PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29680708-2	2018	This study aims to investigate whether SIRT1 is involved in the anxiolytic effect of apelin-13 in CNH-treated mice, and to illustrate the potential underlying mechanism.	1-hydroxy-11-norcadinan-5-en-4-one	98-101	sirtuin 1	Mus musculus	39-44	
29680708-3	2018	We showed that apelin-13 treatment reversed a decrease in SIRT1 and an increase in acetylated p65 (lysine 310) proteins" expression in hippocampus of CNH-treated mice, indicating that apelin-13 inhibited NF-kappaB signaling pathway by activating SIRT1.	1-hydroxy-11-norcadinan-5-en-4-one	150-153	sirtuin 1	Mus musculus	246-251	
29680708-4	2018	Behaviorally, apelin-13 ameliorated CNH-induced anxiety-like behavior, EX-527 blocked the beneficial effect of apelin-13, and the anxiogenic effect of CNH was attenuated by resveratrol pretreatment, suggesting that SIRT1 was involved in the effect of apelin-13 against CNH-induced anxiety-like behavior in mice.	1-hydroxy-11-norcadinan-5-en-4-one	151-154	sirtuin 1	Mus musculus	215-220	
29680708-4	2018	Behaviorally, apelin-13 ameliorated CNH-induced anxiety-like behavior, EX-527 blocked the beneficial effect of apelin-13, and the anxiogenic effect of CNH was attenuated by resveratrol pretreatment, suggesting that SIRT1 was involved in the effect of apelin-13 against CNH-induced anxiety-like behavior in mice.	1-hydroxy-11-norcadinan-5-en-4-one	151-154	sirtuin 1	Mus musculus	215-220	
29680708-7	2018	In conclusion, this study provides the first evidence that SIRT1 mediates the anxiolytic effect of apelin-13 in CNH-treated mice through the inhibition of NF-kappaB pathway.	1-hydroxy-11-norcadinan-5-en-4-one	112-115	sirtuin 1	Mus musculus	59-64	
29680708-8	2018	These results imply that dysfunction of the apelin-SIRT1-NF-kappaB axis in hippocampus represents a potential mechanism that results in the induction of neuroinflammation and reduction in neuroprotection, thus induces anxiety-like behavior in CNH-treated mice.	1-hydroxy-11-norcadinan-5-en-4-one	243-246	sirtuin 1	Mus musculus	51-56