PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9536026-4 1998 Recent studies have provided data in support of a role for protein kinase C and the down-regulation of expression of the myristoylated alanine-rich C kinase substrate (MARCKS) in the long-term therapeutic action of lithium in the brain, which is dependent on both the relative activity of receptor-coupled PI signaling and the concentration of myo-inositol. Inositol 344-356 myristoylated alanine rich protein kinase C substrate Homo sapiens 121-166 9536026-4 1998 Recent studies have provided data in support of a role for protein kinase C and the down-regulation of expression of the myristoylated alanine-rich C kinase substrate (MARCKS) in the long-term therapeutic action of lithium in the brain, which is dependent on both the relative activity of receptor-coupled PI signaling and the concentration of myo-inositol. Inositol 344-356 myristoylated alanine rich protein kinase C substrate Homo sapiens 168-174 9536026-5 1998 Our current results demonstrated that valproate induces a concentration- and time-dependent reduction of MARCKS in immortalized hippocampal cells that appears to be independent of both the level of muscarinic receptor-activated PI signaling as well as the concentration of myo-inositol. Inositol 273-285 myristoylated alanine rich protein kinase C substrate Homo sapiens 105-111