PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32280672-8 2020 The difference of ACAA2 gene expressions between the IDH wild-type (IDH-WT) group and the IDH mutant (IDH-MUT) group suggested that there may be different potential targeted therapies based on the fatty acid metabolic vulnerabilities, which promoted the personalized treatment for LGG patients. Fatty Acids 197-207 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 53-56 12923220-9 2003 These results indicate that IDH1 activity is coordinately regulated with the cholesterol and fatty acid biosynthetic pathways and suggest that it is the source for the cytosolic NADPH required by these pathways. Fatty Acids 93-103 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 28-32 32280672-8 2020 The difference of ACAA2 gene expressions between the IDH wild-type (IDH-WT) group and the IDH mutant (IDH-MUT) group suggested that there may be different potential targeted therapies based on the fatty acid metabolic vulnerabilities, which promoted the personalized treatment for LGG patients. Fatty Acids 197-207 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 68-71 32280672-8 2020 The difference of ACAA2 gene expressions between the IDH wild-type (IDH-WT) group and the IDH mutant (IDH-MUT) group suggested that there may be different potential targeted therapies based on the fatty acid metabolic vulnerabilities, which promoted the personalized treatment for LGG patients. Fatty Acids 197-207 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 68-71 30720071-7 2019 These results indicated that mutation of IDH1 aggravated the fatty acid-induced oxidative stress in HCT116 cells, by suppressing FAO and disrupting the mitochondrial respiratory chain. Fatty Acids 61-71 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 41-45 30720071-0 2019 Mutation of IDH1 aggravates the fatty acid-induced oxidative stress in HCT116 cells by affecting the mitochondrial respiratory chain. Fatty Acids 32-42 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 12-16 30903027-3 2019 Applied to study reductive glutamine metabolism in cancer cells, shown to mediate fatty acid biosynthesis under hypoxia and defective mitochondria, we find a previously unappreciated role of reductive IDH1 as the sole net contributor of carbons to fatty acid biosynthesis under standard normoxic conditions in HeLa cells. Fatty Acids 82-92 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 201-205 30720071-4 2019 Furthermore, mutation of IDH1 inhibited the rate of fatty acid oxidation (FAO), but elevated the glucose consumption in HCT116 cells. Fatty Acids 52-62 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 25-29 30903027-3 2019 Applied to study reductive glutamine metabolism in cancer cells, shown to mediate fatty acid biosynthesis under hypoxia and defective mitochondria, we find a previously unappreciated role of reductive IDH1 as the sole net contributor of carbons to fatty acid biosynthesis under standard normoxic conditions in HeLa cells. Fatty Acids 248-258 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 201-205 30366412-7 2018 Isotopic profiling of fatty acids revealed that higher lipid anabolism in IDH1 mutant cells corroborated with an increase in lipogenesis fluxes. Fatty Acids 22-33 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 74-78 30366412-9 2018 Therefore, we have determined that lipid anabolism is strongly reprogrammed in IDH1 mutant AML cells with a crucial dysregulation of fatty acid metabolism and fluxes, both being mediated by 2-HG (2-Hydroxyglutarate) production. Fatty Acids 133-143 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 79-83 22080945-5 2012 RECENT FINDINGS: Metabolomic studies of IDH1/2 mutant cells have revealed alterations in glutamine, fatty acid, and citrate synthesis pathways. Fatty Acids 100-110 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 40-44 27856334-10 2017 In CTP deficient cells, IDH1 inhibition suppresses lipogenesis from either glucose or glutamine, implicating IDH1 as a required component of fatty acid synthesis in states of CTP deficiency. Fatty Acids 141-151 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 24-28 27856334-10 2017 In CTP deficient cells, IDH1 inhibition suppresses lipogenesis from either glucose or glutamine, implicating IDH1 as a required component of fatty acid synthesis in states of CTP deficiency. Fatty Acids 141-151 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 109-113 26137220-9 2015 PDH suppression also shifted the source of lipogenic acetyl-CoA from glucose to glutamine, and this compensatory pathway required a net reductive isocitrate dehydrogenase (IDH) flux to produce a source of glutamine-derived acetyl-CoA for fatty acids. Fatty Acids 238-249 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 172-175