PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11248224-1 2001 The enzyme DT-diaphorase mediates the two-electron reduction of quinones to hydroquinones. Hydroquinones 76-89 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 11-24 30062552-2 2018 NAD(P)H:quinone oxidoreductase 1 (NQO-1), the enzyme responsible for biotransformation of quinones into hydroquinones, was examined for its involvement in these endothelium-dependent augmentations, establishing a link between the metabolism of quinones by NQO-1 and biased sGC activity. Hydroquinones 104-117 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 0-32 8461317-1 1993 NAD(P)H:quinone reductase, or DT-diaphorase, has been studied primarily in the liver where it appears to function as an antioxidant-like enzyme in the 2-electron reduction of some quinones to less toxic hydroquinones. Hydroquinones 203-216 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 30-43 3129984-1 1988 DT diaphorase catalyzes the transfer of two electrons to quinones to form relatively stable hydroquinones, thus protecting cells from damage by semiquinone production and subsequent superoxide radical formation. Hydroquinones 92-105 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 0-13 30062552-2 2018 NAD(P)H:quinone oxidoreductase 1 (NQO-1), the enzyme responsible for biotransformation of quinones into hydroquinones, was examined for its involvement in these endothelium-dependent augmentations, establishing a link between the metabolism of quinones by NQO-1 and biased sGC activity. Hydroquinones 104-117 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 34-39 25151970-9 2014 We further demonstrated that NQO1 mediated reduction to unstable hydroquinones and subsequent redox cycling was important for the activation of the ER stress response and toxicity for both AC and MD. Hydroquinones 65-78 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 29-33