PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22520752-4	2012	Our selection for prevention of acetylcholinesterase inhibition also resulted in the complete reversion of PON1"s stereospecificity, from an enantiomeric ratio (E) < 6.3 x 10(-4) in favor of the R(P) isomer of a cyclosarin analog in wild-type PON1, to E > 2,500 for the S(P) isomer in an evolved variant.	cyclohexyl methylphosphonofluoridate	215-225	paraoxonase 1	Homo sapiens	107-111	
17129656-2	2007	We have previously identified three key positions in PON1 that affect OP hydrolysis: Leu69, Val346 and His115, that significantly enhance the hydrolysis of cyclosarin (GF), soman, chlorpyrifos-oxon (ChPo), O-isopropyl-O-(p-nitrophenyl)methylphosphonate (IMP-pNP) and diisopropyl fluorophosphate (DFP).	cyclohexyl methylphosphonofluoridate	156-166	paraoxonase 1	Homo sapiens	53-57	
22720164-6	2012	Based on the G2E6 polar mutations, we "humanized" an engineered variant of PON1 with high activity against cyclosarin (GF) and found that it was still very active against GF with much greater similarity to the human sequence.	cyclohexyl methylphosphonofluoridate	107-117	paraoxonase 1	Homo sapiens	75-79	
16640555-2	2006	Mammalian paraoxonase (PON1) was found to be more active than Pseudomonas diminuta OP hydrolase (OPH) and squid O,O-di-isopropyl fluorophosphatase (DFPase) in detoxifying cyclosarin (O-cyclohexyl methylphosphonofluoridate) and soman (O-pinacolyl methylphosphonofluoridate).	cyclohexyl methylphosphonofluoridate	171-181	paraoxonase 1	Homo sapiens	23-27	
16640555-3	2006	Subsequently, nine directly evolved PON1 variants, selected for increased hydrolytic rates with a fluorogenic diethylphosphate ester, were tested for detoxification of cyclosarin, soman, O-isopropyl-O-(p-nitrophenyl) methyl phosphonate (IMP-pNP), DFP, and chlorpyrifos-oxon (ChPo).	cyclohexyl methylphosphonofluoridate	168-178	paraoxonase 1	Homo sapiens	36-40	
16640555-6	2006	Cyclosarin detoxification was approximately 10-fold faster with PON1 mutants V346A and L69V.	cyclohexyl methylphosphonofluoridate	0-10	paraoxonase 1	Homo sapiens	64-68	
16640555-11	2006	GC/pulsed flame photometer detector analysis, compared with assay of residual acetylcholinesterase inhibition, displayed stereoselective hydrolysis of cyclosarin, soman, and IMP-pNP, indicating that PON1 is less active toward the more toxic optical isomers.	cyclohexyl methylphosphonofluoridate	151-161	paraoxonase 1	Homo sapiens	199-203