PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2173558-1 1990 We report that there are distinct thyrotropin-releasing hormone (TRH)-responsive and -unresponsive pools of inositol (Ins) lipids in rat pituitary tumour (GH3) cells, and present evidence that the size of the responsive pool is determined by the number of activated TRH-receptor complexes. Inositol 108-116 thyrotropin releasing hormone Rattus norvegicus 34-63 7529770-1 1995 In Xenopus oocytes injected with total rat pituitary GH3 cell RNA, thyrotropin-releasing hormone (TRH) causes the activation of the inositol lipid transduction pathway and the induction of chloride conductance via calcium-activated channels (Oron et al., 1987, Mol. Inositol 132-140 thyrotropin releasing hormone Rattus norvegicus 67-96 7529770-1 1995 In Xenopus oocytes injected with total rat pituitary GH3 cell RNA, thyrotropin-releasing hormone (TRH) causes the activation of the inositol lipid transduction pathway and the induction of chloride conductance via calcium-activated channels (Oron et al., 1987, Mol. Inositol 132-140 thyrotropin releasing hormone Rattus norvegicus 98-101 8392378-1 1993 Previous work in [3H]inositol-labelled GH3 pituitary tumor cells stimulated with thyrotropin-releasing hormone (TRH) reported the existence of at least ten distinct [3H]inositol-containing substances which were identified as different inositol mono-, bis- and tris-phosphate isomers [1]. Inositol 21-29 thyrotropin releasing hormone Rattus norvegicus 81-110 8392378-1 1993 Previous work in [3H]inositol-labelled GH3 pituitary tumor cells stimulated with thyrotropin-releasing hormone (TRH) reported the existence of at least ten distinct [3H]inositol-containing substances which were identified as different inositol mono-, bis- and tris-phosphate isomers [1]. Inositol 21-29 thyrotropin releasing hormone Rattus norvegicus 112-115 8392378-1 1993 Previous work in [3H]inositol-labelled GH3 pituitary tumor cells stimulated with thyrotropin-releasing hormone (TRH) reported the existence of at least ten distinct [3H]inositol-containing substances which were identified as different inositol mono-, bis- and tris-phosphate isomers [1]. Inositol 169-177 thyrotropin releasing hormone Rattus norvegicus 81-110 8392378-1 1993 Previous work in [3H]inositol-labelled GH3 pituitary tumor cells stimulated with thyrotropin-releasing hormone (TRH) reported the existence of at least ten distinct [3H]inositol-containing substances which were identified as different inositol mono-, bis- and tris-phosphate isomers [1]. Inositol 169-177 thyrotropin releasing hormone Rattus norvegicus 112-115 2173558-1 1990 We report that there are distinct thyrotropin-releasing hormone (TRH)-responsive and -unresponsive pools of inositol (Ins) lipids in rat pituitary tumour (GH3) cells, and present evidence that the size of the responsive pool is determined by the number of activated TRH-receptor complexes. Inositol 108-116 thyrotropin releasing hormone Rattus norvegicus 65-68 2173558-1 1990 We report that there are distinct thyrotropin-releasing hormone (TRH)-responsive and -unresponsive pools of inositol (Ins) lipids in rat pituitary tumour (GH3) cells, and present evidence that the size of the responsive pool is determined by the number of activated TRH-receptor complexes. Inositol 118-121 thyrotropin releasing hormone Rattus norvegicus 34-63 2173558-1 1990 We report that there are distinct thyrotropin-releasing hormone (TRH)-responsive and -unresponsive pools of inositol (Ins) lipids in rat pituitary tumour (GH3) cells, and present evidence that the size of the responsive pool is determined by the number of activated TRH-receptor complexes. Inositol 118-121 thyrotropin releasing hormone Rattus norvegicus 65-68 2174240-5 1990 The effect of TRH was concentration-dependent; half-maximal stimulation of alpha-MSH release and inositol incorporation occurred at 12 and 28 nmol TRH/l respectively. Inositol 97-105 thyrotropin releasing hormone Rattus norvegicus 14-17 2174240-5 1990 The effect of TRH was concentration-dependent; half-maximal stimulation of alpha-MSH release and inositol incorporation occurred at 12 and 28 nmol TRH/l respectively. Inositol 97-105 thyrotropin releasing hormone Rattus norvegicus 147-150 2112545-1 1990 We have shown that there is an inositol (Ins) lipid pool in cloned rat pituitary tumor (GH3) cells that is hydrolyzed in response to thyrotropin-releasing hormone (TRH) and an unresponsive pool. Inositol 31-39 thyrotropin releasing hormone Rattus norvegicus 133-162 2112545-1 1990 We have shown that there is an inositol (Ins) lipid pool in cloned rat pituitary tumor (GH3) cells that is hydrolyzed in response to thyrotropin-releasing hormone (TRH) and an unresponsive pool. Inositol 41-44 thyrotropin releasing hormone Rattus norvegicus 133-162 6439191-6 1984 Addition of TRH to cells suspended in lithium-containing medium depleted cellular inositol levels by around 65% within 30 min. Inositol 82-90 thyrotropin releasing hormone Rattus norvegicus 12-15 2850246-3 1988 The site of action of GPA is at the TRH-induced hydrolysis of phosphoinositides, since increased amounts of mono, bis and tris/tetrakis inositol phosphates were found in treated cells, while the PRL secretion induced by a phorbol ester or a calcium ionophore, treatments which mimic the second messages generated by inositol phospholipid hydrolysis, were not enhanced by GPA. Inositol 136-144 thyrotropin releasing hormone Rattus norvegicus 36-39 3005271-3 1986 In the present study, thyrotropin-releasing hormone (TRH) stimulation of polyphosphoinositide turnover has been characterized in electrically permeabilized, [3H]myoinositol-labeled GH3 cells. Inositol 161-172 thyrotropin releasing hormone Rattus norvegicus 22-51 3005271-3 1986 In the present study, thyrotropin-releasing hormone (TRH) stimulation of polyphosphoinositide turnover has been characterized in electrically permeabilized, [3H]myoinositol-labeled GH3 cells. Inositol 161-172 thyrotropin releasing hormone Rattus norvegicus 53-56 3035101-0 1987 Thyrotropin-releasing hormone reduces myo-inositol content in rat cerebellum pretreated with lithium. Inositol 38-50 thyrotropin releasing hormone Rattus norvegicus 0-29 3035101-1 1987 The effect of thyrotropin-releasing hormone (TRH) and lithium on myo-inositol metabolism has been assessed in rat cerebral cortex, cerebellar cortex, and sciatic nerves. Inositol 65-77 thyrotropin releasing hormone Rattus norvegicus 14-43 3035101-1 1987 The effect of thyrotropin-releasing hormone (TRH) and lithium on myo-inositol metabolism has been assessed in rat cerebral cortex, cerebellar cortex, and sciatic nerves. Inositol 65-77 thyrotropin releasing hormone Rattus norvegicus 45-48 3035101-4 1987 The myo-inositol level of cerebellar cortex reached its nadir (70% of values in untreated control rats) 30 min after addition of TRH and then returned to the control level at 90 min. Inositol 4-16 thyrotropin releasing hormone Rattus norvegicus 129-132 3035101-5 1987 In cerebral cortex, both lithium alone and lithium plus TRH significantly reduced the myo-inositol level. Inositol 86-98 thyrotropin releasing hormone Rattus norvegicus 56-59 3035101-7 1987 These results suggested that the pharmacological dose of TRH activated phosphatidylinositol turnover in rat cerebellar cortex and subsequently reduced the myo-inositol level in the presence of lithium. Inositol 155-167 thyrotropin releasing hormone Rattus norvegicus 57-60 6321943-0 1984 Thyrotropin-releasing hormone-stimulated [3H]inositol metabolism in GH3 pituitary tumor cells. Inositol 45-53 thyrotropin releasing hormone Rattus norvegicus 0-29 6321943-4 1984 Separation of the [3H]inositol metabolites by ion-exchange chromatography revealed that TRH induced a rapid rise in the cellular content of [3H]inositol mono-, bis-, and trisphosphate. Inositol 22-30 thyrotropin releasing hormone Rattus norvegicus 88-91 26297348-4 2015 Occupation of the Gq protein-coupled TRH receptor in the prolactin-producing lactotroph increases the turnover of inositol, which in turn activates the protein kinase C pathway and the release of Ca(2+) from storage sites. Inositol 114-122 thyrotropin releasing hormone Rattus norvegicus 37-40