PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30321197-0 2018 The small molecule rhodomyrtone suppresses TNF-alpha and IL-17A-induced keratinocyte inflammatory responses: A potential new therapeutic for psoriasis. rhodomyrtone 19-31 tumor necrosis factor Homo sapiens 43-52 30321197-4 2018 This study assessed the potential of rhodomyrtone for curtailing TNF/IL-17A-driven inflammation. rhodomyrtone 37-49 tumor necrosis factor Homo sapiens 65-68 30321197-5 2018 Stimulating human skin organ cultures with TNF+IL-17A to model the skin inflammation in psoriasis, we found that rhodomyrtone significantly decreased inflammatory gene expression and the expression and secretion of inflammatory proteins, assessed by qRT-PCR, immunohistochemistry and ELISA assays respectively. rhodomyrtone 113-125 tumor necrosis factor Homo sapiens 43-46 30321197-6 2018 RNA-seq analysis of monolayer primary keratinocytes treated with IL-17A/TNF showed that rhodomyrtone inhibited 724/1587 transcripts >2-fold altered by IL-17A/TNF (p<0.01), a number of which were confirmed at the mRNA and protein level. rhodomyrtone 88-100 tumor necrosis factor Homo sapiens 72-75 30321197-6 2018 RNA-seq analysis of monolayer primary keratinocytes treated with IL-17A/TNF showed that rhodomyrtone inhibited 724/1587 transcripts >2-fold altered by IL-17A/TNF (p<0.01), a number of which were confirmed at the mRNA and protein level. rhodomyrtone 88-100 tumor necrosis factor Homo sapiens 161-164 30321197-7 2018 Suggesting that rhodomyrtone acts by modulating MAP kinase and NF-kappaB signaling pathways, rhodomyrtone inhibited TNF-induced ERK, JNK, p38, and NF-kappaBp65 phosphorylation. rhodomyrtone 93-105 tumor necrosis factor Homo sapiens 116-119