PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9603262-8 1998 This study demonstrates that IL-6 does not play a role in regulating ovulation induced by LH in vitro but is capable of reducing LH/IL-1beta-enhanced ovulation rates. Luteinizing Hormone 129-131 interleukin 1 beta Rattus norvegicus 132-140 21153236-5 1995 LH and cytokine coincubations over 14h revealed that IL-1beta dosedependently inhibited the LH-induced increase in PA activity, up to 85%. Luteinizing Hormone 0-2 interleukin 1 beta Rattus norvegicus 53-61 21153236-9 1995 This study, shows that the earlier reported pro-ovulatory action of IL-1beta is not likely to be mediated by activation of the PA-system and suggests that IL-1beta may mediate a regulatory loop controlling the extent and distribution of LH-induced PA activity in rat preovulatory follicles. Luteinizing Hormone 237-239 interleukin 1 beta Rattus norvegicus 68-76 21153236-9 1995 This study, shows that the earlier reported pro-ovulatory action of IL-1beta is not likely to be mediated by activation of the PA-system and suggests that IL-1beta may mediate a regulatory loop controlling the extent and distribution of LH-induced PA activity in rat preovulatory follicles. Luteinizing Hormone 237-239 interleukin 1 beta Rattus norvegicus 155-163 9048602-1 1997 The intracerebroventricular (icv) injection of the proinflammatory cytokine interleukin (IL)-1 beta is known to significantly decrease plasma LH levels in the male rat, thereby lowering testosterone (T) secretion. Luteinizing Hormone 142-144 interleukin 1 beta Rattus norvegicus 76-99 8756547-2 1996 The purpose of this experiment was to determine whether interleukin-1 beta (IL-1 beta), a known modulator of MMPI expression in other systems and one that is induced by LH in the ovary, is capable of regulating granulosa matrix metalloproteinase inhibitor expression and activity. Luteinizing Hormone 169-171 interleukin 1 beta Rattus norvegicus 56-74 8756547-2 1996 The purpose of this experiment was to determine whether interleukin-1 beta (IL-1 beta), a known modulator of MMPI expression in other systems and one that is induced by LH in the ovary, is capable of regulating granulosa matrix metalloproteinase inhibitor expression and activity. Luteinizing Hormone 169-171 interleukin 1 beta Rattus norvegicus 76-85 8963751-13 1995 IL-1 beta administration caused the expected decrease in LH and testosterone levels, but was also accompanied by a loss of testicular responsiveness to gonadotropins. Luteinizing Hormone 57-59 interleukin 1 beta Rattus norvegicus 0-9 21153236-8 1995 In summary, IL-1beta dose-dependently inhibits the LH-induced increase in PA activity in rat preovulatory folliclesin vitro while, as with TNFalpha, increasing P and PGE synthesis. Luteinizing Hormone 51-53 interleukin 1 beta Rattus norvegicus 12-20 8401568-1 1993 Intracerebroventricular (icv) infusion of interleukin-1 beta (IL-1 beta) significantly lowers plasma LH levels in castrated male rats, and interferes with LHRH release into the median eminence of proestrus female rats. Luteinizing Hormone 101-103 interleukin 1 beta Rattus norvegicus 42-60 8243260-9 1993 When compared to animals treated with the vehicle, rats infused with IL-1 beta showed a significant decrease in circulating LH concentrations, which was accompanied by lowered mRNA levels in the pituitary. Luteinizing Hormone 124-126 interleukin 1 beta Rattus norvegicus 69-78 8243261-3 1993 The acute administration of interleukin-1 beta (IL-1 beta) into the brain ventricles of rats has been shown to cause a significant decrease in plasma LH levels, a phenomenon primarily mediated through inhibition of LHRH release. Luteinizing Hormone 150-152 interleukin 1 beta Rattus norvegicus 28-46 8243261-3 1993 The acute administration of interleukin-1 beta (IL-1 beta) into the brain ventricles of rats has been shown to cause a significant decrease in plasma LH levels, a phenomenon primarily mediated through inhibition of LHRH release. Luteinizing Hormone 150-152 interleukin 1 beta Rattus norvegicus 48-57 7827626-0 1994 The hypothalamic peptides, beta-endorphin, neuropeptide K and interleukin-1 beta, and the opiate morphine, enhance the excitatory amino acid-induced LH release under the influence of gonadal steroids. Luteinizing Hormone 149-151 interleukin 1 beta Rattus norvegicus 62-80 8401568-0 1993 Centrally injected interleukin-1 beta inhibits the hypothalamic LHRH secretion and circulating LH levels via prostaglandins in rats. Luteinizing Hormone 64-66 interleukin 1 beta Rattus norvegicus 19-37 8319564-3 1993 The aim of this study was to test the hypothesis that inhibition of LH release by an opioid [beta-endorphin (beta END)], cytokine [interleukin-1 beta (IL-1 beta)], or tachykinin [neuropeptide-K (NPK)] is a result of diminished excitatory amino acid (EAA) signaling. Luteinizing Hormone 68-70 interleukin 1 beta Rattus norvegicus 151-160 8401568-1 1993 Intracerebroventricular (icv) infusion of interleukin-1 beta (IL-1 beta) significantly lowers plasma LH levels in castrated male rats, and interferes with LHRH release into the median eminence of proestrus female rats. Luteinizing Hormone 101-103 interleukin 1 beta Rattus norvegicus 62-71 8348296-8 1993 In contrast, 50 ng IL-1 beta was less effective (P < 0.05) when administered at 08.30 h, and totally without effect when infused at 14.30 h. Infusion of 50 ng IL-1 beta also markedly suppressed the hypothalamic release of LH-RH in proestrus rats bearing a push-pull cannula into the ME, and significantly decreased plasma LH levels in both gonadectomized male and female rats. Luteinizing Hormone 225-227 interleukin 1 beta Rattus norvegicus 162-171 8348296-8 1993 In contrast, 50 ng IL-1 beta was less effective (P < 0.05) when administered at 08.30 h, and totally without effect when infused at 14.30 h. Infusion of 50 ng IL-1 beta also markedly suppressed the hypothalamic release of LH-RH in proestrus rats bearing a push-pull cannula into the ME, and significantly decreased plasma LH levels in both gonadectomized male and female rats. Luteinizing Hormone 225-227 interleukin 1 beta Rattus norvegicus 19-28 8348296-10 1993 These results provide the first direct evidence that IL-1 beta is a potent inhibitor of LH-RH neuronal activity during the proestrus LH surge in intact cycling rats. Luteinizing Hormone 88-90 interleukin 1 beta Rattus norvegicus 53-62 1327201-3 1992 By using cultured porcine Leydig cells as a model, we found that IL-1 alpha (and to a lesser extent IL-1 beta), contrary to previous reports, is a potent inhibitor of LH/hCG steroidogenic action; and we further localized the steroidogenic biochemical step(s) affected by IL-1 alpha. Luteinizing Hormone 167-169 interleukin 1 beta Rattus norvegicus 100-109 8392427-4 1993 administration of IL-1 alpha or IL-1 beta suppressed LH release, but IL-1 beta was relatively more effective than IL-1 alpha in terms of the onset (IL-1 beta = 30 min; IL-1 alpha = 105 min) as well as the magnitude and duration of LH suppression. Luteinizing Hormone 53-55 interleukin 1 beta Rattus norvegicus 32-41 1907704-1 1991 Interleukin-1 beta (IL-1 beta) at doses of 0.15 and 1.5 nM significantly inhibited FSH secretion and stimulated LH secretion by cultured rat pituitary cells after 24-72 hr incubation whereas 15 pM of IL-1 beta was not effective. Luteinizing Hormone 112-114 interleukin 1 beta Rattus norvegicus 0-18 1597143-2 1992 In orchiectomized rats, recombinant rat IL-1 alpha and IL-1 beta administered into the lateral ventricles almost equipotently suppressed plasma LH levels. Luteinizing Hormone 144-146 interleukin 1 beta Rattus norvegicus 55-64 1597143-7 1992 IL-1ra (10 micrograms) completely blocked LH suppression induced by 1 microgram IL-1 beta, but did not completely reverse the changes of LH induced by 5 micrograms LPS. Luteinizing Hormone 42-44 interleukin 1 beta Rattus norvegicus 80-89 1907704-1 1991 Interleukin-1 beta (IL-1 beta) at doses of 0.15 and 1.5 nM significantly inhibited FSH secretion and stimulated LH secretion by cultured rat pituitary cells after 24-72 hr incubation whereas 15 pM of IL-1 beta was not effective. Luteinizing Hormone 112-114 interleukin 1 beta Rattus norvegicus 20-29 1907704-3 1991 However, treatment with 0.15 and 1.5 nM of IL-1 beta for 72 hr significantly suppressed intracellular content of FSH whereas various doses of IL-1 beta incubated with the cells for 12-72 hr showed no effect on the intracellular content of LH. Luteinizing Hormone 239-241 interleukin 1 beta Rattus norvegicus 43-52 2226323-11 1990 These results suggest that IL-1 alpha and IL-1 beta inhibit LHRH-LH release by stimulating the activity of hypothalamic endogenous opioid peptide systems. Luteinizing Hormone 60-62 interleukin 1 beta Rattus norvegicus 42-51 2115435-7 1990 In gonadectomized animals, 2.5 and 10 ng Il-1 beta administered icv significantly (P less than or equal to 0.01) decreased plasma LH levels for 6 h, while the effect of 40 ng lasted up to 12 h. By contrast, FSH secretion was only measurably altered by 40 ng Il-1 beta 8 and 12 h posttreatment. Luteinizing Hormone 130-132 interleukin 1 beta Rattus norvegicus 41-50 12183018-5 2002 Norepinephrine release in the MPA of control rats increased significantly at 1530, 1600, and 1630 h paralelling an increase in LH at 1600 h. In contrast, IL-1beta treatment blocked the LH surge and the rise in norepinephrine release in the MPA. Luteinizing Hormone 127-129 interleukin 1 beta Rattus norvegicus 154-162 3260876-3 1988 In the presence of maximally effective concentrations of LH, on the contrary, interleukin-1 beta inhibits C19-steroid production by provoking a block at the level of the 17,20-desmolase. Luteinizing Hormone 57-59 interleukin 1 beta Rattus norvegicus 78-96