PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32529290-5 2020 However, the identification of MS patients harboring rare homozygote variants in NLRP1 (p.Ile601Phe and p.Ser1387Ile), a variant in NLRP3 (p.Leu832Ile) resulting in the substitution of a critical amino acid for the formation of its leucine-rich repeat domain, and several MS patients with NLRC4 variants (p.Arg310Ter and p.Glu600Ter) causing protein truncations suggest that rare protein-altering variants in inflammasome-activating NLR receptors may contribute to MS risk. glu600ter 323-332 NLR family pyrin domain containing 3 Homo sapiens 132-137