PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9016940-5	1996	Furthermore, rutaecarpine (40-200 microM) inhibited [3H]inositol monophosphate formation stimulated by collagen and thrombin in [3H]myoinositol-loaded platelets.	Inositol	132-143	coagulation factor II, thrombin	Homo sapiens	116-124	
16793683-5	1998	We conclude that the production of phosphoinositides phosphorylated on the D3 and D5 positions of the inositol ring is restricted to the plasma membrane and that only the enzymes that are present in, or relocated to, the plasma membrane when platelets are activated are stimulated by thrombin.	Inositol	102-110	coagulation factor II, thrombin	Homo sapiens	284-292	
1309423-4	1992	EC significantly blocked the thrombin stimulated breakdown of phosphatidylinositol-4,5-bisphosphate (PIP2) and the production of phosphatidic acid in [32P]orthophosphate-labeled platelets and of inositol trisphosphate in [3H]myoinositol-labeled platelets.	Inositol	225-236	coagulation factor II, thrombin	Homo sapiens	29-37	
1331066-5	1992	In each case, the stimulation of PLD correlated closely with the ability to stimulate inositol phospholipid breakdown and was entirely dependent on the activation of protein kinase C. Moreover, the ability of both thrombin and carbachol to stimulate PLD was found to be rapidly desensitized, with a similar time course of desensitization (t1/2 desensitization, 90 s).	Inositol	86-94	coagulation factor II, thrombin	Homo sapiens	214-222	
1518180-7	1992	Inositol metabolism and Ca mobilization in response to thrombin, STA2, or NaF were also investigated in patient A,B, and impaired aggregation to A23187 in patient C. The responses were normal in patient A, suggested that CO activity did not affect them.	Inositol	0-8	coagulation factor II, thrombin	Homo sapiens	55-63	
1672374-2	1991	Basal and thrombin-induced [3H]inositol monophosphate ([3H]IP1), [3H]inositol bisphosphate ([3H]IP2) and [3H]inositol trisphosphate ([3H]IP3) production were measured in [3H]myoinositol-labeled platelets in the presence of lithium chloride and in the presence or absence of test drugs.	Inositol	174-185	coagulation factor II, thrombin	Homo sapiens	10-18	
3260903-3	1988	In [3H]myoinositol-labeled cells, both thrombin (3 U/ml)- and histamine (10(-4) M)-induced IP3 increases (195% +/- 6% and 98% +/- 4%, respectively) occurred in less than 15 sec and were temporally correlated with [Ca2+]i increases.	Inositol	7-18	coagulation factor II, thrombin	Homo sapiens	39-47	
2495019-9	1989	Thrombin-mediated membrane inositol metabolism and total thrombin binding to endothelium were unaffected by lupus anticoagulant, and another endothelial anticoagulant function related thrombin binding.	Inositol	27-35	coagulation factor II, thrombin	Homo sapiens	0-8	
2846297-4	1988	The thrombin-induced enhancement of inositol phospholipid metabolism was strongly inhibited by the presence of neomycin whereas the TPA- or ionomycin-induced increase in inositol [32P]polyphospholipids remained unaffected.	Inositol	170-180	coagulation factor II, thrombin	Homo sapiens	4-12	
2822018-2	1987	In membranes prepared from WI-38 human lung fibroblasts, thrombin activated an inositol-lipid-specific PLC that hydrolysed [32P]PIP2 and [32P]phosphatidylinositol 4-monophosphate (PIP) to [32P]IP3 and [32P]inositol 1,4-bisphosphate (IP2) respectively.	Inositol	79-87	coagulation factor II, thrombin	Homo sapiens	57-65	
25097470-8	2014	RESULTS: THE FOLLOWING PROFILE OF APL IGG OR IGM WAS OBTAINED FROM PATIENTS WITH LOS: cardiolipin 15/45, phosphatidic acid 41/45, phosphatidyl-choline 0/45, -ethanolamine 6/45, -glycerole 1/45 (patient with Lyme disease), -inositol 7/45, -serine 14/45, annexin V 34/45, beta2GPI 21/45, prothrombin 30/45.	Inositol	223-231	coagulation factor II, thrombin	Homo sapiens	286-297	
3021189-4	1986	Formation of inositol phosphates (IP) was measured in [3H]-inositol labelled platelets after incubation with collagen and thrombin for 30 min, a time at which a maximal increase in [3H]-IP was observed.	Inositol	13-21	coagulation factor II, thrombin	Homo sapiens	122-130	
26869828-4	2015	METHODS: We investigated the Ca(2+)-antagonistic effect of KRG-TS on cyclic nucleotides-associated phosphorylation of inositol 1,4,5-trisphosphate receptor type I (IP3RI) and cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) in thrombin (0.05 U/mL)-stimulated human platelet aggregation.	Inositol	118-126	coagulation factor II, thrombin	Homo sapiens	247-255