PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21747198-0	2011	A uremic solute, P-cresol, inhibits the proliferation of endothelial progenitor cells via the p38 pathway.	4-cresol	17-25	mitogen-activated protein kinase 1	Homo sapiens	94-97	
21993412-0	2011	Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production.	4-cresol	23-31	mitogen-activated protein kinase 1	Homo sapiens	127-130	
21993412-6	2011	P-cresol (2-100 muM) partly inhibited the AA-induced reactive oxygen species (ROS) production as well as the extracellular signal-regulated kinase (ERK1/2) and p38 phosphorylation in platelets.	4-cresol	0-8	mitogen-activated protein kinase 1	Homo sapiens	160-163	
21993412-9	2011	These results indicate that in acute p-cresol-poisoning and long-term exposure to cresol as in severe uremic patients, p-cresol may potentially inhibit blood clot formation and lead to hemorrhagic disorders via inhibition of platelet aggregation, ROS production, ERK/p38 activation and TXA(2) production.	4-cresol	119-127	mitogen-activated protein kinase 1	Homo sapiens	267-270	
21747198-11	2011	CONCLUSIONS: This study has demonstrated that p-cresol inhibits proliferation of EPCs via activation of p38 MAPK pathways.	4-cresol	46-54	mitogen-activated protein kinase 1	Homo sapiens	104-107	
21747198-9	2011	Phosphorylated p38 and Erk1/2 was increased by p-cresol, while P38 inhibitor SB203580 reversed the effect of p-cresol in the MTT assay.	4-cresol	47-55	mitogen-activated protein kinase 1	Homo sapiens	15-18	
21747198-9	2011	Phosphorylated p38 and Erk1/2 was increased by p-cresol, while P38 inhibitor SB203580 reversed the effect of p-cresol in the MTT assay.	4-cresol	109-117	mitogen-activated protein kinase 1	Homo sapiens	63-66