PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25316298-9 2014 In addition, SDG downregulated the renal nuclear factor kappa-B (NF-kappaB), tumor necrosis factor (TNF)-alpha, and inducible nitric oxide synthase (iNOS) and upregulated renal survivin and B-cell lymphoma-2 (Bcl-2) expressions when compared with untreated diabetic control rats. secoisolariciresinol diglucoside 13-16 tumor necrosis factor Rattus norvegicus 77-110 25316298-10 2014 This study demonstrated, for the first time, the renoprotective effects of SDG in HFD/STZ-induced DN in rats through correction of hyperglycemia; attenuation of oxidative/nitrosative stress markers; downregulation of renal expressions of inflammatory markers NF-kappaB, TNF-alpha, and iNOS; along with upregulation of renal expressions of antiapoptotic markers survivin and Bcl-2. secoisolariciresinol diglucoside 75-78 tumor necrosis factor Rattus norvegicus 270-279