippocampus and their potential value as neuroprotective factors after ischemic brain damage in monkey model. Fatty Acids 79-89 fatty acid binding protein 5 Homo sapiens 108-114 21068754-8 2011 The regulation of fatty acid metabolism by E-FABP during keratinocyte differentiation suggests that E-FABP may have a role in the pathogenesis of psoriasis. Fatty Acids 18-28 fatty acid binding protein 5 Homo sapiens 43-49 21068754-8 2011 The regulation of fatty acid metabolism by E-FABP during keratinocyte differentiation suggests that E-FABP may have a role in the pathogenesis of psoriasis. Fatty Acids 18-28 fatty acid binding protein 5 Homo sapiens 100-106 19623607-1 2010 This study aimed at an analysis of expression of epidermal-type and brain-type fatty acid-binding proteins (E-FABP and B-FABP, also called FABP5 and FABP7, respectively) in adult hippocampus and their potential value as neuroprotective factors after ischemic brain damage in monkey model. Fatty Acids 79-89 fatty acid binding protein 5 Homo sapiens 139-144 19623607-4 2010 This indicates a potential role for FABP5 and FABP7 in intracellular fatty acid transport within different neural cells. Fatty Acids 69-79 fatty acid binding protein 5 Homo sapiens 36-41 18805411-3 2008 We show that cellular RA-binding proteins CRABP1 and CRABP2 and the fatty acid-binding protein FABP5 are dynamically expressed during skin development and in adult tissue. Fatty Acids 68-78 fatty acid binding protein 5 Homo sapiens 95-100