PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9370337-15	1997	The upstream regulatory region of the PSS/CHO1 gene responsible for the myo-inositol-choline regulation was identified.	Inositol	72-84	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	42-46	
12950923-6	2003	Surprisingly, expression of genes that are usually derepressed during inositol depletion, including INO1, CHO1 and INO2 (that contain inositol-responsive UASINO sequences) decreased several fold during the first hour, after which expression began to increase.	Inositol	70-78	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	106-110	
12950923-6	2003	Surprisingly, expression of genes that are usually derepressed during inositol depletion, including INO1, CHO1 and INO2 (that contain inositol-responsive UASINO sequences) decreased several fold during the first hour, after which expression began to increase.	Inositol	134-142	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	106-110	
9611229-16	1998	This factor is not functionally identical to Ino2p since other inositol-responsive genes (e.g. CHO1 ) maintain INO2 -dependent expression in nmt1-451D cells.	Inositol	63-71	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	95-99	
7568205-3	1995	However, it was also known that cells which harbor a mutant opi1 allele express constitutively derepressed levels of target genes (INO1 and CHO1), implicating the OPI1 negative regulatory gene in the response to inositol.	Inositol	212-220	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	140-144	
7568205-7	1995	The expression of the INO1 and CHO1 target genes was still responsive to inositol even though expression of the INO2 gene was unresponsive.	Inositol	73-81	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	31-35	
28673963-5	2017	Immunoblot analysis showed that the elevation of PSS activity results from an increase in the level of the enzyme encoded by CHO1 Truncation analysis and site-directed mutagenesis of the CHO1 promoter indicated that Cho1 expression in the pah1Delta mutant is induced through the inositol-sensitive upstream activation sequence (UASINO), a cis-acting element for the phosphatidate-controlled Henry (Ino2-Ino4/Opi1) regulatory circuit.	Inositol	279-287	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	187-191	
28827025-6	2018	The regulation of the CHO1 expression is mediated through the inositol-sensitive upstream activation sequence (UASINO), a cis-acting element for the phosphatidate-controlled Henry (Ino2-Ino4/Opi1) regulatory circuit.	Inositol	62-70	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	22-26	
1313970-1	1992	A 34 base-pair (bp) fragment spanning sequences -154 to -120 of the promoter of the CHO1 gene (structural gene for phosphatidylserine synthase) from the yeast Saccharomyces cerevisiae has been shown to place transcription of a promoter-less Escherichia coli lacZ gene under control of the phospholipid precursors inositol and choline.	Inositol	313-321	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	84-88	
28673963-5	2017	Immunoblot analysis showed that the elevation of PSS activity results from an increase in the level of the enzyme encoded by CHO1 Truncation analysis and site-directed mutagenesis of the CHO1 promoter indicated that Cho1 expression in the pah1Delta mutant is induced through the inositol-sensitive upstream activation sequence (UASINO), a cis-acting element for the phosphatidate-controlled Henry (Ino2-Ino4/Opi1) regulatory circuit.	Inositol	279-287	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	216-220	
16246069-5	2005	The reduction in PS synthase in response to zinc depletion is due to a repression mechanism that involves the UAS(INO) (inositol upstream activating sequence) element in the CHO1 promoter and the negative transcription factor Opi1p.	Inositol	120-128	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	174-178	
19019152-1	2008	In Saccharomyces cerevisiae, transcription of most of the phospholipid biosynthetic genes (e.g. INO1, CHO1, CHO2 and OPI3) is repressed by growth in the presence of inositol and choline and derepressed in their absence.	Inositol	165-173	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	102-106	
16807089-8	2007	In contrast, the negative regulatory protein Opi1p, which is involved in inositol-mediated regulation of phospholipid synthesis, represses the expression of the CHO1 gene through the cis-acting element UAS(INO).	Inositol	73-81	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	161-165	
16246069-6	2005	These factors are also responsible for the inositol-mediated repression of CHO1.	Inositol	43-51	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	75-79