PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22591674-10	2012	We then found that exposure to the PFKFB3 small molecule antagonist, 3PO (1-10 muM), markedly attenuated the stimulation of F2,6BP synthesis, 2-[1-14C]-deoxy-D-glucose uptake, lactate secretion, TNF-alpha secretion and T cell aggregation and proliferation.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	69-72	tumor necrosis factor	Mus musculus	195-204	
32188275-9	2020	Moreover, 3PO induced autophagy, which in turn impaired NF-kappaB (nuclear factor-kappa B) signaling and inhibited TNF-alpha (tumor necrosis factor-alpha)-mediated VCAM-1 (vascular cell adhesion molecule-1) and ICAM-1 (intercellular adhesion molecule-1) upregulation.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	10-13	tumor necrosis factor	Mus musculus	115-124	
32188275-9	2020	Moreover, 3PO induced autophagy, which in turn impaired NF-kappaB (nuclear factor-kappa B) signaling and inhibited TNF-alpha (tumor necrosis factor-alpha)-mediated VCAM-1 (vascular cell adhesion molecule-1) and ICAM-1 (intercellular adhesion molecule-1) upregulation.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	10-13	tumor necrosis factor	Mus musculus	126-153	
30776389-9	2019	3PO also suppressed the LPS-induced secretion of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and lactate in the serum, in addition to lactate in the myocardium.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	0-3	tumor necrosis factor	Mus musculus	49-76