PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26972056-4	2016	CNH induced a significant increase of anxiety- like behavior and inflammation responses, which were ameliorated by NF-kappaB inhibitor, PDTC pretreatment, suggesting that the anxiogenic effect induced by inflammation is through NF-kappaB activation.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-124	
29680708-3	2018	We showed that apelin-13 treatment reversed a decrease in SIRT1 and an increase in acetylated p65 (lysine 310) proteins" expression in hippocampus of CNH-treated mice, indicating that apelin-13 inhibited NF-kappaB signaling pathway by activating SIRT1.	1-hydroxy-11-norcadinan-5-en-4-one	150-153	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	204-213	
29680708-6	2018	Finally, blockade of NF-kappaB activity by PDTC diminished CNH-induced anxiety-like behavior, indicating that NF-kappaB was involved in CNH-induced anxiety-like behavior in mice.	1-hydroxy-11-norcadinan-5-en-4-one	59-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	21-30	
29680708-6	2018	Finally, blockade of NF-kappaB activity by PDTC diminished CNH-induced anxiety-like behavior, indicating that NF-kappaB was involved in CNH-induced anxiety-like behavior in mice.	1-hydroxy-11-norcadinan-5-en-4-one	59-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119	
29680708-6	2018	Finally, blockade of NF-kappaB activity by PDTC diminished CNH-induced anxiety-like behavior, indicating that NF-kappaB was involved in CNH-induced anxiety-like behavior in mice.	1-hydroxy-11-norcadinan-5-en-4-one	136-139	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	21-30	
29680708-6	2018	Finally, blockade of NF-kappaB activity by PDTC diminished CNH-induced anxiety-like behavior, indicating that NF-kappaB was involved in CNH-induced anxiety-like behavior in mice.	1-hydroxy-11-norcadinan-5-en-4-one	136-139	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119	
29680708-7	2018	In conclusion, this study provides the first evidence that SIRT1 mediates the anxiolytic effect of apelin-13 in CNH-treated mice through the inhibition of NF-kappaB pathway.	1-hydroxy-11-norcadinan-5-en-4-one	112-115	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	155-164	
29680708-8	2018	These results imply that dysfunction of the apelin-SIRT1-NF-kappaB axis in hippocampus represents a potential mechanism that results in the induction of neuroinflammation and reduction in neuroprotection, thus induces anxiety-like behavior in CNH-treated mice.	1-hydroxy-11-norcadinan-5-en-4-one	243-246	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66	
28065733-12	2017	Finally, we found that rats with CNH treatment decreased APJ expression while enhanced NF-kappaB activation in the hippocampus, providing additional evidences that NF-kappaB activation in hippocampus in CNH-induced anxiety-like behavior in rats we reported previously might be associated with an inhibition of APJ activity.	1-hydroxy-11-norcadinan-5-en-4-one	33-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-96	
28065733-12	2017	Finally, we found that rats with CNH treatment decreased APJ expression while enhanced NF-kappaB activation in the hippocampus, providing additional evidences that NF-kappaB activation in hippocampus in CNH-induced anxiety-like behavior in rats we reported previously might be associated with an inhibition of APJ activity.	1-hydroxy-11-norcadinan-5-en-4-one	33-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	164-173	
28065733-13	2017	In conclusion, the present results illustrated that inhibition of APJ and promotion of NF-kappaB activation in the microglial of hippocampus might be involved in anxiogenic effect in CNH-exposed mice, and apelin-13 ameliorates CNH-induced anxiety-like behavior might be associated with an inhibition of NF-kappaB activation.	1-hydroxy-11-norcadinan-5-en-4-one	183-186	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-96	
26972056-4	2016	CNH induced a significant increase of anxiety- like behavior and inflammation responses, which were ameliorated by NF-kappaB inhibitor, PDTC pretreatment, suggesting that the anxiogenic effect induced by inflammation is through NF-kappaB activation.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	228-237	
26972056-6	2016	In addition, CNH treatment significantly increased Iba-1, iNOS, COX-2, and p-PKA in hippocampus, which were blocked by PDTC pretreatment, suggesting CNH may activate microglia cells in hippocampus through NF-kappaB pathway.	1-hydroxy-11-norcadinan-5-en-4-one	13-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	205-214	
26972056-6	2016	In addition, CNH treatment significantly increased Iba-1, iNOS, COX-2, and p-PKA in hippocampus, which were blocked by PDTC pretreatment, suggesting CNH may activate microglia cells in hippocampus through NF-kappaB pathway.	1-hydroxy-11-norcadinan-5-en-4-one	149-152	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	205-214