PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11891416-7 2002 Interestingly, expression of aP2 by the macrophage promotes atherogenesis, thus providing a link between insulin resistance, intracellular fatty acid disposition, and foam cell formation. Fatty Acids 139-149 fatty acid binding protein 4 Homo sapiens 29-32 12358531-3 2002 Here we describe an alternative process for hit generation, applied to the human adipocyte fatty acid binding protein FABP4. Fatty Acids 91-101 fatty acid binding protein 4 Homo sapiens 118-123 12479574-1 2002 Two fatty acid binding proteins (FABPs) are expressed in adipose tissue, adipocyte lipid binding protein (ALBP) and keratinocyte lipid binding protein (KLBP). Fatty Acids 4-14 fatty acid binding protein 4 Homo sapiens 73-104 12479574-1 2002 Two fatty acid binding proteins (FABPs) are expressed in adipose tissue, adipocyte lipid binding protein (ALBP) and keratinocyte lipid binding protein (KLBP). Fatty Acids 4-14 fatty acid binding protein 4 Homo sapiens 106-110 11182553-9 2001 Taken together, these results indicate that selected fatty acids modulate porcine adipocyte differentiation and transcripts for adipocyte differentiation-related proteins such as PPARgamma, C/EBPalpha, LPL and aP2. Fatty Acids 53-64 fatty acid binding protein 4 Homo sapiens 210-213 11241671-3 2001 The fatty acid binding protein aP2 increases during adipocyte differentiation and is induced by thiazolidinediones and other peroxisome proliferator activated receptor gamma ligands. Fatty Acids 4-14 fatty acid binding protein 4 Homo sapiens 31-34 10585398-1 1999 The adipocyte fatty acid-binding protein (AFABP) is believed to transfer unesterified fatty acids (FA) to phospholipid membranes via a collisional mechanism that involves ionic interactions between lysine residues on the protein surface and phospholipid headgroups. Fatty Acids 14-24 fatty acid binding protein 4 Homo sapiens 42-47 11108735-1 2000 The adipocyte lipid-binding protein (ALBP/aP2) belongs to a multigene family of fatty acid and retinoid transport proteins. Fatty Acids 80-90 fatty acid binding protein 4 Homo sapiens 37-45 10585398-1 1999 The adipocyte fatty acid-binding protein (AFABP) is believed to transfer unesterified fatty acids (FA) to phospholipid membranes via a collisional mechanism that involves ionic interactions between lysine residues on the protein surface and phospholipid headgroups. Fatty Acids 86-97 fatty acid binding protein 4 Homo sapiens 42-47 10585398-9 1999 These results directly demonstrate that AFABP binds to anionic phospholipid membranes and suggest that, although generally described as a cytosolic protein, AFABP may behave as a peripheral membrane protein to help target fatty acids to and/or from intracellular sites of utilization. Fatty Acids 222-233 fatty acid binding protein 4 Homo sapiens 40-45 10585398-9 1999 These results directly demonstrate that AFABP binds to anionic phospholipid membranes and suggest that, although generally described as a cytosolic protein, AFABP may behave as a peripheral membrane protein to help target fatty acids to and/or from intracellular sites of utilization. Fatty Acids 222-233 fatty acid binding protein 4 Homo sapiens 157-162 10510298-2 1999 AEBP1 binds to a regulatory sequence (termed adipocyte enhancer 1, AE-1) located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. Fatty Acids 171-181 fatty acid binding protein 4 Homo sapiens 120-130 10510298-2 1999 AEBP1 binds to a regulatory sequence (termed adipocyte enhancer 1, AE-1) located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. Fatty Acids 171-181 fatty acid binding protein 4 Homo sapiens 132-135 9849941-1 1998 Adipocyte lipid-binding protein (ALBP) is one of a family of intracellular lipid-binding proteins (iLBPs) that bind fatty acids, retinoids, and other hydrophobic ligands. Fatty Acids 116-127 fatty acid binding protein 4 Homo sapiens 0-31 10423455-1 1999 The fluorescent probe anilinonaphthalene-8-sulfonate binds to adipocyte lipid binding protein at a site that competes with normal physiological ligands, such as fatty acids. Fatty Acids 161-172 fatty acid binding protein 4 Homo sapiens 62-93 10331656-3 1999 ALBP/aP2 and KLBP exhibit similar binding affinities for most long-chain fatty acids; however, ALBP/aP2 exhibits a two to three-fold increased affinity for myristic, palmitic, oleic and linoleic acids, the predominant fatty acids of adipocytes. Fatty Acids 73-84 fatty acid binding protein 4 Homo sapiens 0-8 9849941-1 1998 Adipocyte lipid-binding protein (ALBP) is one of a family of intracellular lipid-binding proteins (iLBPs) that bind fatty acids, retinoids, and other hydrophobic ligands. Fatty Acids 116-127 fatty acid binding protein 4 Homo sapiens 33-37 9070949-0 1997 Assignment of the human adipocyte fatty acid-binding protein gene (FABP4) to chromosome 8q21 using somatic cell hybrid and fluorescence in situ hybridization techniques. Fatty Acids 34-44 fatty acid binding protein 4 Homo sapiens 67-72 9680187-2 1998 The crystal structures of various holo-forms of ALBP have been solved and show the fatty acid ligand bound in a large (approximately 400 A3) cavity isolated from bulk solvent. Fatty Acids 83-93 fatty acid binding protein 4 Homo sapiens 48-52 9609689-1 1998 Adipocyte lipid-binding protein (A-LBP) and muscle fatty acid-binding protein (M-FABP) are members of a family of small ( approximately 15 kDa) cytosolic proteins that are involved in the metabolism of fatty acids and other lipid-soluble molecules. Fatty Acids 202-213 fatty acid binding protein 4 Homo sapiens 0-31 9609689-1 1998 Adipocyte lipid-binding protein (A-LBP) and muscle fatty acid-binding protein (M-FABP) are members of a family of small ( approximately 15 kDa) cytosolic proteins that are involved in the metabolism of fatty acids and other lipid-soluble molecules. Fatty Acids 202-213 fatty acid binding protein 4 Homo sapiens 33-38 9516437-1 1998 We constructed 18 single amino acid mutants of the adipocyte fatty acid-binding protein (A-FABP) and 17 of the intestinal fatty acid-binding protein (I-FABP), at locations in the fatty acid (FA) binding sites. Fatty Acids 61-71 fatty acid binding protein 4 Homo sapiens 89-95 9204877-10 1997 The degree of membrane interaction correlates directly with the rate of fatty acid transfer, suggesting that contact between A-FABP and membranes is functionally related to its fatty acid transport properties. Fatty Acids 72-82 fatty acid binding protein 4 Homo sapiens 125-131 9204877-10 1997 The degree of membrane interaction correlates directly with the rate of fatty acid transfer, suggesting that contact between A-FABP and membranes is functionally related to its fatty acid transport properties. Fatty Acids 177-187 fatty acid binding protein 4 Homo sapiens 125-131 8626681-1 1996 Rate constants for the interaction of fatty acids (FA) with fatty acid binding proteins (FABP) from adipocyte (A-FABP), heart (H-FABP), and intestine (I-FABP) were determined by using stopped-flow fluorometry and ADIFAB, the fluorescent probe of free fatty acids (FFA), or a new FFA probe, ADIFAB2, constructed by derivatizing with acrylodan the Leu72 --> Ala mutant of I-FABP. Fatty Acids 38-49 fatty acid binding protein 4 Homo sapiens 111-117 9361822-17 1997 In aP2 nulls, the fatty acid composition was unaltered but the mass of fatty acid per gram tissue more than doubled relative to wild type. Fatty Acids 71-81 fatty acid binding protein 4 Homo sapiens 3-6 8626681-1 1996 Rate constants for the interaction of fatty acids (FA) with fatty acid binding proteins (FABP) from adipocyte (A-FABP), heart (H-FABP), and intestine (I-FABP) were determined by using stopped-flow fluorometry and ADIFAB, the fluorescent probe of free fatty acids (FFA), or a new FFA probe, ADIFAB2, constructed by derivatizing with acrylodan the Leu72 --> Ala mutant of I-FABP. Fatty Acids 38-48 fatty acid binding protein 4 Homo sapiens 111-117 33813326-6 2021 Among these 97 DEG, some representative genes were related to lipolysis and fatty acid utilization (PPARG, LPL, PLIN2, ACOX1, ACSL1, FABP3, and FABP4). Fatty Acids 76-86 fatty acid binding protein 4 Homo sapiens 144-149 8161548-4 1994 To examine the binding of lipids other than those with a carboxylate headgroup, we have determined the structure of ALBP in complex with a sulfonic acid, hexadecanesulfonic acid, and compared its structure with the natural fatty acid analog, palmitate. Fatty Acids 223-233 fatty acid binding protein 4 Homo sapiens 116-120 1848858-2 1991 It was shown previously that 422 (aP2) protein, a 15-kDa fatty acid binding protein, is phosphorylated on Tyr19 both in vitro by the insulin receptor tyrosine kinase and in intact 3T3-L1 adipocytes treated with insulin and phenylarsine oxide (PAO). Fatty Acids 57-67 fatty acid binding protein 4 Homo sapiens 34-37 8357805-0 1993 Mechanism of fluorescent fatty acid transfer from adipocyte fatty acid binding protein to membranes. Fatty Acids 25-35 fatty acid binding protein 4 Homo sapiens 50-86 1372897-3 1992 We demonstrate here that fatty acids can regulate specific gene expression; mRNAs encoding the fatty acid binding protein adipocyte P2 (aP2) and the Fos-related transcription factor Fra1 are specifically induced at least 20-fold upon treatment of preadipocytes with oleate. Fatty Acids 25-36 fatty acid binding protein 4 Homo sapiens 136-139 1372897-3 1992 We demonstrate here that fatty acids can regulate specific gene expression; mRNAs encoding the fatty acid binding protein adipocyte P2 (aP2) and the Fos-related transcription factor Fra1 are specifically induced at least 20-fold upon treatment of preadipocytes with oleate. Fatty Acids 25-35 fatty acid binding protein 4 Homo sapiens 136-139 2174434-2 1990 It was established previously that the 15-kDa protein phosphorylated in 3T3-L1 adipocytes treated with insulin and phenylarsine oxide is O-phospho-Tyr19 422(aP2) protein, a fatty acid-binding protein. Fatty Acids 173-183 fatty acid binding protein 4 Homo sapiens 157-160 2174434-9 1990 These results indicate that upon binding fatty acid, 422(aP2) protein undergoes a conformational change whereby Tyr19, which lies within a consensus-type sequence for tyrosine kinase substrates, becomes accessible for phosphorylation by the insulin receptor tyrosine kinase and to iodination by lactoperoxidase. Fatty Acids 41-51 fatty acid binding protein 4 Homo sapiens 57-60 2223772-0 1990 Modification of the adipocyte lipid binding protein by sulfhydryl reagents and analysis of the fatty acid binding domain. Fatty Acids 95-105 fatty acid binding protein 4 Homo sapiens 20-51 34502295-1 2021 Adipocyte fatty acid-binding protein (A-FABP), which is also known as ap2 or FABP4, is a fatty acid chaperone that has been further defined as a fat-derived hormone. Fatty Acids 89-99 fatty acid binding protein 4 Homo sapiens 0-36 34502295-1 2021 Adipocyte fatty acid-binding protein (A-FABP), which is also known as ap2 or FABP4, is a fatty acid chaperone that has been further defined as a fat-derived hormone. Fatty Acids 89-99 fatty acid binding protein 4 Homo sapiens 38-44 34502295-1 2021 Adipocyte fatty acid-binding protein (A-FABP), which is also known as ap2 or FABP4, is a fatty acid chaperone that has been further defined as a fat-derived hormone. Fatty Acids 89-99 fatty acid binding protein 4 Homo sapiens 70-73 34502295-1 2021 Adipocyte fatty acid-binding protein (A-FABP), which is also known as ap2 or FABP4, is a fatty acid chaperone that has been further defined as a fat-derived hormone. Fatty Acids 89-99 fatty acid binding protein 4 Homo sapiens 77-82 34389755-2 2021 Adipocyte free fatty acid binding protein (a-FABP) has been shown to signal endothelial dysfunction through fatty acid toxicity, though its role in mediating ventricular-arterial dysfunction remains unclear. Fatty Acids 108-118 fatty acid binding protein 4 Homo sapiens 0-41 34389755-2 2021 Adipocyte free fatty acid binding protein (a-FABP) has been shown to signal endothelial dysfunction through fatty acid toxicity, though its role in mediating ventricular-arterial dysfunction remains unclear. Fatty Acids 108-118 fatty acid binding protein 4 Homo sapiens 43-49 34254912-1 2021 Fatty acid binding protein A (A-FABP) is one of FABPs isoforms found mainly in adipose tissue and macrophages. Fatty Acids 0-10 fatty acid binding protein 4 Homo sapiens 30-36 34030117-0 2021 Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence. Fatty Acids 95-105 fatty acid binding protein 4 Homo sapiens 124-129 35520131-1 2022 Adipocyte fatty acid-binding protein (A-FABP, also called FABP4, aP2) is an adipokine identified as a critical regulator of metabolic function due to its dual functions of fatty acid transport and pro-inflammation. Fatty Acids 172-182 fatty acid binding protein 4 Homo sapiens 0-36 35520131-1 2022 Adipocyte fatty acid-binding protein (A-FABP, also called FABP4, aP2) is an adipokine identified as a critical regulator of metabolic function due to its dual functions of fatty acid transport and pro-inflammation. Fatty Acids 172-182 fatty acid binding protein 4 Homo sapiens 38-44 35520131-1 2022 Adipocyte fatty acid-binding protein (A-FABP, also called FABP4, aP2) is an adipokine identified as a critical regulator of metabolic function due to its dual functions of fatty acid transport and pro-inflammation. Fatty Acids 172-182 fatty acid binding protein 4 Homo sapiens 58-63 35520131-1 2022 Adipocyte fatty acid-binding protein (A-FABP, also called FABP4, aP2) is an adipokine identified as a critical regulator of metabolic function due to its dual functions of fatty acid transport and pro-inflammation. Fatty Acids 172-182 fatty acid binding protein 4 Homo sapiens 65-68 31683588-1 2019 Small molecule inhibitors of adipocyte fatty-acid binding protein 4 (FABP4) have received interest following the recent publication of their pharmacologically beneficial effects. Fatty Acids 39-49 fatty acid binding protein 4 Homo sapiens 69-74 33789996-5 2021 The Fatty acids binding protein (FABPs) family of genes, specifically FABP1, FABP4 and FABP7 were also observed to be synergistically up-regulated in hypoxia by KSHV. Fatty Acids 4-15 fatty acid binding protein 4 Homo sapiens 77-82 33789996-13 2021 Specifically, the Fatty acids binding protein (FABPs) family genes (FABP1, FABP4 and FABP7). Fatty Acids 18-29 fatty acid binding protein 4 Homo sapiens 75-80 34007846-0 2021 Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control Study. Fatty Acids 19-29 fatty acid binding protein 4 Homo sapiens 47-52 33088219-0 2020 FABP4 promotes invasion and metastasis of colon cancer by regulating fatty acid transport. Fatty Acids 69-79 fatty acid binding protein 4 Homo sapiens 0-5 32075656-1 2020 BACKGROUND: Adipocyte fatty acid-binding protein (FABP4) is an adipokine that plays an important role in development of cardiovascular and metabolic diseases. Fatty Acids 22-32 fatty acid binding protein 4 Homo sapiens 50-55 31926616-0 2020 A FABP4-PPARgamma signaling axis regulates human monocyte responses to electrophilic fatty acid nitroalkenes. Fatty Acids 85-108 fatty acid binding protein 4 Homo sapiens 2-17 31926616-5 2020 NO2-FA induced the expression of two PPARgamma reporter genes, Fatty Acid Binding Protein 4 (FABP4) and the scavenger receptor CD36, at early stages of monocyte differentiation into macrophages. Fatty Acids 63-73 fatty acid binding protein 4 Homo sapiens 93-98 33071982-1 2020 Objective: Among fatty acid-binding proteins (FABPs), secreted forms of FABP4 and FABP5, which are expressed in adipocytes and macrophages, act as bioactive molecules. Fatty Acids 17-27 fatty acid binding protein 4 Homo sapiens 72-77 32258957-4 2020 We examined cord blood levels of adipocyte fatty-acid binding protein 4 (A-FABP or FABP4), a novel adipokine correlated with obesity and metabolic disease in children and adults. Fatty Acids 43-53 fatty acid binding protein 4 Homo sapiens 73-79 32258957-4 2020 We examined cord blood levels of adipocyte fatty-acid binding protein 4 (A-FABP or FABP4), a novel adipokine correlated with obesity and metabolic disease in children and adults. Fatty Acids 43-53 fatty acid binding protein 4 Homo sapiens 83-88 31817065-2 2019 Blo t 13 is an allergen from the mite Blomia tropicalis, which belongs to the fatty acid binding protein (FABP) family and has structural homology with human FABPs. Fatty Acids 78-88 fatty acid binding protein 4 Homo sapiens 106-110 31623495-4 2019 Infection with P. gingivalis or F. nucleatum significantly induced the expression of fatty acid binding protein 4 (FABP4), one of the most important adipokines that play a role in the progression of systemic diseases such as atherosclerosis and type 2 diabetes. Fatty Acids 85-95 fatty acid binding protein 4 Homo sapiens 115-120 31413360-3 2019 We tested blood samples from 50 patients with AMI and 43 patients with stable angina pectoris (sAP) for FGF21, fatty acid binding protein 4 (FABP4), a protein secreted from adipocytes in response to adrenergic lipolytic signal, and total and individual fatty acids. Fatty Acids 253-264 fatty acid binding protein 4 Homo sapiens 111-139 31413360-3 2019 We tested blood samples from 50 patients with AMI and 43 patients with stable angina pectoris (sAP) for FGF21, fatty acid binding protein 4 (FABP4), a protein secreted from adipocytes in response to adrenergic lipolytic signal, and total and individual fatty acids. Fatty Acids 253-264 fatty acid binding protein 4 Homo sapiens 141-146 30755372-10 2019 Src inhibition derepressed PPARgamma transcriptional activity leading to induced expression of lipolytic gene fatty acid binding protein (FABP) 4 which accompanies reduced lipid droplets and decreased tumor growth. Fatty Acids 110-120 fatty acid binding protein 4 Homo sapiens 138-145 30529845-2 2019 FABP4 is mainly expressed in macrophages and adipose tissue, where it regulates fatty acid storage and lipolysis, being also an important mediator of inflammation. Fatty Acids 80-90 fatty acid binding protein 4 Homo sapiens 0-5 28893569-1 2018 Fatty acid binding protein 4 (FABP4) is a member of the fatty acid binding protein family which involved in a variety of biological cellular processes, including tumorigenesis. Fatty Acids 56-66 fatty acid binding protein 4 Homo sapiens 0-28 29171144-3 2018 Fatty acid-binding proteins (FABPs) bind long-chain free fatty acids (FFAs) and are expressed in a tissue-specific pattern; FABP1 being the predominant hepatic form, and FABP4 the predominant adipocyte form. Fatty Acids 0-10 fatty acid binding protein 4 Homo sapiens 170-175 28893569-1 2018 Fatty acid binding protein 4 (FABP4) is a member of the fatty acid binding protein family which involved in a variety of biological cellular processes, including tumorigenesis. Fatty Acids 56-66 fatty acid binding protein 4 Homo sapiens 30-35 29441065-6 2018 PA treatment upregulated the expression of adipocyte fatty acid-binding protein (A-FABP), a critical regulator of fatty acid trafficking and lipid metabolism. Fatty Acids 53-63 fatty acid binding protein 4 Homo sapiens 81-87 28955759-1 2017 Adipocyte fatty acid-binding protein (AFABP: FABP4) is a member of the intracellular lipid-binding protein family that is thought to target long-chain fatty acids to nuclear receptors such as peroxisome proliferator-activated receptor gamma (PPARgamma), which in turn plays roles in insulin resistance and obesity. Fatty Acids 10-20 fatty acid binding protein 4 Homo sapiens 38-43 28701570-2 2017 The role of adipose-derived fatty acid-binding protein (FABP) 4 and FABP5 in breast cancer is presently under study, but their circulating levels in this pathology are poorly known. Fatty Acids 28-38 fatty acid binding protein 4 Homo sapiens 56-63 28738306-3 2017 FABP4 is predominantly expressed in macrophages and adipose tissue where it regulates fatty acids (FAs) storage and lipolysis and is an important mediator of inflammation. Fatty Acids 86-97 fatty acid binding protein 4 Homo sapiens 0-5 28738306-3 2017 FABP4 is predominantly expressed in macrophages and adipose tissue where it regulates fatty acids (FAs) storage and lipolysis and is an important mediator of inflammation. Fatty Acids 99-102 fatty acid binding protein 4 Homo sapiens 0-5 28955759-1 2017 Adipocyte fatty acid-binding protein (AFABP: FABP4) is a member of the intracellular lipid-binding protein family that is thought to target long-chain fatty acids to nuclear receptors such as peroxisome proliferator-activated receptor gamma (PPARgamma), which in turn plays roles in insulin resistance and obesity. Fatty Acids 10-20 fatty acid binding protein 4 Homo sapiens 45-50 26992362-1 2016 The study aims to investigate whether cytosolic fatty acid-binding protein-4 (FABP4) is involved in angiogenic growth factors- and fatty acid-induced tube formation in first trimester placental trophoblast cells, HTR8/SVneo. Fatty Acids 48-58 fatty acid binding protein 4 Homo sapiens 78-83 27061264-0 2017 Exogenous FABP4 increases breast cancer cell proliferation and activates the expression of fatty acid transport proteins. Fatty Acids 91-101 fatty acid binding protein 4 Homo sapiens 10-15 27061264-2 2017 Fatty acid binding protein 4 (FABP4) is a key adipokine for fatty acid transport. Fatty Acids 60-70 fatty acid binding protein 4 Homo sapiens 0-28 27061264-2 2017 Fatty acid binding protein 4 (FABP4) is a key adipokine for fatty acid transport. Fatty Acids 60-70 fatty acid binding protein 4 Homo sapiens 30-35 27658368-1 2016 Dual inhibition of fatty acid binding proteins 4 and 5 (FABP4 and FABP5) is expected to provide beneficial effects on a number of metabolic parameters such as insulin sensitivity and blood glucose levels and should protect against atherosclerosis. Fatty Acids 19-29 fatty acid binding protein 4 Homo sapiens 56-61 27446270-1 2016 The main function of adipocyte fatty acid-binding protein (A-FABP) is to regulate fatty acid metabolism as its molecular chaperone. Fatty Acids 31-41 fatty acid binding protein 4 Homo sapiens 59-65 27155388-1 2016 BACKGROUND AND AIMS: Fatty acid binding protein 4 (FABP4) is an intracellular fatty acid (FA) carrier protein that is, in part, secreted into circulation. Fatty Acids 78-88 fatty acid binding protein 4 Homo sapiens 21-49 27155388-1 2016 BACKGROUND AND AIMS: Fatty acid binding protein 4 (FABP4) is an intracellular fatty acid (FA) carrier protein that is, in part, secreted into circulation. Fatty Acids 78-88 fatty acid binding protein 4 Homo sapiens 51-56 27568980-4 2017 We analysed the effect of transient FABP4 knockdown in human umbilical vein endothelial cells on fatty acid metabolism, viability and angiogenesis. Fatty Acids 97-107 fatty acid binding protein 4 Homo sapiens 36-41 28555711-7 2017 In particular, FABP4, PLIN1, and ADIPOQ were related to fatty acid and lipid metabolism. Fatty Acids 56-66 fatty acid binding protein 4 Homo sapiens 15-20 26992362-9 2016 Thus, FABP4 may play a differential role in fatty acids and angiogenic growth factors-mediated tube formation in the first trimester trophoblast cells in vitro. Fatty Acids 44-55 fatty acid binding protein 4 Homo sapiens 6-11 26580122-1 2015 Fatty acid binding protein 4 (FABP4), reversibly binding to fatty acids and other lipids with high affinities, is a potential target for treatment of cancers. Fatty Acids 60-71 fatty acid binding protein 4 Homo sapiens 0-28 27124483-6 2016 Syncytializing cells suppress previously active genes that regulate fatty-acid uptake (SLC27A2/FATP2, FABP4, ACSL5) and lipid metabolism (GPAT3, LPCAT3). Fatty Acids 68-78 fatty acid binding protein 4 Homo sapiens 102-107 26754658-8 2016 Change in FABP4 level by omega-3 fatty acids was negatively correlated with change in levels of EPA + DHA (r = -0.643, P = 0.013), EPA (r = -0.540, P = 0.046) and DHA (r = -0.650, P = 0.011) but not change in the level of triglycerides or other fatty acid composition. Fatty Acids 33-43 fatty acid binding protein 4 Homo sapiens 10-15 26580122-1 2015 Fatty acid binding protein 4 (FABP4), reversibly binding to fatty acids and other lipids with high affinities, is a potential target for treatment of cancers. Fatty Acids 60-71 fatty acid binding protein 4 Homo sapiens 30-35 25370574-1 2015 BACKGROUND: Adipocyte fatty acid-binding protein (FABP4) is a member of a highly conserved family of cytosolic proteins that bind with high affinity to hydrophobic ligands, such as saturated and unsaturated long-chain fatty acids and eicosanoids. Fatty Acids 22-32 fatty acid binding protein 4 Homo sapiens 50-55 26343611-1 2015 Fatty acid-binding protein 4 (FABP4) is an adipose tissue-secreted adipokine that is involved in the regulation of energetic metabolism and inflammation. Fatty Acids 0-10 fatty acid binding protein 4 Homo sapiens 30-35 26343611-10 2015 Pharmacological FABP4 inhibition by BMS309403 results in a slight decrease in the formation of these complexes, indicating that fatty acids may play a role in FABP4 functionality. Fatty Acids 128-139 fatty acid binding protein 4 Homo sapiens 16-21 26343611-10 2015 Pharmacological FABP4 inhibition by BMS309403 results in a slight decrease in the formation of these complexes, indicating that fatty acids may play a role in FABP4 functionality. Fatty Acids 128-139 fatty acid binding protein 4 Homo sapiens 159-164 25958041-3 2015 Fatty acid-binding protein 4 (FABP4), a carrier protein for fatty acids, has been linked to diabetes and diabetic nephropathy (DN). Fatty Acids 60-71 fatty acid binding protein 4 Homo sapiens 0-28 25958041-3 2015 Fatty acid-binding protein 4 (FABP4), a carrier protein for fatty acids, has been linked to diabetes and diabetic nephropathy (DN). Fatty Acids 60-71 fatty acid binding protein 4 Homo sapiens 30-35 25953897-4 2015 Here, we identify adipocyte-type fatty acid-binding protein (A-Fabp) and other members of the fatty acid-binding protein (Fabp) family as interaction partners of Cgi-58. Fatty Acids 33-43 fatty acid binding protein 4 Homo sapiens 61-67 25897794-9 2015 PPARgamma luciferase reporter assays confirmed that FABP4 supports fatty acid-induced PPARgamma activation. Fatty Acids 67-77 fatty acid binding protein 4 Homo sapiens 52-57 22420890-3 2012 Adipocyte fatty acid-binding protein (FABP4) plasma concentrations have been linked to metabolic alterations that are associated with adiposity. Fatty Acids 10-20 fatty acid binding protein 4 Homo sapiens 38-43 25664790-1 2015 Inhibition of human adipocyte fatty-acid binding protein (FABP4) has been proposed as a treatment for type 2 diabetes, fatty liver disease and atherosclerosis. Fatty Acids 30-40 fatty acid binding protein 4 Homo sapiens 58-63 26273425-7 2015 Exposure to GC-DNA leads to an increase in the level of RNAPPARG2 and LPL (RT-PCR), in the level of fatty acid binding protein FABP4 (FACS analysis) and in the level of fat (Oil Red O). Fatty Acids 100-110 fatty acid binding protein 4 Homo sapiens 127-132 24740818-3 2014 Fatty acid binding protein 4 (FABP4), a member of the cytoplasmic fatty acid binding protein multigene family, was recently identified as a novel adipokine. Fatty Acids 66-76 fatty acid binding protein 4 Homo sapiens 0-28 24740818-3 2014 Fatty acid binding protein 4 (FABP4), a member of the cytoplasmic fatty acid binding protein multigene family, was recently identified as a novel adipokine. Fatty Acids 66-76 fatty acid binding protein 4 Homo sapiens 30-35 24740818-8 2014 These promoting effects were reduced by FABP4 inhibitor, which inhibits FABP4 binding to fatty acids. Fatty Acids 89-100 fatty acid binding protein 4 Homo sapiens 40-45 24740818-8 2014 These promoting effects were reduced by FABP4 inhibitor, which inhibits FABP4 binding to fatty acids. Fatty Acids 89-100 fatty acid binding protein 4 Homo sapiens 72-77 24740818-12 2014 These results suggest that exogenous FABP4 might promote human prostate cancer cell progression by binding with fatty acids. Fatty Acids 112-123 fatty acid binding protein 4 Homo sapiens 37-42 24095946-6 2013 In addition to the stimulation of expression of major angiogenic factors such as VEGF and ANGPTL4, fatty acids also stimulate expression of intracellular fatty acid-binding proteins (FABPs) FABP-4 and FABP-3 those are known to directly modulate angiogenesis. Fatty Acids 99-110 fatty acid binding protein 4 Homo sapiens 190-196 24095946-6 2013 In addition to the stimulation of expression of major angiogenic factors such as VEGF and ANGPTL4, fatty acids also stimulate expression of intracellular fatty acid-binding proteins (FABPs) FABP-4 and FABP-3 those are known to directly modulate angiogenesis. Fatty Acids 99-109 fatty acid binding protein 4 Homo sapiens 190-196 23497718-4 2013 FINDINGS: Transcript levels of several PPARalpha target genes involved in fatty acid uptake (FABP4, SLC25A20), fatty acid oxidation (ACOX1, CYP4A24) and ketogenesis (HMGCS2, FGF21) were elevated in the liver of lactating compared to non-lactating sows (P < 0.05). Fatty Acids 74-84 fatty acid binding protein 4 Homo sapiens 93-98 25535287-0 2015 Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity. Fatty Acids 13-23 fatty acid binding protein 4 Homo sapiens 40-43 25073566-2 2014 Elevated levels of FFA and fatty acid-binding protein 4 (FABP4), a key cytoplasmic chaperone of fatty acids, have been associated with adverse cardiovascular outcomes, but limited data are available on the relation of these biomarkers with cardiovascular and total mortality. Fatty Acids 96-107 fatty acid binding protein 4 Homo sapiens 27-55 25073566-2 2014 Elevated levels of FFA and fatty acid-binding protein 4 (FABP4), a key cytoplasmic chaperone of fatty acids, have been associated with adverse cardiovascular outcomes, but limited data are available on the relation of these biomarkers with cardiovascular and total mortality. Fatty Acids 96-107 fatty acid binding protein 4 Homo sapiens 57-62 24024500-4 2014 Due to the ubiquity of endogenous fatty acids and the high intracellular concentration of FABP4, the inhibitors need to have significantly greater intrinsic potency than endogenous fatty acids. Fatty Acids 181-192 fatty acid binding protein 4 Homo sapiens 90-95 24121341-6 2013 The adipocyte-type fatty-acid-binding protein (FABP4) exhibits 67% sequence identity with FABP3 and its crystal structure is almost the same as that of FABP3. Fatty Acids 19-29 fatty acid binding protein 4 Homo sapiens 47-52 23642261-1 2013 BACKGROUND: Circulating adipocyte fatty acid-binding protein (FABP4) levels are considered to be a link between obesity, insulin resistance, diabetes, and cardiovascular (CV) diseases. Fatty Acids 34-44 fatty acid binding protein 4 Homo sapiens 62-67 23511993-1 2013 Adipocyte P2 (aP2), also known as fatty acid-binding protein 4 (FABP4), is a fatty acid-binding protein found in the cytoplasm of cells of adipocyte differentiation. Fatty Acids 34-44 fatty acid binding protein 4 Homo sapiens 14-17 23511993-1 2013 Adipocyte P2 (aP2), also known as fatty acid-binding protein 4 (FABP4), is a fatty acid-binding protein found in the cytoplasm of cells of adipocyte differentiation. Fatty Acids 34-44 fatty acid binding protein 4 Homo sapiens 64-69 23315880-1 2013 Fatty acid binding protein 4 (FABP4) is an important adipocyte gene, with roles in fatty acid transport and fat deposition in animals as well as human metabolic syndrome. Fatty Acids 83-93 fatty acid binding protein 4 Homo sapiens 0-28 23315880-1 2013 Fatty acid binding protein 4 (FABP4) is an important adipocyte gene, with roles in fatty acid transport and fat deposition in animals as well as human metabolic syndrome. Fatty Acids 83-93 fatty acid binding protein 4 Homo sapiens 30-35 23153451-8 2013 In addition, these fatty acids altered expression of several lipid metabolic genes such as ADRP, FABP4, FABP3, and COX-2 those are involved in angiogenesis. Fatty Acids 19-30 fatty acid binding protein 4 Homo sapiens 97-102 23357154-1 2013 BACKGROUND AND METHODS: Adipocyte fatty acid-binding protein (FABP4) is a member of the intracellular lipid-binding protein family highly expressed in adipocytes and macrophages. Fatty Acids 34-44 fatty acid binding protein 4 Homo sapiens 62-67 23505452-7 2013 A marker for fatty acid transport increased (FABP4) during weight loss and remained increased during follow-up. Fatty Acids 13-23 fatty acid binding protein 4 Homo sapiens 45-50 22912462-1 2012 Abundance of duck adipocyte fatty acid-binding protein (A-FABP) mRNA was detected in this study by quantitative real-time PCR. Fatty Acids 28-38 fatty acid binding protein 4 Homo sapiens 56-62 22584136-1 2012 OBJECTIVE: To examine the relation of fatty acid-binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults. Fatty Acids 38-48 fatty acid binding protein 4 Homo sapiens 66-72 21186114-1 2012 BACKGROUND AND AIM: Adipocyte fatty acid-binding protein (FABP4) is abundantly expressed in adipocytes and plays a role in glucose homeostasis. Fatty Acids 30-40 fatty acid binding protein 4 Homo sapiens 58-63 22223390-1 2012 Adipocyte fatty acid binding protein (A-FABP; FABP4), which is predominantly expressed in macrophages and adipose tissue, regulates fatty acid storage and lipolysis, and is also an important mediator of inflammation. Fatty Acids 10-20 fatty acid binding protein 4 Homo sapiens 38-44 22223390-1 2012 Adipocyte fatty acid binding protein (A-FABP; FABP4), which is predominantly expressed in macrophages and adipose tissue, regulates fatty acid storage and lipolysis, and is also an important mediator of inflammation. Fatty Acids 10-20 fatty acid binding protein 4 Homo sapiens 46-51 21720879-1 2011 Increased expression of adipocyte fatty acid binding protein (FABP4) is associated with type 2 diabetic, high triglycerides, increased lipid peroxidation, and inflammation markers. Fatty Acids 34-44 fatty acid binding protein 4 Homo sapiens 62-67 21059735-3 2011 Animal studies revealed that adipocyte fatty acid binding protein (FABP4) is associated with the progression of atherosclerosis; however, FABP4 expression studies in human atherosclerotic plaques are lacking. Fatty Acids 39-49 fatty acid binding protein 4 Homo sapiens 67-72 20823563-4 2010 Adipocyte-specific fatty acid binding protein (aP2) gene expression was increased by 7-O-MA in adipocytes, and both gene and protein level of peroxisome proliferator-activated receptor gamma2 (PPARgamma2) was also increased. Fatty Acids 19-29 fatty acid binding protein 4 Homo sapiens 47-50 19911253-0 2010 Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4. Fatty Acids 70-80 fatty acid binding protein 4 Homo sapiens 97-102 21525163-11 2011 In primary human trophoblasts, fatty acids markedly increased the expression of FABP4 (20- to 40-fold, P < 0.05) and cellular triglyceride content (4-fold, P < 0.05), and this effect was attenuated by small interfering RNA-mediated knockdown of FABP4 or the selective FABP4 inhibitor BMS309403. Fatty Acids 31-42 fatty acid binding protein 4 Homo sapiens 80-85 21525163-11 2011 In primary human trophoblasts, fatty acids markedly increased the expression of FABP4 (20- to 40-fold, P < 0.05) and cellular triglyceride content (4-fold, P < 0.05), and this effect was attenuated by small interfering RNA-mediated knockdown of FABP4 or the selective FABP4 inhibitor BMS309403. Fatty Acids 31-42 fatty acid binding protein 4 Homo sapiens 251-256 21525163-11 2011 In primary human trophoblasts, fatty acids markedly increased the expression of FABP4 (20- to 40-fold, P < 0.05) and cellular triglyceride content (4-fold, P < 0.05), and this effect was attenuated by small interfering RNA-mediated knockdown of FABP4 or the selective FABP4 inhibitor BMS309403. Fatty Acids 31-42 fatty acid binding protein 4 Homo sapiens 251-256 18820256-2 2008 The hormone-sensitive lipase (HSL) and adipocyte fatty acid-binding protein (AFABP/aP2) form a physical complex that affects basal and hormone-stimulated adipocyte fatty acid efflux. Fatty Acids 49-59 fatty acid binding protein 4 Homo sapiens 77-82 19842034-2 2010 Adiopcyte fatty acid binding-protein(A-FABP) is another protein found in adipose tissue;therefore, we investigated the association of A-FABP with the occurrence and prognosis of breast cancer. Fatty Acids 10-20 fatty acid binding protein 4 Homo sapiens 37-43 19827857-6 2009 Further, identified proteins indicate a reduced intracellular scaffolding of GLUT4 (ALDOC, TUBB5, ANXA2), an increased uptake of fatty acids (FABP4), an improved inflammatory profile of the adipose tissue (ApoA1, AOP1) and a change in fat droplet organization (vimentin). Fatty Acids 129-140 fatty acid binding protein 4 Homo sapiens 142-147 19608978-1 2009 RATIONALE: Adipocyte fatty acid-binding protein (FABP4) is a member of the intracellular lipid-binding protein family and is predominantly expressed in adipose tissue. Fatty Acids 21-31 fatty acid binding protein 4 Homo sapiens 49-54 18676720-5 2008 The expression of adipocyte fatty acid binding protein (aP2) and adiponectin in myoblasts stably expressing porcine PPARgamma was increased when docosahexaenoic acid (DHA) was added to the adipogenic medium. Fatty Acids 28-38 fatty acid binding protein 4 Homo sapiens 56-59 20533865-1 2010 Serum adipocyte fatty acid-binding protein (FABP-4) concentrations are linked to human obesity and other features of metabolic syndrome. Fatty Acids 16-26 fatty acid binding protein 4 Homo sapiens 44-50 19135148-5 2009 The nitration of adipocyte fatty acid binding protein (FABP4) at Tyr19 decreases, similar to phosphorylation, the binding of palmitic acid to the fatty acid-free protein. Fatty Acids 27-37 fatty acid binding protein 4 Homo sapiens 55-60 19135148-5 2009 The nitration of adipocyte fatty acid binding protein (FABP4) at Tyr19 decreases, similar to phosphorylation, the binding of palmitic acid to the fatty acid-free protein. Fatty Acids 146-156 fatty acid binding protein 4 Homo sapiens 55-60 18820256-2 2008 The hormone-sensitive lipase (HSL) and adipocyte fatty acid-binding protein (AFABP/aP2) form a physical complex that affects basal and hormone-stimulated adipocyte fatty acid efflux. Fatty Acids 49-59 fatty acid binding protein 4 Homo sapiens 83-86 18501494-6 2008 Real-time PCR and Western blot analysis confirmed the high expression of the specific adipocyte differentiation marker aP2 (adipocyte-specific fatty acid binding protein). Fatty Acids 143-153 fatty acid binding protein 4 Homo sapiens 119-122 18679408-0 2008 The increase of fatty acid-binding protein aP2 in overweight and obese children: interactions with dietary fat and impact on measures of subclinical inflammation. Fatty Acids 16-26 fatty acid binding protein 4 Homo sapiens 43-46 16423904-1 2006 BACKGROUND: Adipocyte fatty acid-binding protein (A-FABP) is traditionally thought to be a cytosolic fatty acid chaperone expressed in adipocytes. Fatty Acids 22-32 fatty acid binding protein 4 Homo sapiens 50-56 18375128-0 2008 NMR evaluation of adipocyte fatty acid binding protein (aP2) with R- and S-ibuprofen. Fatty Acids 28-38 fatty acid binding protein 4 Homo sapiens 56-59 17396233-2 2007 In this report, we describe a novel LXR target, the adipocyte fatty acid binding protein (aP2), which plays an important role in fatty acid metabolism, adipocyte differentiation and atherosclerosis. Fatty Acids 62-72 fatty acid binding protein 4 Homo sapiens 90-93 17396233-2 2007 In this report, we describe a novel LXR target, the adipocyte fatty acid binding protein (aP2), which plays an important role in fatty acid metabolism, adipocyte differentiation and atherosclerosis. Fatty Acids 129-139 fatty acid binding protein 4 Homo sapiens 90-93 17502136-1 2007 Herein we report the first disclosure of biphenyl azoles that are nanomolar binders of adipocyte fatty acid binding protein (aFABP or aP2) with up to thousand-fold selectivity against muscle fatty acid binding protein and epidermal fatty acid binding protein. Fatty Acids 97-107 fatty acid binding protein 4 Homo sapiens 125-130 17502136-1 2007 Herein we report the first disclosure of biphenyl azoles that are nanomolar binders of adipocyte fatty acid binding protein (aFABP or aP2) with up to thousand-fold selectivity against muscle fatty acid binding protein and epidermal fatty acid binding protein. Fatty Acids 97-107 fatty acid binding protein 4 Homo sapiens 134-137 17502136-1 2007 Herein we report the first disclosure of biphenyl azoles that are nanomolar binders of adipocyte fatty acid binding protein (aFABP or aP2) with up to thousand-fold selectivity against muscle fatty acid binding protein and epidermal fatty acid binding protein. Fatty Acids 191-201 fatty acid binding protein 4 Homo sapiens 125-130 17502136-1 2007 Herein we report the first disclosure of biphenyl azoles that are nanomolar binders of adipocyte fatty acid binding protein (aFABP or aP2) with up to thousand-fold selectivity against muscle fatty acid binding protein and epidermal fatty acid binding protein. Fatty Acids 191-201 fatty acid binding protein 4 Homo sapiens 134-137 16841093-0 2006 The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. Fatty Acids 14-24 fatty acid binding protein 4 Homo sapiens 41-44 16841093-1 2006 The adipocyte fatty acid-binding protein aP2 regulates systemic glucose and lipid metabolism. Fatty Acids 14-24 fatty acid binding protein 4 Homo sapiens 41-44 16841093-6 2006 Thus, aP2 regulates allergic airway inflammation and may provide a link between fatty acid metabolism and asthma. Fatty Acids 80-90 fatty acid binding protein 4 Homo sapiens 6-9 16641093-0 2006 A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Fatty Acids 25-35 fatty acid binding protein 4 Homo sapiens 52-55 16641093-3 2006 The fatty acid-binding protein aP2 is a cytoplasmic lipid chaperon expressed in adipocytes and macrophages. Fatty Acids 4-14 fatty acid binding protein 4 Homo sapiens 31-34 15273253-3 2004 The goal of this study was to 1) clone the promoter of the human adipocyte fatty acid binding protein (aP2) gene, namely fatty acid-binding protein-4, 2) characterize its pharmacological regulation, and 3) determine its putative predictability for adipogenesis. Fatty Acids 75-85 fatty acid binding protein 4 Homo sapiens 103-106 15284082-2 2004 We documented that adipocyte fatty acid binding protein (aP2) is expressed in human preadipocyte clones capable of replication, indicating that can be used as a marker of committed preadipocytes. Fatty Acids 29-39 fatty acid binding protein 4 Homo sapiens 57-60 15766256-1 2005 The adipocyte lipid binding protein (ALBP) binds fatty acids (FA) in a cavity that is inaccessible from the bulk. Fatty Acids 49-60 fatty acid binding protein 4 Homo sapiens 4-35 15766256-1 2005 The adipocyte lipid binding protein (ALBP) binds fatty acids (FA) in a cavity that is inaccessible from the bulk. Fatty Acids 49-60 fatty acid binding protein 4 Homo sapiens 37-41 15456755-1 2004 Previous in vitro studies have established that hormone sensitive lipase (HSL) and adipocyte fatty acid-binding protein (AFABP) form a physical complex that presumably positions the FABP to accept a product fatty acid generated during catalysis. Fatty Acids 93-103 fatty acid binding protein 4 Homo sapiens 121-126 15686734-3 2004 Adipocyte fatty acid binding protein (aP2) is a member of the cytoplasmic fatty acid binding protein (FABP) family. Fatty Acids 10-20 fatty acid binding protein 4 Homo sapiens 38-41 15686734-3 2004 Adipocyte fatty acid binding protein (aP2) is a member of the cytoplasmic fatty acid binding protein (FABP) family. Fatty Acids 74-84 fatty acid binding protein 4 Homo sapiens 38-41 15500004-1 2004 Adipocyte-fatty acid binding protein (A-FABP) is a 14-15 kDa cytoplasmic protein that binds unesterified fatty acids (FA). Fatty Acids 105-116 fatty acid binding protein 4 Homo sapiens 0-36 15500004-1 2004 Adipocyte-fatty acid binding protein (A-FABP) is a 14-15 kDa cytoplasmic protein that binds unesterified fatty acids (FA). Fatty Acids 105-116 fatty acid binding protein 4 Homo sapiens 38-44 15015141-3 2004 In turn, FABP4 binds fatty acids and transports them to the nucleus where the FABP4/fatty acid complex activates PPARgamma in a positive feedback loop. Fatty Acids 21-32 fatty acid binding protein 4 Homo sapiens 9-14 15015141-3 2004 In turn, FABP4 binds fatty acids and transports them to the nucleus where the FABP4/fatty acid complex activates PPARgamma in a positive feedback loop. Fatty Acids 21-32 fatty acid binding protein 4 Homo sapiens 78-83 15015141-3 2004 In turn, FABP4 binds fatty acids and transports them to the nucleus where the FABP4/fatty acid complex activates PPARgamma in a positive feedback loop. Fatty Acids 21-31 fatty acid binding protein 4 Homo sapiens 9-14 15015141-3 2004 In turn, FABP4 binds fatty acids and transports them to the nucleus where the FABP4/fatty acid complex activates PPARgamma in a positive feedback loop. Fatty Acids 21-31 fatty acid binding protein 4 Homo sapiens 78-83 14594993-2 2004 The loop connecting beta-strands E and F (the fifth and sixth strands) is the most striking conformational difference between adipocyte lipid binding protein (ALBP; fatty acids) and cellular retinoic acid binding protein type I (CRABP I). Fatty Acids 165-176 fatty acid binding protein 4 Homo sapiens 126-157 14594993-2 2004 The loop connecting beta-strands E and F (the fifth and sixth strands) is the most striking conformational difference between adipocyte lipid binding protein (ALBP; fatty acids) and cellular retinoic acid binding protein type I (CRABP I). Fatty Acids 165-176 fatty acid binding protein 4 Homo sapiens 159-163 12794068-1 2003 Adipocyte lipid-binding protein (ALBP or aP2) is an intracellular fatty acid-binding protein that is found in adipocytes and macrophages and binds a large variety of intracellular lipids with high affinity. Fatty Acids 66-76 fatty acid binding protein 4 Homo sapiens 0-31 12794068-1 2003 Adipocyte lipid-binding protein (ALBP or aP2) is an intracellular fatty acid-binding protein that is found in adipocytes and macrophages and binds a large variety of intracellular lipids with high affinity. Fatty Acids 66-76 fatty acid binding protein 4 Homo sapiens 33-37 12794068-1 2003 Adipocyte lipid-binding protein (ALBP or aP2) is an intracellular fatty acid-binding protein that is found in adipocytes and macrophages and binds a large variety of intracellular lipids with high affinity. Fatty Acids 66-76 fatty acid binding protein 4 Homo sapiens 41-44