PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28373265-7	2017	However, (S)-orteronel and (R)-orteronel bind to distinct CYP17A1 conformations that differ in a region implicated in ligand entry/exit and the presence of a peripheral ligand.	orteronel	9-22	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	58-65	
33004739-2	2020	Many randomized controlled trials (RCTs) showed promising results that men with metastatic castration-resistant PCa (mCRPC) might benefit from treatment with CYP17 inhibitors such as abiraterone acetate and orteronel.	orteronel	207-216	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	158-163	
32223238-0	2020	Multistep Binding of the Non-Steroidal Inhibitors Orteronel and Seviteronel to Human Cytochrome P450 17A1 and Relevance to Inhibition of Enzyme Activity.	orteronel	50-59	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	85-105	
26971992-1	2016	Abiraterone acetate and orteronel are two CYP-17 inhibitors that have been studied in prostate cancer.	orteronel	24-33	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	42-48	
24799061-2	2014	Orteronel inhibits the 17,20 lyase activity of the enzyme CYP17A1, which is important for androgen synthesis in the testes, adrenal glands and prostate cancer cells.	orteronel	0-9	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	58-65	
25560485-13	2015	Furthermore, the most recently identified CYP17A1 inhibitors Orteronel, Galeterone, VT-464, and CFG920 will also be explored.	orteronel	61-70	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	42-49	
24314737-5	2013	Hence, some molecules target the androgen biosynthesis, as abiraterone acetate and orteronel, which are selective inhibitors of the enzyme CYP17.	orteronel	83-92	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	139-144	
23856460-1	2013	Orteronel (TAK-700) is an investigational, non-steroidal inhibitor of CYP17A1 with preferential inhibition of 17,20-lyase in NCI-H295 cells.	orteronel	0-9	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	70-77	
23856460-1	2013	Orteronel (TAK-700) is an investigational, non-steroidal inhibitor of CYP17A1 with preferential inhibition of 17,20-lyase in NCI-H295 cells.	orteronel	11-18	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	70-77	
23371447-6	2013	A new CYP17 inhibitor, with more selective inhibition of 17,20-lyase over 17alpha-hydroxylase, orteronel (TAK-700), is currently undergoing phase III clinical trials in pre- and postchemotherapy CRPC.	orteronel	95-104	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	6-11	
23371447-6	2013	A new CYP17 inhibitor, with more selective inhibition of 17,20-lyase over 17alpha-hydroxylase, orteronel (TAK-700), is currently undergoing phase III clinical trials in pre- and postchemotherapy CRPC.	orteronel	106-113	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	6-11	
22249003-7	2012	In this study, we quantified the inhibitory activity and specificity of orteronel for testicular and adrenal androgen production by evaluating its effects on CYP17A1 enzymatic activity, steroid production in monkey adrenal cells and human adrenal tumor cells, and serum levels of dehydroepiandrosterone (DHEA), cortisol, and testosterone after oral dosing in castrated and intact male cynomolgus monkeys.	orteronel	72-81	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	158-165	
22249003-12	2012	In terms of human CYP17A1 and human adrenal tumor cells, orteronel inhibited 17,20-lyase activity 5.4 times more potently than 17-hydroxylase activity in cell-free enzyme assays and DHEA production 27 times more potently than cortisol production in human adrenal tumor cells, suggesting greater specificity of inhibition between 17,20-lyase and 17-hydroxylase activities in humans vs monkeys.	orteronel	57-66	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	18-25	
22249003-13	2012	In summary, orteronel potently inhibited the 17,20-lyase activity of monkey and human CYP17A1 and reduced serum androgen levels in vivo in monkeys.	orteronel	12-21	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	86-93