PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30858427-11	2019	Consistent with a key role for PFKFB3 is the finding that the PFKFB3 inhibitor, 3PO, attenuated the LPS + Abeta-induced glycolysis.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	80-83	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	31-37	
32051533-7	2020	In addition, PFKFB3 expression and aerobic glycolysis were also detected in the mouse model of LPS-induced pulmonary fibrosis, which could be reversed by the intraperitoneal injection of PFKFB3 inhibitor 3PO.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	204-207	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	13-19	
32051533-7	2020	In addition, PFKFB3 expression and aerobic glycolysis were also detected in the mouse model of LPS-induced pulmonary fibrosis, which could be reversed by the intraperitoneal injection of PFKFB3 inhibitor 3PO.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	204-207	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	187-193	
31213542-3	2019	Heterozygous global deficiency of Pfkfb3 protected mice from developing hypoxia-induced PH, and administration of the PFKFB3 inhibitor 3PO almost completely prevented PH in rats treated with Sugen 5416/hypoxia, indicating a causative role of PFKFB3 in the development of PH.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	135-138	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	118-124	
30776389-6	2019	The potent antagonist 3-(3pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) was used to block PFKFB3 activity in vivo (50 mg/kg, i.p.)	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	22-67	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	92-98	
30858427-11	2019	Consistent with a key role for PFKFB3 is the finding that the PFKFB3 inhibitor, 3PO, attenuated the LPS + Abeta-induced glycolysis.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	80-83	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	62-68	
22591674-4	2012	A small molecule antagonist of PFKFB3, 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO), recently has been shown to reduce F2,6BP synthesis, glucose uptake and proliferation in transformed cells.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	39-85	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	31-37	
22591674-10	2012	We then found that exposure to the PFKFB3 small molecule antagonist, 3PO (1-10 muM), markedly attenuated the stimulation of F2,6BP synthesis, 2-[1-14C]-deoxy-D-glucose uptake, lactate secretion, TNF-alpha secretion and T cell aggregation and proliferation.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	69-72	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	35-41