PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23545566-7 2013 Interestingly, this TLR 4-recognition pathway of bacterial SPLs involves the fatty acid composition of ceramide in addition to the sugar moiety. Fatty Acids 77-87 toll-like receptor 4 Mus musculus 20-25 23805400-4 2013 For instance, TLR4/MD-2 can be ligated by adipose tissue-derived saturated free fatty acids (FAs) and induce adipose tissue inflammation and insulin resistance. Fatty Acids 93-96 toll-like receptor 4 Mus musculus 14-18 22700321-0 2012 Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. Fatty Acids 8-29 toll-like receptor 4 Mus musculus 63-67 22842069-2 2012 TLR4 is upregulated in diabetic cardiomyocytes, and we examined the role of TLR4 in modulating cardiac fatty acid (FA) metabolism and the pathogenesis of diabetic heart disease in nonobese diabetic (NOD) mice. Fatty Acids 103-113 toll-like receptor 4 Mus musculus 76-80 22700321-2 2012 We hypothesized that saturated fatty acids (SFA) directly prime the NLRP3 inflammasome via TLR4 concurrent with IR. Fatty Acids 21-42 toll-like receptor 4 Mus musculus 91-95 22700321-2 2012 We hypothesized that saturated fatty acids (SFA) directly prime the NLRP3 inflammasome via TLR4 concurrent with IR. Fatty Acids 44-47 toll-like receptor 4 Mus musculus 91-95 22396206-9 2012 Finally, the saturated fatty acids, palmitic and stearic acids, are endogenous ligands for TLR4, but they did not activate RP105/MD-1. Fatty Acids 13-34 toll-like receptor 4 Mus musculus 91-95 22580897-2 2012 Toll-like receptor 4 (TLR4) participates in the cross talk between inflammation and insulin resistance, being activated by both lipopolysaccharide and saturated fatty acids. Fatty Acids 151-172 toll-like receptor 4 Mus musculus 0-20 22580897-2 2012 Toll-like receptor 4 (TLR4) participates in the cross talk between inflammation and insulin resistance, being activated by both lipopolysaccharide and saturated fatty acids. Fatty Acids 151-172 toll-like receptor 4 Mus musculus 22-26 22326531-1 2012 Saturated fatty acids, acting as ligands for toll-like receptor 4 (TLR4), induce inflammation and mediate the development of insulin resistance. Fatty Acids 0-21 toll-like receptor 4 Mus musculus 45-65 22326531-1 2012 Saturated fatty acids, acting as ligands for toll-like receptor 4 (TLR4), induce inflammation and mediate the development of insulin resistance. Fatty Acids 0-21 toll-like receptor 4 Mus musculus 67-71 21562237-6 2011 To determine the underlying intracellular mechanisms, we tested whether LPS-induced Toll-like-receptor (TLR) 4 and TLR2 expression were modulated by these fatty acids using Western-blot analysis. Fatty Acids 155-166 toll-like receptor 4 Mus musculus 84-110 21388548-3 2011 It has been reported that dietary fatty acids also modulate inflammation through TLR-4. Fatty Acids 34-45 toll-like receptor 4 Mus musculus 81-86 21490391-0 2011 Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. Fatty Acids 88-108 toll-like receptor 4 Mus musculus 74-78 21490391-2 2011 One mechanism accounting for the increased inflammation associated with obesity is activation of the innate immune signaling pathway triggered by TLR4 recognition of saturated fatty acids, an event that is essential for lipid-induced insulin resistance. Fatty Acids 166-187 toll-like receptor 4 Mus musculus 146-150 21490391-3 2011 Using in vitro and in vivo systems to model lipid induction of TLR4-dependent inflammatory events in rodents, we show here that TLR4 is an upstream signaling component required for saturated fatty acid-induced ceramide biosynthesis. Fatty Acids 181-201 toll-like receptor 4 Mus musculus 63-67 21490391-3 2011 Using in vitro and in vivo systems to model lipid induction of TLR4-dependent inflammatory events in rodents, we show here that TLR4 is an upstream signaling component required for saturated fatty acid-induced ceramide biosynthesis. Fatty Acids 181-201 toll-like receptor 4 Mus musculus 128-132 21282371-1 2011 OBJECTIVE: We have provided evidence that saturated fatty acids, which are released from adipocytes via macrophage-induced adipocyte lipolysis, serve as a naturally occurring ligand for the Toll-like receptor (TLR) 4 complex in macrophages, thereby aggravating obesity-induced adipose tissue inflammation. Fatty Acids 42-63 toll-like receptor 4 Mus musculus 210-213 21282371-10 2011 CONCLUSIONS: Our data suggest that Mincle is induced in adipose tissue macrophages in obesity at least partly through the saturated fatty acid/TLR4/NF-kappaB pathway, thereby suggesting its pathophysiologic role in obesity-induced adipose tissue inflammation. Fatty Acids 122-142 toll-like receptor 4 Mus musculus 143-147 20860587-1 2011 BACKGROUND AND OBJECTIVE: There is general agreement that certain fatty acids and lipopolysaccharides (LPS) promote inflammation through toll-like receptor 4 (TLR4), and that inflammation promotes insulin resistance. Fatty Acids 66-77 toll-like receptor 4 Mus musculus 137-157 20860587-1 2011 BACKGROUND AND OBJECTIVE: There is general agreement that certain fatty acids and lipopolysaccharides (LPS) promote inflammation through toll-like receptor 4 (TLR4), and that inflammation promotes insulin resistance. Fatty Acids 66-77 toll-like receptor 4 Mus musculus 159-163 20966023-2 2010 Saturated fatty acids can directly trigger tissue specific proinflammatory pathways via Toll-like receptor-4 (TLR4)-dependent mechanisms. Fatty Acids 0-21 toll-like receptor 4 Mus musculus 88-108 20966023-2 2010 Saturated fatty acids can directly trigger tissue specific proinflammatory pathways via Toll-like receptor-4 (TLR4)-dependent mechanisms. Fatty Acids 0-21 toll-like receptor 4 Mus musculus 110-114 19052722-1 2009 AIMS/HYPOTHESIS: Toll-like receptor 4 (TLR4) is a receptor for saturated fatty acids (SFAs), global deficiency of which has been shown to protect against inflammation, insulin resistance and atherosclerotic lesion formation. Fatty Acids 63-84 toll-like receptor 4 Mus musculus 17-37 20855545-8 2010 Adipose tissue lipolysis is normal and muscle fatty acid oxidation is increased in TLR4(-/-) mice after fasting. Fatty Acids 46-56 toll-like receptor 4 Mus musculus 83-87 20855545-9 2010 Inhibition of fatty acid synthesis in TLR4(-/-) mice abolished hyperlipidemia, hypoglycemia, and PDC activity increase, suggesting that TLR4-dependent inhibition of muscle lipogenesis may contribute to glucose and lipid homeostasis during fasting. Fatty Acids 14-24 toll-like receptor 4 Mus musculus 38-42 20855545-9 2010 Inhibition of fatty acid synthesis in TLR4(-/-) mice abolished hyperlipidemia, hypoglycemia, and PDC activity increase, suggesting that TLR4-dependent inhibition of muscle lipogenesis may contribute to glucose and lipid homeostasis during fasting. Fatty Acids 14-24 toll-like receptor 4 Mus musculus 136-140 21072264-2 2010 Early studies indicated that adipose tissue from obese mice contains more saturated fatty acids and that the saturated fatty acids activate TLR4-mediated inflammatory signaling, which contributes to inflammation in adipose tissue. Fatty Acids 109-130 toll-like receptor 4 Mus musculus 140-144 20824098-2 2010 Recent observations suggest that saturated fatty acids can act as a ligand for toll-like receptor (TLR) 4, which is thought to mediate obesity-associated insulin resistance. Fatty Acids 33-54 toll-like receptor 4 Mus musculus 79-105 19808018-1 2009 Obesity-associated activation of inflammatory pathways represents a key step in the development of insulin resistance in peripheral organs, partially via activation of TLR4 signaling by fatty acids. Fatty Acids 186-197 toll-like receptor 4 Mus musculus 168-172 20839495-12 2010 Also, the higher mRNA expression of TLR4, which induces pro-inflammatory cytokine production after fatty acid recognition, was strongly inhibited by the exercise training in HFD mice. Fatty Acids 99-109 toll-like receptor 4 Mus musculus 36-40 19478204-2 2009 Evidence has suggested that saturated fatty acids released via adipocyte lipolysis serve as a naturally occurring ligand that stimulates Toll-like receptor (TLR)4 signaling, thereby inducing the inflammatory responses in macrophages in obese adipose tissue. Fatty Acids 28-49 toll-like receptor 4 Mus musculus 157-160 19478204-3 2009 Through a combination of cDNA microarray analyses of saturated fatty acid-stimulated macrophages in vitro and obese adipose tissue in vivo, here we identified activating transcription factor (ATF)3, a member of the ATF/cAMP response element-binding protein family of basic leucine zipper-type transcription factors, as a target gene of saturated fatty acids/TLR4 signaling in macrophages in obese adipose tissue. Fatty Acids 53-73 toll-like receptor 4 Mus musculus 358-362 19478204-3 2009 Through a combination of cDNA microarray analyses of saturated fatty acid-stimulated macrophages in vitro and obese adipose tissue in vivo, here we identified activating transcription factor (ATF)3, a member of the ATF/cAMP response element-binding protein family of basic leucine zipper-type transcription factors, as a target gene of saturated fatty acids/TLR4 signaling in macrophages in obese adipose tissue. Fatty Acids 336-357 toll-like receptor 4 Mus musculus 358-362 19478204-7 2009 This study provides evidence that ATF3, which is induced in obese adipose tissue, acts as a transcriptional repressor of saturated fatty acids/TLR4 signaling, thereby revealing the negative feedback mechanism that attenuates obesity-induced macrophage activation. Fatty Acids 121-142 toll-like receptor 4 Mus musculus 143-147 19052722-1 2009 AIMS/HYPOTHESIS: Toll-like receptor 4 (TLR4) is a receptor for saturated fatty acids (SFAs), global deficiency of which has been shown to protect against inflammation, insulin resistance and atherosclerotic lesion formation. Fatty Acids 63-84 toll-like receptor 4 Mus musculus 39-43 17383612-1 2007 Recent reports suggest the potential role of toll-like receptor 4 (TLR4) in initiation of inflammatory responses and fatty acid-induced insulin resistance. Fatty Acids 117-127 toll-like receptor 4 Mus musculus 45-65 18678477-0 2008 Fatty acid-binding protein regulates LPS-induced TNF-alpha production in mast cells. Fatty Acids 0-10 toll-like receptor 4 Mus musculus 37-40 18421279-0 2008 Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Fatty Acids 79-92 toll-like receptor 4 Mus musculus 0-5 18421279-1 2008 Toll-like receptor-4 (Tlr-4), a key pattern recognition receptor involved in innate immune response, is activated by saturated fatty acids (SFAs). Fatty Acids 117-138 toll-like receptor 4 Mus musculus 0-20 18421279-1 2008 Toll-like receptor-4 (Tlr-4), a key pattern recognition receptor involved in innate immune response, is activated by saturated fatty acids (SFAs). Fatty Acids 117-138 toll-like receptor 4 Mus musculus 22-27 17519423-3 2007 Because it is activated by lipopolysaccharide and saturated fatty acids, which are inducers of insulin resistance, TLR4 may be a candidate for participation in the cross-talk between inflammatory and metabolic signals. Fatty Acids 50-71 toll-like receptor 4 Mus musculus 115-119 17383612-1 2007 Recent reports suggest the potential role of toll-like receptor 4 (TLR4) in initiation of inflammatory responses and fatty acid-induced insulin resistance. Fatty Acids 117-127 toll-like receptor 4 Mus musculus 67-71 17053832-0 2006 TLR4 links innate immunity and fatty acid-induced insulin resistance. Fatty Acids 31-41 toll-like receptor 4 Mus musculus 0-4 17210129-2 2007 We have provided in vitro evidence that saturated fatty acids, which are released from hypertrophied adipocytes via the macrophage-induced adipocyte lipolysis, serve as a naturally occurring ligand for Toll-like receptor 4 (TLR4) to induce the inflammatory changes in macrophages. Fatty Acids 40-61 toll-like receptor 4 Mus musculus 202-222 17210129-2 2007 We have provided in vitro evidence that saturated fatty acids, which are released from hypertrophied adipocytes via the macrophage-induced adipocyte lipolysis, serve as a naturally occurring ligand for Toll-like receptor 4 (TLR4) to induce the inflammatory changes in macrophages. Fatty Acids 40-61 toll-like receptor 4 Mus musculus 224-228 17082484-0 2007 Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Fatty Acids 54-74 toll-like receptor 4 Mus musculus 12-32 17082484-7 2007 We also observed that endogenous FAs, which are released from adipocytes via the beta3-adrenergic stimulation, resulted in the activation of the TLR4/NF-kappaB pathway. Fatty Acids 33-36 toll-like receptor 4 Mus musculus 145-149 17082484-8 2007 CONCLUSIONS: These findings suggest that saturated FAs, which are released in large quantities from hypertrophied adipocytes via the macrophage-induced adipocyte lipolysis, serve as a naturally occurring ligand for TLR4, thereby inducing the inflammatory changes in both adipocytes and macrophages through NF-kappaB activation. Fatty Acids 51-54 toll-like receptor 4 Mus musculus 215-219 17053832-4 2006 Here we show that nutritional fatty acids, whose circulating levels are often increased in obesity, activate TLR4 signaling in adipocytes and macrophages and that the capacity of fatty acids to induce inflammatory signaling in adipose cells or tissue and macrophages is blunted in the absence of TLR4. Fatty Acids 30-41 toll-like receptor 4 Mus musculus 109-113 17053832-4 2006 Here we show that nutritional fatty acids, whose circulating levels are often increased in obesity, activate TLR4 signaling in adipocytes and macrophages and that the capacity of fatty acids to induce inflammatory signaling in adipose cells or tissue and macrophages is blunted in the absence of TLR4. Fatty Acids 30-41 toll-like receptor 4 Mus musculus 296-300 17053832-4 2006 Here we show that nutritional fatty acids, whose circulating levels are often increased in obesity, activate TLR4 signaling in adipocytes and macrophages and that the capacity of fatty acids to induce inflammatory signaling in adipose cells or tissue and macrophages is blunted in the absence of TLR4. Fatty Acids 179-190 toll-like receptor 4 Mus musculus 296-300 12865424-4 2003 Saturated fatty acid (lauric acid)-induced NFkappaB activation was inhibited by a dominant-negative mutant of TLR4, MyD88, IRAK-1, TRAF6, or IkappaBalpha in macrophages (RAW264.7) and 293T cells transfected with TLR4 and MD2. Fatty Acids 0-20 toll-like receptor 4 Mus musculus 110-114 14670733-1 2003 Extraction of dry bacteria of Acinetobacter baumannii strain 24 by phenol-water yielded a lipopolysaccharide (LPS) that was studied by serological methods and fatty acid analysis. Fatty Acids 159-169 toll-like receptor 4 Mus musculus 110-113 3461461-3 1986 In cells incubated with bacterial lipopolysaccharide (LPS), or its monoacyl glucosamine phosphate derivative, fatty acid is incorporated into proteins with molecular mass of 68 kDa and a doublet of approximately 42-45 kDa. Fatty Acids 110-120 toll-like receptor 4 Mus musculus 54-57 34290146-4 2021 We show here that short fatty acid (FA) chain sulfatides directly activate mouse TLR4-MD-2 independent of CD14, trigger MyD88- and TRIF-dependent signaling, and stimulate tumor necrosis factor alpha (TNFalpha) and type I interferon (IFN) production in mouse macrophages. Fatty Acids 24-34 toll-like receptor 4 Mus musculus 81-85 35198063-7 2022 We show that saturated free fatty acids (SFA), which are increased in obesity, together with S100A9 induce TLR4 and inflammasome-dependent IL-1beta release in macrophages which in turn amplifies S100A9 expression initiating a vicious cycle of sustained S100A9 overexpression in skin inflammation in obesity. Fatty Acids 28-39 toll-like receptor 4 Mus musculus 107-111 33971268-4 2021 Toll-like receptor 4 (TLR4) is a transmembrane pattern recognition receptor that can be activated by saturated fatty acids. Fatty Acids 101-122 toll-like receptor 4 Mus musculus 0-20 33971268-4 2021 Toll-like receptor 4 (TLR4) is a transmembrane pattern recognition receptor that can be activated by saturated fatty acids. Fatty Acids 101-122 toll-like receptor 4 Mus musculus 22-26 33971268-9 2021 Moreover, effects of intra-VTA infusion of lauric acid (a saturated fatty acid with 12 carbon) on food reward were abolished in mice lacking TLR4 in DA neurons. Fatty Acids 58-78 toll-like receptor 4 Mus musculus 141-145 3882561-2 1985 The phenol-water-extracted LPS from B. gingivalis 381 was composed of 46% carbohydrate, 23% hexosamine, 18% fatty acid, and 5% protein. Fatty Acids 108-118 toll-like receptor 4 Mus musculus 27-30 3882561-5 1985 The butanol-water-extracted LPS from this strain was composed of 76% glucose, 7% fatty acid, and 13% protein, and it was associated with a number of polypeptides (13 to 56 kilodaltons). Fatty Acids 81-91 toll-like receptor 4 Mus musculus 28-31 3882561-6 1985 The main fatty acid of both LPS preparations was palmitic acid. Fatty Acids 9-19 toll-like receptor 4 Mus musculus 28-31 31822562-7 2020 Compared to NOD TLR4+/+ mice, NOD TLR4-/- animals showed lower muscle mass of the small intestine, higher abundance of Bacteroidetes and lower Firmicutes in the large intestine, along with lower levels of circulating short-chain fatty acids (SCFA). Fatty Acids 229-240 toll-like receptor 4 Mus musculus 34-38 31953218-9 2020 In summary, we have discovered that AA interacts with MD2 and disrupts TLR4 activation by LPS and saturated fatty acids. Fatty Acids 108-119 toll-like receptor 4 Mus musculus 71-75 31953218-4 2020 With the recent discovery that saturated fatty acids activate toll-like receptor-4 (TLR4), we tested the hypothesis that AA directly regulates inflammatory responses through modulating the activity of TLR4. Fatty Acids 31-52 toll-like receptor 4 Mus musculus 62-82 31953218-4 2020 With the recent discovery that saturated fatty acids activate toll-like receptor-4 (TLR4), we tested the hypothesis that AA directly regulates inflammatory responses through modulating the activity of TLR4. Fatty Acids 31-52 toll-like receptor 4 Mus musculus 84-88 31953218-5 2020 In cultured cardiomyocytes and macrophages, we found that AA prevents saturated fatty acid-induced TLR4 complex formation with accessory proteins and the induction of proinflammatory cytokines. Fatty Acids 80-90 toll-like receptor 4 Mus musculus 99-103 31953218-6 2020 We discovered that AA directly binds to TLR4 co-receptor, myeloid differentiation factor 2 (MD2) and prevents saturated fatty acids from activating TLR4 pro-inflammatory signaling pathway. Fatty Acids 120-131 toll-like receptor 4 Mus musculus 148-152 31726089-2 2020 In this situation, fatty acids cause inflammation via TLR4 (toll like receptor 4) and the nuclei become less responsive to the hormones leptin and insulin, contributing to the development of obesity. Fatty Acids 19-30 toll-like receptor 4 Mus musculus 54-58 31754736-6 2020 We further characterized the metabolomic alterations caused by LPS challenge, which predicted activity of metabolic pathways related to fatty acids and eicosanoids. Fatty Acids 136-147 toll-like receptor 4 Mus musculus 63-66 31726089-2 2020 In this situation, fatty acids cause inflammation via TLR4 (toll like receptor 4) and the nuclei become less responsive to the hormones leptin and insulin, contributing to the development of obesity. Fatty Acids 19-30 toll-like receptor 4 Mus musculus 60-80 31842409-4 2019 Therefore, we used LPS to explore the underlying mechanism of E. coli that causes the inhibition of fatty acid absorption in the intestine. Fatty Acids 100-110 toll-like receptor 4 Mus musculus 19-22 31842409-0 2019 LPS Inhibits Fatty Acid Absorption in Enterocytes through TNF-alpha Secreted by Macrophages. Fatty Acids 13-23 toll-like receptor 4 Mus musculus 0-3 31842409-14 2019 Based on the above results, we hold the opinion that LPS does not suppress fatty acid absorption directly in the intestine, but may work on macrophages that secrete cytokines, such as TNF-alpha, inducing caspase-3 activation and finally leading to the inhibition of fatty acid absorption in intestine. Fatty Acids 266-276 toll-like receptor 4 Mus musculus 53-56 28776958-4 2017 Saturated fatty acids can activate TLR4, and TLR4-deficient mice were protected from high fat diet (HFD)-induced obesity and insulin resistance, suggesting that TLR4-mediated inflammation may cause metabolic dysfunction, such as obesity and insulin resistance. Fatty Acids 0-21 toll-like receptor 4 Mus musculus 35-39 29804861-11 2018 Fatty acid oxidation and protein oxidation increased significantly 24 h after LPS administration, whereas carbohydrate oxidation decreased significantly. Fatty Acids 0-10 toll-like receptor 4 Mus musculus 78-81 28575583-7 2017 Interestingly, LPS-treated mice showed less lipid accumulation in liver than fasted mice despite increased fatty acid uptake and lipid synthesis-associated genes. Fatty Acids 107-117 toll-like receptor 4 Mus musculus 15-18 28797566-6 2017 Fatty acid induces the FetA gene and protein expression in the pancreatic beta-cells via TLR4 and over-expression of NF-kappaB. Fatty Acids 0-10 toll-like receptor 4 Mus musculus 89-93 25251395-8 2014 Activation of macrophages by low levels of LPS (50 ng/ml) and its exacerbation by fatty acids is likely the mechanism by which release of trace amounts of LPS into circulation due to disruption of intestinal barrier function induces the development of these diseases. Fatty Acids 82-93 toll-like receptor 4 Mus musculus 155-158 25528444-1 2015 OBJECTIVE: We have previously demonstrated that activation of toll-like receptor 4 (TLR4) in skeletal muscle results in an increased reliance on glucose as an energy source and a concomitant decrease in fatty acid oxidation under basal conditions. Fatty Acids 203-213 toll-like receptor 4 Mus musculus 62-82 25528444-1 2015 OBJECTIVE: We have previously demonstrated that activation of toll-like receptor 4 (TLR4) in skeletal muscle results in an increased reliance on glucose as an energy source and a concomitant decrease in fatty acid oxidation under basal conditions. Fatty Acids 203-213 toll-like receptor 4 Mus musculus 84-88 25408476-3 2015 This study investigated the influence of membrane fatty acid profile on TLR4-mediated inflammation in RAW 264.7 macrophages. Fatty Acids 50-60 toll-like receptor 4 Mus musculus 72-76 25408476-9 2015 These data suggest that membrane fatty acid profiles influence the TLR4-mediated inflammatory response in macrophages, via mechanisms that occur downstream of TLR4 receptor activation. Fatty Acids 33-43 toll-like receptor 4 Mus musculus 67-71 25408476-9 2015 These data suggest that membrane fatty acid profiles influence the TLR4-mediated inflammatory response in macrophages, via mechanisms that occur downstream of TLR4 receptor activation. Fatty Acids 33-43 toll-like receptor 4 Mus musculus 159-163 25150729-5 2015 RESULTS: Using a lipopolysaccharide (LPS)-treated mouse model, we found that the fatty acid profiles after LPS treatment were similar between the conventional single-sample analysis approach and the proposed comparative approach, with a Pearson"s correlation coefficient of approximately 0.96. Fatty Acids 81-91 toll-like receptor 4 Mus musculus 107-110 29227069-2 2016 In obese adipose tissue, saturated fatty acids, which are released as a danger signal from hypertrophied adipocytes, stimulates a pathogen sensor TLR4 in the infiltrating macrophages, thus establishing a vicious cycle between adipocytes and macrophages to stimulate adipose tissue inflammation. Fatty Acids 25-46 toll-like receptor 4 Mus musculus 146-150 27627966-4 2016 Hepatic Fas, Acc, Scd-1 and Dgat-2, the key genes for fatty acid and TG synthesis, were up-regulated in alcohol-treated Tlr4-wild-type mice but not in Tlr4-mutant mice. Fatty Acids 54-64 toll-like receptor 4 Mus musculus 120-124 27910769-3 2016 We analyzed the influence of I. badia extracts and/or lipopolysaccharide (LPS) cotreatment on the fatty acid profile of cell membranes. Fatty Acids 98-108 toll-like receptor 4 Mus musculus 74-77 26522062-3 2015 Saturated fatty acids (SFA) activate TLR4, which induces ER stress and endothelial dysfunction. Fatty Acids 0-21 toll-like receptor 4 Mus musculus 37-41 26522062-3 2015 Saturated fatty acids (SFA) activate TLR4, which induces ER stress and endothelial dysfunction. Fatty Acids 23-26 toll-like receptor 4 Mus musculus 37-41 26522062-4 2015 Therefore, we determined whether TLR4-mediated ER stress is an obligatory step mediating SFA-induced endothelial dysfunction. Fatty Acids 89-92 toll-like receptor 4 Mus musculus 33-37 26522062-12 2015 Taken together, the results suggest that TLR4-induced ER stress may be an obligatory step mediating the SFA-mediated endothelial dysfunction. Fatty Acids 104-107 toll-like receptor 4 Mus musculus 41-45 26172853-9 2015 On the other hand, TLR4 deficiency enhanced the expression of several enzymes involved in the oxidation of fatty acids, as follows: ACOX, CPT-1, MTPa, MTBb, PBE and 3-ketoacyl-CoA thiolase. Fatty Acids 107-118 toll-like receptor 4 Mus musculus 19-23 26172853-11 2015 Our results indicate that TLR4 may have an important role in the onset of steatosis, once its depletion enhances fatty acid oxidation in the liver of mice, preventing triglyceride accumulation. Fatty Acids 113-123 toll-like receptor 4 Mus musculus 26-30 24043885-1 2013 Many studies have shown that TLR4- and TLR2-deficient mice are protected from high-fat diet-induced inflammation and insulin resistance, suggesting that saturated fatty acids derived from the high-fat diet activate TLR-mediated proinflammatory signaling pathways and induce insulin resistance. Fatty Acids 153-174 toll-like receptor 4 Mus musculus 29-33 23840067-2 2013 Recent studies have suggested that saturated fatty acids induce hepatic insulin resistance through activation of the toll-like receptor 4 (TLR-4) receptor in the liver, which in turn transcriptionally activates hepatic ceramide synthesis leading to inhibition of insulin signaling. Fatty Acids 35-56 toll-like receptor 4 Mus musculus 117-137 23840067-2 2013 Recent studies have suggested that saturated fatty acids induce hepatic insulin resistance through activation of the toll-like receptor 4 (TLR-4) receptor in the liver, which in turn transcriptionally activates hepatic ceramide synthesis leading to inhibition of insulin signaling. Fatty Acids 35-56 toll-like receptor 4 Mus musculus 139-144